triiodothyronine has been researched along with Atherogenesis in 22 studies
Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Since thyroid hormones may mediate the association between ARG derivatives and atherosclerosis, this study investigated whether asymmetric and symmetric dimethylarginines (ADMA and SDMA, respectively) as well as homoarginine (hARG) are associated with parameters of thyroid function in the general population." | 7.83 | L-Arginine Derivatives Are Associated with the Hyperthyroid State in the General Population. ( Atzler, D; Bahls, M; Böger, RH; Dörr, M; Felix, SB; Friedrich, N; Ittermann, T; Schwedhelm, E; Völzke, H, 2016) |
| " These findings uncover WAT as a viable target mediating the therapeutic benefits of TH and provide a safe and efficient therapeutic strategy for obesity and its complications by delivering TH to adipose tissue." | 5.72 | Adipose-targeted triiodothyronine therapy counteracts obesity-related metabolic complications and atherosclerosis with negligible side effects. ( Chen, K; Cheong, LY; Feng, T; Gao, Y; Honoré, E; Hui, X; Jin, L; Lam, KSL; Wang, Q; Wang, W; Xu, A; Zhang, Y, 2022) |
| "Concentrations of thyroid stimulating hormone (TSH), free thyroxine (FT4), triiodothyronine (T3) and thyroid peroxidase antibody (TPOAb) were quantified in 12 785 black and white participants of the ongoing community-based prospective Atherosclerosis Risk in Communities study." | 3.85 | Thyroid function, reduced kidney function and incident chronic kidney disease in a community-based population: the Atherosclerosis Risk in Communities study. ( Coresh, J; Daya, N; Grams, ME; Köttgen, A; Schultheiss, UT; Selvin, E; Seufert, J; Steffes, M, 2017) |
| " Since thyroid hormones may mediate the association between ARG derivatives and atherosclerosis, this study investigated whether asymmetric and symmetric dimethylarginines (ADMA and SDMA, respectively) as well as homoarginine (hARG) are associated with parameters of thyroid function in the general population." | 3.83 | L-Arginine Derivatives Are Associated with the Hyperthyroid State in the General Population. ( Atzler, D; Bahls, M; Böger, RH; Dörr, M; Felix, SB; Friedrich, N; Ittermann, T; Schwedhelm, E; Völzke, H, 2016) |
| "Free triiodothyronine (FT3) level was associated with GS≥22 (Median GS) in Model I adjusted for age and sex [Continuous: OR=0." | 1.72 | The Association of Thyroid Hormones with Coronary Atherosclerotic Severity in Euthyroid Patients. ( Chen, S; Gong, F; Pan, H; Wang, L; Yu, N; Zeng, Y; Zhao, Y; Zhu, H, 2022) |
| " These findings uncover WAT as a viable target mediating the therapeutic benefits of TH and provide a safe and efficient therapeutic strategy for obesity and its complications by delivering TH to adipose tissue." | 1.72 | Adipose-targeted triiodothyronine therapy counteracts obesity-related metabolic complications and atherosclerosis with negligible side effects. ( Chen, K; Cheong, LY; Feng, T; Gao, Y; Honoré, E; Hui, X; Jin, L; Lam, KSL; Wang, Q; Wang, W; Xu, A; Zhang, Y, 2022) |
