triiodothyronine has been researched along with Generalized Resistance to Thyroid Hormone in 115 studies
Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Iodine deficiency goiter can develop in children on a restrictive diet and most have normal thyroid function." | 8.12 | Thyroid function tests of iodine deficiency goiter can mimic thyroid hormone resistance alpha. ( Quintos, JB; Sasidharan Pillai, S, 2022) |
| " Missense mutations of the TTR gene produce familial amyloidotic polyneuropathy and rarely, euthyroid hyperthyroxinemia (EHT)." | 7.69 | A new family with hyperthyroxinemia caused by transthyretin Val109 misdiagnosed as thyrotoxicosis and resistance to thyroid hormone--a clinical research center study. ( Byrne, MM; Marinov, VS; Refetoff, S; Sunthornthepvarakul, T; Tunca, H; Weiss, RE, 1996) |
| " During pregnancy, mildly elevated maternal free thyroxine levels less than 20% above the upper limit may not be harmful to unaffected fetuses." | 4.98 | Resistance to thyroid hormone β in autoimmune thyroid disease: a case report and review of literature. ( Guan, H; Guo, H; Guo, R; Li, Y; Shan, Z; Wu, D, 2018) |
| "Iodine deficiency goiter can develop in children on a restrictive diet and most have normal thyroid function." | 4.12 | Thyroid function tests of iodine deficiency goiter can mimic thyroid hormone resistance alpha. ( Quintos, JB; Sasidharan Pillai, S, 2022) |
| " Missense mutations of the TTR gene produce familial amyloidotic polyneuropathy and rarely, euthyroid hyperthyroxinemia (EHT)." | 3.69 | A new family with hyperthyroxinemia caused by transthyretin Val109 misdiagnosed as thyrotoxicosis and resistance to thyroid hormone--a clinical research center study. ( Byrne, MM; Marinov, VS; Refetoff, S; Sunthornthepvarakul, T; Tunca, H; Weiss, RE, 1996) |
| "This study investigated the response of TSH secretion to 3,5,3'-triiodothyronine (T3) and 3,5,3'-triiodothyroacetic acid (Triac) in patients with resistance to thyroid hormone, and compared the responses with those in patients with TSH-secreting pituitary adenoma and normal subjects." | 3.69 | Differences in response of thyrotropin to 3,5,3'-triiodothyronine and 3,5,3'-triiodothyroacetic acid in patients with resistance to thyroid hormone. ( Fukata, S; Kuma, K; Ohsawa, N; Sakata, S; Shimizu, N; Takamatsu, J; Tanaka, K; Ueda, S; Yamaji, T, 1996) |
| "Thyroid hormone resistance syndrome is characterized by a reduced target tissue response to the action of thyroid hormone, which leads to high levels of free thyroxine and free triiodothyronine with non-suppressed levels of thyrotropin (TSH)." | 1.39 | Differentiated thyroid carcinoma in a girl with resistance to thyroid hormone management with triiodothyroacetic acid. ( Antonia Pérez-Lázaro, M; Isabel del Olmo-García, M; León-de Zayas, B; Merino-Torres, JF; Moreno-Macián, F; Navas-de Solis, S; Ramos-Prol, A, 2013) |
| "In Patient 1, histology showed a papillary thyroid carcinoma pT2." | 1.37 | Differentiated thyroid cancer in two patients with resistance to thyroid hormone. ( Capoluongo, E; Concolino, P; Corsello, SM; Locantore, P; Lovicu, RM; Paragliola, RM; Pontecorvi, A; Senes, P, 2011) |
| "These results indicated that Graves' disease (GD) caused primary hyperthyroidism." | 1.36 | Clinical features of primary hyperthyroidism caused by Graves' disease admixed with resistance to thyroid hormone (P453T). ( Sato, H, 2010) |
| "We failed to find evidence of generalized resistance to thyroid hormone." | 1.29 | ADHD and thyroid abnormalities: a research note. ( Biederman, J; Guite, J; Harding, M; Spencer, T; Wilens, T, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 36 (31.30) | 18.2507 |
| 2000's | 40 (34.78) | 29.6817 |
| 2010's | 26 (22.61) | 24.3611 |
| 2020's | 13 (11.30) | 2.80 |
| Authors | Studies |
|---|---|
| Li, Q | 1 |
| Yao, B | 2 |
| Zhao, S | 1 |
| Lu, Z | 1 |
| Zhang, Y | 1 |
| Xiang, Q | 1 |
| Wu, X | 1 |
| Yu, H | 1 |
| Zhang, C | 1 |
| Li, J | 1 |
| Zhuang, X | 1 |
| Wu, D | 2 |
| Li, Y | 3 |
| Xu, Y | 1 |
| Goettemoeller, T | 1 |
| McShane, AJ | 1 |
| Rao, P | 1 |
| Santos Mata, MA | 1 |
| Ariza Jimenez, AB | 1 |
| Macias Lopez, F | 1 |
| de la Camara Moraño, C | 1 |
| Xi, Y | 1 |
| Zhang, D | 1 |
| Liang, Y | 1 |
| Shan, Z | 2 |
| Teng, X | 1 |
| Teng, W | 1 |
| Ding, X | 1 |
| Wang, Y | 4 |
| Liu, J | 1 |
| Wang, G | 1 |
| Yang, C | 1 |
| Pan, C | 1 |
| Sasidharan Pillai, S | 1 |
| Quintos, JB | 1 |
| Wang, M | 1 |
| Roggero, VR | 1 |
| Allison, LA | 1 |
| Liu, Y | 3 |
| Ma, M | 3 |
| Li, L | 3 |
| Liu, F | 3 |
| Li, Z | 3 |
| Yu, L | 3 |
| Yang, T | 3 |
| Gao, S | 6 |
| Yang, R | 3 |
| Yu, C | 3 |
| Corica, D | 2 |
| Licenziati, MR | 2 |
