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triiodothyronine and Follicular Thyroid Carcinoma

triiodothyronine has been researched along with Follicular Thyroid Carcinoma in 25 studies

Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.

Research Excerpts

ExcerptRelevanceReference
"We experienced two cases of follicular thyroid carcinoma with distant metastases, which showed high levels of free triiodothyronine (T(3)) while free thyroxine (T(4)) levels remained in the low or normal range."7.73Thyroxine to triiodothyronine hyperconversion thyrotoxicosis in patients with large metastases of follicular thyroid carcinoma. ( Amino, N; Ito, Y; Miyauchi, A; Takano, T, 2006)
"We experienced two cases of follicular thyroid carcinoma with distant metastases, which showed high levels of free triiodothyronine (T(3)) while free thyroxine (T(4)) levels remained in the low or normal range."3.73Thyroxine to triiodothyronine hyperconversion thyrotoxicosis in patients with large metastases of follicular thyroid carcinoma. ( Amino, N; Ito, Y; Miyauchi, A; Takano, T, 2006)
"In both, thyroid cancer is driven by overactivation of PI3K-AKT signaling."1.43SAHA-induced loss of tumor suppressor Pten gene promotes thyroid carcinogenesis in a mouse model. ( Cheng, SY; Kim, DW; Willingham, MC; Zhao, L; Zhu, X, 2016)
"We used the human follicular thyroid cancer cell lines (FTC-133 and FTC-236 cells) to elucidate how functional expression of the THRB gene could affect tumorigenesis."1.40Inhibition of tumorigenesis by the thyroid hormone receptor β in xenograft models. ( Cheng, SY; Kim, DW; Kim, WG; Willingham, MC; Zhao, L, 2014)
"In patients with differentiated thyroid cancer (DTC), the stimulated serum thyroglobulin (Tg) level at radioiodine ablation is a known predictive factor of persistent disease."1.40Stimulated thyroglobulin level at ablation in differentiated thyroid cancer: the impact of treatment preparation modalities and tumor burden. ( Bardet, S; Blanchard, D; Ciappuccini, R; de Raucourt, D; Hardouin, J; Heutte, N; Quak, E; Rame, JP; Vaur, D, 2014)
"Trifluralin treatment increased bile flow, caused a 3."1.35Mechanism of trifluralin-induced thyroid tumors in rats. ( Bartels, MJ; Brzak, KA; Charles, GD; Clark, AJ; Dryzga, MD; Kan, LH; Saghir, SA, 2008)
"We report a case of follicular thyroid carcinoma discovered after surgical treatment of a toxic multinodular goiter, in which solitary adrenal gland metastasis was detected five years later."1.31Solitary adrenal gland metastasis of a follicular thyroid carcinoma presenting with hyperthyroidism. ( López-Aznar, D; Ponce, JL; Prieto, M; Sancho-Fornos, S; Yunta, PJ, 2001)