| "Thyroid cysts could have a positive effect on the supply of thyroid hormones." | 1.62 | Association between thyroid cysts and hypertension by atherosclerosis status: a cross-sectional study. ( Hayashida, N; Kawashiri, SY; Maeda, T; Nagata, Y; Noguchi, Y; Shimizu, Y, 2021) |
| "Clinical hypothyroidism was prevalent (>20% of individuals studied) and was associated with cerebrovascular disease but not Alzheimer's disease-type neuropathology." | 1.48 | Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer's disease pathology in older adults. ( Brenowitz, WD; Han, F; Kukull, WA; Nelson, PT, 2018) |
| "Hypothyroidism was successfully induced in PTU/LI mice." | 1.39 | Decreased expression of hepatic low-density lipoprotein receptor-related protein 1 in hypothyroidism: a novel mechanism of atherogenic dyslipidemia in hypothyroidism. ( Cha, BS; Choi, SH; Jang, HC; Kim, HJ; Kim, HM; Lim, S; Moon, JH; Park, YJ, 2013) |
| "These findings suggest that elevated cholesterol concentrations in the blood, especially against the background of suppressed thyroid function, can directly induce considerable damage to cardiomyocytes, intramural vessels, and erythrocytes without the development of myocardial ischemia and in the absence of atherosclerotic plaques." | 1.39 | Structural changes in the myocardium and serum lipid spectrum in experimental hypercholesterolemia and hypothyroidism. ( Klinnikova, MG; Lushnikova, EL; Molodykh, OP; Nepomnyashchikh, LM; Nepomnyashchikh, RD; Pichigin, VI; Polyakov, LP; Poteryaeva, ON; Russkikh, GS, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (9.09) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (18.18) | 29.6817 |
| 2010's | 13 (59.09) | 24.3611 |
| 2020's | 3 (13.64) | 2.80 |
| Authors | Studies |
|---|---|
| Yu, N | 1 |
| Wang, L | 1 |
| Zeng, Y | 1 |
| Zhao, Y | 1 |
| Chen, S | 1 |
| Pan, H | 1 |
| Gong, F | 1 |
| Zhu, H | 1 |
| Chen, K | 1 |
| Cheong, LY | 1 |
| Gao, Y | 1 |
| Zhang, Y | 2 |
| Feng, T | 1 |
| Wang, Q | 2 |
| Jin, L | 1 |
| Honoré, E | 1 |
| Lam, KSL | 1 |
| Wang, W | 1 |
| Hui, X | 1 |
| Xu, A | 1 |
| Shimizu, Y | 1 |
| Kawashiri, SY | 1 |
| Noguchi, Y | 1 |
| Nagata, Y | 1 |
| Maeda, T | 1 |
| Hayashida, N | 1 |
| Brenowitz, WD | 1 |
| Han, F | 1 |
| Kukull, WA | 1 |
| Nelson, PT | 1 |
| Balzan, S | 1 |
| Sabatino, L | 1 |
| Lubrano, V | 1 |
| Neggazi, S | 1 |
| Canaple, L | 1 |
| Hamlat, N | 1 |
| Gauthier, K | 2 |
| Samarut, J | 1 |
| Bricca, G | 1 |
| Aouichat-Bouguerra, S | 1 |
| Beylot, M | 1 |
| Moon, JH | 1 |
| Kim, HJ | 1 |
| Kim, HM | 1 |
| Choi, SH | 1 |
| Lim, S | 1 |
| Park, YJ | 1 |
| Jang, HC | 1 |
| Cha, BS | 1 |
| Nepomnyashchikh, LM | 1 |
| Lushnikova, EL | 1 |
| Polyakov, LP | 1 |
| Molodykh, OP | 1 |
| Klinnikova, MG | 1 |
| Russkikh, GS | 1 |
| Poteryaeva, ON | 1 |
| Nepomnyashchikh, RD | 1 |
| Pichigin, VI | 1 |
| Li, Q | 1 |
| Lu, P | 1 |
| Ittermann, T | 1 |
| Bahls, M | 1 |
| Atzler, D | 1 |
| Friedrich, N | 1 |
| Schwedhelm, E | 1 |
| Böger, RH | 1 |
| Felix, SB | 1 |
| Völzke, H | 1 |
| Dörr, M | 1 |
| Salerno, M | 1 |
| Capalbo, D | 1 |
| Cerbone, M | 1 |
| De Luca, F | 1 |
| Schultheiss, UT | 1 |
| Daya, N | 1 |
| Grams, ME | 1 |
| Seufert, J | 1 |
| Steffes, M | 1 |
| Coresh, J | 1 |
| Selvin, E | 1 |
| Köttgen, A | 1 |
| Finan, B | 1 |
| Clemmensen, C | 1 |
| Zhu, Z | 1 |
