triiodothyronine has been researched along with Depression, Endogenous in 166 studies
Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In an open trial, we investigated the efficacy of triiodothyronine (T(3)) adjuvant to selective serotonin reuptake inhibitors (SSRIs) in subjects with major depressive disorder (MDD) resistant to SSRI treatment." | 9.11 | An open study of triiodothyronine augmentation of selective serotonin reuptake inhibitors in treatment-resistant major depressive disorder. ( Alpert, JE; Fava, M; Iosifescu, DV; Mischoulon, D; Nierenberg, AA; Papakostas, GI; Perlis, RH; Ryan, JL, 2005) |
| "A total of 142 adult outpatients with nonpsychotic major depressive disorder who had not achieved remission or who were intolerant to an initial prospective treatment with citalopram and a second switch or augmentation trial were randomly assigned to augmentation with lithium (up to 900 mg/day; N=69) or with T(3) (up to 50 mug/day; N=73) for up to 14 weeks." | 5.12 | A comparison of lithium and T(3) augmentation following two failed medication treatments for depression: a STAR*D report. ( Alpert, JE; Fava, M; Lebowitz, B; Luther, JF; McGrath, PJ; Niederehe, G; Nierenberg, AA; Rush, AJ; Shores-Wilson, K; Thase, ME; Trivedi, MH; Warden, D; Wisniewski, SR, 2006) |
| "In an open trial, we investigated the efficacy of triiodothyronine (T(3)) adjuvant to selective serotonin reuptake inhibitors (SSRIs) in subjects with major depressive disorder (MDD) resistant to SSRI treatment." | 5.11 | An open study of triiodothyronine augmentation of selective serotonin reuptake inhibitors in treatment-resistant major depressive disorder. ( Alpert, JE; Fava, M; Iosifescu, DV; Mischoulon, D; Nierenberg, AA; Papakostas, GI; Perlis, RH; Ryan, JL, 2005) |
| " Four hypotheses suggest an effect in these ailments: 1) a local relative T4 excess present (or better postulated to be present) in the brain of depressed patients is lowered by triiodothyronine (T3), by lowering serum levels of thyroxine (T4), 2) the effect of a depression-mediated cerebral lack of catecholamines is compensated by the T3/T4 induced activation of beta-receptors, 3) a postulated depression-induced local cerebral hypothyroidism can be counteracted by T3 and T4." | 4.80 | [Administration of thyroid hormones in therapy of psychiatric illnesses]. ( Weissel, M, 1999) |
| "Triiodothyronine (T3) has been shown to accelerate and potentiate the clinical response to tricyclic antidepressant (TCA) treatment in depressive disorders." | 3.71 | Chronic effects of triiodothyronine in combination with imipramine on 5-HT transporter, 5-HT(1A) and 5-HT(2A) receptors in adult rat brain. ( Jeanningros, R; Mazzola-Pomietto, P; Moreau, X, 2001) |
| "The authors used a Cox regression survival analysis to evaluate the relationship between life course of depressive illness and basal levels of thyroid hormones (triiodothyronine [T(3)], thyroxine [T(4)], and thyrotropin) in 75 outpatients with unipolar major depressive disorder." | 3.70 | Thyroid hormone levels and recurrence of major depression. ( Joffe, RT; Marriott, M, 2000) |
| "To describe a patient with longstanding depression and hypothyroidism who had marked mood improvement only after triiodothyronine (T3) was added to her thyroxine (T4) replacement therapy." | 3.70 | Hypothyroidism and depression: a therapeutic challenge. ( Makela, EH; Rack, SK, 2000) |
| "Serum concentrations of thyrotropine (TSH), thyroxine (T4), free T4 (fT4), triiodothyronine (T3) and reverse T3 (rT3) were measured 4 x during a 12-month period in 28 patients with major depressive disorder maintained on lithium prophylaxis for 4-23 years (mean = 11." | 3.69 | The hypothalamic-pituitary-thyroid axis in patients maintained on lithium prophylaxis for years: high triiodothyronine serum concentrations are correlated to the prophylactic efficacy. ( Baumgartner, A; Gräf, KJ; Kürten, I; Müller-Oerlinghausen, B; von Stuckrad, M, 1995) |
| "Medication-free inpatients with major depression or bipolar disorder were studied with oxygen-15 water and positron emission tomography (PET) to measure CBF (N = 19) or with [18F] fluorodeoxyglucose and PET to measure cerebral glucose metabolism (N = 29)." | 3.69 | Inverse relationship of peripheral thyrotropin-stimulating hormone levels to brain activity in mood disorders. ( Andreason, PJ; Callahan, AM; George, MS; Herscovitch, P; Horwitz, B; Ketter, TA; Marangell, LB; Parekh, P; Pazzaglia, PJ; Post, RM, 1997) |
| "In the present study, the levels of the baseline cortisol, thyrotropin (TSH), triiodothyronine (T3), thyroxine (T4) and growth hormone (GH) were determined in 64 depressive patients, 17 patients with other depressive disorders and 19 normal controls." | 3.68 | [The endocrine abnormalities of depressive patients]. ( Yang, Q, 1992) |
| "Thyrotropin (TSH), thyroxine (T4), free T4, triiodothyronine (T3), and free T3 (fT3) concentrations were measured in 25 patients with major depressive disorder at 8 a." | 3.68 | Thyrotropin (TSH) and thyroid hormone concentrations during partial sleep deprivation in patients with major depressive disorder. ( Baumgartner, A; Gräf, KJ; Kürten, I; Meinhold, H, 1990) |
| " In the present study, thyroid functions (TFTs) and thyrotropin-releasing hormone (TRH) stimulation of thyroid-stimulating hormone (TSH) were measured before and after treatment with desipramine (DMI) in 13 men with a diagnosis of major depressive disorder." | 3.67 | The thyroid axis and desipramine treatment in depression. ( Anton, RF; Brady, KT, 1989) |
| "Levels of circulating total thyroxine (TT4), free thyroxine (FT4), total triiodothyronine TT3 and thyrotropin (TSH) were determined in 27 men with unipolar major depressive disorder ages 24-50, mean +/- SEM 36." | 3.67 | Serum concentrations of circulating thyroid hormones in a group of depressed men. ( Friedenthal, S; Giller, E; Ibrahim, G; Kosten, T; Mason, J; Wahby, V, 1989) |