| Calcaterra, V | 2 |
| Currò, M | 2 |
| Di Mento, C | 2 |
| Curatola, S | 2 |
| Zuccotti, G | 2 |
| Alibrandi, A | 2 |
| Ientile, R | 2 |
| Aversa, T | 2 |
| Wasniewska, M | 2 |
| Çetin, S | 1 |
| Güven, M | 1 |
| Bolayır, B | 1 |
| Şimşek, M | 1 |
| Soylu, H | 1 |
| Geneş, D | 1 |
| Ay, N | 1 |
| Diri, H | 1 |
| Fujisawa, H | 1 |
| Gagné, J | 1 |
| Dumitrescu, AM | 3 |
| Refetoff, S | 14 |
| Dieu, X | 1 |
| Sueur, G | 1 |
| Moal, V | 1 |
| Boux de Casson, F | 1 |
| Bouzamondo, N | 1 |
| Bouhours, N | 1 |
| Briet, C | 2 |
| Illouz, F | 2 |
| Reynier, P | 1 |
| Coutant, R | 1 |
| Rodien, P | 3 |
| Mirebeau-Prunier, D | 2 |
| Visser, WE | 3 |
| le Maire, A | 1 |
| Bouhours-Nouet, N | 1 |
| Soamalala, J | 1 |
| Paloni, M | 1 |
| Guee, L | 1 |
| Heron, D | 1 |
| Mignot, C | 1 |
| Joubert, F | 1 |
| Bourguet, W | 1 |
| Flamant, F | 2 |
| Guyot, R | 1 |
| Ramos, LS | 1 |
| Kizys, MML | 1 |
| Kunii, IS | 1 |
| Spinola-Castro, AM | 1 |
| Nesi-França, S | 1 |
| Guerra, RA | 1 |
| Camacho, CP | 1 |
| Martins, JRM | 1 |
| Maciel, RMB | 1 |
| Dias-da-Silva, MR | 1 |
| Chiamolera, MI | 2 |
| Guo, R | 1 |
| Guo, H | 1 |
| Guan, H | 1 |
| Wejaphikul, K | 1 |
| Groeneweg, S | 2 |
| Hilhorst-Hofstee, Y | 1 |
| Chatterjee, VK | 8 |
| Peeters, RP | 2 |
| Meima, ME | 1 |
| Ramos-Prol, A | 1 |
| Antonia Pérez-Lázaro, M | 1 |
| Isabel del Olmo-García, M | 1 |
| León-de Zayas, B | 1 |
| Moreno-Macián, F | 1 |
| Navas-de Solis, S | 1 |
| Merino-Torres, JF | 1 |
| Roelfsema, F | 1 |
| Veldhuis, JD | 1 |
| Vella, KR | 1 |
| Ramadoss, P | 1 |
| Costa-E-Sousa, RH | 1 |
| Astapova, I | 1 |
| Ye, FD | 1 |
| Holtz, KA | 1 |
| Harris, JC | 1 |
| Hollenberg, AN | 2 |
| Tsunekawa, K | 1 |
| Murakami, M | 1 |
| Jiskra, J | 1 |
| Límanová, Z | 1 |
| Cardoso, LF | 1 |
| Maciel, LM | 1 |
| Paula, FJ | 1 |
| Krude, H | 1 |
| Kühnen, P | 1 |
| Biebermann, H | 1 |
| Vlaeminck-Guillem, V | 2 |
| Espiard, S | 1 |
| Wémeau, JL | 3 |
| Ma, S | 1 |
| Hu, M | 1 |
| Yang, H | 1 |
| Lian, X | 1 |
| Jiang, Y | 1 |
| Maruo, Y | 1 |
| Mori, A | 1 |
| Morioka, Y | 1 |
| Sawai, C | 1 |
| Mimura, Y | 1 |
| Matui, K | 1 |
| Takeuchi, Y | 1 |
| Visser, TJ | 2 |
| Jimenez, R | 1 |
| Privalsky, ML | 2 |
| Schweizer, U | 1 |
| Weitzel, JM | 1 |
| Schomburg, L | 2 |
| Burman, KD | 1 |
| Owen, PJ | 1 |
| John, R | 1 |
| Halsall, D | 1 |
| Lazarus, JH | 1 |
| Asadi, AB | 1 |
| Torjesen, PA | 1 |
| Haug, E | 1 |
| Berg, JP | 1 |
| Machado, DS | 1 |
| Sabet, A | 1 |
| Santiago, LA | 1 |
| Sidhaye, AR | 1 |
| Ortiga-Carvalho, TM | 2 |
| Wondisford, FE | 6 |
| Rodrigues Dare, GL | 1 |
| Ribeiro Magalhaes, PK | 1 |
| de Castro, M | 1 |
| Zanini Maciel, LM | 1 |
| Webb, P | 1 |
| Guran, T | 1 |
| Turan, S | 1 |
| Bircan, R | 1 |
| Bereket, A | 1 |
| Sato, H | 1 |
| Weiss, RE | 11 |
| Dumitrescu, A | 1 |
| Moeller, LC | 2 |
| Haselhorst, NE | 1 |
| Cao, X | 1 |
| Seo, H | 3 |
| Mann, K | 2 |
| Janssen, OE | 1 |
| Kersseboom, S | 1 |
| Filho, HC | 1 |
| Marui, S | 1 |
| Manna, TD | 1 |
| Brust, ES | 1 |
| Radonsky, V | 1 |
| Kuperman, H | 1 |
| Dichtchekenian, V | 1 |
| Setian, N | 1 |
| Damiani, D | 1 |
| Paragliola, RM | 1 |
| Lovicu, RM | 1 |
| Locantore, P | 1 |
| Senes, P | 1 |
| Concolino, P | 1 |
| Capoluongo, E | 1 |
| Pontecorvi, A | 1 |
| Corsello, SM | 1 |
| Mittag, J | 1 |
| Behrends, T | 1 |
| Nordström, K | 1 |
| Anselmo, J | 1 |
| Vennström, B | 1 |
| Anzai, R | 1 |
| Adachi, M | 1 |
| Sho, N | 1 |
| Muroya, K | 1 |
| Asakura, Y | 1 |
| Onigata, K | 3 |
| Beato-Víbora, P | 1 |
| Arroyo-Díez, J | 1 |
| Rodríguez-López, R | 1 |
| Huber, BR | 1 |
| Sandler, B | 1 |
| West, BL | 2 |
| Cunha Lima, ST | 1 |
| Nguyen, HT | 1 |
| Apriletti, JW | 1 |
| Baxter, JD | 1 |
| Fletterick, RJ | 2 |
| Sadow, PM | 2 |
| Koo, E | 1 |
| Chassande, O | 1 |
| Gauthier, K | 1 |
| Samarut, J | 1 |
| Xu, J | 1 |
| O'Malley, BW | 1 |
| Murata, Y | 1 |
| Suzuki, H | 3 |
| Zhang, XY | 1 |
| Forrest, D | 4 |
| Willingham, MC | 1 |
| Cheng, SY | 5 |
| Nakano, K | 1 |
| Matsushita, A | 1 |
| Sasaki, S | 2 |
| Misawa, H | 1 |
| Nishiyama, K | 2 |
| Kashiwabara, Y | 1 |
| Nakamura, H | 3 |
| Hashimoto, K | 3 |
| Pazos-Moura, CC | 1 |
| Geenen, D | 1 |
| Cohen, R | 1 |
| Lang, RM | 1 |
| Bayer, Y | 1 |
| Fasshauer, M | 1 |
| Paschke, R | 1 |
| Miller, LD | 1 |
| McPhie, P | 1 |
| Kato, Y | 1 |
| Liu, ET | 1 |
| Ishii, S | 1 |
| Yamada, M | 2 |
| Satoh, T | 1 |
| Monden, T | 1 |
| Shibusawa, N | 1 |
| Morikawa, A | 2 |
| Mori, M | 1 |
| Romeo, S | 1 |
| Menzaghi, C | 2 |
| Bruno, R | 1 |
| Sentinelli, F | 1 |
| Fallarino, M | 1 |
| Fioretti, F | 1 |
| Filetti, S | 1 |
| Balsamo, A | 2 |
| Di Mario, U | 1 |
| Baroni, MG | 1 |
| Mannavola, D | 4 |
| Beck-Peccoz, P | 5 |
| Persani, L | 4 |