| Stemmer, K | 1 |
| Müller, L | 1 |
| De Angelis, M | 1 |
| Moreth, K | 1 |
| Neff, F | 1 |
| Perez-Tilve, D | 1 |
| Fischer, K | 1 |
| Lutter, D | 1 |
| Sánchez-Garrido, MA | 1 |
| Liu, P | 1 |
| Tuckermann, J | 1 |
| Malehmir, M | 1 |
| Healy, ME | 1 |
| Weber, A | 1 |
| Heikenwalder, M | 1 |
| Jastroch, M | 1 |
| Kleinert, M | 1 |
| Jall, S | 1 |
| Brandt, S | 1 |
| Flamant, F | 1 |
| Schramm, KW | 1 |
| Biebermann, H | 1 |
| Döring, Y | 1 |
| Weber, C | 1 |
| Habegger, KM | 1 |
| Keuper, M | 1 |
| Gelfanov, V | 1 |
| Liu, F | 1 |
| Köhrle, J | 1 |
| Rozman, J | 1 |
| Fuchs, H | 1 |
| Gailus-Durner, V | 1 |
| Hrabě de Angelis, M | 1 |
| Hofmann, SM | 1 |
| Yang, B | 1 |
| Tschöp, MH | 1 |
| DiMarchi, R | 1 |
| Müller, TD | 1 |
| Parmar, HS | 1 |
| Kar, A | 1 |
| Ladenson, PW | 1 |
| Mishra, P | 1 |
| Samanta, L | 1 |
| Mugii, S | 1 |
| Hanada, H | 1 |
| Okubo, M | 1 |
| Masuda, D | 1 |
| Takeoka, K | 1 |
| Hidaka, Y | 1 |
| Ohama, T | 1 |
| Matsuyama, A | 1 |
| Nakagawa-Toyama, Y | 1 |
| Nishida, M | 1 |
| Ishigami, M | 1 |
| Komuro, I | 1 |
| Yamashita, S | 1 |
| CUTHBERTSON, WF | 1 |
| ELCOATE, PV | 1 |
| IRELAND, DM | 1 |
| MILLS, DC | 1 |
| SHEARLEY, P | 1 |
| KRITCHEVSKY, D | 1 |
| Chen, WJ | 1 |
| Lin, KH | 1 |
| Lai, YJ | 1 |
| Yang, SH | 1 |
| Pang, JH | 1 |
| Liou, YM | 1 |
| Chang, LY | 1 |
| Liaw, JM | 1 |
| Jiang, MJ | 1 |
| Xiang, GD | 1 |
| He, YS | 1 |
| Zhao, LS | 1 |
| Hou, J | 1 |
| Yue, L | 1 |
| Xiang, HJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Dapagliflozin on Hyperlipidemia, Glycemic Control and Insulin Resistance in Type 2 Diabetic Patients (DAPHNIS Study)[NCT02577159] | Phase 4 | 50 participants (Anticipated) | Interventional | 2015-07-01 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for triiodothyronine and Atherogenesis
| Article | Year |
|---|---|
Subclinical hypothyroidism in childhood - current knowledge and open issues.
Topics: Anticonvulsants; Antiviral Agents; Asymptomatic Diseases; Atherosclerosis; Bone Diseases, Metabolic; | 2016 |
Oxidative stress and heart failure in altered thyroid States.
Topics: Animals; Atherosclerosis; Cardiomyopathies; Coronary Artery Disease; Heart Defects, Congenital; Hear | 2012 |
1 trial available for triiodothyronine and Atherogenesis
| Article | Year |
|---|---|
Association between Hyperhomocysteinemia and Thyroid Hormones in Euthyroid Diabetic Subjects.
Topics: Adult; Aged; Atherosclerosis; Cross-Sectional Studies; Diabetes Complications; Female; Humans; Hyper | 2015 |
19 other studies available for triiodothyronine and Atherogenesis
| Article | Year |
|---|---|
The Association of Thyroid Hormones with Coronary Atherosclerotic Severity in Euthyroid Patients.
Topics: Atherosclerosis; Euthyroid Sick Syndromes; Female; Humans; Male; Mass Screening; Middle Aged; Regres | 2022 |
Adipose-targeted triiodothyronine therapy counteracts obesity-related metabolic complications and atherosclerosis with negligible side effects.
Topics: Adipose Tissue, Brown; Adipose Tissue, White; Animals; Atherosclerosis; Drug-Related Side Effects an | 2022 |
Association between thyroid cysts and hypertension by atherosclerosis status: a cross-sectional study.