| "The serum levels of thyroxine and triiodothyronine (T4 and T3) were investigated at 10 different time points during a 24 h period in 31 inpatients meeting the RDC criteria for acute major depressive disorder." | 3.67 | Twenty-four-hour serum levels of T4 and T3 in relation to decreased TSH serum levels and decreased TSH response to TRH in affective disorders. ( Beck-Friis, J; Kjellman, BF; Ljunggren, JG; Undén, F; Wetterberg, L, 1986) |
| " Each of these nine patients with symptomless autoimmune thyroiditis had normal baseline serum thyrotropin concentrations and normal thyroid function (as assessed by T4, T3 uptake, and free thyroxine index)." | 3.67 | Antithyroid antibodies in depressed patients. ( Evans, DL; Haggerty, JJ; Nemeroff, CB; Simon, JS, 1985) |
| " In one case, the excess thyroid hormone was the product of hyperthyroidism; whenever the hyperthyroidism was treated, the remission induced by imipramine was negated." | 3.66 | Dependency of tricyclic antidepressant efficacy on thyroid hormone potentiation: case studies. ( Swartz, CM, 1982) |
| "We treated with fluoxetine 235 outpatients meeting DSM-IV criteria for major depression." | 2.70 | T3 blood levels and treatment outcome in depression. ( Alpert, JE; Fava, M; Howarth, S; Iosifescu, DV; Nierenberg, AA; Worthington, JJ, 2001) |
| "The evolution of kinetic parameters (Vmax, maximal velocity, and Km, Michaelis constant) of red blood cell (RBC) triiodothyronine (L-T3) initial uptake was followed in 19 inpatients suffering from unipolar depression after 1 week (D7) and 4 weeks (D28) of a chronic administration of fluvoxamine, in relation with the clinical efficacy of the drug." | 2.69 | Red blood cell triiodothyronine uptake in unipolar major depression: effect of a chronic antidepressant treatment. ( Azorin, JM; Jeanningros, R; Lejeune, PJ; Moreau, X, 2000) |
| " T3 augmentation was performed over a four-week period; during the last three weeks the daily dosage was 37." | 2.68 | An open study of triiodothyronine augmentation of tricyclic antidepressants in inpatients with refractory depression. ( Birkenhäger, TK; Nolen, WA; Vegt, M, 1997) |
| "The literature suggests that sleep deprivation can potentiate the effect of antidepressant medication in depressed patients." | 2.67 | A clinical trial of sleep deprivation in combination with antidepressant medication. ( Leibenluft, E; Madden, PA; Moul, DE; Schwartz, PJ; Wehr, TA, 1993) |
| " The authors report on the lack of efficacy of adjunctive L-triiodothyronine (T3; 25 micrograms/day) in a sample of 20 outpatient unipolar depressives who had not responded to greater than or equal to 12 weeks of treatment with imipramine (mean dosage = 240 mg/day) and interpersonal psychotherapy." | 2.66 | Treatment of imipramine-resistant recurrent depression: I. An open clinical trial of adjunctive L-triiodothyronine. ( Jarrett, DB; Kupfer, DJ; Thase, ME, 1989) |
| "Furthermore, primary hypothyroidism can be associated with mood disturbances, mainly depression, and a reduced response to antidepressants." | 2.46 | [The use of thyroid hormones in the treatment of depression]. ( Cooper, R; Lerer, B, 2010) |
| " According to these guidelines a substantial number of patients is not sufficiently treated and, thus, should be reassessed for dosage and length of antidepressant medications." | 2.40 | [Therapy refractory depression]. ( Hatzinger, M; Holsboer-Trachsler, E, 1999) |
| "The prevalence of autoimmune thyroiditis in the general population is estimated to be at about 5-14 %." | 1.42 | Association between autoimmune thyroiditis and depressive disorder in psychiatric outpatients. ( Degner, D; Haust, M; Meller, J; Reulbach, U; Rüther, E, 2015) |
| "Treatment with sertraline for 4 weeks increased plasma cortisol levels, while 24 weeks of sertraline treatment increased plasma T(3) levels in depressed patients." | 1.31 | Effects of sertraline treatment on plasma cortisol, prolactin and thyroid hormones in female depressed patients. ( Jakovljević, M; Korsić, M; Mihaljević-Peles, A; Mück-Seler, D; Pivac, N; Sagud, M, 2002) |
| " The most popular treatment choices were increasing dosage of tricyclic medication and change of medication of SSRI." | 1.30 | Pharmacological choices after one antidepressant fails: a survey of UK psychiatrists. ( Katona, CL; Shergill, SS, 1997) |
| "Triiodothyronine (T3) has been shown to augment the therapeutic effect of tricyclic antidepressants as well as monoamine oxidase inhibitors." | 1.28 | Triiodothyronine potentiation of fluoxetine in depressed patients. ( Joffe, RT, 1992) |
| " There was no change in alpha MT6s excretion, and thus the previously reported potentiation of the efficacy of tricyclic antidepressants in combination with T3 does not appear to be mediated through an alteration in noradrenergic neurotransmission." | 1.28 | A study of the effects of desipramine treatment alone and in combination with L-triiodothyronine on 6-sulphatoxymelatonin excretion in depressed patients. ( Arendt, J; Bearn, J; Checkley, SA; Franey, C, 1989) |
| "Piribedil is a relatively selective dopamine agonist with moderate antidepressant activity." | 1.27 | Neuroendocrine effects of the dopamine agonist piribedil in depressed patients. ( Ballenger, JC; Gold, PW; Joffe, RT; Post, RM; Rakita, R; Rebar, R, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 62 (37.35) | 18.7374 |
| 1990's | 59 (35.54) | 18.2507 |
| 2000's | 37 (22.29) | 29.6817 |
| 2010's | 8 (4.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Markova, N | 1 |
| Chernopiatko, A | 1 |
| Schroeter, CA | 1 |
| Malin, D | 1 |
| Kubatiev, A | 1 |
| Bachurin, S | 1 |
| Costa-Nunes, J | 1 |
| Steinbusch, HM | 1 |
| Strekalova, T | 1 |
| Fjaellegaard, K | 1 |
| Kvetny, J | 1 |
| Allerup, PN | 1 |
| Bech, P | 1 |
| Ellervik, C | 1 |
| Degner, D | 1 |
| Haust, M | 1 |
| Meller, J | 1 |
| Rüther, E | 1 |
| Reulbach, U | 1 |
| Cooper-Kazaz, R | 1 |
| van der Deure, WM | 1 |
| Medici, M | 1 |
| Visser, TJ | 1 |
| Alkelai, A | 1 |
| Glaser, B | 1 |
| Peeters, RP | 1 |
| Lerer, B | 3 |
| Carvalho, AF | 2 |
| Machado, JR | 1 |
| Cavalcante, JL | 2 |
| Holtmann, M | 1 |
| Duketis, E | 1 |
| Goth, K | 1 |
| Poustka, L | 1 |
| Boelte, S | 1 |
| Schmauss, M | 3 |
| Messer, T | 2 |
| Shukla, PK | 1 |
| Sittig, LJ | 1 |
| Andrus, BM | 1 |
| Schaffer, DJ | 1 |
| Batra, KK | 1 |
| Redei, EE | 1 |