| Kong, AP | 1 |
| Lam, CW | 1 |
| Chan, AO | 1 |
| Yiu, SF | 1 |
| Tiu, SC | 1 |
| Wu, SY | 1 |
| Ercan, O | 1 |
| Roberts, MR | 1 |
| Srinivas, M | 1 |
| Morreale de Escobar, G | 1 |
| Reh, TA | 1 |
| Krysiak, R | 1 |
| Okopień, B | 1 |
| Herman, ZS | 1 |
| Mamanasiri, S | 1 |
| Yesil, S | 1 |
| Liao, XH | 1 |
| Demir, T | 1 |
| Tonacchera, M | 1 |
| Di Cosmo, C | 1 |
| De Marco, G | 1 |
| Agretti, P | 1 |
| Banco, M | 1 |
| Perri, A | 1 |
| Gianetti, E | 1 |
| Montanelli, L | 1 |
| Vitti, P | 1 |
| Pinchera, A | 3 |
| Fardella, CE | 1 |
| Artigas, RA | 1 |
| Gloger, S | 1 |
| Jiménez, M | 1 |
| Carvajal, CA | 1 |
| Krall, PM | 1 |
| Quiroz, D | 1 |
| Campino, C | 1 |
| Mosso, LM | 1 |
| Hamon, B | 1 |
| Hamon, P | 1 |
| Bovier-Lapierre, M | 1 |
| Pugeat, M | 1 |
| Savagner, F | 1 |
| Orgiazzi, J | 1 |
| Spencer, T | 1 |
| Biederman, J | 1 |
| Wilens, T | 1 |
| Guite, J | 1 |
| Harding, M | 1 |
| Hayashi, Y | 3 |
| Sarne, DH | 1 |
| Yen, PM | 4 |
| Sunthornthepvarakul, T | 2 |
| Marcocci, C | 1 |
| Chin, WW | 1 |
| Meier-Heusler, SC | 1 |
| Zhu, X | 1 |
| Juge-Aubry, C | 1 |
| Pernin, A | 1 |
| Burger, AG | 1 |
| Meier, CA | 1 |
| Wing, JR | 1 |
| Sarne, D | 1 |
| Chyna, B | 1 |
| Wong, R | 1 |
| Zhu, XG | 1 |
| Pineda, MA | 1 |
| Weintraub, BD | 1 |
| Yagi, H | 2 |
| Sakurai, A | 2 |
| Nagashima, T | 1 |
| Nomura, Y | 1 |
| Nagashima, K | 1 |
| Hashizume, K | 1 |
| Hanebuth, E | 1 |
| Smeyne, RJ | 1 |
| Everds, N | 1 |
| Stewart, CL | 1 |
| Wehner, JM | 1 |
| Curran, T | 1 |
| Marinov, VS | 1 |
| Tunca, H | 1 |
| Byrne, MM | 1 |
| Yang, YZ | 1 |
| Burgos-Trinidad, M | 1 |
| Wu, Y | 1 |
| Koenig, RJ | 1 |
| Behr, M | 1 |
| Loos, U | 1 |
| Ueda, S | 1 |
| Takamatsu, J | 2 |
| Fukata, S | 1 |
| Tanaka, K | 1 |
| Shimizu, N | 1 |
| Sakata, S | 1 |
| Yamaji, T | 1 |
| Kuma, K | 1 |
| Ohsawa, N | 2 |
| Ghazi, AA | 1 |
| Akiyoshi, F | 1 |
| Okamura, K | 1 |
| Fujikawa, M | 1 |
| Sato, K | 1 |
| Yoshinari, M | 1 |
| Mizokami, T | 1 |
| Hattori, K | 1 |
| Kuwayama, A | 1 |
| Takahashi, Y | 1 |
| Fujishima, M | 1 |
| Ito, M | 1 |
| Yamano, Y | 1 |
| Fukao, T | 1 |
| Sakane, S | 1 |
| Yoh, SM | 1 |
| Pohlenz, J | 3 |
| Stein, MA | 1 |
| Radetti, G | 1 |
| Molinaro, G | 1 |
| Cortelazzi, D | 2 |
| Reinhardt, W | 1 |
| Jockenhövel, F | 1 |
| Deuble, J | 1 |
| Reinwein, D | 1 |
| Miyoshi, Y | 1 |
| Tagami, T | 2 |
| Dorin, RI | 1 |
| Taniyama, M | 1 |
| Nakao, K | 1 |
| Clifton-Bligh, RJ | 2 |
| de Zegher, F | 1 |
| Wagner, RL | 1 |
| Collingwood, TN | 2 |
| Francois, I | 1 |
| Van Helvoirt, M | 1 |
| Macchia, E | 2 |
| Agostini, M | 2 |
| Sarkissian, G | 3 |
| Giorgilli, G | 1 |
| Canale, D | 1 |
| Scartabelli, G | 1 |
| Margotat, A | 4 |
| Torresani, J | 4 |
| Andoh, S | 1 |
| Kitahara, A | 1 |
| Natsume, H | 1 |
| Mikami, T | 1 |
| Genma, R | 1 |
| Safer, JD | 3 |
| Cohen, RN | 1 |
| Gu, WX | 2 |
| Peairs, PT | 1 |
| Jameson, JL | 2 |
| Abel, ED | 1 |
| Kaulbach, HC | 1 |
| Campos-Barros, A | 1 |
| Ahima, RS | 1 |
| Boers, ME | 1 |
| Asteria, C | 1 |
| Rajanayagam, O | 2 |
| Romoli, R | 1 |
| Zamperini, P | 1 |
| Buzi, F | 1 |
| Ciralli, F | 1 |
| Di Paola, R | 1 |
| Gallone, G | 1 |
| Rossi, C | 1 |
| Tassi, V | 1 |
| Fonzo, D | 1 |
| De Filippis, V | 1 |
| Dace, A | 1 |
| Mesmacque, A | 1 |
| Bony-Trifunovic, H | 1 |
| Malezet-Desmoulins, C | 2 |
| Zargar, AH | 1 |
| Laway, BA | 1 |
| Masoodi, SR | 1 |
| Wani, MM | 1 |
| Bashir, MI | 1 |
| Wani, AI | 1 |
| Salahuddin, M | 1 |
| Nagaya, T | 1 |
| Benvenga, S | 1 |
| Robbins, J | 1 |
| O'Connor, MG | 1 |
| Colan, SD | 2 |
| Srinivasan, S | 1 |
| Tollin, SR | 1 |
| Schönberger, W | 1 |
| Koffler, T | 1 |
| Macchia, PE | 1 |
| Pannain, S | 1 |
| Lau, IT | 1 |
| Ho, H | 1 |
| Gurnell, M | 1 |
| Wang, T | 1 |
| Zelissen, PM | 1 |
| van der Horst, F | 1 |
| van de Wiel, A | 1 |
| Schwabe, JW | 1 |
| D'herbomez, M | 1 |
| Decoulx, M | 1 |
| Furlanetto, TW | 1 |
| Kopp, P | 1 |
| Peccin, S | 1 |
| Fraser, LM | 1 |
| Peyrol, N | 1 |
| Vlaeminck Guillem, V | 1 |
| Ciulla, MM | 1 |
| Paliotti, R | 1 |
| Tortora, G | 1 |
| Barelli, MV | 1 |
| Buonamici, V | 1 |
| Magrini, F | 1 |
| Phillips, SA | 1 |
| Rotman-Pikielny, P | 1 |
| Lazar, J | 1 |
| Ando, S | 3 |
| Hauser, P | 1 |
| Skarulis, MC | 2 |
| Brucker-Davis, F | 1 |
| Sarlis, NJ | 2 |
| Oldfield, EH | 1 |
| Schneider, MJ | 1 |
| Fiering, SN | 1 |
| Pallud, SE | 1 |
| Parlow, AF | 1 |
| St Germain, DL | 1 |
| Galton, VA | 1 |
| Parikh, S | 1 |
| Schneider, A | 1 |
| Vannucchi, G | 1 |
| Fugazzola, L | 1 |
| Cerutti, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| NOMOTHETICOS: Nonlinear Modelling of Thyroid Hormones' Effect on Thyrotropin Incretion in Confirmed Open-loop Situation. A Correlation Study[NCT01145040] | 138 participants (Actual) | Observational | 2010-06-01 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
