triiodothyronine has been researched along with Cardiac Remodeling, Ventricular in 21 studies
Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In heart failure (HF) the main alteration of thyroid function is referred to as "low-triiodothyronine (T3) syndrome" (LT3S) characterized by decreased total serum T3 and free T3 (fT3) with normal levels of thyroxine (T4) and thyrotropin (TSH)." | 4.86 | The role of thyroid hormone in the pathophysiology of heart failure: clinical evidence. ( Galli, E; Iervasi, G; Pingitore, A, 2010) |
| "3,5,3'-Levo-triiodothyronine (L-T3) is essential for DNA transcription, mitochondrial biogenesis and respiration, but its circulating levels rapidly decrease after myocardial infarction (MI)." | 3.77 | Early long-term L-T3 replacement rescues mitochondria and prevents ischemic cardiac remodelling in rats. ( Ardehali, H; Cecchetti, F; Forini, F; Ghanefar, M; Ichikawa, Y; Iervasi, G; Lionetti, V; Nannipieri, M; Nicolini, G; Pucci, A; Recchia, FA, 2011) |
| "Cardiac hypertrophy was evident in AMI hearts after 13 weeks but not at 2 weeks." | 1.34 | Time-dependent changes in the expression of thyroid hormone receptor alpha 1 in the myocardium after acute myocardial infarction: possible implications in cardiac remodelling. ( Cokkinos, DV; Dimopoulos, A; Kokkinos, AD; Kostopanagiotou, G; Markakis, K; Mourouzis, I; Panagiotou, M; Pantos, C; Saranteas, T; Xinaris, C, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (28.57) | 29.6817 |
| 2010's | 14 (66.67) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Bogush, N | 1 |
| Tan, L | 1 |
| Naqvi, E | 1 |
| Calvert, JW | 1 |
| Graham, RM | 1 |
| Taylor, WR | 1 |
| Naqvi, N | 1 |
| Husain, A | 1 |
| An, S | 1 |
| Gilani, N | 1 |
| Huang, Y | 1 |
| Muncan, A | 1 |
| Zhang, Y | 1 |
| Tang, YD | 1 |
| Gerdes, AM | 3 |
| Ojamaa, K | 1 |
| Pingitore, A | 3 |
| Mastorci, F | 1 |
| Piaggi, P | 1 |
| Aquaro, GD | 1 |
| Molinaro, S | 1 |
| Ravani, M | 1 |
| De Caterina, A | 1 |
| Trianni, G | 1 |
| Ndreu, R | 1 |
| Berti, S | 1 |
| Vassalle, C | 1 |
| Iervasi, G | 4 |
| Chen, YF | 1 |
| Weltman, NY | 1 |
| Li, X | 1 |
| Youmans, S | 1 |
| Krause, D | 1 |
| Jankauskienė, E | 1 |
| Orda, P | 1 |
| Barauskienė, G | 1 |
| Mickuvienė, N | 1 |
| Brožaitienė, J | 1 |
| Vaškelytė, JJ | 1 |
| Bunevičius, R | 1 |
| Corssac, GB | 1 |
| de Castro, AL | 1 |
| Tavares, AV | 1 |
| Campos, C | 1 |
| Fernandes, RO | 1 |
| Ortiz, VD | 1 |
| Siqueira, R | 1 |
| Fernandes, TR | 1 |
| Belló-Klein, A | 1 |
| Araujo, AS | 1 |
| Galli, E | 1 |
| Borbély, A | 1 |
| van Heerebeek, L | 1 |
| Paulus, WJ | 1 |
| Forini, F | 1 |
| Lionetti, V | 1 |
| Ardehali, H | 1 |
| Pucci, A | 1 |
| Cecchetti, F | 1 |
| Ghanefar, M | 1 |
| Nicolini, G | 1 |
| Ichikawa, Y | 1 |
| Nannipieri, M | 1 |
| Recchia, FA | 1 |
| Wang, YY | 1 |
| Morimoto, S | 1 |
| Du, CK | 1 |
| Lu, QW | 1 |
| Zhan, DY | 1 |
| Tsutsumi, T | 1 |
| Ide, T | 1 |
| Miwa, Y | 1 |
| Takahashi-Yanaga, F | 1 |
| Sasaguri, T | 1 |
| Kalofoutis, C | 1 |
| Mourouzis, I | 5 |
| Galanopoulos, G | 2 |
| Dimopoulos, A | 3 |
| Perimenis, P | 1 |
| Spanou, D | 1 |
| Cokkinos, DV | 6 |
| Singh, J | 1 |
| Pantos, C | 6 |
| Chen, Y | 1 |
| Celikyurt, U | 1 |
| Agacdiken, A | 1 |
| Geyik, B | 1 |
| Kozdag, G | 1 |
| Vural, A | 1 |
| Ural, D | 1 |
| Mantzouratou, P | 1 |
| Kostakou, E | 1 |
| Roukounakis, N | 1 |
| Kokkinos, AD | 3 |
| Mishra, P | 1 |
| Samanta, L | 1 |
| Degens, H | 1 |
| Gilde, AJ | 1 |
| Lindhout, M | 1 |
| Willemsen, PH | 1 |
| Van Der Vusse, GJ | 1 |
| Van Bilsen, M | 1 |
| Xinaris, C | 3 |
| Malliopoulou, V | 1 |
| Kardami, E | 1 |
| Markakis, K | 2 |
| Panagiotou, M | 2 |
| Saranteas, T | 1 |
| Kostopanagiotou, G | 1 |
| Ciulla, MM | 1 |
| Paliotti, R | 1 |
| Cortelazzi, D | 1 |
| Tortora, G | 1 |
| Barelli, MV | 1 |
| Buonamici, V | 1 |
| Magrini, F | 1 |
| Beck-Peccoz, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Thyroid Hormone Replacement for Hypothyroidism and Acute Myocardial Infarction[NCT02512978] | Phase 4 | 160 participants (Anticipated) | Interventional | 2015-08-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for triiodothyronine and Cardiac Remodeling, Ventricular
| Article | Year |
|---|---|
The role of thyroid hormone in the pathophysiology of heart failure: clinical evidence.
