triiodothyronine has been researched along with Carcinogenesis in 8 studies
Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
Carcinogenesis: The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Different rat and mouse models of hepatocarcinogenesis were investigated." | 1.56 | Thyroid hormone inhibits hepatocellular carcinoma progression via induction of differentiation and metabolic reprogramming. ( Bellomo, SE; Cabras, L; Columbano, A; Follenzi, A; Fornari, F; Giordano, S; Gramantieri, L; Kowalik, MA; Ledda-Columbano, GM; Merlin, S; Morandi, A; Orrù, C; Parri, M; Perra, A; Petrelli, A; Puliga, E; Rasola, A; Sanchez-Martin, C; Sebastian, C; Sulas, P, 2020) |
| "In both, thyroid cancer is driven by overactivation of PI3K-AKT signaling." | 1.43 | SAHA-induced loss of tumor suppressor Pten gene promotes thyroid carcinogenesis in a mouse model. ( Cheng, SY; Kim, DW; Willingham, MC; Zhao, L; Zhu, X, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Kowalik, MA | 1 |
| Puliga, E | 1 |
| Cabras, L | 1 |
| Sulas, P | 1 |
| Petrelli, A | 1 |
| Perra, A | 1 |
| Ledda-Columbano, GM | 1 |
| Morandi, A | 1 |
| Merlin, S | 1 |
| Orrù, C | 1 |
| Sanchez-Martin, C | 1 |
| Fornari, F | 1 |
| Gramantieri, L | 1 |
| Parri, M | 1 |
| Rasola, A | 1 |
| Bellomo, SE | 1 |
| Sebastian, C | 1 |
| Follenzi, A | 1 |
| Giordano, S | 1 |
| Columbano, A | 1 |
| Chi, HC | 2 |
| Chen, SL | 2 |
| Lin, SL | 1 |
| Tsai, CY | 2 |
| Chuang, WY | 2 |
| Lin, YH | 1 |
| Huang, YH | 2 |
| Tsai, MM | 2 |
| Yeh, CT | 2 |
| Lin, KH | 2 |
| Hercbergs, A | 1 |
| Mousa, SA | 1 |
| Leinung, M | 1 |
| Lin, HY | 1 |
| Davis, PJ | 1 |
| Carr, FE | 1 |
| Tai, PW | 1 |
| Barnum, MS | 1 |
| Gillis, NE | 1 |
| Evans, KG | 1 |
| Taber, TH | 1 |
| White, JH | 1 |
| Tomczak, JA | 1 |
| Jaworski, DM | 1 |
| Zaidi, SK | 1 |
| Lian, JB | 1 |
| Stein, JL | 1 |
| Stein, GS | 1 |
| Zhu, X | 1 |
| Kim, DW | 1 |
| Zhao, L | 1 |
| Willingham, MC | 1 |
| Cheng, SY | 1 |
| Wu, SM | 1 |
| Sun, CP | 1 |
| SHERWIN-WEIDENREICH, R | 1 |
| HERRMANN, F | 2 |
| WEIDENREICH-SHERWIN, R | 1 |
1 review available for triiodothyronine and Carcinogenesis
| Article | Year |
|---|---|
Thyroid Hormone in the Clinic and Breast Cancer.
Topics: Animals; Breast Neoplasms; Carcinogenesis; Hormone Replacement Therapy; Humans; Hypothyroidism; Thyr | 2018 |
7 other studies available for triiodothyronine and Carcinogenesis
| Article | Year |
|---|---|
Thyroid hormone inhibits hepatocellular carcinoma progression via induction of differentiation and metabolic reprogramming.
Topics: Aged; Animals; Anticarcinogenic Agents; Carcinogenesis; Carcinoma, Hepatocellular; Cell Differentiat | 2020 |
Thyroid hormone protects hepatocytes from HBx-induced carcinogenesis by enhancing mitochondrial turnover.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; DNA Damage; Hep G2 Cells; Hepatocytes; Humans; L | 2017 |
Thyroid Hormone Receptor-β (TRβ) Mediates Runt-Related Transcription Factor 2 (Runx2) Expression in Thyroid Cancer Cells: A Novel Signaling Pathway in Thyroid Cancer.
Topics: Carcinogenesis; Cell Line, Tumor; Core Binding Factor Alpha 1 Subunit; Gene Expression Regulation, N | 2016 |
SAHA-induced loss of tumor suppressor Pten gene promotes thyroid carcinogenesis in a mouse model.
Topics: Adenocarcinoma, Follicular; Animals; Carcinogenesis; Disease Models, Animal; Hydroxamic Acids; Mice, | 2016 |
Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy.
Topics: Animals; Autophagy; Carcinogenesis; Carcinoma, Hepatocellular; Death-Associated Protein Kinases; Die | 2016 |
Hair cycle and chemically induced epidermal carcinogenesis in mice receiving tri-iodothyronine. I. Findings after single application of 9,10-dimethyl-1,2-benzanthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinogenesis; Epidermis; Hair; Mice | 1963 |
HAIR CYCLE AND CHEMICALLY INDUCED EPIDERMAL CARCINOGENESIS IN MICE RECEIVING LIOTHYRONINE. II. FINDINGS AFTER MULTIPLE APPLICATIONS OF METHYLCHOLANTHRENE.
Topics: Animals; Carcinogenesis; Epidermis; Hair; Methylcholanthrene; Mice; Neoplasms; Neoplasms, Experiment | 1964 |