15 reviews available for triiodothyronine and Generalized Resistance to Thyroid Hormone
| Article | Year |
|---|---|
Thyroid hormone resistance: Mechanisms and therapeutic development.
Topics: Humans; Mutation; Receptors, Thyroid Hormone; Thyroid Hormone Receptors alpha; Thyroid Hormone Recep | 2022 |
Therapeutic applications of thyroid hormone analogues.
Topics: Animals; Humans; Monocarboxylic Acid Transporters; Mutation; Symporters; Thyroid Diseases; Thyroid H | 2021 |
Resistance to thyroid hormone β in autoimmune thyroid disease: a case report and review of literature.
Topics: Adult; Diabetes Mellitus, Type 2; Female; Hashimoto Disease; Humans; Hypothyroidism; Mutation; Postp | 2018 |
Thyrotropin secretion patterns in health and disease.
Topics: Adult; Animals; Circadian Rhythm; Female; Health Status; Humans; Hypothalamo-Hypophyseal System; Hyp | 2013 |
[Thyroid disease caused by receptor abnormality].
Topics: Biomarkers; Humans; Hyperpituitarism; Hypothyroidism; Molecular Diagnostic Techniques; Mutation; Thy | 2014 |
The multiple effects of thyroid disorders on bone and mineral metabolism.
Topics: Animals; Bone and Bones; Calcification, Physiologic; Calcium; Databases, Bibliographic; Epiphyses; H | 2014 |
Treatment of congenital thyroid dysfunction: Achievements and challenges.
Topics: Congenital Hypothyroidism; Hormone Replacement Therapy; Humans; Hydrolases; Infant, Newborn; Iodide | 2015 |
TRα receptor mutations extend the spectrum of syndromes of reduced sensitivity to thyroid hormone.
Topics: Abnormalities, Multiple; Adolescent; Adult; Age of Onset; Bradycardia; Child; Codon, Nonsense; Dwarf | 2015 |
Therapeutic applications of thyroid hormone analogues in resistance to thyroid hormone (RTH) syndromes.
Topics: Biomimetic Materials; Female; Humans; Male; Monocarboxylic Acid Transporters; Mutation; Signal Trans | 2017 |
Think globally: act locally. New insights into the local regulation of thyroid hormone availability challenge long accepted dogmas.
Topics: Animals; Biological Transport; Brain; Humans; Iodide Peroxidase; Mice; Mice, Knockout; Mice, Transge | 2008 |
Long-term 3,5,3'-triiodothyroacetic acid therapy in a child with hyperthyroidism caused by thyroid hormone resistance: pharmacological study and therapeutic recommendations.
Topics: Adolescent; Adult; Atrial Premature Complexes; Attention Deficit Disorder with Hyperactivity; Child; | 2012 |
Thyroid Hormone Resistance in children.
Topics: Biomarkers; Child; Dextrothyroxine; Humans; Mutation; Risk Factors; Thyroid Hormone Receptors beta; | 2003 |
[Thyroid hormone resistance syndrome].
Topics: Diagnosis, Differential; Humans; Thyroid Hormone Resistance Syndrome; Thyrotropin; Thyroxine; Triiod | 2006 |
[Resistance to thyroid hormone].
Topics: Biomarkers; Diagnosis, Differential; Humans; Mutation; Thyroid Hormone Receptors beta; Thyroid Hormo | 2006 |
Molecular basis of resistance to thyroid hormone (RTH).
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Cell Nucleus; Dimerization; Dise | 1998 |
4 trials available for triiodothyronine and Generalized Resistance to Thyroid Hormone
| Article | Year |
|---|---|
Can a novel drug dose be used for T3 suppression test?
Topics: Humans; Prospective Studies; Tachycardia; Thyroid Hormone Resistance Syndrome; Thyrotropin; Thyroxin | 2023 |
Resistance to thyroid hormone in subjects from two unrelated families is associated with a point mutation in the thyroid hormone receptor beta gene resulting in the replacement of the normal proline 453 with serine.
Topics: Adult; Base Sequence; DNA; Genotype; Humans; Male; Molecular Sequence Data; Pedigree; Phenotype; Poi | 1994 |
Behavioral effects of liothyronine (L-T3) in children with attention deficit hyperactivity disorder in the presence and absence of resistance to thyroid hormone.
Topics: Attention Deficit Disorder with Hyperactivity; Behavior; Child; Cross-Over Studies; Double-Blind Met | 1997 |
Somatic mutation of TRbeta can cause a defect in negative regulation of TSH in a TSH-secreting pituitary tumor.
Topics: Adult; Aged; Cells, Cultured; DNA; DNA Mutational Analysis; Female; Genetic Vectors; Humans; Male; M | 2001 |
96 other studies available for triiodothyronine and Generalized Resistance to Thyroid Hormone
| Article | Year |
|---|---|
Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor β Agonist.
Topics: Humans; Mutation; Thyroid Hormone Receptors beta; Thyroid Hormone Resistance Syndrome; Thyroid Hormo | 2022 |
Misleading FT4 and FT3 Due to Immunoassay Interference From Autoantibodies.
