triiodothyronine has been researched along with Down Syndrome in 26 studies
Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the background of untreated hypothyroidism, a possible association of ovarian hyperstimulation syndrome (OHSS) and reactive pituitary hyperplasia should be kept in mind, thus preventing unnecessary interventions." | 1.72 | Myxedema crisis and ovarian hyperstimulation in a child with Down syndrome. ( Abraham, MS; Jagannathan, P; Narayanan, R; Sampathkumar, G, 2022) |
| "Down's syndrome is associated with higher TSH levels." | 1.38 | Hyperthyrotropinaemia in untreated subjects with Down's syndrome aged 6 months to 64 years: a comparative analysis. ( Antebi, F; Bar-Tal, O; Greenberg-Dotan, S; Hochberg, Z; Meyerovitch, J, 2012) |
| "Serum TSH in the trisomy 21 pregnancies was lower [0." | 1.37 | Maternal thyroid function at 11-13 weeks of gestation in fetal trisomies 21 and 18. ( Ashoor, G; Cuckle, H; Jawdat, F; Maiz, N; Nicolaides, KH, 2011) |
| "Down Syndrome (DS) or trisomy 21 (T21) is the most frequent and the best known malformation syndrome associated with mental deficiency that appears in human,." | 1.33 | Down Syndrome and thyroid gland. ( Hasanhodzić, M; Lukinac, L; Tahirović, H, 2006) |
| "These data suggest that autoimmune thyroiditis associated with a mild "subclinical" form of hypothyroidism is common in adult DS patients and more pronounced in patients with AD manifestations than in those without." | 1.28 | Autoimmune thyroiditis associated with mild "subclinical" hypothyroidism in adults with Down syndrome: a comparison of patients with and without manifestations of Alzheimer disease. ( Andrews, DF; Crapper McLachlan, DR; Dalton, AJ; Gera, E; Hummel, JT; Markovic, VD; Percy, ME; Rusk, AC; Somerville, MJ; Walfish, PG, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (42.31) | 18.7374 |
| 1990's | 7 (26.92) | 18.2507 |
| 2000's | 2 (7.69) | 29.6817 |
| 2010's | 3 (11.54) | 24.3611 |
| 2020's | 3 (11.54) | 2.80 |
| Authors | Studies |
|---|---|
| Abraham, MS | 1 |
| Sampathkumar, G | 1 |
| Narayanan, R | 1 |
| Jagannathan, P | 1 |
| Calcaterra, V | 1 |
| Gazzarri, A | 2 |
| De Silvestri, A | 1 |
| Madia, C | 1 |
| Baldassarre, P | 1 |
| Rossi, V | 1 |
| Garella, V | 1 |
| Zuccotti, G | 1 |
| Cattoni, A | 1 |
| Molinari, S | 1 |
| Capitoli, G | 1 |
| Masera, N | 1 |
| Nicolosi, ML | 1 |
| Barzaghi, S | 1 |
| Marziali, G | 1 |
| Lazzerotti, A | 1 |
| Vimercati, C | 1 |
| Sala, D | 1 |
| Biondi, A | 1 |
| Galimberti, S | 1 |
| Fossati, C | 1 |
| Salerno, M | 1 |
| Capalbo, D | 1 |
| Cerbone, M | 1 |
| De Luca, F | 1 |
| Ashoor, G | 1 |
| Maiz, N | 1 |
| Cuckle, H | 1 |
| Jawdat, F | 1 |
| Nicolaides, KH | 1 |
| Meyerovitch, J | 1 |
| Antebi, F | 1 |
| Greenberg-Dotan, S | 1 |
| Bar-Tal, O | 1 |
| Hochberg, Z | 1 |
| JACKIM, E | 1 |
| WORTIS, J | 1 |
| ADESMAN, J | 1 |
| SPINELLI-RESSI, F | 1 |
| BERGONZI, F | 1 |
| FISHER, DA | 1 |
| ODDIE, TH | 1 |
| WAIT, JC | 1 |
| WALL, RL | 1 |
| UMLAUF, HJ | 1 |
| GEPPERT, LJ | 1 |
| KOCH, R | 1 |
| SHARE, J | 1 |
| GRALIKER, B | 1 |
| FERRIER, PE | 1 |
| LEMARCHAND-BERAUD, T | 1 |
| Magni, P | 1 |
| Ruscica, M | 1 |
| Dozio, E | 1 |
| Roti, E | 1 |
| Licastro, F | 3 |
| Motta, M | 1 |
| Corsi, MM | 1 |
| Hasanhodzić, M | 1 |
