Page last updated: 2024-11-08

triiodothyronine and Cerebral Ischemia

triiodothyronine has been researched along with Cerebral Ischemia in 24 studies

Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.

Research Excerpts

ExcerptRelevanceReference
"It is uncertain that the effect of free triiodothyronine (FT3) within normal ranges on initial severity and early functional outcomes in acute ischemic stroke (AIS) patients with Intracranial Atherosclerotic Stenosis (ICAS)."7.91Low-normal free triiodothyronine and high leukocyte levels in relation to stroke severity and poor outcome in acute ischemic stroke with intracranial atherosclerotic stenosis. ( Feng, X; Li, Z; Liu, Y; Liu, Z; Wang, J; Xia, J; Yang, Q; Yu, F; Zhan, Q; Zhou, X, 2019)
"Patients with acute ischemic stroke (AIS) frequently experience low free triiodothyronine (fT3) concentrations."7.83Low triiodothyronine: A new facet of inflammation in acute ischemic stroke. ( Chen, X; Jiang, Y; Liu, M; Liu, Y; Ma, L; Ma, X; Zhu, D, 2016)
"Low free triiodothyronine (fT3) levels have been associated with increased mortality and poor functional outcomes in patients with stroke."7.83Low free triiodothyronine levels are related to symptomatic intracranial hemorrhage and poor functional outcomes after intravenous thrombolysis in acute ischemic stroke patients. ( Liu, J; Liu, M; Tao, W; Wang, D; Xiong, Y; Yuan, R, 2016)
"SAP in individuals with low T3 syndrome was substantially greater (p < ."5.72Low triiodothyronine syndrome is associated with stroke-associated pneumonia. ( Chen, H; He, J; Huang, Y; Ren, W; Xu, M, 2022)
"It is uncertain that the effect of free triiodothyronine (FT3) within normal ranges on initial severity and early functional outcomes in acute ischemic stroke (AIS) patients with Intracranial Atherosclerotic Stenosis (ICAS)."3.91Low-normal free triiodothyronine and high leukocyte levels in relation to stroke severity and poor outcome in acute ischemic stroke with intracranial atherosclerotic stenosis. ( Feng, X; Li, Z; Liu, Y; Liu, Z; Wang, J; Xia, J; Yang, Q; Yu, F; Zhan, Q; Zhou, X, 2019)
"Serum triiodothyronine (T3) concentration was reported to be associated with the prognosis after acute ischemic stroke."3.91The prognostic value of total T3 after acute cerebral infarction is age-dependent: a retrospective study on 768 patients. ( Hu, XY; Li, LQ; Li, WY; Lv, W; Xu, XY, 2019)
"Several studies have shown that high level of plasma C-reactive protein (CRP) is associated with stroke outcomes and future vascular events, and a decrease in serum triiodothyronine (T3) was reported to be associated with stroke severity and poor prognosis."3.88C-Reactive Protein and T3: New Prognostic Factors in Acute Ischemic Stroke. ( Ifteni, PI; Irimie, CA; Irimie, M; Minea, DI; Vârciu, M, 2018)
"Low serum triiodothyronine levels can be a predictive marker of short-term outcome after ischemic stroke."3.85Low T ( Bao, J; Pan, S; Wang, Y; Zhang, X; Zhou, S, 2017)
"Patients with acute ischemic stroke (AIS) frequently experience low free triiodothyronine (fT3) concentrations."3.83Low triiodothyronine: A new facet of inflammation in acute ischemic stroke. ( Chen, X; Jiang, Y; Liu, M; Liu, Y; Ma, L; Ma, X; Zhu, D, 2016)
"Low free triiodothyronine (fT3) levels have been associated with increased mortality and poor functional outcomes in patients with stroke."3.83Low free triiodothyronine levels are related to symptomatic intracranial hemorrhage and poor functional outcomes after intravenous thrombolysis in acute ischemic stroke patients. ( Liu, J; Liu, M; Tao, W; Wang, D; Xiong, Y; Yuan, R, 2016)
" In a previous investigation, post-resuscitation infusion of levothyroxine sodium (L-T4) to normalize serum 3,5,3'-triiodothyronine (T3) concentrations was associated with significant reduction of neurologic deficit caused by severe global cerebral ischemia."3.69Acute administration of T3 or rT3 failed to improve outcome following resuscitation from cardiac arrest in dogs. ( D'Alecy, LG; Mayor, GH; Nachreiner, RF; Whitesall, SE; Zwemer, CF, 1996)
"Stroke is the fifth leading cause of mortality in the United States and a leading cause of disability."2.55Ischemic Stroke and Impact of Thyroid Profile at Presentation: A Systematic Review and Meta-analysis of Observational Studies. ( Basnet, S; Dhital, R; Gyawali, B; Karmacharya, P; Poudel, DR; Shrestha, P; Tachamo, N, 2017)
"SAP in individuals with low T3 syndrome was substantially greater (p < ."1.72Low triiodothyronine syndrome is associated with stroke-associated pneumonia. ( Chen, H; He, J; Huang, Y; Ren, W; Xu, M, 2022)
"Focal cerebral ischemia was induced under Laser Doppler Flowmetry (LDF) guide by 45 min of middle cerebral artery occlusion (MCAO), followed by 7 days of reperfusion in albino mice."1.46Effects of the combined treatment of bone marrow stromal cells with mild exercise and thyroid hormone on brain damage and apoptosis in a mouse focal cerebral ischemia model. ( Akhoundzadeh, K; Mohammadkhani, R; Rashidy-Pour, A; Safari, M; Sameni, HR; Vafaei, AA; Vakili, A, 2017)
"Cerebral ischemia was induced by middle cerebral artery occlusion in male Wistar rats."1.46Stimulation of neurotrophic factors and inhibition of proinflammatory cytokines by exogenous application of triiodothyronine in the rat model of ischemic stroke. ( Akbari, M; Hassanzadeh, G; Kashani, IR; Mortezaee, K; Sabbaghziarani, F; Soleimani, M; Zendedel, A, 2017)
"The effect of cerebral ischemia and subsequent recirculation on the nuclear thyroid hormone receptors was investigated."1.27Nuclear binding sites for triiodothyronine in the gerbil brain following ischemia and recirculation. ( Thrall, CL; Yanagihara, T, 1984)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.17)18.7374
1990's4 (16.67)18.2507
2000's1 (4.17)29.6817
2010's15 (62.50)24.3611
2020's3 (12.50)2.80

