triiodothyronine has been researched along with Decreased Muscle Tone in 30 studies
Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (3.33) | 29.6817 |
| 2010's | 22 (73.33) | 24.3611 |
| 2020's | 7 (23.33) | 2.80 |
| Authors | Studies |
|---|---|
| van Geest, FS | 2 |
| Groeneweg, S | 3 |
| van den Akker, ELT | 1 |
| Bacos, I | 1 |
| Barca, D | 1 |
| van den Berg, SAA | 1 |
| Bertini, E | 1 |
| Brunner, D | 1 |
| Brunetti-Pierri, N | 1 |
| Cappa, M | 1 |
| Cappuccio, G | 1 |
| Chatterjee, K | 1 |
| Chesover, AD | 1 |
| Christian, P | 1 |
| Coutant, R | 1 |
| Craiu, D | 1 |
| Crock, P | 1 |
| Dewey, C | 1 |
| Dica, A | 1 |
| Dimitri, P | 1 |
| Dubey, R | 1 |
| Enderli, A | 1 |
| Fairchild, J | 1 |
| Gallichan, J | 1 |
| Garibaldi, LR | 1 |
| George, B | 1 |
| Hackenberg, A | 1 |
| Heinrich, B | 1 |
| Huynh, T | 1 |
| Kłosowska, A | 1 |
| Lawson-Yuen, A | 1 |
| Linder-Lucht, M | 1 |
| Lyons, G | 1 |
| Monti Lora, F | 1 |
| Moran, C | 1 |
| Müller, KE | 1 |
| Paone, L | 1 |
| Paul, PG | 1 |
| Polak, M | 1 |
| Porta, F | 1 |
| Reinauer, C | 1 |
| de Rijke, YB | 1 |
| Seckold, R | 1 |
| Menevşe, TS | 1 |
| Simm, P | 1 |
| Simon, A | 1 |
| Spada, M | 1 |
| Stoupa, A | 1 |
| Szeifert, L | 1 |
| Tonduti, D | 1 |
| van Toor, H | 1 |
| Turan, S | 1 |
| Vanderniet, J | 1 |
| de Waart, M | 1 |
| van der Wal, R | 1 |
| van der Walt, A | 1 |
| van Wermeskerken, AM | 1 |
| Wierzba, J | 1 |
| Zibordi, F | 1 |
| Zung, A | 1 |
| Peeters, RP | 5 |
| Visser, WE | 5 |
| Braun, D | 2 |
| Bohleber, S | 1 |
| Vatine, GD | 1 |
| Svendsen, CN | 1 |
| Schweizer, U | 3 |
| Kersseboom, S | 4 |
| van den Berge, A | 1 |
| Dolcetta-Capuzzo, A | 1 |
| van Heerebeek, REA | 1 |
| Arjona, FJ | 1 |
| Meima, ME | 2 |
| Visser, TJ | 6 |
| Salveridou, E | 1 |
| Mayerl, S | 2 |
| Sundaram, SM | 1 |
| Markova, B | 1 |
| Heuer, H | 4 |
| Wilpert, NM | 1 |
| Krueger, M | 1 |
| Opitz, R | 1 |
| Sebinger, D | 1 |
| Paisdzior, S | 1 |
| Mages, B | 1 |
| Schulz, A | 1 |
| Spranger, J | 1 |
| Wirth, EK | 1 |
| Stachelscheid, H | 1 |
| Mergenthaler, P | 1 |
| Vajkoczy, P | 1 |
| Krude, H | 3 |
| Kühnen, P | 2 |
| Bechmann, I | 1 |
| Biebermann, H | 4 |
| Herrmann, B | 1 |
| Harder, L | 1 |
| Oelkrug, R | 1 |
| Chen, J | 2 |
| Gachkar, S | 1 |
| Nock, S | 1 |
| Resch, J | 1 |
| Korkowski, M | 1 |
| Mittag, J | 1 |
| Schuelke, M | 1 |
| Müller, TD | 1 |
| Tschöp, M | 1 |
| Wassner, AJ | 1 |
| Yamamoto, T | 1 |
| Lu, Y | 1 |
| Nakamura, R | 1 |
| Shimojima, K | 1 |
| Kira, R | 1 |
| Lima de Souza, EC | 1 |
| Islam, MS | 1 |
| Namba, N | 1 |
| Ohata, Y | 1 |
| Fujiwara, M | 1 |
| Nakano, C | 1 |
| Takeyari, S | 1 |
| Miyata, K | 1 |
| Nakano, Y | 1 |
| Yamamoto, K | 1 |
| Nakayama, H | 1 |
| Kitaoka, T | 1 |
| Kubota, T | 1 |
| Ozono, K | 1 |
| Bauer, AJ | 1 |
| Boccone, L | 1 |
| Dessì, V | 1 |
| Meloni, A | 1 |
| Loudianos, G | 1 |
| Kremers, GJ | 1 |
| Friesema, EC | 2 |
| Klootwijk, W | 1 |
| López-Marín, L | 1 |
| Martín-Belinchón, M | 1 |
| Gutiérrez-Solana, LG | 1 |
| Morte-Molina, B | 1 |
| Duat-Rodríguez, A | 1 |
| Bernal, J | 3 |
| Fu, J | 1 |
| Dumitrescu, AM | 1 |
| Müller, J | 1 |
| Bauer, R | 1 |
| Richert, S | 1 |
| Kassmann, CM | 1 |
| Darras, VM | 1 |
| Buder, K | 1 |
| Boelen, A | 1 |
| Rodrigues, F | 1 |
| Grenha, J | 1 |
| Ortez, C | 1 |
| Nascimento, A | 1 |
| Morte, B | 2 |
| M-Belinchón, M | 1 |