Topics: Adult; Aged; Antihypertensive Agents; Atherosclerosis; Cross-Sectional Studies; Cysts; Female; Human | 2021 |
Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer's disease pathology in older adults.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Atherosclerosis; Cerebrovascular Disorders; Drug Combina | 2018 |
Lectin-Like Oxidized Low-Density Lipoprotein Receptor (Lox-1), Thyroid Hormone (T3) And Reactive Oxygen Species (Ros): Possible Cross-Talk In Angiogenesis.
Topics: Atherosclerosis; Capillaries; Humans; Models, Biological; Neovascularization, Pathologic; Neovascula | 2017 |
Thyroid Hormone Receptor Alpha Deletion in ApoE-/- Mice Alters the Arterial Renin-Angiotensin System and Vascular Smooth Muscular Cell Cholesterol Metabolism.
Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; ATP Binding Cassette Transporter 1; Cells, Cultu | 2018 |
Decreased expression of hepatic low-density lipoprotein receptor-related protein 1 in hypothyroidism: a novel mechanism of atherogenic dyslipidemia in hypothyroidism.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Disease Models, Animal; Down-Regulation; Dyslipidemias; | 2013 |
Structural changes in the myocardium and serum lipid spectrum in experimental hypercholesterolemia and hypothyroidism.
Topics: Animals; Atherosclerosis; Body Weight; Cholesterol, HDL; Cholesterol, LDL; Coronary Artery Disease; | 2013 |
L-Arginine Derivatives Are Associated with the Hyperthyroid State in the General Population.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Atherosclerosis; Cross-Sectional Studies; Female; Germany; | 2016 |
Thyroid function, reduced kidney function and incident chronic kidney disease in a community-based population: the Atherosclerosis Risk in Communities study.
Topics: Atherosclerosis; Biomarkers; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Humans; Hy | 2017 |
Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease.
Topics: Animals; Atherosclerosis; Body Weight; Bone and Bones; Chemical Engineering; Cholesterol; Diabetes M | 2016 |
Possible amelioration of atherogenic diet induced dyslipidemia, hypothyroidism and hyperglycemia by the peel extracts of Mangifera indica, Cucumis melo and Citrullus vulgaris fruits in rats.
Topics: Animals; Ascorbic Acid; Atherosclerosis; Blood Glucose; Citrullus; Creatine Kinase, MB Form; Cucumis | 2008 |
Thyroid hormone analogues: ready for prime time.
Topics: Atherosclerosis; Humans; Hypercholesterolemia; Ischemia; Neoplasms; Thyroid Hormones; Thyrotoxicosis | 2011 |
Thyroid function influences serum apolipoprotein B-48 levels in patients with thyroid disease.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Apolipoprotein B-48; Atherosclerosis; Case-Control Studi | 2012 |
Serum-cholesterol levels and atherosclerosis: effects of composition of diet and tri-iodothyronine on the rat.
Topics: Animals; Arteriosclerosis; Atherosclerosis; Cholesterol; Diet; Rats; Triiodothyronine | 1959 |
[THE ACTION OF THYROMIMETIC COMPOUNDS ON EXPERIMENTAL ATHEROSCLEROSIS IN RABBITS AND ON CHOLESTEROL METABOLISM IN RATS].
Topics: Arteriosclerosis; Atherosclerosis; Cholesterol; Dinitrophenols; Lipid Metabolism; Lipoproteins; Phar | 1963 |
Protective effect of propylthiouracil independent of its hypothyroid effect on atherogenesis in cholesterol-fed rabbits: PTEN induction and inhibition of vascular smooth muscle cell proliferation and migration.
Topics: Animals; Antioxidants; Aorta; Aortic Diseases; Apoptosis; Atherosclerosis; Cell Division; Cell Movem | 2004 |
Osteopontin gene expression in the aorta and the heart of propylthiouracil-induced hypothyroid mice.
Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Blood Pressure; Blotting, Western; Body Weight; | 2005 |
Impairment of endothelium-dependent arterial dilation in Hashimoto's thyroiditis patients with euthyroidism.
Topics: Atherosclerosis; Autoantibodies; Brachial Artery; Case-Control Studies; Cholesterol, LDL; Endotheliu | 2006 |