triiodothyronine has been researched along with Deficiency, Mental in 27 studies
Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Severe mental retardation of the child can occur due to compromised iodine intake or thyroid disease." | 2.43 | Thyroid hormones and fetal brain development. ( Franklyn, JA; Kilby, MD; Pemberton, HN, 2005) |
| "Thyroid hormone levels may affect intellectual disability in children." | 1.91 | Alterations of Thyroid Hormone Levels in Children with Intellectual Disability. ( Su, M; Wang, D; Wang, XN; Ye, J; Zhao, Z, 2023) |
| "The prevalence of unrecognized primary hypothyroidism and hyperthyroidism was 5·2% and 2·8%, respectively." | 1.37 | Thyroid status in a large cohort of patients with mental retardation: the TOP-R (Thyroid Origin of Psychomotor Retardation) study. ( de Rijke, YB; van Toor, H; Visser, TJ; Visser, WE, 2011) |
| "The patient showed severe mental retardation (IQ41), disturbance in speech development, and attention deficit hyperactivity disorder." | 1.29 | Two consecutive nucleotide substitutions resulting in the T3 receptor beta gene resulting in an 11-amino acid truncation in a patient with generalized resistance to thyroid hormone. ( Konishi, J; Misaki, T; Miyoshi, Y; Nakamura, H; Nakao, K; Sasaki, S; Tagami, T, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (33.33) | 18.7374 |
| 1990's | 4 (14.81) | 18.2507 |
| 2000's | 10 (37.04) | 29.6817 |
| 2010's | 3 (11.11) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, Z | 1 |
| Su, M | 1 |
| Wang, D | 1 |
| Ye, J | 1 |
| Wang, XN | 1 |
| López-Marín, L | 1 |
| Martín-Belinchón, M | 1 |
| Gutiérrez-Solana, LG | 1 |
| Morte-Molina, B | 1 |
| Duat-Rodríguez, A | 1 |
| Bernal, J | 1 |
| Langley, KG | 1 |
| Trau, S | 1 |
| Bean, LJ | 1 |
| Narravula, A | 1 |
| Schrier Vergano, SA | 1 |
| Visser, WE | 2 |
| Jansen, J | 3 |
| Friesema, EC | 3 |
| Kester, MH | 3 |
| Mancilla, E | 1 |
| Lundgren, J | 2 |
| van der Knaap, MS | 1 |
| Lunsing, RJ | 1 |
| Brouwer, OF | 1 |
| Visser, TJ | 4 |
| Fuchs, O | 1 |
| Pfarr, N | 1 |
| Pohlenz, J | 1 |
| Schmidt, H | 1 |
| de Rijke, YB | 1 |
| van Toor, H | 1 |
| FISHER, DA | 1 |
| Guo, TW | 1 |
| Zhang, FC | 1 |
| Yang, MS | 1 |
| Gao, XC | 1 |
| Bian, L | 1 |
| Duan, SW | 1 |
| Zheng, ZJ | 1 |
| Gao, JJ | 1 |
| Wang, H | 2 |
| Li, RL | 1 |
| Feng, GY | 1 |
| St Clair, D | 1 |
| He, L | 1 |
| Wu, XY | 1 |
| Huang, DM | 1 |
| Lei, HX | 1 |
| Hu, R | 1 |
| Ma, L | 1 |
| Zou, SJ | 1 |
| Yu, H | 1 |
| Maranduba, CM | 1 |
| Kok, F | 1 |
| Sertié, AL | 1 |
| Passos-Bueno, MR | 1 |
| Pemberton, HN | 1 |
| Franklyn, JA | 1 |
| Kilby, MD | 1 |
| Vasil'eva, EM | 1 |
| Shor, TA | 1 |
| Poddubnaia, AE | 1 |
| Herzovich, V | 1 |
| Vaiani, E | 1 |
| Marino, R | 1 |
| Dratler, G | 1 |
| Lazzati, JM | 1 |
| Tilitzky, S | 1 |
| Ramirez, P | 1 |
| Iorcansky, S | 1 |
| Rivarola, MA | 1 |
| Belgorosky, A | 1 |
| Milici, C | 1 |
| Reeser, M | 1 |
| Grüters, A | 1 |
| Barrett, TG | 1 |
| Mancilla, EE | 1 |
| Svensson, J | 1 |
| Wemeau, JL | 1 |
| Busi da Silva Canalli, MH | 1 |
