Page last updated: 2024-11-08

triiodothyronine and Brain Neoplasms

triiodothyronine has been researched along with Brain Neoplasms in 23 studies

Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.

Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.

Research Excerpts

ExcerptRelevanceReference
"From Jan 1998 to Feb 2001, a total of 37 euthyroid children scheduled for CSI for medulloblastoma/primitive neuroectodermal tumor underwent thyroid ultrasound and free triiodothyronine (FT3), free thyroxine (FT4), and TSH evaluation at the beginning and end of CSI."3.74Thyroid-stimulating hormone suppression for protection against hypothyroidism due to craniospinal irradiation for childhood medulloblastoma/primitive neuroectodermal tumor. ( Biassoni, V; Bombardieri, E; Collini, P; Fossati-Bellani, F; Gandola, L; Marchianò, A; Massimino, M; Pallotti, F; Pignoli, E; Seregni, E; Serra, A; Spreafico, F; Terenziani, M, 2007)
"We have determined the cellular concentration of thyroxine (T4) and triiodothyronine (T3) and the activities of two brain iodothyronine deiodinases, type II (5'-D2) and type III (5-D3), in two types of tissues --tumour (26) and non-tumour (5), derived either from human gliomas with various histological malignancies or from non-tumoural surrounding brain tissue."3.72The concentration of thyroid hormones and activities of iodothyronine deiodinases are altered in human brain gliomas. ( Bonicki, W; Czernicki, Z; Michalik, R; Nauman, P; Warzecha, A, 2004)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19909 (39.13)18.7374
1990's4 (17.39)18.2507
2000's6 (26.09)29.6817
2010's3 (13.04)24.3611
2020's1 (4.35)2.80

Authors

AuthorsStudies
Tian, J1
Wu, J1
Yan, Z1
Huang, H1
Bunevicius, A3
Deltuva, V2
Tamasauskas, S2
Tamasauskas, A3
Laws, ER3
Bunevicius, R2
Deltuva, VP1
Smith, T1
Iervasi, G1
Lin, HY1
Sun, M1
Tang, HY1
Lin, C1
Luidens, MK1
Mousa, SA1
Incerpi, S1
Drusano, GL1
Davis, FB1
Davis, PJ1
Fernandes, JK1
Klein, MJ1
Ater, JL1
Kuttesch, JF1
Vassilopoulou-Sellin, R1
SPENGLER, JR1
CRUMMY, AB1
VERMUND, H1
BELL, RL1
Nauman, P1
Bonicki, W1
Michalik, R1
Warzecha, A1
Czernicki, Z1
Monden, T1
Nakajima, Y1
Hashida, T1
Ishii, S1
Tomaru, T1
Shibusawa, N1
Hashimoto, K1
Satoh, T1
Yamada, M1
Mori, M1
Kasai, K1
Zamoner, A1
Funchal, C1
Jacques-Silva, MC1
Gottfried, C1
Barreto Silva, FR1
Pessoa-Pureur, R1
Massimino, M1
Gandola, L1
Collini, P1
Seregni, E1
Marchianò, A1
Serra, A1
Pignoli, E1
Spreafico, F1
Pallotti, F1
Terenziani, M1
Biassoni, V1
Bombardieri, E1
Fossati-Bellani, F1
Preslock, JP1
Trejbal, D1
Sulla, I1
Trejbalová, L1
Lazúrová, I1
Schwartz, P1
Machánová, Y1
Suter-Crazzolara, C1
Unsicker, K1
Pinna, G1
Meinhold, H1
Hiedra, L1
Thoma, R1
Hoell, T1
Gräf, KJ1
Stoltenburg-Didinger, G1
Eravci, M1
Prengel, H1
Brödel, O1
Finke, R1
Baumgartner, A1
Calvo, RM1
Roda, JM1
Obregón, MJ1
Morreale de Escobar, G1
Faglia, G1
Bitensky, L1
Pinchera, A1
Ferrari, C1
Paracchi, A1
Beck-Peccoz, P1
Ambrosi, B1
Spada, A1
Croxson, MS1
Ibbertson, HK1
Shalet, SM1
Beardwell, CG1
MacFarlane, IA1
Jones, PH1
Pearson, D1
Lascelles, PT1
Lewis, PD1
Snyder, PJ1
Jacobs, LS1
Rabello, MM1
Sterling, FH1
Shore, RN1
Utiger, RD1
Daughaday, WH1
Patel, YC1
Burger, HG1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Protection From Iatrogenic Hypothyroidism Patients With MBL and Pediatric Patients With HL and Non-HL Needing Radiotherapy on Thyroid Site[NCT05316922]Phase 368 participants (Anticipated)Interventional2021-12-13Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for triiodothyronine and Brain Neoplasms