Topics: Aged; Autoantibodies; Diagnostic Errors; Female; Humans; Immunoassay; Pituitary Neoplasms; Thyroid F | 2022 |
Thyroid Hormone Resistance: Multicentrical Case Series Study.
Topics: Adolescent; Adult; Child; Child, Preschool; Cross-Sectional Studies; Humans; Infant; Infant, Newborn | 2022 |
Proteomic Analysis of the Intestinal Resistance to Thyroid Hormone Mouse Model With Thyroid Hormone Receptor Alpha Mutations.
Topics: Animals; Disease Models, Animal; Humans; Intestines; Mice; Mutation; Proteomics; Receptors, Thyroid | 2022 |
Impaired Sensitivity to Thyroid Hormones Is Associated With Elevated Homocysteine Levels in the Euthyroid Population.
Topics: Adult; Congenital Hypothyroidism; Homocysteine; Humans; Receptors, Thyrotropin; Thyroid Function Tes | 2022 |
Thyroid function tests of iodine deficiency goiter can mimic thyroid hormone resistance alpha.
Topics: Child; Female; Goiter; Goiter, Endemic; Humans; Hypothyroidism; Iodine; Malnutrition; Thyroglobulin; | 2022 |
Mediator subunit MED1 differentially modulates mutant thyroid hormone receptor intracellular dynamics in Resistance to Thyroid Hormone syndrome.
Topics: Cell Nucleus; Humans; Mediator Complex Subunit 1; Mutation; Receptors, Thyroid Hormone; Thyroid Horm | 2023 |
Association between sensitivity to thyroid hormones and dyslipidemia in patients with coronary heart disease.
Topics: Coronary Disease; Dyslipidemias; Glucose; Humans; Retrospective Studies; Thyroid Hormone Resistance | 2023 |
Association between sensitivity to thyroid hormones and dyslipidemia in patients with coronary heart disease.
Topics: Coronary Disease; Dyslipidemias; Glucose; Humans; Retrospective Studies; Thyroid Hormone Resistance | 2023 |
Association between sensitivity to thyroid hormones and dyslipidemia in patients with coronary heart disease.
Topics: Coronary Disease; Dyslipidemias; Glucose; Humans; Retrospective Studies; Thyroid Hormone Resistance | 2023 |
Association between sensitivity to thyroid hormones and dyslipidemia in patients with coronary heart disease.
Topics: Coronary Disease; Dyslipidemias; Glucose; Humans; Retrospective Studies; Thyroid Hormone Resistance | 2023 |
Association between sensitivity to thyroid hormones and dyslipidemia in patients with coronary heart disease.
Topics: Coronary Disease; Dyslipidemias; Glucose; Humans; Retrospective Studies; Thyroid Hormone Resistance | 2023 |
Association between sensitivity to thyroid hormones and dyslipidemia in patients with coronary heart disease.
Topics: Coronary Disease; Dyslipidemias; Glucose; Humans; Retrospective Studies; Thyroid Hormone Resistance | 2023 |
Association between sensitivity to thyroid hormones and dyslipidemia in patients with coronary heart disease.
Topics: Coronary Disease; Dyslipidemias; Glucose; Humans; Retrospective Studies; Thyroid Hormone Resistance | 2023 |
Association between sensitivity to thyroid hormones and dyslipidemia in patients with coronary heart disease.
Topics: Coronary Disease; Dyslipidemias; Glucose; Humans; Retrospective Studies; Thyroid Hormone Resistance | 2023 |
Association between sensitivity to thyroid hormones and dyslipidemia in patients with coronary heart disease.
Topics: Coronary Disease; Dyslipidemias; Glucose; Humans; Retrospective Studies; Thyroid Hormone Resistance | 2023 |
Central and peripheral sensitivity to thyroid hormones and glucose metabolism in prepubertal children with obesity: pilot multicenter evaluation.
Topics: Child; Glucose; Humans; Insulin Resistance; Obesity; Overweight; Thyroid Hormone Resistance Syndrome | 2023 |
Central and peripheral sensitivity to thyroid hormones and glucose metabolism in prepubertal children with obesity: pilot multicenter evaluation.
Topics: Child; Glucose; Humans; Insulin Resistance; Obesity; Overweight; Thyroid Hormone Resistance Syndrome | 2023 |
Central and peripheral sensitivity to thyroid hormones and glucose metabolism in prepubertal children with obesity: pilot multicenter evaluation.
Topics: Child; Glucose; Humans; Insulin Resistance; Obesity; Overweight; Thyroid Hormone Resistance Syndrome | 2023 |
Central and peripheral sensitivity to thyroid hormones and glucose metabolism in prepubertal children with obesity: pilot multicenter evaluation.
Topics: Child; Glucose; Humans; Insulin Resistance; Obesity; Overweight; Thyroid Hormone Resistance Syndrome | 2023 |
Very Severe Resistance to Thyroid Hormone β in One of Three Affected Members of a Family with a Novel Mutation in the
Topics: Adolescent; Family; Female; Fibroblasts; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; In Vitro | 2019 |
Apparent resistance to thyroid hormones: From biological interference to genetics.
Topics: Adolescent; Adult; Aged; Carrier Proteins; Child; Child, Preschool; Diagnostic Errors; Female; Human | 2019 |
Two Novel Cases of Resistance to Thyroid Hormone Due to
Topics: Child, Preschool; Computer Simulation; Dimerization; Female; Heterozygote; Humans; Infant; Infant, N | 2020 |
Assessing the clinical and molecular diagnosis of inherited forms of impaired sensitivity to thyroid hormone from a single tertiary center.
Topics: Adolescent; Adult; Child; Child, Preschool; Diagnosis, Differential; Female; Humans; Infant; Male; M | 2018 |
Insight Into Molecular Determinants of T3 vs T4 Recognition From Mutations in Thyroid Hormone Receptor α and β.
Topics: Female; Humans; Mutation; Thyroid Hormone Receptors alpha; Thyroid Hormone Receptors beta; Thyroid H | 2019 |
Differentiated thyroid carcinoma in a girl with resistance to thyroid hormone management with triiodothyroacetic acid.
Topics: Carcinoma; Carcinoma, Papillary; Cell Differentiation; Child; Female; Humans; Thyroid Cancer, Papill | 2013 |
Thyroid hormone signaling in vivo requires a balance between coactivators and corepressors.
Topics: Animals; Co-Repressor Proteins; Female; Gene Deletion; Humans; Male; Mice; Mutation; Nuclear Recepto | 2014 |
[Resistance to thyroid hormones].
Topics: Arrhythmias, Cardiac; Humans; Mutation; Thyroid Hormone Receptors beta; Thyroid Hormone Resistance S | 2014 |
Periodic Paralysis as a New Phenotype of Resistance to Thyroid Hormone Syndrome in a Chinese Male Adult.