| McEntagart, ME | 1 |
| Hopper, N | 1 |
| Arts, WF | 1 |
| Suzuki, T | 1 |
| Abe, T | 1 |
| Hayashi, Y | 1 |
| Janssen, OE | 1 |
| Weiss, RE | 1 |
| Murata, Y | 1 |
| Seo, H | 1 |
| Refetoff, S | 1 |
| Miyoshi, Y | 2 |
| Nakamura, H | 2 |
| Sasaki, S | 2 |
| Tagami, T | 2 |
| Misaki, T | 1 |
| Konishi, J | 1 |
| Nakao, K | 2 |
| Behr, M | 1 |
| Ramsden, DB | 1 |
| Loos, U | 1 |
| Dorin, RI | 1 |
| Taniyama, M | 1 |
| Cunningham, RD | 1 |
| Himwich, HE | 1 |
| Vigi, V | 1 |
| Pinca, A | 1 |
| Guerrini, P | 1 |
| Scappaticci, S | 1 |
| Volpato, S | 1 |
| Morreale de Escobar, G | 1 |
| Obregon, MJ | 1 |
| Escobar del Rey, F | 1 |
| Greig, WR | 1 |
| Campbell, M | 1 |
| Fish, B | 1 |
| David, R | 1 |
| Shapiro, T | 1 |
| Collins, P | 1 |
| Koh, C | 1 |
| Marescotti, V | 1 |
| Saba, P | 1 |
| Pariante, F | 1 |
| Galeone, F | 1 |
| Holt, WA | 1 |
| Talbert, LM | 1 |
| Thomas, CG | 1 |
| Rankin, P | 1 |
5 reviews available for triiodothyronine and Deficiency, Mental
| Article | Year |
|---|---|
[MCT8-specific thyroid hormone cell transporter deficiency: a case report and review of the literature].
Topics: Amino Acid Substitution; Anticonvulsants; Biological Transport; Brain; Child, Preschool; Cord Blood | 2013 |
Thyroid hormones and fetal brain development.
Topics: Animals; Brain; Disease Models, Animal; Female; Fetal Development; Fetal Growth Retardation; Fetus; | 2005 |
Thyroid hormone transporters in the brain.
Topics: Animals; Blood-Brain Barrier; Brain; Cerebral Cortex; Humans; Intellectual Disability; Mammals; Memb | 2008 |
Radionuclide evaluation of thyroid disease in children.
Topics: Adult; Child; Child, Preschool; Congenital Hypothyroidism; Deafness; Diagnosis, Differential; Goiter | 1973 |
Hyperthyroidism during pregnancy.
Topics: Abortion, Spontaneous; Congenital Hypothyroidism; Female; Fetal Death; Humans; Hyperthyroidism; Infa | 1970 |
1 trial available for triiodothyronine and Deficiency, Mental
| Article | Year |
|---|---|
Liothyronine treatment in psychotic and nonpsychotic children under 6 years.
Topics: Age Factors; Brain Damage, Chronic; Child; Child Behavior Disorders; Child, Preschool; Clinical Tria | 1973 |
21 other studies available for triiodothyronine and Deficiency, Mental
| Article | Year |
|---|---|
Alterations of Thyroid Hormone Levels in Children with Intellectual Disability.
Topics: Child; Humans; Intellectual Disability; Thyroid Function Tests; Thyroid Hormones; Thyroxine; Triiodo | 2023 |
A 7-month-old male with Allan-Herndon-Dudley syndrome and the power of T3.
Topics: Abnormalities, Multiple; Humans; Infant; Intellectual Disability; Male; Mental Retardation, X-Linked | 2015 |
Novel pathogenic mechanism suggested by ex vivo analysis of MCT8 (SLC16A2) mutations.
Topics: Base Sequence; Cells, Cultured; Fibroblasts; Humans; Intellectual Disability; Molecular Sequence Dat | 2009 |
Elevated serum triiodothyronine and intellectual and motor disability with paroxysmal dyskinesia caused by a monocarboxylate transporter 8 gene mutation.