Authors

AuthorsStudies
Doshi, M1
Watanabe, S1
Natori, Y1
Hosoyamada, M1
Hirashima-Akae, Y1
Chen, H3
Xu, M1
Huang, Y1
He, J2
Ren, W1
Chen, Z1
Sun, Y1
Zhang, Y1
He, Y1
Su, Y1
Akhoundzadeh, K1
Vakili, A1
Sameni, HR1
Vafaei, AA1
Rashidy-Pour, A1
Safari, M1
Mohammadkhani, R1
Dhital, R1
Poudel, DR1
Tachamo, N1
Gyawali, B1
Basnet, S1
Shrestha, P1
Karmacharya, P1
Irimie, CA1
Vârciu, M1
Irimie, M1
Ifteni, PI1
Minea, DI1
Wu, Y1
Huang, G1
He, W1
Lin, S1
Zhang, X2
Feng, X1
Zhou, X1
Yu, F1
Liu, Z1
Wang, J2
Li, Z1
Zhan, Q1
Yang, Q1
Liu, Y2
Xia, J1
Li, LQ1
Xu, XY1
Li, WY1
Hu, XY1
Lv, W1
Xi, L1
Zheng, H1
Wang, Q1
Sayre, NL1
Sifuentes, M1
Holstein, D1
Cheng, SY1
Zhu, X1
Lechleiter, JD1
Ma, L1
Zhu, D1
Jiang, Y1
Ma, X1
Liu, M2
Chen, X1
Liu, J1
Wang, D1
Xiong, Y1
Yuan, R1
Tao, W1
Wang, Y1
Zhou, S1
Bao, J1
Pan, S1
Suda, S1
Muraga, K1
Kanamaru, T1
Okubo, S1
Abe, A1
Aoki, J1
Suzuki, K1
Sakamoto, Y1
Shimoyama, T1
Nito, C1
Kimura, K1
Sabbaghziarani, F1
Mortezaee, K1
Akbari, M1
Kashani, IR1
Soleimani, M1
Hassanzadeh, G1
Zendedel, A1
Skalny, AV1
Klimenko, LL1
Turna, AA1
Budanova, MN1
Baskakov, IS1
Savostina, MS1
Mazilina, AN1
Deyev, AI1
Skalnaya, MG1
Tinkov, AA1
Neidert, S1
Katan, M1
Schuetz, P1
Fluri, F1
Ernst, A1
Bingisser, R1
Kappos, L1
Engelter, ST1
Steck, A1
Müller, B1
Christ-Crain, M1
Schwarz, S1
Schwab, S1
Klinga, K1
Maser-Gluth, C1
Bettendorf, M1
Thrall, CL1
Yanagihara, T1
Shuaib, A1
Ijaz, S1
Hemmings, S1
Galazka, P1
Ishaqzay, R1
Liu, L1
Ravindran, J1
Miyashita, H1
Whitesall, SE1
Mayor, GH1
Nachreiner, RF1
Zwemer, CF1
D'Alecy, LG1
Dolgov, AM1
Stadnikov, AA1
Ozeredenko, VG1
Fedorova, LP1
Mikhaĭlova, EIu1