Topics: Adult; DNA; Hormone Antagonists; Humans; Male; Mutation; Paralyses, Familial Periodic; Sex Hormone-B | 2016 |
Successful every-other-day liothyronine therapy for severe resistance to thyroid hormone beta with a novel THRB mutation; case report.
Topics: Base Sequence; Child; Congenital Hypothyroidism; DNA Mutational Analysis; Female; Hormone Replacemen | 2016 |
A resistance to thyroid hormone syndrome mutant operates through the target gene repertoire of the wild-type thyroid hormone receptor.
Topics: Adenoviridae; Gene Expression Regulation; Gene Ontology; Genetic Vectors; HEK293 Cells; Hep G2 Cells | 2017 |
Commentary: discordant measurements of serum triiodothyronine (T4), thyroxine (T3) and thyroid-stimulating hormone (TSH).
Topics: Antibodies, Heterophile; Attention Deficit Disorder with Hyperactivity; Female; Humans; Immunoassay; | 2008 |
Augmentation index in resistance to thyroid hormone (RTH).
Topics: Adult; Blood Glucose; Cardiovascular Diseases; Case-Control Studies; Cholesterol, LDL; Cohort Studie | 2009 |
Biochemical characterization of four novel mutations in the thyroid hormone receptor beta gene in patients with resistance to thyroid hormone.
Topics: Adult; Aged; Child; Child, Preschool; Female; Humans; Male; Thyroid Hormone Receptors beta; Thyroid | 2008 |
A thyroid hormone receptor mutation that dissociates thyroid hormone regulation of gene expression in vivo.
Topics: Animals; Gene Knock-In Techniques; Humans; Mice; Mice, Transgenic; Point Mutation; Repressor Protein | 2009 |
Peripheral parameters of thyroid hormone action in resistance to thyroid hormone syndrome: a focus on mineral metabolism.
Topics: Alkaline Phosphatase; Animals; Calcium; Creatinine; Humans; Magnesium; Parathyroid Hormone; Phosphor | 2009 |
Another story of mice and men: the types of RTH.
Topics: Animals; Humans; Mice; Thyroid Hormone Receptors beta; Thyroid Hormone Resistance Syndrome; Thyrotro | 2009 |
9 years follow-up of a patient with pituitary form of resistance to thyroid hormones (PRTH): comparison of two treatment periods of D-thyroxine and triiodothyroacetic acid (TRIAC).
Topics: Alkaline Phosphatase; Child; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Prenatal | 2009 |
Clinical features of primary hyperthyroidism caused by Graves' disease admixed with resistance to thyroid hormone (P453T).
Topics: Adult; Antithyroid Agents; Female; Graves Disease; Hashimoto Disease; Humans; Immunoglobulins, Thyro | 2010 |
Approach to the patient with resistance to thyroid hormone and pregnancy.
Topics: Adolescent; Female; Humans; Mutation; Pregnancy; Prenatal Diagnosis; Thyroid Hormone Receptors beta; | 2010 |
Stanniocalcin 1 induction by thyroid hormone depends on thyroid hormone receptor β and phosphatidylinositol 3-kinase activation.
Topics: Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Fibroblasts; Gene Expression R | 2011 |
Tissue-specific effects of mutations in the thyroid hormone transporter MCT8.
Topics: Brain Diseases; Humans; Male; Monocarboxylic Acid Transporters; Mutation; Symporters; Thyroid Hormon | 2011 |
Novel mutation in MCT8 gene in a Brazilian boy with thyroid hormone resistance and severe neurologic abnormalities.
Topics: Amino Acid Sequence; Brain Diseases; Child; Humans; Male; Monocarboxylic Acid Transporters; Muscle H | 2011 |
Differentiated thyroid cancer in two patients with resistance to thyroid hormone.
Topics: Carcinoma; Carcinoma, Papillary; Humans; Male; Middle Aged; Thyroid Cancer, Papillary; Thyroid Hormo | 2011 |
Serum copper as a novel biomarker for resistance to thyroid hormone.
Topics: Adolescent; Adult; Animals; Biomarkers; Ceruloplasmin; Child; Child, Preschool; Copper; Female; Gene | 2012 |
Thyroid hormone resistance caused by a novel deleterious variant of the thyroid hormone receptor beta gene.
Topics: Adult; Female; Humans; Infant; Infant, Newborn; Mutation, Missense; Thyroid Hormone Receptors beta; | 2013 |
Two resistance to thyroid hormone mutants with impaired hormone binding.
Topics: Arginine; Binding Sites; Crystallography, X-Ray; Histidine; Humans; Hydrogen Bonding; Models, Molecu | 2003 |
Thyroid hormone receptor-specific interactions with steroid receptor coactivator-1 in the pituitary.
Topics: Animals; Cell Nucleus; Female; Histone Acetyltransferases; Male; Mice; Mice, Mutant Strains; Nuclear | 2003 |
Marked potentiation of the dominant negative action of a mutant thyroid hormone receptor beta in mice by the ablation of one wild-type beta allele.
Topics: Alleles; Animals; Binding, Competitive; Cell Nucleus; Gene Expression Regulation; Genes, Dominant; H | 2003 |
Compensatory role of thyroid hormone receptor (TR) alpha 1 in resistance to thyroid hormone: study in mice with a targeted mutation in the TR beta gene and deficient in TR alpha 1.
Topics: Animals; Animals, Newborn; Gene Expression Regulation; Genes, erbA; Growth Disorders; Mice; Mice, Mu | 2003 |
Thyroid-hormone-dependent negative regulation of thyrotropin beta gene by thyroid hormone receptors: study with a new experimental system using CV1 cells.
Topics: Animals; Cell Line; Gene Silencing; Genes, Reporter; Haplorhini; Humans; Mutation; Pituitary Gland; | 2004 |
Thyroid hormone resistance in the heart: role of the thyroid hormone receptor beta isoform.
Topics: Animals; Body Weight; Echocardiography; Gene Expression; Germ-Line Mutation; Heart; Hemodynamics; Hu | 2004 |
The novel missense mutation methionine 442 threonine in the thyroid hormone receptor beta causes thyroid hormone resistance: a case report.
Topics: Atrial Fibrillation; Goiter, Nodular; Humans; Male; Methionine; Middle Aged; Mutation, Missense; Ped | 2004 |
Multi-tissue gene-expression analysis in a mouse model of thyroid hormone resistance.
Topics: Adipose Tissue; Animals; Cerebellum; Cluster Analysis; Disease Models, Animal; Gene Expression Profi | 2004 |
Aberrant dynamics of histone deacetylation at the thyrotropin-releasing hormone gene in resistance to thyroid hormone.
Topics: Acetylation; Animals; Cell Line; Child; Dimerization; DNA; Female; Histone Acetyltransferases; Histo | 2004 |
Search for genetic variants in the retinoid X receptor-gamma-gene by polymerase chain reaction-single-strand conformation polymorphism in patients with resistance to thyroid hormone without mutations in thyroid hormone receptor beta gene.
