Page last updated: 2024-11-08

triiodothyronine and Combat Disorders

triiodothyronine has been researched along with Combat Disorders in 3 studies

Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.

Combat Disorders: Neurotic reactions to unusual, severe, or overwhelming military stress.

Research Excerpts

ExcerptRelevanceReference
"Post-traumatic stress disorder (PTSD) is a relatively new psychiatric disorder with three clusters of symptoms: trauma re-experiencing, avoidance, and increased arousal."2.71Increase of serum triiodothyronine concentration in soldiers with combat-related chronic post-traumatic stress disorder with or without alcohol dependence. ( Karlović, D; Martinac, M; Marusić, S, 2004)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (66.67)18.2507
2000's1 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Karlović, D1
Marusić, S1
Martinac, M1
Mason, J2
Southwick, S2
Yehuda, R2
Wang, S2
Riney, S2
Bremner, D1
Johnson, D1
Lubin, H1
Blake, D1
Zhou, G1
Charney, D1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparing Virtual Reality Exposure Therapy to Prolonged Exposure in the Treatment of Soldiers With Post Traumatic Stress Disorder (PTSD)[NCT01459705]162 participants (Actual)Interventional2011-10-31Completed
Comparing Virtual Reality Exposure Therapy to Prolonged Exposure in the Treatment of Soldiers With PTSD[NCT01193725]162 participants (Actual)Interventional2009-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Clinician-Administered PTSD Scale (CAPS)

The CAPS is a structured interview that assesses all Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) PTSD criteria in terms of frequency and intensity. We used total scores as the primary outcome. Minimum possible score was 0, maximum possible score was 136. Higher scores indicated higher levels of symptoms. (NCT01459705)
Timeframe: Screening Visit (Day 1)

Interventionunits on scale (Mean)
Prolonged Exposure Therapy (PE)78.28
Virtual Reality Exposure Therapy (VRET)80.44
Waitlist78.89

Clinician-Administered PTSD Scale (CAPS)

The CAPS is a structured interview that assesses all DSM-IV PTSD criteria in terms of frequency and intensity. Scores are computed for Intrusion, Avoidance and Hyperarousal symptom clusters, as well as a Total score.We used total scores as the primary outcome. Minimum possible score was 0, maximum possible score was 136. Higher scores indicated higher levels of symptoms. (NCT01459705)
Timeframe: 12 week follow up

Interventionunits on a scale (Mean)
Prolonged Exposure Therapy (PE)36.63
Virtual Reality Exposure Therapy (VRET)55.88

Clinician-Administered PTSD Scale (CAPS)

The CAPS is a structured interview that assesses all DSM-IV PTSD criteria in terms of frequency and intensity. Scores are computed for Intrusion, Avoidance and Hyperarousal symptom clusters, as well as a Total score.We used total scores as the primary outcome. Minimum possible score was 0, maximum possible score was 136. Higher scores indicated higher levels of symptoms. (NCT01459705)
Timeframe: 2.5 weeks (or after treatment session 5)

Interventionunits on a scale (Mean)
Prolonged Exposure Therapy (PE)65.03
Virtual Reality Exposure Therapy (VRET)71.19
Waitlist74.73

Clinician-Administered PTSD Scale (CAPS)

The CAPS is a structured interview that assesses all DSM-IV PTSD criteria in terms of frequency and intensity. Scores are computed for Intrusion, Avoidance and Hyperarousal symptom clusters, as well as a Total score.We used total scores as the primary outcome. Minimum possible score was 0, maximum possible score was 136. Higher scores indicated higher levels of symptoms. (NCT01459705)
Timeframe: 26 Week follow up

Interventionunits on a scale (Mean)
Prolonged Exposure Therapy (PE)38.33
Virtual Reality Exposure Therapy (VRET)54.47

Clinician-Administered PTSD Scale (CAPS)

The CAPS is a structured interview that assesses all DSM-IV PTSD criteria in terms of frequency and intensity. Scores are computed for Intrusion, Avoidance and Hyperarousal symptom clusters, as well as a Total score.We used total scores as the primary outcome. Minimum possible score was 0, maximum possible score was 136. Higher scores indicated higher levels of symptoms. (NCT01459705)
Timeframe: 5 weeks (or after treatment session 10)

Interventionunits on a scale (Mean)
Prolonged Exposure Therapy (PE)44.28
Virtual Reality Exposure Therapy (VRET)57.07
Waitlist68.06

Trials

1 trial available for triiodothyronine and Combat Disorders

ArticleYear
Increase of serum triiodothyronine concentration in soldiers with combat-related chronic post-traumatic stress disorder with or without alcohol dependence.
    Wiener klinische Wochenschrift, 2004, Jun-30, Volume: 116, Issue:11-12

    Topics: Adult; Alcoholism; Combat Disorders; Comorbidity; Croatia; Educational Status; Humans; Male; Marital

2004

Other Studies

2 other studies available for triiodothyronine and Combat Disorders

ArticleYear
Elevation of serum free triiodothyronine, total triiodothyronine, thyroxine-binding globulin, and total thyroxine levels in combat-related posttraumatic stress disorder.
    Archives of general psychiatry, 1994, Volume: 51, Issue:8

    Topics: Adult; Combat Disorders; Comorbidity; Follow-Up Studies; Humans; Hyperthyroidism; Male; Pilot Projec

1994
Elevation of serum free triiodothyronine, total triiodothyronine, thyroxine-binding globulin, and total thyroxine levels in combat-related posttraumatic stress disorder.
    Archives of general psychiatry, 1994, Volume: 51, Issue:8

    Topics: Adult; Combat Disorders; Comorbidity; Follow-Up Studies; Humans; Hyperthyroidism; Male; Pilot Projec

1994
Elevation of serum free triiodothyronine, total triiodothyronine, thyroxine-binding globulin, and total thyroxine levels in combat-related posttraumatic stress disorder.
    Archives of general psychiatry, 1994, Volume: 51, Issue:8

    Topics: Adult; Combat Disorders; Comorbidity; Follow-Up Studies; Humans; Hyperthyroidism; Male; Pilot Projec

1994
Elevation of serum free triiodothyronine, total triiodothyronine, thyroxine-binding globulin, and total thyroxine levels in combat-related posttraumatic stress disorder.
    Archives of general psychiatry, 1994, Volume: 51, Issue:8

    Topics: Adult; Combat Disorders; Comorbidity; Follow-Up Studies; Humans; Hyperthyroidism; Male; Pilot Projec

1994
Relationships between hormonal profile and novelty seeking in combat-related posttraumatic stress disorder.
    Biological psychiatry, 1997, Jan-15, Volume: 41, Issue:2

    Topics: Adult; Arousal; Combat Disorders; Hormones; Humans; Hydrocortisone; Middle Aged; Norepinephrine; Per

1997