triiodothyronine has been researched along with Fatty Liver in 14 studies
Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
Fatty Liver: Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the study is to explore the independent association of free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) with hepatic steatosis and insulin resistance." | 4.02 | Independent associations of thyroid-related hormones with hepatic steatosis and insulin resistance in euthyroid overweight/obese Chinese adults. ( Chen, Y; Huang, B; Li, Z; Lin, M; Liu, C; Ma, D; Xiao, F; Yan, F; Ye, J; Zeng, J; Zeng, X; Zheng, X, 2021) |
| "Effectively treating metabolic syndrome and its progression to type 2 diabetes, steatohepatitis and cardiovascular disease remain a major clinical challenge." | 1.46 | Metabolic Syndrome: One Speckled Stone Kills a Flock of Birds? ( Angelin, B; Bonde, Y, 2017) |
| "NAFLD was diagnosed by conventional ultrasound examination." | 1.40 | Thyroid hormone levels in obese children and adolescents with non-alcoholic fatty liver disease. ( Aydın, S; Cesur, Y; Gökçe, S; Özgen, IT; Torun, E, 2014) |
| "Fatty liver is an important complication of obesity; however, regulatory mechanisms mediating altered gene expression patterns have not been identified." | 1.35 | Thyroid hormone-related regulation of gene expression in human fatty liver. ( Bianco, AC; Boes, T; Dearie, F; Goldfine, AB; Kim, BW; Kim, EY; Mun, E; Nasser, I; Park, PJ; Patti, ME; Pihlajamäki, J; Schroeder, J, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 6 (42.86) | 24.3611 |
| 2020's | 3 (21.43) | 2.80 |
| Authors | Studies |
|---|---|
| Ma, D | 1 |
| Zeng, J | 1 |
| Huang, B | 1 |
| Yan, F | 1 |
| Ye, J | 1 |
| Chen, Y | 2 |
| Zeng, X | 1 |
| Zheng, X | 1 |
| Xiao, F | 1 |
| Lin, M | 1 |
| Liu, C | 1 |
| Li, Z | 1 |
| Merchan-Ramirez, E | 1 |
| Sanchez-Delgado, G | 1 |
| Arrizabalaga-Arriazu, C | 1 |
| Acosta, FM | 1 |
| Arias-Tellez, MJ | 1 |
| Muñoz-Torres, M | 1 |
| Garcia-Lario, JV | 1 |
| Llamas-Elvira, JM | 1 |
| Ruiz, JR | 1 |
| Xia, B | 1 |
| Shi, XC | 1 |
| Xie, BC | 1 |
| Zhu, MQ | 1 |
| Chu, XY | 1 |
| Cai, GH | 1 |
| Liu, M | 1 |
| Yang, SZ | 1 |
| Mitchell, GA | 1 |
| Pang, WJ | 1 |
| Wu, JW | 1 |
| Torun, E | 1 |
| Özgen, IT | 1 |
| Gökçe, S | 1 |
| Aydın, S | 1 |
| Cesur, Y | 1 |
| Liu, X | 1 |
| Wang, S | 1 |
| You, Y | 1 |
| Meng, M | 1 |
| Zheng, Z | 1 |
| Dong, M | 1 |
| Lin, J | 1 |
| Zhao, Q | 1 |
| Zhang, C | 1 |
| Yuan, X | 1 |
| Hu, T | 1 |
| Liu, L | 1 |
| Huang, Y | 1 |
| Zhang, L | 1 |
| Wang, D | 1 |
| Zhan, J | 1 |
| Jong Lee, H | 1 |
| Speakman, JR | 1 |
| Jin, W | 1 |
| Fonseca, TL | 1 |
| Fernandes, GW | 1 |
| McAninch, EA | 1 |
| Bocco, BM | 1 |
| Abdalla, SM | 1 |
| Ribeiro, MO | 1 |
| Mohácsik, P | 1 |
| Fekete, C | 1 |
| Li, D | 1 |
| Xing, X | 1 |
| Wang, T | 1 |
| Gereben, B | 1 |
| Bianco, AC | 2 |
| Bonde, Y | 1 |
| Angelin, B | 1 |
| Hyde, MJ | 1 |
| Griffin, JL | 1 |
| Herrera, E | 1 |
| Byrne, CD | 1 |
| Clarke, L | 1 |
| Kemp, PR | 1 |
| Pihlajamäki, J | 1 |
| Boes, T | 1 |
| Kim, EY | 1 |
| Dearie, F | 1 |
| Kim, BW | 1 |
| Schroeder, J | 1 |
| Mun, E | 1 |
| Nasser, I | 1 |
| Park, PJ | 1 |
| Goldfine, AB | 1 |
| Patti, ME | 1 |
| Zhu, X | 1 |
| Cheng, SY | 1 |
| Grasselli, E | 1 |
| Voci, A | 1 |
| Canesi, L | 1 |
| De Matteis, R | 1 |
| Goglia, F | 1 |
| Cioffi, F | 1 |
| Fugassa, E | 1 |
| Gallo, G | 1 |
| Vergani, L | 1 |
| Frangioni, G | 1 |
| Atzori, A | 1 |
| Balzi, M | 1 |
| Fuzzi, G | 1 |
| Ghinassi, A | 1 |
| Pescosolido, N | 1 |
| Bianchi, S | 1 |
| Borgioli, G | 1 |
| Perra, A | 1 |
| Simbula, G | 1 |
| Simbula, M | 1 |
| Pibiri, M | 1 |
| Kowalik, MA | 1 |
| Sulas, P | 1 |
| Cocco, MT | 1 |
| Ledda-Columbano, GM | 1 |