ArticleYear
Intracranial Germinoma Misdiagnosed as Hyperthyroidism: A Case Report and Review of the Literature.
    Frontiers in endocrinology, 2021, Volume: 12

    Topics: Adrenal Insufficiency; Brain Neoplasms; Diagnostic Errors; Germinoma; Humans; Hyperprolactinemia; Hy

2021
The pineal gland: basic implications and clinical correlations.
    Endocrine reviews, 1984,Spring, Volume: 5, Issue:2

    Topics: Adrenal Glands; Animals; Arginine Vasopressin; Brain Neoplasms; Cricetinae; Female; Gonads; Humans;

1984

Other Studies

21 other studies available for triiodothyronine and Brain Neoplasms

ArticleYear
Low triiodothyronine syndrome as a predictor of poor outcomes in patients undergoing brain tumor surgery: a pilot study: clinical article.
    Journal of neurosurgery, 2013, Volume: 118, Issue:6

    Topics: Aged; Anxiety; Biomarkers; Brain Neoplasms; Depression; Female; Follow-Up Studies; Humans; Male; Mid

2013
Association of thyroid hormone concentrations with quality of life of primary brain tumor patients: a pilot study.
    Journal of neuro-oncology, 2017, Volume: 131, Issue:2

    Topics: Brain Neoplasms; Female; Humans; Male; Middle Aged; Pilot Projects; Quality of Life; Thyrotropin; Th

2017
Preoperative low tri-iodothyronine concentration is associated with worse health status and shorter five year survival of primary brain tumor patients.
    Oncotarget, 2017, Jan-31, Volume: 8, Issue:5

    Topics: Adult; Aged; Brain Neoplasms; Chi-Square Distribution; Cognition; Down-Regulation; Female; Health St

2017
L-Thyroxine vs. 3,5,3'-triiodo-L-thyronine and cell proliferation: activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase.
    American journal of physiology. Cell physiology, 2009, Volume: 296, Issue:5

    Topics: Brain Neoplasms; Cell Division; Cell Line, Tumor; Cell Nucleus; Cytoplasm; Glioma; Humans; Hypoxia-I

2009
Triiodothyronine supplementation for hypothalamic obesity.
    Metabolism: clinical and experimental, 2002, Volume: 51, Issue:11

    Topics: Adult; Brain Neoplasms; Child; Female; Humans; Hypothalamic Diseases; Male; Obesity; Treatment Outco

2002
Response of mouse breast tumors to L-triiodohyronine and irradiation.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1960, Volume: 104

    Topics: Animals; Brain Neoplasms; Breast Neoplasms; Fibroadenoma; Humans; Mice; Neoplasms; Radiation Effects

1960
Concentration of labeled tri-iodothyronine and radioactive albumin in human cerebral neoplasms.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1960, Volume: 1

    Topics: Albumins; Brain Neoplasms; Humans; Radioactivity; Radiometry; Serum Albumin; Triiodothyronine

1960
The concentration of thyroid hormones and activities of iodothyronine deiodinases are altered in human brain gliomas.
    Folia neuropathologica, 2004, Volume: 42, Issue:2

    Topics: Adult; Aged; Analysis of Variance; Brain Neoplasms; Female; Glioma; Humans; Iodide Peroxidase; Male;

2004
Expression of thyroid hormone receptor isoforms down-regulated by thyroid hormone in human medulloblastoma cells.
    Endocrine journal, 2006, Volume: 53, Issue:2

    Topics: Brain Neoplasms; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression Profiling; Gene