| Armstrong, J | 1 |
| Colomer, J | 1 |
| Horn, S | 1 |
| Vaurs-Barrière, C | 1 |
| García-de Teresa, B | 1 |
| González-Del Angel, A | 1 |
| Reyna-Fabián, ME | 1 |
| Ruiz-Reyes, Mde L | 1 |
| Calzada-León, R | 1 |
| Pérez-Enríquez, B | 1 |
| Alcántara-Ortigoza, MA | 1 |
| Langley, KG | 1 |
| Trau, S | 1 |
| Bean, LJ | 1 |
| Narravula, A | 1 |
| Schrier Vergano, SA | 1 |
| Kim, JH | 1 |
| Kim, YM | 1 |
| Yum, MS | 1 |
| Choi, JH | 1 |
| Lee, BH | 1 |
| Kim, GH | 1 |
| Yoo, HW | 1 |
| Guadaño-Ferraz, A | 1 |
| Armour, CM | 1 |
| Yoon, G | 1 |
| Crushell, E | 1 |
| Reardon, W | 1 |
| Filho, HC | 1 |
| Marui, S | 1 |
| Manna, TD | 1 |
| Brust, ES | 1 |
| Radonsky, V | 1 |
| Kuperman, H | 1 |
| Dichtchekenian, V | 1 |
| Setian, N | 1 |
| Damiani, D | 1 |
| Ambrugger, P | 1 |
| Tarnow, P | 1 |
| von Moers, A | 1 |
| Grueters, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Expanded Access Program for Tiratricol in Patients With Monocarboxylate Transporter 8 Deficiency Also Known as Allan-Herndon-Dudley Syndrome (AHDS)[NCT05911399] | 0 participants | Expanded Access | Available | ||||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for triiodothyronine and Decreased Muscle Tone
| Article | Year |
|---|---|
Tissue-Specific Function of Thyroid Hormone Transporters: New Insights from Mouse Models.
Topics: Animals; Humans; Mental Retardation, X-Linked; Monocarboxylic Acid Transporters; Muscle Hypotonia; M | 2020 |
Allan-Herndon-Dudley-Syndrome: Considerations about the Brain Phenotype with Implications for Treatment Strategies.
Topics: Basal Ganglia; Cerebellum; Humans; Mental Retardation, X-Linked; Monocarboxylic Acid Transporters; M | 2020 |
[MCT8-specific thyroid hormone cell transporter deficiency: a case report and review of the literature].
Topics: Amino Acid Substitution; Anticonvulsants; Biological Transport; Brain; Child, Preschool; Cord Blood | 2013 |
Inherited defects in thyroid hormone cell-membrane transport and metabolism.
Topics: Cell Membrane; Humans; Male; Membrane Transport Proteins; Mental Retardation, X-Linked; Monocarboxyl | 2014 |
Thyroid hormone transporters--functions and clinical implications.
Topics: Animals; Blood-Brain Barrier; Brain; Choroid Plexus; Humans; Membrane Transport Proteins; Mental Ret | 2015 |
Treatment of congenital thyroid dysfunction: Achievements and challenges.
Topics: Congenital Hypothyroidism; Hormone Replacement Therapy; Humans; Hydrolases; Infant, Newborn; Iodide | 2015 |
Thyroid hormone transport in developing brain.
Topics: Animals; Biological Transport; Brain; Humans; Mental Retardation, X-Linked; Monocarboxylic Acid Tran | 2011 |
23 other studies available for triiodothyronine and Decreased Muscle Tone
| Article | Year |
|---|---|
Long-Term Efficacy of T3 Analogue Triac in Children and Adults With MCT8 Deficiency: A Real-Life Retrospective Cohort Study.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Infant; Male; M | 2022 |
Sodium Phenylbutyrate Rescues Thyroid Hormone Transport in Brain Endothelial-Like Cells.
Topics: Biological Transport; Brain; Humans; Mental Retardation, X-Linked; Monocarboxylic Acid Transporters; | 2022 |
Topics: Animals; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Diiodothyronines; Disease Models, Animal | 2019 |
Spatiotemporal Changes of Cerebral Monocarboxylate Transporter 8 Expression.