Reviews

1 review available for triiodothyronine and Cerebral Ischemia

ArticleYear
Ischemic Stroke and Impact of Thyroid Profile at Presentation: A Systematic Review and Meta-analysis of Observational Studies.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2017, Volume: 26, Issue:12

    Topics: Asymptomatic Diseases; Biomarkers; Brain Ischemia; Chi-Square Distribution; Humans; Hyperthyroidism;

2017

Other Studies

23 other studies available for triiodothyronine and Cerebral Ischemia

ArticleYear
Triiodothyronine Aggravates Global Cerebral Ischemia-Reperfusion Injury in Mice.
    Biological & pharmaceutical bulletin, 2021, Volume: 44, Issue:12

    Topics: Animals; Astrocytes; Brain Ischemia; Cell Death; Cerebral Infarction; Disease Models, Animal; DNA Fr

2021
Low triiodothyronine syndrome is associated with stroke-associated pneumonia.
    European journal of clinical investigation, 2022, Volume: 52, Issue:11

    Topics: Brain Ischemia; Euthyroid Sick Syndromes; Humans; Pneumonia; Stroke; Thyrotropin; Triiodothyronine

2022
Low TSH level predicts a poor clinical outcome in patients with anterior circulation ischemic stroke after endovascular thrombectomy.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2020, Volume: 41, Issue:7

    Topics: Aged; Brain Ischemia; Female; Humans; Ischemic Stroke; Male; Middle Aged; Retrospective Studies; Thr

2020
Effects of the combined treatment of bone marrow stromal cells with mild exercise and thyroid hormone on brain damage and apoptosis in a mouse focal cerebral ischemia model.
    Metabolic brain disease, 2017, Volume: 32, Issue:4

    Topics: Animals; Apoptosis; Brain; Brain Ischemia; Combined Modality Therapy; Disease Models, Animal; Male;

2017
C-Reactive Protein and T3: New Prognostic Factors in Acute Ischemic Stroke.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2018, Volume: 27, Issue:10

    Topics: Aged; Aged, 80 and over; Biomarkers; Brain Ischemia; C-Reactive Protein; Cognition; Disability Evalu

2018
Low Tri-iodothyronine Syndrome Is Associated With Cognitive Impairment in Patients With Acute Ischemic Stroke: A Prospective Cohort Study.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2018, Volume: 26, Issue:12

    Topics: Adult; Brain Ischemia; Cognitive Dysfunction; Female; Follow-Up Studies; Humans; Hypothyroidism; Mal

2018
Low-normal free triiodothyronine and high leukocyte levels in relation to stroke severity and poor outcome in acute ischemic stroke with intracranial atherosclerotic stenosis.
    The International journal of neuroscience, 2019, Volume: 129, Issue:7

    Topics: Brain Ischemia; Female; Humans; Intracranial Arteriosclerosis; Leukocyte Count; Male; Middle Aged; R

2019
The prognostic value of total T3 after acute cerebral infarction is age-dependent: a retrospective study on 768 patients.
    BMC neurology, 2019, Apr-05, Volume: 19, Issue:1

    Topics: Age Factors; Aged; Biomarkers; Brain Ischemia; Female; Humans; Male; Middle Aged; Odds Ratio; Progno

2019
[Mechanism of cytoprotective effect of thyroid hormone on the hippocampus of rats with chronic cerebral ischemia].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2013, Volume: 33, Issue:5

    Topics: Animals; Apoptosis; Brain Ischemia; CA1 Region, Hippocampal; Male; Neurons; Proto-Oncogene Proteins