Topics: Adult; DNA Primers; Exons; Female; Genetic Variation; Goiter; Humans; Introns; Male; Middle Aged; Mu | 2004 |
A novel splice variant involving the 5' untranslated region of thyroid hormone receptor beta1 (TRbeta1).
Topics: 5' Untranslated Regions; Alternative Splicing; Base Sequence; Cells, Cultured; Fibroblasts; Genetic | 2004 |
Resistance to thyroid hormone in a Chinese family with R429Q mutation in the thyroid hormone receptor beta gene.
Topics: Adult; Humans; Male; Mutation; Receptors, Thyroid Hormone; Thyroid Hormone Receptors beta; Thyroid H | 2005 |
Tissue responses to thyroid hormone in a kindred with resistance to thyroid hormone harboring a commonly occurring mutation in the thyroid hormone receptor beta gene (P453T).
Topics: Adult; Child, Preschool; Cholesterol; Creatine Kinase; Female; Ferritins; Genotype; Humans; Liver; M | 2005 |
Making the gradient: thyroid hormone regulates cone opsin expression in the developing mouse retina.
Topics: Animals; Mice; Mice, Transgenic; Retina; Retinal Cone Photoreceptor Cells; Rod Opsins; Thyroid Hormo | 2006 |
Mosaicism of a thyroid hormone receptor-beta gene mutation in resistance to thyroid hormone.
Topics: Adult; Base Sequence; DNA; Female; Humans; Male; Mosaicism; Pedigree; Polymerase Chain Reaction; Pol | 2006 |
Identification of TSH receptor mutations in three families with resistance to TSH.
Topics: Adolescent; Adult; Animals; Base Sequence; Child; Chlorocebus aethiops; COS Cells; Cyclic AMP; Femal | 2007 |
Refractory depression in a patient with peripheral resistance to thyroid hormone (RTH) and the effect of triiodothyronine treatment.
Topics: Adult; Antidepressive Agents; Chronic Disease; Depressive Disorder; Drug Resistance, Multiple; Femal | 2007 |
"They have ears but do not hear" (Psalms 135:17): non-thyroid hormone receptor beta (non-TRbeta) resistance to thyroid hormone.
Topics: Aging; Diagnosis, Differential; DNA, Complementary; Genetic Linkage; Humans; Mutation; Phenotype; Sy | 2008 |
A child with resistance to thyroid hormone without thyroid hormone receptor gene mutation: a 20-year follow-up.
Topics: Adult; Bone Density; DNA-Binding Proteins; Follow-Up Studies; Heart Rate; Histone Acetyltransferases | 2008 |
ADHD and thyroid abnormalities: a research note.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Diagnosis, Diffe | 1995 |
Do clinical manifestations of resistance to thyroid hormone correlate with the functional alteration of the corresponding mutant thyroid hormone-beta receptors?
Topics: Adolescent; Adult; Base Sequence; Binding, Competitive; Child; Child, Preschool; Female; Humans; Mal | 1995 |
Modulation of thyroid hormone action by mutant thyroid hormone receptors, c-erbA alpha 2 and peroxisome proliferator-activated receptor: evidence for different mechanisms of inhibition.
Topics: DNA; DNA, Complementary; Gene Expression Regulation; Genes, Dominant; Humans; Models, Biological; Pr | 1995 |
Cell type-dependent modulation of the dominant negative action of human mutant thyroid hormone beta 1 receptors.
Topics: 3T3 Cells; Animals; Base Sequence; DNA Probes; Gene Expression Regulation; Genes, Dominant; HeLa Cel | 1995 |
A novel point mutation (R243Q) in exon 7 of the c-erbA beta thyroid hormone receptor gene in a family with resistance to thyroid hormone.
Topics: Amino Acid Sequence; Base Sequence; Exons; Female; Humans; Infant, Newborn; Male; Molecular Sequence | 1995 |
Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: evidence for tissue-specific modulation of receptor function.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brain; Disease Models, Animal; Female; Genes, Recessive | 1996 |
A new family with hyperthyroxinemia caused by transthyretin Val109 misdiagnosed as thyrotoxicosis and resistance to thyroid hormone--a clinical research center study.
Topics: Adolescent; Adult; Aged; Base Sequence; Diagnosis, Differential; Female; Humans; Hyperthyroxinemia; | 1996 |
Thyroid hormone receptor variant alpha2. Role of the ninth heptad in dna binding, heterodimerization with retinoid X receptors, and dominant negative activity.
Topics: Amino Acid Sequence; Animals; Base Sequence; DNA; DNA-Binding Proteins; Mice; Molecular Sequence Dat | 1996 |
Periodically hyperthyroid phenotype in thyroid hormone resistance is associated with mutation D322N in the thyroid hormone receptor beta gene: transcriptional properties of the mutant and the role of retinoid X receptor.
Topics: Adult; Child, Preschool; Codon; Humans; Hyperthyroidism; Male; Phenotype; Point Mutation; Receptors, | 1996 |
Differences in response of thyrotropin to 3,5,3'-triiodothyronine and 3,5,3'-triiodothyroacetic acid in patients with resistance to thyroid hormone.
Topics: Adenoma; Adolescent; Child, Preschool; Female; Ferritins; Glycoprotein Hormones, alpha Subunit; Huma | 1996 |
Evaluation of pituitary and peripheral tissue markers of thyroid hormone action in an Iranian family with resistance to thyroid hormone.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Ferritins; Humans; Iran; Male; Pedigree; | 1996 |
Difficulty in differentiating thyrotropin secreting pituitary microadenoma from pituitary-selective thyroid hormone resistance accompanied by pituitary incidentaloma.
Topics: Adenoma; Adult; Female; Gadolinium; Humans; Magnetic Resonance Imaging; Pituitary Neoplasms; Thyroid | 1996 |
Defective response of body height to growth hormone treatment in resistance to thyroid hormone with short stature.
Topics: Adolescent; Body Height; Drug Resistance; Female; Growth Disorders; Human Growth Hormone; Humans; In | 1996 |
Thyroid hormone resistance syndrome manifests as an aberrant interaction between mutant T3 receptors and transcriptional corepressors.
Topics: Cell Line; Chromosome Mapping; DNA-Binding Proteins; Humans; Models, Molecular; Mutagenesis, Site-Di | 1997 |
Resistance to thyroid hormone caused by two mutant thyroid hormone receptors beta, R243Q and R243W, with marked impairment of function that cannot be explained by altered in vitro 3,5,3'-triiodothyroinine binding affinity.
Topics: Animals; Cell Nucleus; DNA; Humans; Macromolecular Substances; Mutation; Pituitary Gland; Receptors, | 1997 |
Clinical and hormonal outcome after two years of triiodothyroacetic acid treatment in a child with thyroid hormone resistance.