Topics: Arginine; Child; Chorea; Developmental Disabilities; DNA Mutational Analysis; Enzyme-Linked Immunoso | 2009 |
Thyroid status in a large cohort of patients with mental retardation: the TOP-R (Thyroid Origin of Psychomotor Retardation) study.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Cohort Studies; Cross-Sectional Studies; Drug Therapy, | 2011 |
MANAGEMENT OF HYPOTHYROIDISM DURING INFANCY AND CHILDHOOD.
Topics: Adolescent; Alkaline Phosphatase; Antithyroid Agents; Body Height; Body Weight; Child; Cholesterol; | 1964 |
Positive association of the DIO2 (deiodinase type 2) gene with mental retardation in the iodine-deficient areas of China.
Topics: Adolescent; Child; Child, Preschool; China; Female; Genetic Markers; Haplotypes; Humans; Intellectua | 2004 |
[Screening for congenital hypothyroidism in 106 224 neonates in Hunan Province].
Topics: China; Congenital Hypothyroidism; Female; Humans; Infant, Newborn; Intellectual Disability; Male; Ne | 2005 |
Decreased cellular uptake and metabolism in Allan-Herndon-Dudley syndrome (AHDS) due to a novel mutation in the MCT8 thyroid hormone transporter.
Topics: Adult; Aged; Biological Transport; DNA Mutational Analysis; Female; Frameshift Mutation; Genetic Dis | 2006 |
[Changes of the thyroid hormone status in children with cerebral palsy and other neurological pathology].
Topics: Age Factors; Birth Injuries; Brain Injuries; Cerebral Palsy; Child; Child, Preschool; Cystitis; Fema | 2005 |
Unexpected peripheral markers of thyroid function in a patient with a novel mutation of the MCT8 thyroid hormone transporter gene.
Topics: Age Determination by Skeleton; Biomarkers; Chromosomes, Human, X; Codon, Nonsense; Humans; Hyperthyr | 2007 |
Functional analysis of monocarboxylate transporter 8 mutations identified in patients with X-linked psychomotor retardation and elevated serum triiodothyronine.
Topics: Cell Line, Tumor; Codon, Nonsense; Gene Deletion; Genetic Diseases, X-Linked; Humans; Intellectual D | 2007 |
The relative expression of mutant and normal thyroid hormone receptor genes in patients with generalized resistance to thyroid hormone determined by estimation of their specific messenger ribonucleic acid products.
Topics: Alleles; Base Sequence; Drug Resistance; Exons; Female; Gene Expression; Growth Disorders; Humans; I | 1993 |
Two consecutive nucleotide substitutions resulting in the T3 receptor beta gene resulting in an 11-amino acid truncation in a patient with generalized resistance to thyroid hormone.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; Child; Codon, Terminator; DNA Primers; Drug | 1995 |
Deoxyribonucleic acid binding and transcriptional silencing by a truncated c-erbA beta 1 thyroid hormone receptor identified in a severely retarded patient with resistance to thyroid hormone.
Topics: Adolescent; Animals; Cell Line; COS Cells; DNA; Drug Resistance; Female; Fetus; Gene Deletion; Genes | 1997 |
Comparison of the functional properties of three different truncated thyroid hormone receptors identified in subjects with resistance to thyroid hormone.
Topics: Adolescent; Adult; Animals; Base Sequence; Child; COS Cells; Dimerization; DNA; DNA Probes; Drug Res | 1998 |
Neonatal thyroid screening.
Topics: Congenital Hypothyroidism; Fetal Blood; Humans; Hypothyroidism; Infant; Infant, Newborn; Intellectua | 1979 |
Summary of symposium.
Topics: Antipsychotic Agents; Autistic Disorder; Brain; Bufotenin; Central Nervous System Diseases; Electroe | 1975 |
Endocrine function and diagnostic problems in a prepubertal case of 48,XXYY.
Topics: Bone and Bones; Child, Preschool; DNA Replication; Female; Follicle Stimulating Hormone; Humans; Int | 1978 |
Maternal-fetal thyroid hormone relationships and the fetal brain.
Topics: Animals; Brain; Female; Humans; Intellectual Disability; Maternal-Fetal Exchange; Pregnancy; Pregnan | 1988 |
[Multiendocrine changes in patients with neurological lesions].
Topics: Adrenal Glands; Adult; Circadian Rhythm; Humans; Hydrocortisone; Intellectual Disability; Iodine; Mi | 1973 |