2013
Stimulation of astrocyte fatty acid oxidation by thyroid hormone is protective against ischemic stroke-induced damage.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017, Volume: 37, Issue:2

    Topics: Adenosine Triphosphate; Animals; Astrocytes; Brain Ischemia; Cell Survival; Cells, Cultured; Fatty A

2017
Low triiodothyronine: A new facet of inflammation in acute ischemic stroke.
    Clinica chimica acta; international journal of clinical chemistry, 2016, Jul-01, Volume: 458

    Topics: Adult; Aged; Aged, 80 and over; Brain Ischemia; Female; Humans; Inflammation; Male; Middle Aged; Str

2016
Low free triiodothyronine levels are related to symptomatic intracranial hemorrhage and poor functional outcomes after intravenous thrombolysis in acute ischemic stroke patients.
    Neurological research, 2016, Volume: 38, Issue:5

    Topics: Aged; Aged, 80 and over; Brain Ischemia; Female; Fibrinolytic Agents; Humans; Injections, Intravenou

2016
Low T
    The International journal of neuroscience, 2017, Volume: 127, Issue:7

    Topics: Aged; Biomarkers; Brain Ischemia; Female; Follow-Up Studies; Humans; Male; Middle Aged; Outcome Asse

2017
Low free triiodothyronine predicts poor functional outcome after acute ischemic stroke.
    Journal of the neurological sciences, 2016, Sep-15, Volume: 368

    Topics: Aged; Biomarkers; Brain; Brain Ischemia; Female; Hospitalization; Humans; Logistic Models; Male; Pro

2016
Stimulation of neurotrophic factors and inhibition of proinflammatory cytokines by exogenous application of triiodothyronine in the rat model of ischemic stroke.
    Cell biochemistry and function, 2017, Volume: 35, Issue:1

    Topics: Animals; Blotting, Western; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cytokines; Disease Mo

2017
Serum trace elements are interrelated with hormonal imbalance in men with acute ischemic stroke.
    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2017, Volume: 43

    Topics: Aged; Brain Ischemia; Estradiol; Humans; Iodine; Male; Middle Aged; Progesterone; Stroke; Testostero

2017
Anterior pituitary axis hormones and outcome in acute ischaemic stroke.
    Journal of internal medicine, 2011, Volume: 269, Issue:4

    Topics: Aged; Aged, 80 and over; Biomarkers; Brain Ischemia; Epidemiologic Methods; Female; Human Growth Hor

2011
Neuroendocrine changes in patients with acute space occupying ischaemic stroke.
    Journal of neurology, neurosurgery, and psychiatry, 2003, Volume: 74, Issue:6

    Topics: Adrenocorticotropic Hormone; Brain; Brain Ischemia; Cerebrovascular Circulation; Combined Modality T

2003
Nuclear binding sites for triiodothyronine in the gerbil brain following ischemia and recirculation.
    Brain research, 1984, May-28, Volume: 301, Issue:1

    Topics: Animals; Brain Ischemia; Cell Nucleus; Cerebral Cortex; Cerebrovascular Circulation; Gerbillinae; Ki

1984
Decreased glutamate release during hypothyroidism may contribute to protection in cerebral ischemia.
    Experimental neurology, 1994, Volume: 128, Issue:2

    Topics: Animals; Brain Ischemia; Gerbillinae; Glutamates; Glutamic Acid; Hypothyroidism; Male; Microdialysis

1994
Acute administration of T3 or rT3 failed to improve outcome following resuscitation from cardiac arrest in dogs.
    Resuscitation, 1996, Volume: 33, Issue:1

    Topics: Animals; Brain Ischemia; Dogs; Heart Arrest; Male; Neurologic Examination; Radioimmunoassay; Resusci

1996
[Dependence of the outcome of cerebral ischemia on the types of neurohypophysis reactions and dynamics of the level of hormones of hypophysis-dependent endocrine glands].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 1998, Volume: 98, Issue:10

    Topics: Animals; Brain Ischemia; Hydrocortisone; Male; Pituitary Gland, Posterior; Rats; Thyroxine; Time Fac

1998
[Plasma levels of cyclic nucleotides, phosphodiesterase, thyroid hormones and insulin in patients with ischemic stroke].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1990, Volume: 90, Issue:7

    Topics: Acute Disease; Brain Ischemia; Cerebral Infarction; Cyclic AMP; Cyclic GMP; Humans; Insulin; Nucleot

1990