Topics: Biomarkers; Child, Preschool; Female; Follow-Up Studies; Humans; Male; Pituitary Gland; Point Mutati | 1997 |
[Thyroid hormone resistance: variable clinical manifestations in five patients].
Topics: Adult; Child; Female; Humans; Iodine Radioisotopes; Male; Middle Aged; Pedigree; Point Mutation; Rad | 1997 |
Comparison of the functional properties of three different truncated thyroid hormone receptors identified in subjects with resistance to thyroid hormone.
Topics: Adolescent; Adult; Animals; Base Sequence; Child; COS Cells; Dimerization; DNA; DNA Probes; Drug Res | 1998 |
A novel TR beta mutation (R383H) in resistance to thyroid hormone syndrome predominantly impairs corepressor release and negative transcriptional regulation.
Topics: Arginine; Child; Crystallization; Female; Gene Expression Regulation; Histidine; Humans; Ligands; Mo | 1998 |
Detection of a new de novo mutation at codon 251 of exon 8 of thyroid hormone receptor beta gene in an Italian kindred with resistance to thyroid hormone.
Topics: Adult; Codon; Exons; Genotype; Heterozygote; Humans; Italy; Male; Mutation; Pedigree; Polymerase Cha | 1998 |
Difference in dominant negative activities between mutant thyroid hormone receptors alpha1 and beta1 with an identical truncation in the extreme carboxyl-terminal tau4 domain.
Topics: Animals; Cell Line; Chickens; Child; Chloramphenicol O-Acetyltransferase; Dimerization; Female; Huma | 1998 |
Defective release of corepressor by hinge mutants of the thyroid hormone receptor found in patients with resistance to thyroid hormone.
Topics: Dimerization; DNA; Electrophoresis, Polyacrylamide Gel; Histone Acetyltransferases; Humans; Ligands; | 1998 |
A novel natural mutation in the thyroid hormone receptor defines a dual functional domain that exchanges nuclear receptor corepressors and coactivators.
Topics: Cell Nucleus; Codon; Dimerization; DNA; Female; Histone Acetyltransferases; Humans; Infant; Leucine; | 1998 |
Novel insight from transgenic mice into thyroid hormone resistance and the regulation of thyrotropin.
Topics: Animals; Disease Models, Animal; Mice; Mice, Transgenic; Mutation; Pituitary Gland; Protein Precurso | 1999 |
Prenatal diagnosis of thyroid hormone resistance.
Topics: Adult; DNA; Female; Fetal Blood; Fetal Diseases; Gestational Age; Heterozygote; Humans; Mutation; Pr | 1999 |
Association between an R338L mutation in the thyroid hormone receptor-beta gene and thyrotoxic features in two unrelated kindreds with resistance to thyroid hormone.
Topics: Adolescent; Aged; Alleles; Amino Acid Substitution; Arginine; Female; Follow-Up Studies; Haplotypes; | 1999 |
A novel resistance to thyroid hormone associated with a new mutation (T329N) in the thyroid hormone receptor beta gene.
Topics: Abortion, Habitual; Adult; Dextrothyroxine; Dimerization; Female; Humans; Male; Pedigree; Point Muta | 1999 |
Generalized resistance to thyroid hormones.
Topics: Adult; Body Height; Child; Child, Preschool; Consanguinity; Female; Human Growth Hormone; Humans; Hy | 1998 |
Altered thyroid hormone binding to plasma lipoproteins in the syndrome of resistance to thyroid hormones.
Topics: Cholesterol; Humans; Hypothyroidism; Lipid Metabolism; Lipoproteins; Syndrome; Thyroid Hormone Resis | 1999 |
The thyroid hormone receptor-beta gene mutation R383H is associated with isolated central resistance to thyroid hormone.
Topics: Body Weight; Female; Heart; Humans; Hypothalamus; Liver; Mental Processes; Middle Aged; Mutation; Pe | 1999 |
Resistance to thyroid hormone caused by a new mutation (V336M) in the thyroid hormone receptor beta gene.
Topics: Adenine; Adult; Chromosomes, Human, Pair 3; Female; Gestational Age; Guanine; Heterozygote; Humans; | 1999 |
Five new families with resistance to thyroid hormone not caused by mutations in the thyroid hormone receptor beta gene.
Topics: Adult; Child; Child, Preschool; Female; Genetic Linkage; Genotype; Haplotypes; Humans; Male; Mutatio | 1999 |
Three novel mutations at serine 314 in the thyroid hormone beta receptor differentially impair ligand binding in the syndrome of resistance to thyroid hormone.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Crystallization; Dimerization; DNA; Female; Gene E | 1999 |
Resistance to thyroid hormone in a family with no TRbeta gene anomaly: pathogenic hypotheses.
Topics: Adult; Dinucleotide Repeats; Female; Genetic Linkage; Haplotypes; Humans; Mutation; Pedigree; Polymo | 2000 |
A novel mutation (M310L) in the thyroid hormone receptor beta causing resistance to thyroid hormone in a Brazilian kindred and a neonate.
Topics: Adolescent; Amino Acid Substitution; Base Sequence; Binding, Competitive; Brazil; Cell Line; DNA; DN | 2000 |
A pituitary tumor in a patient with thyroid hormone resistance: a diagnostic dilemma.
Topics: Adenoma; Adult; Female; Humans; Magnetic Resonance Imaging; Pedigree; Pituitary Neoplasms; Point Mut | 2001 |
[Identification of eight new mutations in the c-erbAB gene of patients with resistance to thyroid hormone].
Topics: Adolescent; Adult; Aged; Amino Acid Sequence; Binding Sites; Child; Child, Preschool; DNA Mutational | 2001 |
Effects of thyroid hormones on cardiac structure: a tissue characterization study in patients with thyroid disorders before and after treatment.
Topics: Adult; Antithyroid Agents; Collagen; Echocardiography; Electrocardiography; Female; Humans; Hyperthy | 2001 |
Extreme thyroid hormone resistance in a patient with a novel truncated TR mutant.
Topics: Bone Development; Brain; Cells, Cultured; Female; Frameshift Mutation; Gene Deletion; Humans; Infant | 2001 |
Targeted disruption of the type 2 selenodeiodinase gene (DIO2) results in a phenotype of pituitary resistance to T4.
Topics: Adipose Tissue, Brown; Animals; Astrocytes; Blotting, Northern; Colforsin; Female; Hypothyroidism; I | 2001 |
Resistance to thyroid hormone in a patient without thyroid hormone receptor mutations.
Topics: Adult; DNA-Binding Proteins; Fatigue; Female; Goiter; Humans; Intelligence Tests; Mutation; National | 2002 |
Genetic analyses and evaluation of peripheral parameters of thyroid hormone action for the differential diagnosis of RTH. A novel heterozygous missense mutation (M334T) discovered.
Topics: Collagen Type I; Diagnosis, Differential; Female; Heterozygote; Humans; Magnetic Resonance Imaging; | 2002 |