| Duval, F | 2 |
| Mokrani, MC | 2 |
| Lopera, FG | 1 |
| Diep, TS | 2 |
| Rabia, H | 1 |
| Fattah, S | 1 |
| Cooper, R | 1 |
| Shelton, RC | 2 |
| BAUER, HG | 1 |
| McGAVACK, TH | 1 |
| SWELL, L | 1 |
| Kolawole, BA | 1 |
| Ikem, RT | 1 |
| Bahls, SC | 1 |
| de Carvalho, GA | 1 |
| Lifschytz, T | 1 |
| Gur, E | 1 |
| Newman, ME | 1 |
| Inoue, T | 1 |
| Kitaichi, T | 1 |
| Ogawa, T | 1 |
| Joffe, RT | 20 |
| Sawka, AM | 1 |
| Marriott, MJ | 1 |
| MacQueen, GM | 1 |
| Gernstein, HC | 1 |
| Schüle, C | 1 |
| Baghai, TC | 1 |
| Tsikolata, V | 1 |
| Zwanzger, P | 1 |
| Eser, D | 1 |
| Schaaf, L | 1 |
| Rupprecht, R | 2 |
| Monteleone, P | 1 |
| Santonastaso, P | 1 |
| Pannuto, M | 1 |
| Favaro, A | 1 |
| Caregaro, L | 1 |
| Castaldo, E | 1 |
| Zanetti, T | 1 |
| Maj, M | 1 |
| Iosifescu, DV | 2 |
| Nierenberg, AA | 4 |
| Mischoulon, D | 1 |
| Perlis, RH | 1 |
| Papakostas, GI | 1 |
| Ryan, JL | 1 |
| Alpert, JE | 3 |
| Fava, M | 5 |
| Helmreich, DL | 1 |
| Crouch, M | 1 |
| Dorr, NP | 1 |
| Parfitt, DB | 1 |
| Ros, S | 1 |
| Agüera, L | 1 |
| de la Gándara, J | 1 |
| Rojo, JE | 1 |
| de Pedro, JM | 1 |
| Grajower, MM | 1 |
| Bunevicius, R | 1 |
| Varoneckas, G | 1 |
| Prange, AJ | 11 |
| Hinderliter, AL | 1 |
| Gintauskiene, V | 1 |
| Girdler, SS | 1 |
| Trivedi, MH | 1 |
| Wisniewski, SR | 1 |
| Thase, ME | 3 |
| McGrath, PJ | 1 |
| Warden, D | 1 |
| Luther, JF | 1 |
| Niederehe, G | 1 |
| Lebowitz, B | 1 |
| Shores-Wilson, K | 1 |
| Rush, AJ | 2 |
| Heath, S | 1 |
| Castelo, MS | 1 |
| Lima, MC | 1 |
| Fardella, CE | 1 |
| Artigas, RA | 1 |
| Gloger, S | 1 |
| Jiménez, M | 1 |
| Carvajal, CA | 1 |
| Krall, PM | 1 |
| Quiroz, D | 1 |
| Campino, C | 1 |
| Mosso, LM | 1 |
| Tadić, A | 1 |
| Lieb, K | 1 |
| Jokinen, J | 1 |
| Samuelsson, M | 1 |
| Nordström, AL | 1 |
| Nordström, P | 1 |
| Sulser, F | 1 |
| Stern, SL | 1 |
| Mendels, J | 1 |
| Extein, I | 4 |
| Gold, MS | 5 |
| Pottash, AL | 3 |
| Loosen, PT | 8 |
| Whybrow, PC | 3 |
| Czekalski, S | 1 |
| Horodnicki, JM | 1 |
| Spychalska-Mauritsch, T | 1 |
| Wdowiak, J | 1 |
| Gołebiowska, I | 1 |
| Hullett, FJ | 1 |
| Bidder, TG | 1 |
| Dackis, CA | 1 |
| Bailey, J | 1 |
| Stuckey, RF | 1 |
| Extein, IL | 3 |
| Wilson, IC | 2 |
| Dew, BW | 2 |
| Tipermas, A | 1 |
| Kjellman, BF | 3 |
| Ljunggren, JG | 3 |
| Beck-Friis, J | 3 |
| Wetterberg, L | 3 |
| Targum, SD | 1 |
| Greenberg, RD | 1 |
| Harmon, RL | 1 |
| Kessler, K | 1 |
| Salerian, AJ | 1 |
| Fram, DH | 1 |
| Schwarcz, G | 1 |
| Halaris, A | 1 |
| Baxter, L | 1 |
| Escobar, J | 1 |
| Thompson, M | 1 |
| Young, M | 1 |
| Roy-Byrne, PP | 1 |
| Uhde, TW | 2 |
| Post, RM | 7 |
| Calloway, SP | 1 |
| Dolan, RJ | 1 |
| Fonagy, P | 1 |
| De Souza, VF | 1 |
| Wakeling, A | 1 |
| Linnoila, M | 3 |
| Cowdry, R | 1 |
| Lamberg, BA | 2 |
| Makinen, T | 1 |
| Rubinow, D | 1 |
| Walsh, BT | 1 |
| Potter, WZ | 1 |
| Gold, PW | 3 |
| Goodwin, FK | 3 |
| Kent, S | 1 |
| Swartz, CM | 1 |
| Muscettola, G | 1 |
| Lipton, MA | 1 |
| Prange, A | 1 |
| Stewart, JW | 2 |
| Weeke, A | 1 |
| Weeke, J | 1 |
| Baumgartner, A | 6 |
| von Stuckrad, M | 1 |
| Müller-Oerlinghausen, B | 1 |
| Gräf, KJ | 3 |
| Kürten, I | 3 |
| Labbate, LA | 1 |
| Abraham, ME | 1 |
| Rosenbaum, JF | 1 |
| Samson, JA | 1 |
| Mirin, SM | 1 |
| Griffin, M | 1 |
| Borrelli, D | 1 |
| Schildkraut, JJ | 1 |
| Barsano, CP | 1 |
| Garces, J | 1 |
| Iqbal, Z | 1 |
| Scherer, J | 1 |
| Dommisse, J | 1 |
| Winn, S | 1 |
| Ekhatore, N | 1 |
| Singer, W | 4 |
| Levitt, AJ | 5 |
| MacDonald, C | 1 |
| Leibenluft, E | 1 |
| Moul, DE | 1 |
| Schwartz, PJ | 1 |
| Madden, PA | 1 |
| Wehr, TA | 1 |
| Joffe, R | 1 |
| Segal, Z | 1 |
| Sokolov, ST | 2 |
| Crocq, MA | 1 |
| Jautz, M | 1 |
| Bailey, P | 1 |
| Macher, JP | 1 |
| Aronson, R | 1 |
| Offman, HJ | 1 |
| Naylor, CD | 1 |
| Volz, HP | 1 |
| Campos-Barros, A | 1 |
| Stieglitz, RD | 1 |
| Mansmann, U | 1 |
| Mackert, A | 1 |
| Marangell, LB | 1 |
| Ketter, TA | 2 |
| George, MS | 1 |
| Pazzaglia, PJ | 1 |
| Callahan, AM | 2 |
| Parekh, P | 1 |
| Andreason, PJ | 1 |
| Horwitz, B | 1 |
| Herscovitch, P | 1 |
| Erfurth, A | 1 |
| Birkenhäger, TK | 1 |
| Vegt, M | 1 |
| Nolen, WA | 1 |
| Shergill, SS | 1 |
| Katona, CL | 1 |
| Motohashi, N | 1 |
| Parekh, PI | 1 |
| Altshuler, L | 1 |
| Frye, MA | 3 |
| Callahan, A | 1 |
| Marangell, L | 1 |
| Moreau, X | 3 |
| Azorin, JM | 2 |
| Maurel, M | 1 |
| Jeanningros, R | 3 |
| Sussman, N | 1 |
| Nelson, JC | 3 |
| Dunn, RT | 1 |
| Gary, KA | 1 |
| Kimbrell, TA | 1 |
| Luckenbaugh, DA | 1 |
| Corá-Locatelli, G | 1 |
| Vanderham, E | 1 |
| Winokur, A | 1 |
| Weissel, M | 1 |
| Hatzinger, M | 1 |
| Holsboer-Trachsler, E | 1 |
| Lejeune, PJ | 1 |
| Coryell, W | 1 |
| Marriott, M | 1 |
| Rack, SK | 1 |
| Makela, EH | 1 |
| Dhar, HL | 1 |
| Vasanti, T | 1 |
| Wada, T | 1 |
| Kanno, M | 1 |
| Aoshima, T | 1 |
| Otani, K | 1 |
| Mazzola-Pomietto, P | 1 |
| Nemeroff, CB | 4 |
| Altshuler, LL | 2 |
| Bauer, M | 1 |
| Gitlin, MJ | 1 |
| Mintz, J | 1 |
| Szuba, MP | 2 |
| Leight, KL | 1 |
| Howarth, S | 1 |
| Worthington, JJ | 1 |
| Sagud, M | 1 |
| Pivac, N | 1 |
| Mück-Seler, D | 1 |
| Jakovljević, M | 1 |
| Mihaljević-Peles, A | 1 |
| Korsić, M | 1 |
| Weetman, AP | 1 |
| Stern, RA | 2 |
| Nevels, CT | 2 |
| Shelhorse, ME | 2 |
| Prohaska, ML | 2 |
| Mason, GA | 3 |
| Yang, Q | 1 |
| Wilson, DA | 1 |
| Mulder, RT | 1 |
| Joyce, PR | 1 |
| Geracioti, TD | 1 |
| Kling, MA | 1 |
| Bagby, RM | 1 |
| Baxter, LR | 1 |
| Roy, A | 1 |
| Bissette, G | 1 |
| DeJong, J | 1 |
| Ravitz, B | 1 |
| Adinoff, B | 1 |
| Patten, SB | 1 |
| Lupin, DA | 1 |
| Boucher, SA | 1 |
| Lamarre, CJ | 1 |
| Cooke, RG | 2 |
| Gupta, S | 1 |
| Masand, P | 1 |
| Tanquary, JF | 1 |
| Kirkegaard, C | 3 |
| Faber, J | 3 |
| Meinhold, H | 3 |
| Roca, RP | 1 |
| Blackman, MR | 1 |
| Ackerley, MB | 1 |
| Harman, SM | 1 |
| Gregerman, RI | 1 |
| Maes, M | 2 |
| Vandewoude, M | 2 |
| Schotte, C | 2 |
| Martin, M | 2 |
| Blockx, P | 2 |
| Carstens, ME | 1 |
| Taljaard, JJ | 1 |
| van Zyl, AM | 1 |
| D'Hondt, P | 1 |
| Scharpe, S | 1 |
| Denicoff, KD | 1 |
| Lakshmanan, MC | 1 |
| Robbins, J | 1 |
| Rubinow, DR | 1 |
| Kørner, A | 1 |
| Browne, JL | 1 |