"The most probable cause of the inadequate TSH suppression in our patients was the reduction in bioavailability in certain batches of Levothroid, although we are unable to rule out the possibility that the results obtained after the changeover to Dexnon were due to its greater bioavailability."1.30Altered bioavailability due to changes in the formulation of a commercial preparation of levothyroxine in patients with differentiated thyroid carcinoma. ( Almaraz, MC; Garriga, MJ; Gonzalez-Romero, S; Olveira, G; Ruiz de Adana, MS; Soriguer, F; Tinahones, F, 1997)
"In the follicular thyroid carcinoma line FTC-133, nanomolar concentrations of 9-cis, 13-cis-, and all-trans-RA induced 5'DI activity."1.29Retinoids stimulate type I iodothyronine 5'-deiodinase activity in human follicular thyroid carcinoma cell lines. ( Köhrle, J; Schmutzler, C; Schnieders, F; Schreck, R, 1994)
"In a study of 136 differentiated thyroid cancer patients referred for radioiodine therapy since January 1991, it was observed that 80 patients had metastatic disease."1.29Thyroid hormones in differentiated thyroid cancer. ( Desai, KB; Mehta, MN; Samuel, AM, 1994)
"in an advanced stage with multiple metastases in the skeletal system, lungs and hilar lymph nodes."1.29[T3 hyperthyroidism with metastatic follicular thyroid carcinoma in substitution therapy]. ( Flesch, M; Lang, M, 1996)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's9 (36.00)18.2507
2000's9 (36.00)29.6817
2010's7 (28.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fussey, JM1
Khan, H1
Ahsan, F1
Prashant, R1
Pettit, L1
Kim, WG1
Zhao, L3
Kim, DW2
Willingham, MC3
Cheng, SY3
Ciappuccini, R1
Hardouin, J1
Heutte, N1
Vaur, D1
Quak, E1
Rame, JP1
Blanchard, D1
de Raucourt, D1
Bardet, S1
Zhu, X1
Saghir, SA1
Charles, GD1
Bartels, MJ1
Kan, LH1
Dryzga, MD1
Brzak, KA1
Clark, AJ1
Gen, R1
Akbay, E1
Camsari, A1
Ozcan, T1
Lu, C1
Ying, H1
Taïeb, D1
Sebag, F1
Farman-Ara, B1
Portal, T1
Baumstarck-Barrau, K1
Fortanier, C1
Bourrelly, M1
Mancini, J1
De Micco, C1
Auquier, P1
Conte-Devolx, B1
Henry, JF1
Mundler, O1
Depczynski, B1
Lillioja, S1
Takano, T1
Miyauchi, A2
Ito, Y2
Amino, N2
Takamura, Y1
Miya, A1
Kobayashi, K1
Matsuzuka, F1
Toyoda, N1
Nomura, E1
Nishikawa, M1
David, E1
Rosen, IB1
Bain, J1
James, J1
Kirsh, JC1
Francia, G1
Davì, MV1
Petroziello, A1
Sussi, PL1
Schreck, R1
Schnieders, F1
Schmutzler, C2
Köhrle, J2
Samuel, AM1
Mehta, MN1
Desai, KB1
Johansen, AH1
Nielsen, BV1
Lang, M1
Flesch, M1
Olveira, G1
Almaraz, MC1
Soriguer, F1
Garriga, MJ1
Gonzalez-Romero, S1
Tinahones, F1
Ruiz de Adana, MS1
Naito, Y1
Sone, T1
Kataoka, K1
Sawada, M1
Yamazaki, K1
Konukoğlu, D1
Hatemi, HH1
Arikan, S1
Demir, M1
Akçay, T1
Schönberger, J1
Bauer, J1
Spruss, T1
Weber, G1
Chahoud, I1
Eilles, C1
Grimm, D1
Kondo, T1
Katoh, R1
Omata, K1
Oyama, T1
Yagawa, A1
Kawaoi, A1
Yunta, PJ1
Ponce, JL1
Prieto, M1
López-Aznar, D1
Sancho-Fornos, S1
Schmitt, TL1
Glaser, F1
Loos, U1
Ishihara, T1
Ikekubo, K1
Shimodahira, M1
Iwakura, T1
Kobayashi, M1
Hino, M1
Oobayashi, M1
Kohno, K1
Kimura, K1
Kawamura, S1
Kurahachi, H1