| Tahirović, H | 1 |
| Lukinac, L | 1 |
| Samuel, AM | 1 |
| Krishna Murthy, DS | 1 |
| Kadival, GV | 1 |
| Patel, ZM | 1 |
| Mehta, MN | 1 |
| Ganatra, RD | 1 |
| Ambani, LM | 1 |
| Sustrová, M | 1 |
| Strbák, V | 1 |
| Mocchegiani, E | 1 |
| Masi, M | 1 |
| Fabris, N | 1 |
| Morini, MC | 1 |
| Davis, LJ | 1 |
| Allison, DB | 1 |
| Gomez, JE | 1 |
| Heshka, S | 1 |
| Babbitt, RL | 1 |
| Geliebter, A | 1 |
| Kreibich, K | 1 |
| Heymsfield, SB | 1 |
| Toledo, C | 1 |
| Alembik, Y | 1 |
| Dott, B | 1 |
| Finck, S | 1 |
| Stoll, C | 1 |
| Schmidt, BJ | 1 |
| Carvalho, N | 1 |
| Ortega, CC | 1 |
| Libermam, J | 1 |
| Biazzi, JM | 1 |
| Tapajós, PM | 1 |
| Krynski, S | 1 |
| Murdoch, JC | 1 |
| Ratcliffe, WA | 1 |
| McLarty, DG | 1 |
| Rodger, JC | 1 |
| Ratcliffe, JG | 1 |
| Korsager, S | 1 |
| Chatham, EM | 1 |
| Ostergaard Kristensen, HP | 1 |
| Sharav, T | 1 |
| Landau, H | 1 |
| Zadik, Z | 1 |
| Einarson, TR | 1 |
| Percy, ME | 1 |
| Dalton, AJ | 1 |
| Markovic, VD | 1 |
| Crapper McLachlan, DR | 1 |
| Gera, E | 1 |
| Hummel, JT | 1 |
| Rusk, AC | 1 |
| Somerville, MJ | 1 |
| Andrews, DF | 1 |
| Walfish, PG | 1 |
| Hasen, J | 1 |
1 review available for triiodothyronine and Down Syndrome
| Article | Year |
|---|---|
Subclinical hypothyroidism in childhood - current knowledge and open issues.
Topics: Anticonvulsants; Antiviral Agents; Asymptomatic Diseases; Atherosclerosis; Bone Diseases, Metabolic; | 2016 |
2 trials available for triiodothyronine and Down Syndrome
| Article | Year |
|---|---|
Thyroid function and plasma immunoglobulins in subjects with Down's syndrome (DS) during ontogenesis and zinc therapy.
Topics: Adolescent; Adult; Aging; Child; Child, Preschool; Down Syndrome; Female; Humans; Immunoglobulin A; | 1994 |
Modulation of the neuroendocrine system and immune functions by zinc supplementation in children with Down's syndrome.
Topics: Down Syndrome; Female; Follow-Up Studies; Humans; Male; Sulfates; Thymic Factor, Circulating; Thyroi | 1993 |
23 other studies available for triiodothyronine and Down Syndrome
| Article | Year |
|---|---|
Myxedema crisis and ovarian hyperstimulation in a child with Down syndrome.
Topics: Adolescent; Down Syndrome; Female; Humans; Hypothyroidism; Myxedema; Ovarian Hyperstimulation Syndro | 2022 |
Thyroid function, sensitivity to thyroid hormones, and metabolic syndrome in euthyroid children and adolescents with Down syndrome.
Topics: Adolescent; Child; Cholesterol, HDL; Down Syndrome; Humans; Metabolic Syndrome; Thyroid Gland; Thyro | 2023 |
Thyroid Function Tests in Children and Adolescents With Trisomy 21: Definition of Syndrome-Specific Reference Ranges.
Topics: Adolescent; Child; Down Syndrome; Humans; Hypothyroidism; Reference Values; Retrospective Studies; T | 2023 |
Maternal thyroid function at 11-13 weeks of gestation in fetal trisomies 21 and 18.
Topics: Adult; Chorionic Gonadotropin, beta Subunit, Human; Chromosomes, Human, Pair 18; Down Syndrome; Fema | 2011 |
Hyperthyrotropinaemia in untreated subjects with Down's syndrome aged 6 months to 64 years: a comparative analysis.
Topics: Adolescent; Adult; Age Distribution; Case-Control Studies; Child; Child, Preschool; Down Syndrome; H | 2012 |
Triidothyronine uptake by erythrocytes in mongolism.