| Rice, JL | 1 |
| Evans, DL | 2 |
| Brady, KT | 1 |
| Anton, RF | 1 |
| Rao, ML | 1 |
| Vartzopoulos, D | 1 |
| Fels, K | 1 |
| Gillette, GM | 2 |
| Garbutt, JC | 2 |
| Quade, DE | 1 |
| Bearn, J | 1 |
| Franey, C | 1 |
| Arendt, J | 1 |
| Checkley, SA | 1 |
| Wahby, V | 1 |
| Ibrahim, G | 1 |
| Friedenthal, S | 1 |
| Giller, E | 1 |
| Kosten, T | 1 |
| Mason, J | 1 |
| Kupfer, DJ | 1 |
| Jarrett, DB | 1 |
| Price, LH | 1 |
| Wang, SY | 1 |
| Shin, SJ | 1 |
| Rupprecht, C | 1 |
| Rupprecht, M | 1 |
| Noder, M | 1 |
| Mahlstedt, J | 1 |
| Martin, P | 1 |
| Brochet, D | 1 |
| Soubrie, P | 1 |
| Simon, P | 1 |
| Undén, F | 2 |
| Mayo, JP | 1 |
| Little, KY | 1 |
| Marciniak, R | 1 |
| Thadani, K | 1 |
| Rubin, RT | 1 |
| Poland, RE | 1 |
| Lesser, IM | 1 |
| Martin, DJ | 1 |
| Müller, B | 1 |
| Böning, J | 1 |
| Laessle, RG | 1 |
| Schweiger, U | 1 |
| Pirke, KM | 1 |
| Gewirtz, GR | 1 |
| Malaspina, D | 1 |
| Hatterer, JA | 1 |
| Feureisen, S | 1 |
| Klein, D | 1 |
| Gorman, JM | 1 |
| Harrison, W | 1 |
| Thomas, DR | 1 |
| Ross, SB | 1 |
| Ballenger, JC | 1 |
| Rebar, R | 1 |
| Rakita, R | 1 |
| Orsulak, PJ | 1 |
| Crowley, G | 1 |
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| Cook, EH | 1 |
| Leventhal, BL | 1 |
| Simon, JS | 1 |
| Haggerty, JJ | 1 |
| Blank, DW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Biochemical Brain Changes Correlated With The Antidepressant Effect Of Thyroid Hormones[NCT00562367] | 30 participants (Actual) | Interventional | 2001-10-31 | Completed | |||
| Sequenced Treatment Alternatives to Relieve Depression[NCT00021528] | Phase 4 | 4,000 participants | Interventional | 2001-07-31 | Completed | ||
| Double Blind, Placebo Controlled Pilot Study to Evaluate the Use of Selenium as an Augmentation Treatment for Sertraline Resistant Major Depression[NCT02890212] | 60 participants (Anticipated) | Interventional | 2005-08-31 | Suspended (stopped due to due to COVID19 pandemic) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
36 reviews available for triiodothyronine and Depression, Endogenous
| Article | Year |
|---|---|
Augmentation strategies for treatment-resistant depression.
Topics: Antidepressive Agents; Antipsychotic Agents; Buspirone; Central Nervous System Stimulants; Depressiv | 2009 |
[Treatment-resistant depression].
Topics: Antidepressive Agents; Antipsychotic Agents; Combined Modality Therapy; Depressive Disorder; Drug Re | 2010 |
[The use of thyroid hormones in the treatment of depression].
Topics: Antidepressive Agents; Antidepressive Agents, Tricyclic; Depressive Disorder; Drug Therapy, Combinat | 2010 |
The use of antidepressants in novel combination therapies.
Topics: Algorithms; Antidepressive Agents; Antipsychotic Agents; Cognitive Behavioral Therapy; Combined Moda | 2003 |
[The relation between thyroid function and depression: a review].
Topics: Biogenic Monoamines; Brain; Depressive Disorder; Humans; Hypothalamo-Hypophyseal System; Pituitary-A | 2004 |
[Therapeutic strategy for drug resistant depression].
Topics: Animals; Antidepressive Agents; Biogenic Monoamines; Bupropion; Clomipramine; Depressive Disorder; D | 2004 |
Potentiation strategies for treatment-resistant depression.
Topics: Antidepressive Agents; Buspirone; Depressive Disorder; Drug Resistance; Drug Synergism; Drug Therapy | 2005 |
[Augmentation strategies for therapy resistant depression - a review].
Topics: Antidepressive Agents; Benzhydryl Compounds; Clinical Trials as Topic; Depressive Disorder; Dose-Res | 2007 |
Augmentation strategies for treatment-resistant depression: a literature review.
Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Benzodiazepines; Buspirone; Central Ne | 2007 |
[Pharmacological therapy for therapy-resistant depression. New developments].
Topics: Antidepressive Agents; Brain; Buspirone; Depressive Disorder; Drug Interactions; Drug Resistance; Dr | 2007 |
Antidepressant treatments and regulation of norepinephrine-receptor-coupled adenylate cyclase systems in brain.
Topics: Adenylyl Cyclases; Adrenal Cortex Hormones; Animals; Antidepressive Agents; Brain; Brain Chemistry; | 1984 |
Drug combinations in the treatment of refractory depression: a review.
Topics: Allopurinol; Antidepressive Agents; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Depressi | 1981 |
Psychopharmacologic treatment of depression.
Topics: Affective Disorders, Psychotic; Antidepressive Agents; Antidepressive Agents, Tricyclic; Antipsychot | 1984 |
A hypothesis of thyroid-catecholamine-receptor interaction. Its relevance to affective illness.
Topics: Adenosine Monophosphate; Bipolar Disorder; Catecholamines; Depressive Disorder; Humans; Lithium; Moo | 1981 |
[Serum thyrotropin, thyroxine, 3,3',5-triiodothyronine and 3,3',5'-triiodothyronine concentrations in patients with endogenous depression].
Topics: Adult; Antidepressive Agents, Tricyclic; Depressive Disorder; Female; Humans; Male; Middle Aged; Thy | 1983 |
The therapeutic use of triiodothyronine and high dose thyroxine in psychiatric disorder.
Topics: Bipolar Disorder; Brain; Depressive Disorder; Dose-Response Relationship, Drug; Drug Therapy, Combin | 1994 |
Augmentation strategies: focus on anxiolytics.
Topics: Anti-Anxiety Agents; Antidepressive Agents; Benzodiazepines; Buspirone; Depressive Disorder; Drug Ad | 1996 |
Triiodothyronine augmentation in the treatment of refractory depression. A meta-analysis.
Topics: Adult; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Confidence Intervals; Depressive | 1996 |
[Combination therapies in antidepressive drug refractory depression--an overview].
Topics: Antidepressive Agents; Depressive Disorder; Double-Blind Method; Drug Therapy, Combination; Humans; | 1996 |
Refractory depression: treatment strategies, with particular reference to the thyroid axis.
Topics: Depressive Disorder; Drug Resistance; Humans; Recurrence; Thyroid Gland; Triiodothyronine | 1997 |
[Background and therapy of intractable depression].
Topics: Adult; Antidepressive Agents; Depressive Disorder; Dopamine Agents; Electroconvulsive Therapy; Human | 1997 |
The use of thyroid supplements to augment antidepressant medication.
