Page last updated: 2024-11-08

triiodothyronine and Froehlich's Syndrome

triiodothyronine has been researched along with Froehlich's Syndrome in 16 studies

Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.

Research Excerpts

ExcerptRelevanceReference
"To evaluate the influence of estriol administration on the hypothalamus-pituitary function and gonadotropins secretion in patients affected by functional hypothalamic amenorrhea (FHA)."9.16Estriol administration modulates luteinizing hormone secretion in women with functional hypothalamic amenorrhea. ( Chierchia, E; Genazzani, AD; Meczekalski, B; Podfigurna-Stopa, A; Rattighieri, E; Ricchieri, F; Santagni, S; Simoncini, T, 2012)
"To further characterize hypothyroidemia with decreased serum concentrations of total triiodothyronine and total T4 in women with functional hypothalamic amenorrhea."7.69Altered binding of serum thyroid hormone to thyroxine-binding globulin in women with functional hypothalamic amenorrhea. ( Dominguez, CE; Laughlin, GA; Nelson, JC; Yen, SS, 1997)
"To evaluate the influence of estriol administration on the hypothalamus-pituitary function and gonadotropins secretion in patients affected by functional hypothalamic amenorrhea (FHA)."5.16Estriol administration modulates luteinizing hormone secretion in women with functional hypothalamic amenorrhea. ( Chierchia, E; Genazzani, AD; Meczekalski, B; Podfigurna-Stopa, A; Rattighieri, E; Ricchieri, F; Santagni, S; Simoncini, T, 2012)
"To further characterize hypothyroidemia with decreased serum concentrations of total triiodothyronine and total T4 in women with functional hypothalamic amenorrhea."3.69Altered binding of serum thyroid hormone to thyroxine-binding globulin in women with functional hypothalamic amenorrhea. ( Dominguez, CE; Laughlin, GA; Nelson, JC; Yen, SS, 1997)
"Hypothyroidism is associated with accumulation of hyaluronic acid within various tissues, additional fluid retention due to reduced cardiac output and reduced thermogenesis."2.44Classical endocrine diseases causing obesity. ( Weaver, JU, 2008)
"We conclude that central hypothyroidism is characterized by a deficient nocturnal surge of TSH, and accordingly, we suggest that evaluation of the circadian pattern of TSH may be a useful adjunct in making the diagnosis of hypothyroidism in patients with diseases involving the pituitary or hypothalamus."1.27Deficient nocturnal surge of thyrotropin in central hypothyroidism. ( Caron, PJ; Nieman, LK; Nisula, BC; Rose, SR, 1986)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19906 (37.50)18.7374
1990's4 (25.00)18.2507
2000's3 (18.75)29.6817
2010's3 (18.75)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Michopoulos, V1
Mancini, F1
Loucks, TL1
Berga, SL1
van Santen, HM1
Schouten-Meeteren, AY1
Serlie, M1
Meijneke, RW1
van Trotsenburg, AS1
Verberne, H1
Holleman, F1
Fliers, E1
Bjørn, AM1
Bojesen, A1
Gravholt, CH1
Laurberg, P1
Genazzani, AD1
Meczekalski, B1
Podfigurna-Stopa, A1
Santagni, S1
Rattighieri, E1
Ricchieri, F1
Chierchia, E1
Simoncini, T1
Fernandes, JK1
Klein, MJ1
Ater, JL1
Kuttesch, JF1
Vassilopoulou-Sellin, R1
Weaver, JU1
Cobb, WE1
Reichlin, S1
Jackson, IM1
Kupari, M1
Pelkonen, R1
Valtonen, V1
Clar, HE1
Andler, W1
Erbs, I1
Reinhard, V1
Gerhard, L1
Kruczewski, F1
List, B1
Horimoto, M1
Nishikawa, M1
Ishihara, T1
Yoshikawa, N1
Yoshimura, M1
Inada, M1
Lee, KO1
Persani, L1
Tan, M1
Sundram, FX1
Beck-Peccoz, P1
Dominguez, CE1
Laughlin, GA1
Nelson, JC1
Yen, SS1
Rose, SR2
Manasco, PK1
Pearce, S1
Nisula, BC2
Bellinger, LL1
Bernardis, LL1
McCusker, RH1
Campion, DR1
Caron, PJ1
Nieman, LK1
Webster, B1
Bain, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pathogenesis of Functional Hypothalamic Amenorrhea[NCT01674426]17 participants (Actual)Interventional1997-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for triiodothyronine and Froehlich's Syndrome

ArticleYear
Classical endocrine diseases causing obesity.
    Frontiers of hormone research, 2008, Volume: 36

    Topics: Catecholamines; Cushing Syndrome; Endocrine System Diseases; Female; Glucocorticoids; Humans; Hypoth

2008

Trials

3 trials available for triiodothyronine and Froehlich's Syndrome

ArticleYear
Neuroendocrine recovery initiated by cognitive behavioral therapy in women with functional hypothalamic amenorrhea: a randomized, controlled trial.
    Fertility and sterility, 2013, Volume: 99, Issue:7

