Page last updated: 2024-11-08

triiodothyronine and Diabetic Nephropathies

triiodothyronine has been researched along with Diabetic Nephropathies in 8 studies

Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.

Diabetic Nephropathies: KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.

Research Excerpts

ExcerptRelevanceReference
"The objective of the study was to describe the clinical and biochemical findings of four patients with chronic hypothyroidism, previously euthyroid on fixed doses of L-T4 for several years, in whom the metformin was initiated."3.73Thyrotropin suppression by metformin. ( Filmore-Nassar, A; Glass, AR; Vigersky, RA, 2006)
"41."1.91Free triiodothyronine predicts the risk of developing diabetic kidney disease. ( Duan, P; Hu, W; Jiang, S; Li, S; Li, W; Tu, P; Wan, Z; Yang, Z, 2023)
"Notably, diabetic nephropathy was accompanied by a significant decrease in PI3K activity and an increase in TGF-β1 expression in kidneys."1.37Thyroid hormone ameliorates diabetic nephropathy in a mouse model of type II diabetes. ( Lin, Y; Sun, Z, 2011)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's2 (25.00)29.6817
2010's3 (37.50)24.3611
2020's2 (25.00)2.80

Authors

AuthorsStudies
Liu, MC1
Li, JL1
Wang, YF1
Meng, Y1
Cai, Z1
Shen, C1
Wang, MD1
Zhao, WJ1
Niu, WQ1
Li, W1
Yang, Z1
Li, S1
Jiang, S1
Hu, W1
Wan, Z1
Tu, P1
Duan, P1
Benedetti, V1
Lavecchia, AM1
Locatelli, M1
Brizi, V1
Corna, D1
Todeschini, M1
Novelli, R1
Benigni, A1
Zoja, C1
Remuzzi, G1
Xinaris, C1
Han, Q1
Zhang, J1
Wang, Y1
Li, H1
Zhang, R1
Guo, R1
Li, L1
Teng, G1
Wang, J1
Wang, T1
Liu, F1
Lin, Y1
Sun, Z1
Piccoli, GB1
Mezza, E1
Burdese, M1
Terzolo, M1
Grassi, G1
Bermond, F1
Soragna, G1
Gai, M1
Dani, F1
Jeantet, A1
Segoloni, GP1
Piccoli, G1
Vigersky, RA1
Filmore-Nassar, A1
Glass, AR1
Evers, J1
Scheid, H1

Other Studies

8 other studies available for triiodothyronine and Diabetic Nephropathies

ArticleYear
Association between thyroid hormones and diabetic kidney disease in Chinese adults.
    BMC endocrine disorders, 2023, Mar-08, Volume: 23, Issue:1

    Topics: Adult; Diabetes Mellitus; Diabetic Nephropathies; East Asian People; Humans; Retrospective Studies;

2023
Free triiodothyronine predicts the risk of developing diabetic kidney disease.
    BMC nephrology, 2023, 10-11, Volume: 24, Issue:1

    Topics: Biomarkers; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Glomerular Filtration Rate; Humans; R

2023
Alteration of thyroid hormone signaling triggers the diabetes-induced pathological growth, remodeling, and dedifferentiation of podocytes.
    JCI insight, 2019, 09-19, Volume: 4, Issue:18

    Topics: Animals; Cell Cycle Checkpoints; Cell Line; Diabetes Mellitus, Experimental; Diabetic Nephropathies;

2019
Thyroid hormones and diabetic nephropathy: An essential relationship to recognize.
    Nephrology (Carlton, Vic.), 2019, Volume: 24, Issue:2

    Topics: Adult; Aged; Biomarkers; Biopsy; Creatinine; Diabetic Nephropathies; Female; Glomerular Filtration R

2019
Thyroid hormone ameliorates diabetic nephropathy in a mouse model of type II diabetes.
    The Journal of endocrinology, 2011, Volume: 209, Issue:2

    Topics: Albuminuria; Animals; Collagen; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic

2011
Progression of renal failure without proteinuria in a patient with type 1 diabetes.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2004, Volume: 19, Issue:12

    Topics: Adult; Biopsy; Creatine Kinase; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Disease Progressi

2004
Thyrotropin suppression by metformin.
    The Journal of clinical endocrinology and metabolism, 2006, Volume: 91, Issue:1

    Topics: Aged; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Drug Interactions; Female; Goiter; Graves D

2006
Low serum TSH levels and negative TRH test in dialysis patients.
    Nephron, 1995, Volume: 71, Issue:3

    Topics: Aged; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Female; Goiter, Nodular; Humans; Kidney Fai

1995