Topics: Antidepressive Agents; Bipolar Disorder; Clinical Trials as Topic; Depressive Disorder; Drug Adminis | 1998 |
Treatment of antidepressant nonresponders: augmentation or switch?
Topics: Antidepressive Agents; Bupropion; Clinical Trials as Topic; Depressive Disorder; Drug Administration | 1998 |
Overcoming treatment resistance in depression.
Topics: Antidepressive Agents; Buspirone; Depressive Disorder; Drug Administration Schedule; Drug Resistance | 1998 |
[Administration of thyroid hormones in therapy of psychiatric illnesses].
Topics: Antidepressive Agents; Depressive Disorder; Drug Therapy, Combination; Humans; Hypothyroidism; Thyro | 1999 |
[Therapy refractory depression].
Topics: Antidepressive Agents; Depressive Disorder; Drug Therapy, Combination; Humans; Lithium Carbonate; Tr | 1999 |
New approaches to the treatment of refractory depression.
Topics: Antidepressive Agents; Buspirone; Depressive Disorder; Drug Therapy, Combination; Humans; Lithium; M | 2000 |
Augmentation strategies in depression 2000.
Topics: Antidepressive Agents; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Buspirone; Depressive | 2000 |
Does thyroid supplementation accelerate tricyclic antidepressant response? A review and meta-analysis of the literature.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Controlled Clinical Trials as Topic; Depressive Dis | 2001 |
What role do atypical antipsychotic drugs have in treatment-resistant depression?
Topics: Antidepressive Agents, Tricyclic; Antipsychotic Agents; Controlled Clinical Trials as Topic; Depress | 2002 |
Thyroxine treatment in biochemically euthyroid but clinically hypothyroid individuals.
Topics: Depressive Disorder; Diagnosis, Differential; Fatigue Syndrome, Chronic; Humans; Hypothyroidism; Mid | 2002 |
Pharmacologic management of refractory depression.
Topics: Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder; Drug Therapy, Combination; Hum | 1992 |
Augmentation regimens for depression.
Topics: Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder; Drug Administration Schedule; | 1991 |
Thyroid hormone potentiation of tricyclics.
Topics: Antidepressive Agents, Tricyclic; Depressive Disorder; Drug Synergism; Humans; Hypothyroidism; Lithi | 1988 |
The hypothalamic-pituitary-thyroid axis in psychiatric patients and healthy subjects: Parts 1-4.
Topics: Adolescent; Adult; Aged; Arousal; Depressive Disorder; Female; Humans; Male; Middle Aged; Prognosis; | 1988 |
Psychotropic drugs and the thyroid axis: a review of interactions.
Topics: Animals; Body Temperature; Brain; Chlorpromazine; Depressive Disorder; Desipramine; Drug Interaction | 1985 |
19 trials available for triiodothyronine and Depression, Endogenous
| Article | Year |
|---|---|
Does substitution of T4 with T3 plus T4 for T4 replacement improve depressive symptoms in patients with hypothyroidism?
Topics: Adult; Aged; Depressive Disorder; Drug Therapy, Combination; Female; Hormone Replacement Therapy; Hu | 2004 |
The combined T3/TRH test in depressed patients and healthy controls.
Topics: Adult; Aged; Blood Pressure; Depressive Disorder; Drug Interactions; Female; Heart Rate; Hormones; H | 2005 |
An open study of triiodothyronine augmentation of selective serotonin reuptake inhibitors in treatment-resistant major depressive disorder.
Topics: Adult; Depressive Disorder; Depressive Disorder, Major; Drug Resistance; Drug Therapy, Combination; | 2005 |
A comparison of lithium and T(3) augmentation following two failed medication treatments for depression: a STAR*D report.
Topics: Adolescent; Adult; Aged; Ambulatory Care; Antidepressive Agents; Depressive Disorder; Drug Administr | 2006 |
Hypothyroidism and hyperthyroidism in major depression revisited.
Topics: Adolescent; Adult; Aged; Ambulatory Care; Depressive Disorder; Female; Fluoxetine; Humans; Hyperthyr | 1995 |
A placebo-controlled comparison of lithium and triiodothyronine augmentation of tricyclic antidepressants in unipolar refractory depression.
Topics: Adult; Ambulatory Care; Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Double-B | 1993 |
A clinical trial of sleep deprivation in combination with antidepressant medication.
Topics: Adult; Antidepressive Agents; Bipolar Disorder; Body Temperature Regulation; Circadian Rhythm; Combi | 1993 |
Effect of antidepressant medication on morning and evening thyroid function tests during a major depressive episode.
Topics: Adult; Antidepressive Agents; Circadian Rhythm; Depressive Disorder; Female; Hospitalization; Humans | 1996 |
Serum concentrations of thyroid hormones in patients with nonseasonal affective disorders during treatment with bright and dim light.
Topics: Adult; Aged; Depressive Disorder; Female; Humans; Male; Middle Aged; Personality Inventory; Photothe | 1996 |
An open study of triiodothyronine augmentation of tricyclic antidepressants in inpatients with refractory depression.
Topics: Adult; Antidepressive Agents, Tricyclic; Depressive Disorder; Drug Resistance; Drug Synergism; Drug | 1997 |
Relationships between thyroid hormone and antidepressant responses to total sleep deprivation in mood disorder patients.
Topics: Adult; Depressive Disorder; Female; Humans; Male; Mood Disorders; Psychiatric Status Rating Scales; | 1998 |
Lack of correlation between cerebrospinal fluid thyrotropin-releasing hormone (TRH) and TRH-stimulated thyroid-stimulating hormone in patients with depression.
Topics: Adult; Bipolar Disorder; Depressive Disorder; Double-Blind Method; Female; Humans; Hydrocortisone; M | 1999 |
Red blood cell triiodothyronine uptake in unipolar major depression: effect of a chronic antidepressant treatment.
Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Depressive Disorder; Erythrocytes; Female; Fl | 2000 |
T3 blood levels and treatment outcome in depression.
Topics: Adolescent; Adult; Aged; Depressive Disorder; Female; Fluoxetine; Humans; Male; Middle Aged; Psychia | 2001 |
Antidepressants and thyroid hormone levels.
Topics: Depressive Disorder; Desipramine; Drug Therapy, Combination; Humans; Thyroid Hormones; Thyrotropin; | 1992 |
Antidepressant and memory effects of combined thyroid hormone treatment and electroconvulsive therapy: preliminary findings.
Topics: Adult; Aged; Arousal; Bipolar Disorder; Combined Modality Therapy; Depressive Disorder; Double-Blind | 1991 |
A comparison of triiodothyronine and thyroxine in the potentiation of tricyclic antidepressants.
Topics: Adult; Depressive Disorder; Desipramine; Double-Blind Method; Drug Synergism; Drug Therapy, Combinat | 1990 |
Treatment of imipramine-resistant recurrent depression: I. An open clinical trial of adjunctive L-triiodothyronine.
Topics: Adult; Ambulatory Care; Clinical Trials as Topic; Depressive Disorder; Drug Administration Schedule; | 1989 |
T3 and lithium potentiation of tricyclic antidepressants.
Topics: Adult; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Depressive Disorder; Drug Synergi | 1988 |
111 other studies available for triiodothyronine and Depression, Endogenous
| Article | Year |
|---|---|
Hippocampal gene expression of deiodinases 2 and 3 and effects of 3,5-diiodo-L-thyronine T2 in mouse depression paradigms.
Topics: Animals; Depressive Disorder; Diiodothyronines; Gene Expression Regulation, Enzymologic; Hippocampus | 2013 |
Well-being and depression in individuals with subclinical hypothyroidism and thyroid autoimmunity - a general population study.
Topics: Adult; Autoantibodies; Autoimmunity; Biomarkers; Denmark; Depression; Depressive Disorder; Female; H | 2015 |
Association between autoimmune thyroiditis and depressive disorder in psychiatric outpatients.