    Topics: Academic Medical Centers; Amenorrhea; Analysis of Variance; Cognitive Behavioral Therapy; Female; Hu

2013
Estriol administration modulates luteinizing hormone secretion in women with functional hypothalamic amenorrhea.
    Fertility and sterility, 2012, Volume: 97, Issue:2

    Topics: 17-alpha-Hydroxyprogesterone; Adult; Amenorrhea; Analysis of Variance; Androstenedione; Estradiol; E

2012
Antidiuretic effect and complications of chlorpropamide therapy in diabetes insipidus.
    The Journal of clinical endocrinology and metabolism, 1970, Volume: 30, Issue:2

    Topics: Adolescent; Adult; Chlorpropamide; Clinical Trials as Topic; Craniopharyngioma; Diabetes Insipidus;

1970

Other Studies

12 other studies available for triiodothyronine and Froehlich's Syndrome

ArticleYear
Effects of T3 treatment on brown adipose tissue and energy expenditure in a patient with craniopharyngioma and hypothalamic obesity.
    Journal of pediatric endocrinology & metabolism : JPEM, 2015, Volume: 28, Issue:1-2

    Topics: Adipose Tissue, Brown; Child; Craniopharyngioma; Energy Metabolism; Female; Humans; Hypothalamic Dis

2015
Hypothyroidism secondary to hypothalamic-pituitary dysfunction may be part of the phenotype in klinefelter syndrome: a case-control study.
    The Journal of clinical endocrinology and metabolism, 2009, Volume: 94, Issue:7

    Topics: Adult; Autoantibodies; Case-Control Studies; Hormone Replacement Therapy; Humans; Hypothalamic Disea

2009
Triiodothyronine supplementation for hypothalamic obesity.
    Metabolism: clinical and experimental, 2002, Volume: 51, Issue:11

    Topics: Adult; Brain Neoplasms; Child; Female; Humans; Hypothalamic Diseases; Male; Obesity; Treatment Outco

2002
Growth hormone secretory status is a determinant of the thyrotropin response to thyrotropin-releasing hormone in euthyroid patients with hypothalamic-pituitary disease.
    The Journal of clinical endocrinology and metabolism, 1981, Volume: 52, Issue:2

    Topics: Adolescent; Adult; Female; Growth Hormone; Humans; Hypothalamic Diseases; Male; Middle Aged; Pituita

1981
Post-encephalitic hypothalamic-pituitary insufficiency.
    Acta endocrinologica, 1980, Volume: 94, Issue:4

    Topics: Adult; Diabetes Insipidus; Encephalitis, Arbovirus; Female; Growth Hormone; Herpes Simplex; Humans;

1980
Experimental hypothalamic dysfunction in dogs.
    Neurosurgical review, 1980, Volume: 3, Issue:1

    Topics: Animals; Disease Models, Animal; Dogs; Hypothalamic Diseases; Male; Thyroid Diseases; Triiodothyroni

1980
Bioactivity of thyrotropin (TSH) in patients with central hypothyroidism: comparison between in vivo 3,5,3'-triiodothyronine response to TSH and in vitro bioactivity of TSH.
    The Journal of clinical endocrinology and metabolism, 1995, Volume: 80, Issue:4

    Topics: Adult; Aged; Female; Humans; Hypothalamic Diseases; Hypothyroidism; Middle Aged; Pituitary Diseases;

1995
Thyrotropin with decreased biological activity, a delayed consequence of cranial irradiation for nasopharyngeal carcinoma.
    Journal of endocrinological investigation, 1995, Volume: 18, Issue:10

    Topics: Adult; Aged; Humans; Hypothalamic Diseases; Hypothyroidism; Kinetics; Middle Aged; Nasopharyngeal Ne

1995
Altered binding of serum thyroid hormone to thyroxine-binding globulin in women with functional hypothalamic amenorrhea.
    Fertility and sterility, 1997, Volume: 68, Issue:6

    Topics: Adult; Amenorrhea; Cohort Studies; Electrophoresis; Female; Follicular Phase; Humans; Hypothalamic D

1997
Hypothyroidism and deficiency of the nocturnal thyrotropin surge in children with hypothalamic-pituitary disorders.
    The Journal of clinical endocrinology and metabolism, 1990, Volume: 70, Issue:6

    Topics: Adolescent; Child; Child, Preschool; Circadian Rhythm; Humans; Hypothalamic Diseases; Hypothyroidism

1990
Plasma hormone levels in growth-retarded rats with dorsomedial hypothalamic lesions.
    Physiology & behavior, 1985, Volume: 34, Issue:5

    Topics: Animals; Dorsomedial Hypothalamic Nucleus; Growth Disorders; Growth Hormone; Hypothalamic Diseases;

1985
Deficient nocturnal surge of thyrotropin in central hypothyroidism.
    The Journal of clinical endocrinology and metabolism, 1986, Volume: 62, Issue:5

    Topics: Adolescent; Adult; Circadian Rhythm; Female; Humans; Hypothalamic Diseases; Hypothyroidism; Male; Mi

1986