Reviews

1 review available for triiodothyronine and Follicular Thyroid Carcinoma

ArticleYear
Thyroid-stimulating hormone suppression therapy for differentiated thyroid cancer: The role for a combined T3/T4 approach.
    Head & neck, 2017, Volume: 39, Issue:12

    Topics: Adenocarcinoma, Follicular; Combined Modality Therapy; Drug Therapy, Combination; Evidence-Based Med

2017

Trials

1 trial available for triiodothyronine and Follicular Thyroid Carcinoma

ArticleYear
Iodine biokinetics and radioiodine exposure after recombinant human thyrotropin-assisted remnant ablation in comparison with thyroid hormone withdrawal.
    The Journal of clinical endocrinology and metabolism, 2010, Volume: 95, Issue:7

    Topics: Ablation Techniques; Adenocarcinoma, Follicular; Carcinoma, Papillary; Combined Modality Therapy; Ha

2010

Other Studies

23 other studies available for triiodothyronine and Follicular Thyroid Carcinoma

ArticleYear
Inhibition of tumorigenesis by the thyroid hormone receptor β in xenograft models.
    Thyroid : official journal of the American Thyroid Association, 2014, Volume: 24, Issue:2

    Topics: Adenocarcinoma, Follicular; Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Heterografts; Humans

2014
Stimulated thyroglobulin level at ablation in differentiated thyroid cancer: the impact of treatment preparation modalities and tumor burden.
    European journal of endocrinology, 2014, Volume: 171, Issue:2

    Topics: Adenocarcinoma, Follicular; Adult; Aged; Carcinoma; Carcinoma, Papillary; Female; Humans; Iodine Rad

2014
SAHA-induced loss of tumor suppressor Pten gene promotes thyroid carcinogenesis in a mouse model.
    Endocrine-related cancer, 2016, Volume: 23, Issue:7

    Topics: Adenocarcinoma, Follicular; Animals; Carcinogenesis; Disease Models, Animal; Hydroxamic Acids; Mice,

2016
Mechanism of trifluralin-induced thyroid tumors in rats.
    Toxicology letters, 2008, Jul-30, Volume: 180, Issue:1

    Topics: Adenocarcinoma, Follicular; Administration, Oral; Animal Feed; Animals; Dose-Response Relationship,

2008
P-wave dispersion in endogenous and exogenous subclinical hyperthyroidism.
    Journal of endocrinological investigation, 2010, Volume: 33, Issue:2

    Topics: Adenocarcinoma, Follicular; Adenoma; Atrial Fibrillation; Carcinoma, Papillary; Electrocardiography;

2010
Growth activation alone is not sufficient to cause metastatic thyroid cancer in a mouse model of follicular thyroid carcinoma.
    Endocrinology, 2010, Volume: 151, Issue:4

    Topics: Adenocarcinoma, Follicular; Animals; Blotting, Western; Cell Proliferation; Disease Models, Animal;

2010
Two cases of thyroid carcinoma that were not stimulated by recombinant human thyrotropin.
    The Journal of clinical endocrinology and metabolism, 2004, Volume: 89, Issue:9

    Topics: Adenocarcinoma, Follicular; Humans; Recombinant Proteins; Thyroid Neoplasms; Thyrotropin; Triiodothy

2004
Thyroxine to triiodothyronine hyperconversion thyrotoxicosis in patients with large metastases of follicular thyroid carcinoma.
    Thyroid : official journal of the American Thyroid Association, 2006, Volume: 16, Issue:6

    Topics: Adenocarcinoma, Follicular; Adult; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Mid

2006
3,5,3'-Triiodothyronine thyrotoxicosis due to increased conversion of administered levothyroxine in patients with massive metastatic follicular thyroid carcinoma.
    The Journal of clinical endocrinology and metabolism, 2008, Volume: 93, Issue:6

    Topics: Adenocarcinoma, Follicular; Adult; Aged; Aged, 80 and over; Disease Progression; Female; Humans; Iod

2008
Management of the hot thyroid nodule.
    American journal of surgery, 1995, Volume: 170, Issue:5

    Topics: Adenocarcinoma; Adenocarcinoma, Follicular; Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma; D

1995
[Hormonal therapy in differentiated carcinoma of the thyroid gland].
    Chirurgia italiana, 1994, Volume: 46, Issue:4

    Topics: Adenocarcinoma, Follicular; Adenylyl Cyclases; Biomarkers, Tumor; Carcinoma; Carcinoma, Papillary; H