2006
Thyroid hormones reorganize the cytoskeleton of glial cells through Gfap phosphorylation and Rhoa-dependent mechanisms.
    Cellular and molecular neurobiology, 2007, Volume: 27, Issue:7

    Topics: Animals; Astrocytes; Brain Neoplasms; Cell Division; Cell Line, Tumor; Cytoskeleton; Glial Fibrillar

2007
Thyroid-stimulating hormone suppression for protection against hypothyroidism due to craniospinal irradiation for childhood medulloblastoma/primitive neuroectodermal tumor.
    International journal of radiation oncology, biology, physics, 2007, Oct-01, Volume: 69, Issue:2

    Topics: Adolescent; Adult; Biomarkers; Brain Neoplasms; Child; Child, Preschool; Cranial Irradiation; Diseas

2007
Central hypothyroidism--various types of TSH responses to TRH stimulation.
    Endocrine regulations, 1994, Volume: 28, Issue:1

    Topics: Adolescent; Adult; Aged; Brain Neoplasms; Diencephalon; Female; Humans; Hypothyroidism; Male; Middle

1994
GDNF mRNA levels are induced by FGF-2 in rat C6 glioblastoma cells.
    Brain research. Molecular brain research, 1996, Sep-05, Volume: 41, Issue:1-2

    Topics: Animals; Astrocytes; Brain Neoplasms; Cell Division; Colforsin; Dexamethasone; Fibroblast Growth Fac

1996
Elevated 3,5-diiodothyronine concentrations in the sera of patients with nonthyroidal illnesses and brain tumors.
    The Journal of clinical endocrinology and metabolism, 1997, Volume: 82, Issue:5

    Topics: Astrocytoma; Brain Injuries; Brain Neoplasms; Craniocerebral Trauma; Diiodothyronines; Glioblastoma;

1997
Thyroid hormones in human tumoral and normal nervous tissues.
    Brain research, 1998, Aug-10, Volume: 801, Issue:1-2

    Topics: Adolescent; Adult; Aged; Brain Chemistry; Brain Neoplasms; Cerebral Cortex; Female; Humans; Iodide P

1998
Thyrotropin secretion in patients with central hypothyroidism: evidence for reduced biological activity of immunoreactive thyrotropin.
    The Journal of clinical endocrinology and metabolism, 1979, Volume: 48, Issue:6

    Topics: Biological Assay; Brain Neoplasms; Dexamethasone; Humans; Hypothalamus; Hypothyroidism; Pituitary Ne

1979
Low serum triiodothyronine (T3) and hypothyroidism in anorexia nervosa.
    The Journal of clinical endocrinology and metabolism, 1977, Volume: 44, Issue:1

    Topics: Achilles Tendon; Adolescent; Adult; Anorexia Nervosa; Body Weight; Brain Neoplasms; Female; Humans;

1977
Endocrine morbidity in adults treated with cerebral irradiation for brain tumours during childhood.
    Acta endocrinologica, 1977, Volume: 84, Issue:4

    Topics: Adolescent; Adult; Blood Glucose; Body Height; Brain Neoplasms; Child; Dose-Response Relationship, R

1977
Hypodipsia and hypernatraemia associated with hypothalamic and suprasellar lesions.
    Brain : a journal of neurology, 1972, Volume: 95, Issue:2

    Topics: Adolescent; Adult; Blood Urea Nitrogen; Brain Neoplasms; Chlorides; Craniopharyngioma; Diabetes Insi

1972
Diagnostic value of thyrotrophin-releasing hormone in pituitary and hypothalamic diseases. Assessment of thyrotrophin and prolactin secretion in 100 patients.
    Annals of internal medicine, 1974, Volume: 81, Issue:6

    Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Brain Diseases; Brain Neoplasms; Drug Evaluati

1974
Effect of synthetic thyrotrophin releasing hormone (TRH) in man.
    Australian and New Zealand journal of medicine, 1972, Volume: 2, Issue:4

    Topics: 11-Hydroxycorticosteroids; Adult; Aged; Brain Neoplasms; Female; Follicle Stimulating Hormone; Grave

1972