Topics: Adult; Aged; Aged, 80 and over; Autoantibodies; Bipolar Disorder; Depressive Disorder; Female; Human | 2015 |
Preliminary evidence that a functional polymorphism in type 1 deiodinase is associated with enhanced potentiation of the antidepressant effect of sertraline by triiodothyronine.
Topics: Antidepressive Agents; Depressive Disorder; DNA; Drug Therapy, Combination; Genotype; Humans; Iodide | 2009 |
Severe affective and behavioral dysregulation in youth is associated with increased serum TSH.
Topics: Adolescent; Aggression; Antisocial Personality Disorder; Anxiety Disorders; Attention Deficit Disord | 2010 |
Prenatal thyroxine treatment disparately affects peripheral and amygdala thyroid hormone levels.
Topics: Amygdala; Animals; Anxiety; Corticosterone; Corticotropin-Releasing Hormone; Depressive Disorder; Di | 2010 |
Thyroid axis activity and suicidal behavior in depressed patients.
Topics: Adult; Depressive Disorder; Female; Humans; Hypothalamus; Male; Middle Aged; Pituitary Gland; Suicid | 2010 |
Depression of the serum cholesterol level by triiodothyropropionic acid.
Topics: Cholesterol; Depression; Depressive Disorder; Triiodothyronine | 1959 |
A study of psychiatric symptoms in thyrotoxic Nigerians.
Topics: Adult; Affective Symptoms; Anxiety Disorders; Case-Control Studies; Cross-Sectional Studies; Depress | 2003 |
Effects of triiodothyronine and fluoxetine on 5-HT1A and 5-HT1B autoreceptor activity in rat brain: regional differences.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoreceptors; Brain; Brain Chemistry; Depressive D | 2004 |
Enhanced serum cholesterol and triglyceride levels in bulimia nervosa: relationships to psychiatric comorbidity, psychopathology and hormonal variables.
Topics: Adult; Anorexia Nervosa; Blood Glucose; Borderline Personality Disorder; Bulimia; Cholesterol; Comor | 2005 |
Peripheral triiodothyronine (T(3)) levels during escapable and inescapable footshock.
Topics: Adaptation, Psychological; Analysis of Variance; Animals; Depressive Disorder; Disease Models, Anima | 2006 |
Medical management of depression.
Topics: Algorithms; Antidepressive Agents; Depressive Disorder; Humans; Thyroxine; Triiodothyronine | 2006 |
Depression and thyroid axis function in coronary artery disease: impact of cardiac impairment and gender.
Topics: Coronary Artery Disease; Depressive Disorder; Female; Humans; Hypothyroidism; Incidence; Lithuania; | 2006 |
Reactive depression and remission rates in the STAR*D trials.
Topics: Adjustment Disorders; Anger; Depressive Disorder; Female; Humans; Lithium Compounds; Psychotherapy; | 2007 |
Refractory depression in a patient with peripheral resistance to thyroid hormone (RTH) and the effect of triiodothyronine treatment.
Topics: Adult; Antidepressive Agents; Chronic Disease; Depressive Disorder; Drug Resistance, Multiple; Femal | 2007 |
HPT axis, CSF monoamine metabolites, suicide intent and depression severity in male suicide attempters.
Topics: Adult; Control Groups; Depressive Disorder; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Mal | 2008 |
Some endocrine aspects of affective disorders.
Topics: Adrenocorticotropic Hormone; Depressive Disorder; Drug Therapy, Combination; Female; Follicle Stimul | 1980 |
Phenelzine plus triiodothyronine combination in a case of refractory depression.
Topics: Aged; Depressive Disorder; Female; Humans; Phenelzine; Thyrotropin; Thyrotropin-Releasing Hormone; T | 1983 |
The specificity of the thyrotropin-releasing hormone (TRH) test and dexamethasone suppression test (DST) for major depressive illness in alcoholics.
Topics: Adult; Alcoholism; Depressive Disorder; Dexamethasone; Female; Humans; Male; Middle Aged; Thyrotropi | 1983 |
Thyrotropin-releasing hormone (TRH) in abstinent alcoholic men.
Topics: Adult; Aged; Alcohol Drinking; Alcoholism; Depressive Disorder; Growth Hormone; Humans; Male; Middle | 1983 |
Reverse T3 levels in affective disorders.
Topics: Adult; Bipolar Disorder; Depressive Disorder; Dexamethasone; Female; Humans; Hydrocortisone; Male; M | 1983 |
The TRH test and thyroid hormone in refractory depression.
Topics: Antidepressive Agents; Depressive Disorder; Drug Therapy, Combination; Female; Humans; Male; Thyrotr | 1984 |
Normal thyroid function in desipramine nonresponders converted to responders by the addition of L-triiodothyronine.
Topics: Adult; Depressive Disorder; Desipramine; Drug Synergism; Drug Therapy, Combination; Female; Humans; | 1984 |
Carbamazepine and thyroid function in affectively ill patients. Clinical and theoretical implications.
Topics: Adult; Carbamazepine; Depressive Disorder; Female; Humans; Male; Middle Aged; Radioimmunoassay; Thyr | 1984 |
Endocrine changes and clinical profiles in depression: II. The thyrotropin-releasing hormone test.
Topics: Adult; Depressive Disorder; Humans; Psychological Tests; Thyrotropin; Thyrotropin-Releasing Hormone; | 1984 |
Endocrine and behavioral changes in depression after thyrotropin-releasing hormone (TRH). Alteration by pretreatment with thyroid hormones.
Topics: Adult; Behavior; Depressive Disorder; Female; Humans; Middle Aged; Self-Assessment; Thyroid Hormones | 1980 |
CSF triiodothyronine (rT3) levels in patients with affective disorders.
Topics: Adult; Bipolar Disorder; Depressive Disorder; Female; Humans; Male; Middle Aged; Norepinephrine; Tri | 1983 |
Endocrine disturbances in anorexia nervosa and depression.
Topics: Anorexia Nervosa; Depressive Disorder; Dexamethasone; Hormones; Humans; Hydrocortisone; Thyrotropin; | 1982 |
"Symptomless" autoimmune thyroiditis in depression.
Topics: Depressive Disorder; Humans; Hypothyroidism; Thyroiditis, Autoimmune; Thyrotropin; Thyrotropin-Relea | 1982 |
High reverse T3 levels in manic an unipolar depressed women.
Topics: Adult; Affective Disorders, Psychotic; Bipolar Disorder; Depressive Disorder; Female; Humans; Thyrox | 1982 |
New treatments for depression.
Topics: 5-Hydroxytryptophan; Amino Acids; Antidepressive Agents, Tricyclic; Depressive Disorder; Humans; Nor | 1982 |
Dependency of tricyclic antidepressant efficacy on thyroid hormone potentiation: case studies.
Topics: Adult; Depressive Disorder; Drug Synergism; Drug Therapy, Combination; Female; Humans; Hyperthyroidi | 1982 |
Potentiation of antidepressant effects by L-triiodothyronine in tricyclic nonresponders.
Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Bipolar Disorder; Depressive Dis | 1982 |
Hormone therapy in depressive diseases.
Topics: Antidepressive Agents, Tricyclic; Depressive Disorder; Drug Therapy, Combination; Endocrine System D | 1982 |
Questions about L-triiodothyronine and depression.
Topics: Antidepressive Agents, Tricyclic; Depressive Disorder; Drug Synergism; Humans; Triiodothyronine | 1982 |
Case reports of L-triiodothyronine potentiation.
Topics: Adult; Antidepressive Agents, Tricyclic; Depressive Disorder; Drug Synergism; Female; Humans; Male; | 1982 |
Thyroid stimulating hormone and depression.
Topics: Depressive Disorder; Female; Humans; Thyrotropin; Thyroxine; Triiodothyronine | 1982 |
The 24-hour pattern of serum TSH in patients with endogenous depression.