1994
Retinoids stimulate type I iodothyronine 5'-deiodinase activity in human follicular thyroid carcinoma cell lines.
    The Journal of clinical endocrinology and metabolism, 1994, Volume: 79, Issue:3

    Topics: Adenocarcinoma, Follicular; Affinity Labels; Butyrates; Butyric Acid; Cycloheximide; Dactinomycin; H

1994
Thyroid hormones in differentiated thyroid cancer.
    Clinical nuclear medicine, 1994, Volume: 19, Issue:1

    Topics: Adenocarcinoma, Follicular; Bone Neoplasms; Humans; Iodine Radioisotopes; Thyroglobulin; Thyroid Neo

1994
[T3 thyrotoxicosis in a patient with a hormonally active, metastasizing follicular thyroid carcinoma].
    Ugeskrift for laeger, 1994, Jan-24, Volume: 156, Issue:4

    Topics: Adenocarcinoma, Follicular; Female; Humans; Lung Neoplasms; Middle Aged; Thyroid Neoplasms; Thyrotox

1994
[T3 hyperthyroidism with metastatic follicular thyroid carcinoma in substitution therapy].
    Nuklearmedizin. Nuclear medicine, 1996, Volume: 35, Issue:5

    Topics: Adenocarcinoma, Follicular; Adult; Female; Humans; Hyperthyroidism; Iodine Radioisotopes; Lymphatic

1996
Altered bioavailability due to changes in the formulation of a commercial preparation of levothyroxine in patients with differentiated thyroid carcinoma.
    Clinical endocrinology, 1997, Volume: 46, Issue:6

    Topics: Adenocarcinoma, Follicular; Adult; Aged; Biological Availability; Carcinoma, Papillary; Chemistry, P

1997
Thyroid storm due to functioning metastatic thyroid carcinoma in a burn patient.
    Anesthesiology, 1997, Volume: 87, Issue:2

    Topics: Adenocarcinoma, Follicular; Burns; Humans; Male; Middle Aged; Thyroid Crisis; Thyroid Neoplasms; Thy

1997
Radioiodine treatment and oxidative stress in thyroidectomised patients for differentiated thyroid cancers.
    Pharmacological research, 1998, Volume: 38, Issue:4

    Topics: Adenocarcinoma, Follicular; Adult; Biomarkers; Carcinoma, Papillary; Erythrocyte Count; Erythrocytes

1998
Establishment and characterization of the follicular thyroid carcinoma cell line ML-1.
    Journal of molecular medicine (Berlin, Germany), 2000, Volume: 78, Issue:2

    Topics: Adenocarcinoma, Follicular; Animals; Cell Transplantation; Deoxyglucose; DNA, Neoplasm; Female; Flow

2000
Incidentally detected liver metastasis of well-differentiated follicular carcinoma of the thyroid, mimicking ectopic thyroid.
    Pathology international, 2000, Volume: 50, Issue:6

    Topics: Adenocarcinoma, Follicular; Cell Differentiation; Choristoma; Diagnosis, Differential; Female; Human

2000
Solitary adrenal gland metastasis of a follicular thyroid carcinoma presenting with hyperthyroidism.
    Annales d'endocrinologie, 2001, Volume: 62, Issue:3

    Topics: Adenocarcinoma, Follicular; Adrenal Gland Neoplasms; Diagnosis, Differential; Goiter, Nodular; Human

2001
The promoter of the human sodium/iodide-symporter gene responds to retinoic acid.
    Molecular and cellular endocrinology, 2002, Mar-28, Volume: 189, Issue:1-2

    Topics: Adenocarcinoma, Follicular; Animals; Genes, Reporter; Humans; Iodine Radioisotopes; Oligonucleotides

2002
A case of TSH receptor antibody-positive hyperthyroidism with functioning metastases of thyroid carcinoma.
    Endocrine journal, 2002, Volume: 49, Issue:2

    Topics: Adenocarcinoma, Follicular; Aged; Antithyroid Agents; Autoantibodies; Bone Neoplasms; Female; Humans

2002