Page last updated: 2024-11-08

triiodothyronine and Brain Edema

triiodothyronine has been researched along with Brain Edema in 5 studies

Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.

Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)

Research Excerpts

ExcerptRelevanceReference
"Heterozygous mutations in the thyroid hormone receptor alpha (THRA) gene cause resistance to thyroid hormone alpha (RTHα), a disease characterized by variable manifestations reminiscent of untreated congenital hypothyroidism but a raised triiodothyronine/thyroxine ratio and normal thyrotropin levels."3.85In vivo Functional Consequences of Human THRA Variants Expressed in the Zebrafish. ( Carra, S; Cotelli, F; Marelli, F; Persani, L; Rurale, G, 2017)
"We have used both transient middle cerebral artery occlusion (t-MCAO) and permanent (p-MCAO) models of ischemic brain stroke."1.42Anti-edema action of thyroid hormone in MCAO model of ischemic brain stroke: Possible association with AQP4 modulation. ( Burke, J; Coughlin, L; Mdzinarishvili, A; Sadana, P; Woods, R, 2015)
"Thyroid storm is a rare disorder with a sudden onset, rapid progression and high mortality."1.38Thyroid storm with multiple organ failure, disseminated intravascular coagulation, and stroke with a normal serum FT3 level. ( Akiyama, H; Handa, M; Harada, Y; Ryuzaki, M; Urao, Y; Yoshimoto, T, 2012)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19901 (20.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (80.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Li, J1
Donangelo, I1
Abe, K1
Scremin, O1
Ke, S1
Li, F1
Milanesi, A1
Liu, YY1
Brent, GA1
Sadana, P1
Coughlin, L1
Burke, J1
Woods, R1
Mdzinarishvili, A1
Marelli, F1
Carra, S1
Rurale, G1
Cotelli, F1
Persani, L1
Harada, Y1
Akiyama, H1
Yoshimoto, T1
Urao, Y1
Ryuzaki, M1
Handa, M1
Nelson, JH1

Other Studies

5 other studies available for triiodothyronine and Brain Edema

ArticleYear
Thyroid hormone treatment activates protective pathways in both in vivo and in vitro models of neuronal injury.
    Molecular and cellular endocrinology, 2017, 09-05, Volume: 452

    Topics: Animals; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Brain Edema; Brain Injuries; Cell

2017
Anti-edema action of thyroid hormone in MCAO model of ischemic brain stroke: Possible association with AQP4 modulation.
    Journal of the neurological sciences, 2015, Jul-15, Volume: 354, Issue:1-2

    Topics: Animals; Aquaporin 4; Brain Edema; Cerebrovascular Circulation; Diiodothyronines; Infarction, Middle

2015
In vivo Functional Consequences of Human THRA Variants Expressed in the Zebrafish.
    Thyroid : official journal of the American Thyroid Association, 2017, Volume: 27, Issue:2

    Topics: Anemia; Animals; Animals, Genetically Modified; Brain Edema; Congenital Hypothyroidism; Craniofacial

2017
Thyroid storm with multiple organ failure, disseminated intravascular coagulation, and stroke with a normal serum FT3 level.
    Internal medicine (Tokyo, Japan), 2012, Volume: 51, Issue:17

    Topics: Anti-Inflammatory Agents; Anticoagulants; Antithyroid Agents; Brain Edema; Decompression, Surgical;

2012
Selecting the optimum oral contraceptive.
    The Journal of reproductive medicine, 1973, Volume: 11, Issue:4

    Topics: Acne Vulgaris; Blood Coagulation Disorders; Brain Edema; Breast; Candidiasis; Capillaries; Carbohydr

1973