Topics: Aged; Aged, 80 and over; Animals; Brain; Cell Line; Dogs; Endothelial Cells; Gene Expression Profili | 2020 |
Central Hypothyroidism Impairs Heart Rate Stability and Prevents Thyroid Hormone-Induced Cardiac Hypertrophy and Pyrexia.
Topics: Animals; Cardiomegaly; Crosses, Genetic; Enzyme-Linked Immunosorbent Assay; Fever; Gene Expression P | 2020 |
MCT8 deficiency: collaborative rare disease phenotyping for care and research.
Topics: Cohort Studies; Humans; Mental Retardation, X-Linked; Muscle Hypotonia; Muscular Atrophy; Rare Disea | 2020 |
Novel A178P mutation in SLC16A2 in a patient with Allan-Herndon-Dudley syndrome.
Topics: Base Sequence; Exome Sequencing; Failure to Thrive; Gene Expression; Humans; Infant; Magnetic Resona | 2018 |
Outward-Open Model of Thyroid Hormone Transporter Monocarboxylate Transporter 8 Provides Novel Structural and Functional Insights.
Topics: Animals; Arginine; Binding Sites; Biological Transport; Cell Line; Chlorocebus aethiops; COS Cells; | 2017 |
Functional analysis of monocarboxylate transporter 8 mutations in Japanese Allan-Herndon-Dudley syndrome patients.
Topics: Adolescent; Asian People; Cell Line, Tumor; Cell Membrane; Child; Child, Preschool; Cytoplasm; Genet | 2019 |
Triac in the treatment of Allan-Herndon-Dudley syndrome.
Topics: Adult; Child; Humans; Mental Retardation, X-Linked; Muscle Hypotonia; Muscular Atrophy; Triiodothyro | 2019 |
Allan-Herndon-Dudley syndrome (AHDS) in two consecutive generations caused by a missense MCT8 gene mutation. Phenotypic variability with the presence of normal serum T3 levels.
Topics: Adult; Child; Female; Heterozygote; Humans; Infant; Male; Mental Retardation, X-Linked; Middle Aged; | 2013 |
Mutations in MCT8 in patients with Allan-Herndon-Dudley-syndrome affecting its cellular distribution.
Topics: Animals; Blotting, Western; Cell Extracts; Cell Line; Cell Survival; Fluorescence Recovery After Pho | 2013 |
Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis.
Topics: Animals; Cerebral Cortex; GABAergic Neurons; Homeostasis; Membrane Transport Proteins; Mental Retard | 2014 |
Hypotonic male infant and MCT8 deficiency - a diagnosis to think about.
Topics: Child, Preschool; Humans; Male; Mental Retardation, X-Linked; Monocarboxylic Acid Transporters; Musc | 2014 |
In vitro and mouse studies supporting therapeutic utility of triiodothyroacetic acid in MCT8 deficiency.
Topics: Animals; Biological Transport; Cell Differentiation; Cell Line, Tumor; Cells, Cultured; Chlorocebus | 2014 |
Deletion of exon 1 of the SLC16A2 gene: a common occurrence in patients with Allan-Herndon-Dudley syndrome.
Topics: Child, Preschool; Computational Biology; Exons; Female; Gene Deletion; Humans; Hypothyroidism; Male; | 2015 |
A 7-month-old male with Allan-Herndon-Dudley syndrome and the power of T3.
Topics: Abnormalities, Multiple; Humans; Infant; Intellectual Disability; Male; Mental Retardation, X-Linked | 2015 |
Clinical and endocrine features of two Allan-Herndon-Dudley syndrome patients with monocarboxylate transporter 8 mutations.
Topics: Brain; Child, Preschool; Humans; Infant; Magnetic Resonance Imaging; Male; Mental Retardation, X-Lin | 2015 |
Efficient Activation of Pathogenic ΔPhe501 Mutation in Monocarboxylate Transporter 8 by Chemical and Pharmacological Chaperones.
Topics: Animals; Cell Membrane; Cysteine Proteinase Inhibitors; Dimethyl Sulfoxide; Dogs; Genistein; Iodine | 2015 |
Further Insights into the Allan-Herndon-Dudley Syndrome: Clinical and Functional Characterization of a Novel MCT8 Mutation.
Topics: Adolescent; Adult; Cells, Cultured; Female; Fibroblasts; Heterozygote; Humans; Immunoenzyme Techniqu | 2015 |
Elevated TSH levels in a mentally retarded boy.
Topics: Gene Deletion; Gene Duplication; Humans; Hypothyroidism; Infant; Male; Mental Retardation, X-Linked; | 2010 |
Novel mutation in MCT8 gene in a Brazilian boy with thyroid hormone resistance and severe neurologic abnormalities.
Topics: Amino Acid Sequence; Brain Diseases; Child; Humans; Male; Monocarboxylic Acid Transporters; Muscle H | 2011 |
Extended clinical phenotype, endocrine investigations and functional studies of a loss-of-function mutation A150V in the thyroid hormone specific transporter MCT8.
Topics: Animals; Child, Preschool; CHO Cells; Cricetinae; Female; Humans; Male; Mental Retardation, X-Linked | 2005 |