Topics: Adult; Aged; Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Female; Humans; Male; Middle A | 1980 |
The hypothalamic-pituitary-thyroid axis in patients maintained on lithium prophylaxis for years: high triiodothyronine serum concentrations are correlated to the prophylactic efficacy.
Topics: Adult; Aged; Aged, 80 and over; Bipolar Disorder; Depressive Disorder; Female; Humans; Hypothalamo-H | 1995 |
Urinary MHPG and clinical symptoms in patients with unipolar depression.
Topics: Adult; Body Weight; Cognition Disorders; Depressive Disorder; Dexamethasone; Female; Humans; Hydroco | 1994 |
Metabolic implications of low-dose triiodothyronine administration in rats: relevance to the adjunctive use of triiodothyronine in the treatment of depression.
Topics: Animals; Body Weight; Brain; Depressive Disorder; Energy Metabolism; Glycerolphosphate Dehydrogenase | 1994 |
The prevalence of goiter in psychiatric outpatients suffering from affective disorder.
Topics: Adult; Ambulatory Care; Antidepressive Agents; Comorbidity; Depressive Disorder; Drug Therapy, Combi | 1994 |
T3 is at least as important as T4 in all hypothyroid patients.
Topics: Antidepressive Agents; Depressive Disorder; Drug Therapy, Combination; Humans; Hypothyroidism; Thyro | 1993 |
The effects of antidepressants on the thyroid axis in depression.
Topics: Ambulatory Care; Antidepressive Agents; Depressive Disorder; Desipramine; Female; Fluoxetine; Humans | 1993 |
Change in thyroid hormone levels following response to cognitive therapy for major depression.
Topics: Adult; Ambulatory Care; Cognitive Behavioral Therapy; Depressive Disorder; Female; Humans; Male; Thy | 1996 |
Inverse relationship of peripheral thyrotropin-stimulating hormone levels to brain activity in mood disorders.
Topics: Adult; Bipolar Disorder; Brain; Cerebrovascular Circulation; Deoxyglucose; Depressive Disorder; Fema | 1997 |
Thyroid hormone levels before unsuccessful antidepressant therapy are associated with later response to T3 augmentation.
Topics: Adult; Antidepressive Agents; Depressive Disorder; Desipramine; Drug Therapy, Combination; Female; H | 1997 |
Pharmacological choices after one antidepressant fails: a survey of UK psychiatrists.
Topics: Antidepressive Agents; Antidepressive Agents, Tricyclic; Attitude of Health Personnel; Depressive Di | 1997 |
Increase in red blood cell triiodothyronine uptake in untreated unipolar major depressed patients compared to healthy volunteers.
Topics: Adult; Aged; Biological Transport; Depressive Disorder; Erythrocytes; Female; Humans; Male; Middle A | 1998 |
Antidepressant augmentation: conclusions and recommendations.
Topics: Anticonvulsants; Antidepressive Agents; Benzodiazepines; Buspirone; Depressive Disorder; Drug Synerg | 1998 |
Augmentation strategies for inadequate antidepressant response: a review of placebo-controlled studies.
Topics: Adjuvants, Immunologic; Dehydroepiandrosterone; Depressive Disorder; Drug Therapy, Combination; Huma | 2000 |
Thyroid hormone levels and recurrence of major depression.
Topics: Adult; Ambulatory Care; Depressive Disorder; Female; Humans; Male; Recurrence; Survival Analysis; Th | 2000 |
Hypothyroidism and depression: a therapeutic challenge.
Topics: Antidepressive Agents; Depressive Disorder; Female; Hormone Replacement Therapy; Humans; Hypothyroid | 2000 |
Endogenous depression, thyroid function and acupuncture.
Topics: Acupuncture Therapy; Adolescent; Adult; Depressive Disorder; Female; Humans; Male; Middle Aged; Thyr | 2001 |
Dose-dependent augmentation effect of bromocriptine in a case with refractory depression.
Topics: Bromocriptine; Depressive Disorder; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Therap | 2001 |
Chronic effects of triiodothyronine in combination with imipramine on 5-HT transporter, 5-HT(1A) and 5-HT(2A) receptors in adult rat brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents, Tricyclic; Body Weight; Brai | 2001 |
Progress in the battle with the black dog: advances in the treatment of depression.
Topics: Antidepressive Agents; Clinical Trials as Topic; Comorbidity; Depression, Postpartum; Depressive Dis | 2001 |
Effects of sertraline treatment on plasma cortisol, prolactin and thyroid hormones in female depressed patients.
Topics: Antidepressive Agents; Case-Control Studies; Depressive Disorder; Female; Humans; Hydrocortisone; Mi | 2002 |
The use of T3 to enhance the effects of ECT.
Topics: Combined Modality Therapy; Depressive Disorder; Electroconvulsive Therapy; Humans; Male; Psychiatric | 1992 |
[The endocrine abnormalities of depressive patients].
Topics: Adolescent; Adult; Depressive Disorder; Female; Growth Hormone; Humans; Hydrocortisone; Hypothalamo- | 1992 |
Diurnal profiles of thyroid hormones are altered in depression.
Topics: Adolescent; Adult; Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Female; Humans; Male; Mi | 1992 |
Triiodothyronine potentiation of fluoxetine in depressed patients.
Topics: Adult; Depressive Disorder; Drug Synergism; Drug Therapy, Combination; Female; Fluoxetine; Humans; M | 1992 |
Cortisol, thyroid hormone, and mood in atypical depression: a longitudinal case study.
Topics: Adult; Affect; Depressive Disorder; Disorders of Excessive Somnolence; Female; Fluoxetine; Humans; H | 1992 |
The thyroid and melancholia.
Topics: Adult; Depressive Disorder; Female; Humans; Male; Neurocognitive Disorders; Psychiatric Status Ratin | 1992 |
Thyroid function and partial sleep deprivation response.
Topics: Adolescent; Adult; Aged; Arousal; Depressive Disorder; Female; Humans; Male; Middle Aged; Sleep Depr | 1992 |
Cerebrospinal fluid thyrotropin-releasing hormone concentrations in alcoholics and normal controls.
Topics: Adult; Alcoholism; Depressive Disorder; Female; Humans; Hydroxyindoleacetic Acid; Hypothalamo-Hypoph | 1990 |
T3 augmentation of antidepressant treatment in T4-replaced thyroid patients.
Topics: Antidepressive Agents; Depressive Disorder; Drug Synergism; Drug Therapy, Combination; Humans; Hypot | 1992 |
Thyroid hormone supplementation of fluoxetine in the treatment of major depression.
Topics: Adult; Combined Modality Therapy; Depressive Disorder; Dose-Response Relationship, Drug; Drug Therap | 1991 |
Free thyroxine and 3,3',5'-triiodothyronine levels in cerebrospinal fluid in patients with endogenous depression.
Topics: Aged; Depressive Disorder; Electroconvulsive Therapy; Female; Humans; Hyperthyroidism; Hypothyroidis | 1991 |
Treatment choice after one antidepressant fails: a survey of northeastern psychiatrists.
Topics: Antidepressive Agents; Attitude of Health Personnel; Bupropion; Decision Making; Depressive Disorder | 1991 |
Recent fluoxetine treatment and complications of tricyclic therapy.
Topics: Depressive Disorder; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Female | 1991 |
Thyrotropin (TSH) and thyroid hormone concentrations during partial sleep deprivation in patients with major depressive disorder.
Topics: Adult; Aged; Arousal; Bipolar Disorder; Depressive Disorder; Female; Humans; Male; Middle Aged; Slee | 1990 |
Long-term predictors of outcome in abstinent alcoholic men.
Topics: Adult; Aged; Alcoholism; Comorbidity; Depressive Disorder; Follow-Up Studies; Growth Hormone; Humans | 1990 |
Thyroid hormone elevations during acute psychiatric illness: relationship to severity and distinction from hyperthyroidism.