| Columbano, A | 1 |
| Akiba, Y | 1 |
| Jensen, LS | 1 |
| Barb, CR | 1 |
| Kraeling, RR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Activating Brown Adipose Tissue Through Exercise: Randomized Controlled Trial[NCT02365129] | 180 participants (Anticipated) | Interventional | 2015-02-28 | Recruiting | |||
| Effects of 4-month Therapy of Levothyroxine on Non-Alcoholic Fatty Liver Disease (NAFLD) and Diabetes Control in Diabetic Patients[NCT03281083] | Phase 2 | 29 participants (Actual) | Interventional | 2014-03-28 | Terminated (stopped due to Difficult recruitment and end of funding.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for triiodothyronine and Fatty Liver
| Article | Year |
|---|---|
New insights into regulation of lipid metabolism by thyroid hormone.
Topics: Adipose Tissue; Animals; Fatty Acids; Fatty Liver; Gene Knock-In Techniques; Humans; Lipid Metabolis | 2010 |
13 other studies available for triiodothyronine and Fatty Liver
| Article | Year |
|---|---|
Independent associations of thyroid-related hormones with hepatic steatosis and insulin resistance in euthyroid overweight/obese Chinese adults.
Topics: Adult; China; Cross-Sectional Studies; Fatty Liver; Humans; Insulin Resistance; Obesity; Overweight; | 2021 |
Circulating concentrations of free triiodothyronine are associated with central adiposity and cardiometabolic risk factors in young euthyroid adults.
Topics: Adiposity; Body Mass Index; Cardiometabolic Risk Factors; Cross-Sectional Studies; Fatty Liver; Fema | 2022 |
Urolithin A exerts antiobesity effects through enhancing adipose tissue thermogenesis in mice.
Topics: Adipocytes, Brown; Adipocytes, White; Adipose Tissue, Brown; Adipose Tissue, White; Animals; Anti-Ob | 2020 |
Thyroid hormone levels in obese children and adolescents with non-alcoholic fatty liver disease.
Topics: Adolescent; Anthropometry; Biomarkers; Case-Control Studies; Child; Fatty Liver; Female; Follow-Up S | 2014 |
Brown Adipose Tissue Transplantation Reverses Obesity in Ob/Ob Mice.
Topics: Adiponectin; Adipose Tissue; Adipose Tissue, Brown; Adipose Tissue, White; Animals; Energy Metabolis | 2015 |
Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity.
Topics: Analysis of Variance; Animals; Animals, Newborn; Calorimetry, Indirect; Diet, High-Fat; Disease Susc | 2015 |
Metabolic Syndrome: One Speckled Stone Kills a Flock of Birds?
Topics: Animals; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Fatty Liver; Glucagon; Hormones; Humans | 2017 |
Delivery by Caesarean section, rather than vaginal delivery, promotes hepatic steatosis in piglets.
Topics: Animals; Blood Glucose; Cesarean Section; Delivery, Obstetric; Fatty Liver; Female; Gene Expression | 2009 |
Thyroid hormone-related regulation of gene expression in human fatty liver.
Topics: Adult; Animals; Diabetes Mellitus, Type 2; Fatty Liver; Female; Gene Expression Regulation; Heat-Sho | 2009 |
Direct effects of iodothyronines on excess fat storage in rat hepatocytes.
Topics: Acyl-CoA Oxidase; Animals; Catalase; Cells, Cultured; Diiodothyronines; Fatty Liver; Gene Expression | 2011 |
Thyroid and hypoxic stress in the newt Triturus carnifex.
Topics: Animals; Fatty Liver; Female; Heart Rate; Histocytochemistry; Hypoxia; Kidney; Male; Melanosis; Pitu | 2006 |
Thyroid hormone (T3) and TRbeta agonist GC-1 inhibit/reverse nonalcoholic fatty liver in rats.
Topics: Acetates; Animals; Base Sequence; Diet; Disease Models, Animal; DNA Primers; Fatty Liver; Lipid Pero | 2008 |
Plasma estradiol, thyroid hormones, and liver lipid content in laying hens fed different isocaloric diets.
Topics: Animals; Chickens; Diet; Energy Intake; Estradiol; Fatty Liver; Female; Fish Products; Lipids; Liver | 1982 |