Topics: Down Syndrome; Erythrocytes; Triiodothyronine | 1961 |
RED CELL TRIIODOTHYRONINE UPTAKE AS A MEASURE OF THYROID FUNCTION IN MONGOLISM.
Topics: Adolescent; Basal Metabolism; Blood Protein Electrophoresis; Child; Down Syndrome; Erythrocytes; Hep | 1963 |
THYROID FUNCTION TESTS. FINDINGS IN ARKANSAS CHILDREN AND YOUNG ADULTS.
Topics: Adolescent; Adult; Arkansas; Biological Phenomena; Child; Down Syndrome; Growth; Humans; Physiologic | 1964 |
MUSCLE REFLEX PATTERNS IN INFANCY AND CHILDHOOD. NORMAL PATTERNS AND PATTERNS IN THYROID DISORDERS, CEREBRAL PALSY, AND MENINGOPATHIES.
Topics: Cerebral Palsy; Child; Clinical Laboratory Techniques; Down Syndrome; Electrocardiography; Electroph | 1964 |
THE EFFECTS OF CYTOMEL ON YOUNG CHILDREN WITH DOWN'S SYNDROME (MONGOLISM): A DOUBLE-BLIND LONGITUDINAL STUDY.
Topics: Biomedical Research; Body Height; Child; Double-Blind Method; Down Syndrome; Drug Therapy; Growth; H | 1965 |
VARIATIONS OF THYROID HORMONE TRANSPORT IN THE BLOOD OF NORMAL CHILDREN AND OF CHILDREN WITH MONGOLISM.
Topics: Blood Protein Electrophoresis; Blood Proteins; Child; Down Syndrome; Erythrocytes; Humans; Infant; I | 1965 |
Free and bound leptin in prepubertal children with Down's syndrome and different degrees of adiposity.
Topics: Adipose Tissue; Adolescent; Body Mass Index; Child; Child, Preschool; Down Syndrome; Female; Humans; | 2004 |
Down Syndrome and thyroid gland.
Topics: Adolescent; Age Factors; Child; Child, Preschool; Down Syndrome; Female; Humans; Infant; Infant, New | 2006 |
Thyroid function studies in young Down's syndrome.
Topics: Child; Child, Preschool; Down Syndrome; Female; Humans; Infant; Infant, Newborn; Male; Thyroid Gland | 1981 |
Neuroendocrine immune modulation induced by zinc in a progeroid disease--Down's syndrome.
Topics: Adolescent; Adult; Aging; Brain; Child; Child, Preschool; Down Syndrome; Female; Granulocytes; Human | 1994 |
Decreased resting metabolic rate among persons with Down Syndrome.
Topics: Absorptiometry, Photon; Adult; Analysis of Variance; Body Composition; Calorimetry, Indirect; Down S | 1995 |
[Anomalies of thyroid function in children with Down syndrome].
Topics: Adolescent; Adult; Age Determination by Skeleton; Child; Child, Preschool; Down Syndrome; Female; Hu | 1997 |
Studies of the thyroid function in children with Down's syndrome.
Topics: Adolescent; Child; Child, Preschool; Down Syndrome; Female; Humans; Infant; Male; Thyroid Function T | 1975 |
Thyroid function in adults with Down's syndrome.
Topics: Adult; Aged; Antibodies; Down Syndrome; Female; Humans; Hypothyroidism; Male; Middle Aged; Thyroid G | 1977 |
Thyroid function tests in adults with Down's syndrome.
Topics: Adult; Autoantibodies; Down Syndrome; Female; Humans; Hypothyroidism; Male; Middle Aged; Thyroid Fun | 1978 |
Age-related patterns of thyroid-stimulating hormone response to thyrotropin-releasing hormone stimulation in Down syndrome.
Topics: Analysis of Variance; Child; Child, Preschool; Down Syndrome; Female; Humans; Infant; Male; Thyrotro | 1991 |
Autoimmune thyroiditis associated with mild "subclinical" hypothyroidism in adults with Down syndrome: a comparison of patients with and without manifestations of Alzheimer disease.
Topics: Adult; Aged; Alzheimer Disease; Antibodies; Down Syndrome; Female; Humans; Hypothyroidism; Male; Mic | 1990 |
Endocrine studies in a patient with G-21-trisomy.
Topics: Brain; Dihydroxyphenylalanine; Down Syndrome; Glucose; Growth Hormone; Humans; Karyotyping; Pituitar | 1974 |