Topics: Adult; Bipolar Disorder; Blood Pressure; Depressive Disorder; Down-Regulation; Feedback; Female; Hal | 1990 |
Suppressive effects of dexamethasone on hypothalamic-pituitary-thyroid axis function in depressed patients.
Topics: Depressive Disorder; Dexamethasone; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Thyroid | 1990 |
The beta-adrenoceptor and endocrine abnormalities in juvenile depression.
Topics: Adolescent; Binding Sites; Child; Depressive Disorder; Humans; Hydrocortisone; Lymphocytes; Receptor | 1990 |
The decreased availability of L-tryptophan in depressed females: clinical and biological correlates.
Topics: Adrenocorticotropic Hormone; Adult; Amino Acids; Analysis of Variance; Depression; Depressive Disord | 1990 |
Neuropsychiatric manifestations of altered thyroid state.
Topics: Adult; Affect; Attitude to Health; Cognition; Depressive Disorder; Female; Humans; Male; Mental Diso | 1990 |
T3 augmentation of a tricyclic antidepressant in a patient receiving T4 maintenance therapy.
Topics: Adult; Antidepressive Agents, Tricyclic; Depressive Disorder; Drug Synergism; Female; Humans; Thyrox | 1990 |
Increased production of thyroxine and inappropriately elevated serum thyrotropin in levels in endogenous depression.
Topics: Adult; Aged; Aged, 80 and over; Depressive Disorder; Female; Humans; Hypothyroidism; Male; Middle Ag | 1990 |
Triiodothyronine augmentation of the antidepressant effect of the nontricyclic antidepressant trazodone.
Topics: Depressive Disorder; Drug Synergism; Drug Therapy, Combination; Female; Humans; Middle Aged; Trazodo | 1990 |
The thyroid axis and desipramine treatment in depression.
Topics: Adult; Aged; Bipolar Disorder; Depressive Disorder; Desipramine; Humans; Male; Middle Aged; Psycholo | 1989 |
Thyroid function in anxious and depressed patients.
Topics: Adult; Anxiety; Depressive Disorder; Female; Humans; Male; Middle Aged; Thyroid Function Tests; Thyr | 1989 |
TSH response to TRH in depression with and without panic attacks.
Topics: Adult; Depressive Disorder; Fear; Female; Humans; Hydrocortisone; Male; Panic; Recurrence; Sex Facto | 1989 |
A study of the effects of desipramine treatment alone and in combination with L-triiodothyronine on 6-sulphatoxymelatonin excretion in depressed patients.
Topics: Adult; Aged; Depressive Disorder; Desipramine; Drug Therapy, Combination; Female; Humans; Male; Mela | 1989 |
Serum concentrations of circulating thyroid hormones in a group of depressed men.
Topics: Adult; Depressive Disorder; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Thyroid Hor | 1989 |
What is the duration for augmentation with T3 or lithium in resistant depression?
Topics: Antidepressive Agents, Tricyclic; Depressive Disorder; Drug Therapy, Combination; Humans; Lithium; P | 1989 |
Alterations in thyroid function tests in major depression.
Topics: Adult; Depressive Disorder; Female; Humans; Male; Middle Aged; Thyroid Gland; Thyroxine; Triiodothyr | 1989 |
Triiodothyronine, thyroxine, and TSH response to dexamethasone in depressed patients and normal controls.
Topics: Adult; Aged; Antidepressive Agents; Bipolar Disorder; Depressive Disorder; Dexamethasone; Female; Fo | 1989 |
Triiodothyronine-induced reversal of learned helplessness in rats.
Topics: Animals; Brain; Depressive Disorder; Electroshock; Helplessness, Learned; Humans; Male; Norepinephri | 1985 |
Twenty-four-hour serum levels of T4 and T3 in relation to decreased TSH serum levels and decreased TSH response to TRH in affective disorders.
Topics: Adult; Body Weight; Depressive Disorder; Female; Humans; Male; Middle Aged; Receptors, Cell Surface; | 1986 |
Psychiatric applications of thyroid tests.
Topics: Antidepressive Agents, Tricyclic; Bipolar Disorder; Depressive Disorder; Diagnosis, Differential; Dr | 1986 |
Central thyroid stimulation in severely ill depressed, manic and schizophrenic patients.
Topics: Bipolar Disorder; Depressive Disorder; Dexamethasone; Humans; Pituitary Gland, Anterior; Schizophren | 1986 |
Lithium potentiation of tricyclic antidepressants following lack of T3 potentiation.
Topics: Adult; Antidepressive Agents, Tricyclic; Depressive Disorder; Drug Resistance; Drug Synergism; Drug | 1986 |
Influence of free thyroid hormone levels on the TSH response to TRH in endogenous depression.
Topics: Aged; Depressive Disorder; Electroshock; Female; Humans; Male; Middle Aged; Thyroid Hormones; Thyrot | 1986 |
TRH-induced TSH response in healthy volunteers: relationship to psychiatric history.
Topics: Adult; Alcoholism; Depressive Disorder; Female; Humans; Male; Sex Factors; Thyrotropin; Thyrotropin- | 1987 |
Neuroendocrine aspects of primary endogenous depression--IV. Pituitary-thyroid axis activity in patients and matched control subjects.
Topics: Adult; Aged; Body Weight; Depressive Disorder; Female; Humans; Hydrocortisone; Male; Middle Aged; Pi | 1987 |
Changes in the pituitary-thyroid axis accompanying major affective disorders.
Topics: Adolescent; Adult; Affective Disorders, Psychotic; Aged; Antidepressive Agents; Bipolar Disorder; De | 1988 |
Triiodothyronine potentiation of the antidepressant effect of phenelzine.
Topics: Adult; Depressive Disorder; Drug Synergism; Drug Therapy, Combination; Female; Humans; Male; Middle | 1988 |
Depression as a correlate of starvation in patients with eating disorders.
Topics: 3-Hydroxybutyric Acid; Adult; Anorexia Nervosa; Body Image; Body Weight; Bulimia; Depressive Disorde | 1988 |
Occult thyroid dysfunction in patients with refractory depression.
Topics: Adult; Basal Metabolism; Depressive Disorder; Female; Humans; Hypothyroidism; Middle Aged; Thyroid G | 1988 |
Potentiation of antidepressants by T3 and lithium.
Topics: Antidepressive Agents, Tricyclic; Depressive Disorder; Drug Synergism; Humans; Lithium; Triiodothyro | 1987 |
T3 and T4 in unipolar depression.
Topics: Body Weight; Depressive Disorder; Humans; Thyroxine; Triiodothyronine | 1986 |
Serum dopamine-beta-hydroxylase activity in patients with major depressive disorders.
Topics: Adult; Depressive Disorder; Dopamine beta-Hydroxylase; Female; Humans; Hypothalamo-Hypophyseal Syste | 1986 |
Neuroendocrine effects of the dopamine agonist piribedil in depressed patients.
Topics: Adult; Bipolar Disorder; Depressive Disorder; Female; Humans; Male; Middle Aged; Piperazines; Piribe | 1986 |
Sleep deprivation and thyroid hormone concentrations.
Topics: Adult; Aged; Depressive Disorder; Female; Humans; Male; Middle Aged; Sleep Deprivation; Thyrotropin; | 1986 |
Free triiodothyronine (T3) and thyroxine (T4) in a group of unipolar depressed patients and normal subjects.
Topics: Adolescent; Adult; Aged; Depressive Disorder; Female; Humans; Male; Middle Aged; Radioimmunoassay; T | 1985 |
Triiodothyronines, depression, and fasting.
Topics: Depressive Disorder; Energy Intake; Humans; Triiodothyronine | 1986 |
Antithyroid antibodies in depressed patients.
Topics: Adolescent; Adult; Aged; Autoantibodies; Autoimmune Diseases; Depressive Disorder; Dexamethasone; Fe | 1985 |
Decreased triiodothyronines in depression: a preliminary report.
Topics: Adult; Bipolar Disorder; Depressive Disorder; Female; Humans; Male; Thyroxine; Triiodothyronine | 1985 |