Topics: Heart Failure; Humans; Hypothyroidism; Prognosis; Thyroid Hormones; Triiodothyronine; Ventricular Fu | 2010 |
Acute myocardial infarction and thyroid function: new pathophysiological and therapeutic perspectives.
Topics: Cell Survival; Heart; Humans; Myocardial Infarction; Myocytes, Cardiac; Receptors, Thyroid Hormone; | 2012 |
Oxidative stress and heart failure in altered thyroid States.
Topics: Animals; Atherosclerosis; Cardiomyopathies; Coronary Artery Disease; Heart Defects, Congenital; Hear | 2012 |
1 trial available for triiodothyronine and Cardiac Remodeling, Ventricular
| Article | Year |
|---|---|
Usefulness of Triiodothyronine Replacement Therapy in Patients With ST Elevation Myocardial Infarction and Borderline/Reduced Triiodothyronine Levels (from the THIRST Study).
Topics: Adult; Aged; Biomarkers; Coronary Angiography; Dose-Response Relationship, Drug; Echocardiography; F | 2019 |
17 other studies available for triiodothyronine and Cardiac Remodeling, Ventricular
| Article | Year |
|---|---|
Remuscularization with triiodothyronine and β
Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Metoprolol; Mice; Myocardial Infarction; Myocardium | 2022 |
Adverse transverse-tubule remodeling in a rat model of heart failure is attenuated with low-dose triiodothyronine treatment.
Topics: Animals; Calcium; Cells, Cultured; Female; Heart Failure; Myocytes, Cardiac; Rats; Rats, Sprague-Daw | 2019 |
Improvement of left ventricular remodeling after myocardial infarction with eight weeks L-thyroxine treatment in rats.
Topics: Animals; Arterioles; Body Weight; Collagen; Echocardiography; Female; Myocardial Infarction; Organ S | 2013 |
Relationship between left ventricular mechanics and low free triiodothyronine levels after myocardial infarction: a prospective study.
Topics: Area Under Curve; Biomarkers; Cohort Studies; Echocardiography; Female; Follow-Up Studies; Hospitals | 2016 |
Thyroid hormones effects on oxidative stress and cardiac remodeling in the right ventricle of infarcted rats.
Topics: Animals; Echocardiography; Hydrogen Peroxide; Hypertrophy, Right Ventricular; Myocardial Infarction; | 2016 |
Transcriptional and posttranslational modifications of titin: implications for diastole.
Topics: Alternative Splicing; Animals; Connectin; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent | 2009 |
Early long-term L-T3 replacement rescues mitochondria and prevents ischemic cardiac remodelling in rats.
Topics: Animals; Apoptosis; Blotting, Western; Capillaries; Cells, Cultured; Hemodynamics; Hormone Replaceme | 2011 |
Up-regulation of type 2 iodothyronine deiodinase in dilated cardiomyopathy.
Topics: Animals; Antithyroid Agents; Cardiomyopathy, Dilated; Cells, Cultured; Cyclic AMP; Disease Models, A | 2010 |
Thyroid hormone can favorably remodel the diabetic myocardium after acute myocardial infarction.
Topics: Animals; Diabetes Mellitus, Experimental; Down-Regulation; Genes, erbA; Myocardial Infarction; Rats; | 2010 |
Effect of cardiac resynchronization therapy on thyroid function.
Topics: Adult; Aged; Biomarkers; Cardiac Resynchronization Therapy; Female; Heart Failure; Humans; Male; Mid | 2011 |
[Type 1 diabetes impairs compensatory response after myocardial infarction; role of tissue hypothyroidism and effects of thyroid hormone administration].
Topics: Animals; Diabetes Mellitus, Type 1; Hypothyroidism; Male; Myocardial Infarction; Myocardium; Rats; T | 2011 |
Dose-dependent effects of thyroid hormone on post-ischemic cardiac performance: potential involvement of Akt and ERK signalings.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MA | 2012 |
Functional and metabolic adaptation of the heart to prolonged thyroid hormone treatment.
Topics: Adaptation, Physiological; Animals; Biomarkers; Cardiomegaly; Echocardiography; Heart; Male; Myocard | 2003 |
Thyroid hormone changes cardiomyocyte shape and geometry via ERK signaling pathway: potential therapeutic implications in reversing cardiac remodeling?
Topics: Animals; Animals, Newborn; Cell Shape; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Flavono | 2007 |
Time-dependent changes in the expression of thyroid hormone receptor alpha 1 in the myocardium after acute myocardial infarction: possible implications in cardiac remodelling.
Topics: Animals; Cardiomegaly; Cardiotonic Agents; Cell Shape; Echocardiography; In Vitro Techniques; Isomet | 2007 |
Thyroid hormone attenuates cardiac remodeling and improves hemodynamics early after acute myocardial infarction in rats.
Topics: Administration, Oral; Animals; Calcium-Binding Proteins; Cardiomegaly; Disease Models, Animal; Echoc | 2007 |
Effects of thyroid hormones on cardiac structure: a tissue characterization study in patients with thyroid disorders before and after treatment.
Topics: Adult; Antithyroid Agents; Collagen; Echocardiography; Electrocardiography; Female; Humans; Hyperthy | 2001 |