Page last updated: 2024-11-08

triiodothyronine and Amenorrhea

triiodothyronine has been researched along with Amenorrhea in 35 studies

Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.

Amenorrhea: Absence of menstruation.

Research Excerpts

ExcerptRelevanceReference
"To evaluate the influence of estriol administration on the hypothalamus-pituitary function and gonadotropins secretion in patients affected by functional hypothalamic amenorrhea (FHA)."9.16Estriol administration modulates luteinizing hormone secretion in women with functional hypothalamic amenorrhea. ( Chierchia, E; Genazzani, AD; Meczekalski, B; Podfigurna-Stopa, A; Rattighieri, E; Ricchieri, F; Santagni, S; Simoncini, T, 2012)
"To further characterize hypothyroidemia with decreased serum concentrations of total triiodothyronine and total T4 in women with functional hypothalamic amenorrhea."7.69Altered binding of serum thyroid hormone to thyroxine-binding globulin in women with functional hypothalamic amenorrhea. ( Dominguez, CE; Laughlin, GA; Nelson, JC; Yen, SS, 1997)
"The effect of thyroxine treatment in cases of functional amenorrhea accompanied by low normally thyroid function was studied."7.66Amenorrhea with low normal thyroid function and thyroxine treatment. ( Kontula, K; Kujala, P; Ylöstalo, P, 1980)
"In order to determine the role of thyroid hormone in prolactin (PRL) secretion in patients with amenorrhea-galactorrhae, PRL response to 500 mug of iv thyrotropin-releasing hormone (TRH) was studied before and after the administration of triiodothyronine (T3) in 10 patients with amenorrhea-galactorrhea."7.65Effect of triiodothyronine treatment on prolactin secretion in patients with amenorrhea-galactorrhea. ( Aono, T; Kurachi, K; Miyai, K; Onishi, T; Shioji, T, 1977)
"To evaluate the influence of estriol administration on the hypothalamus-pituitary function and gonadotropins secretion in patients affected by functional hypothalamic amenorrhea (FHA)."5.16Estriol administration modulates luteinizing hormone secretion in women with functional hypothalamic amenorrhea. ( Chierchia, E; Genazzani, AD; Meczekalski, B; Podfigurna-Stopa, A; Rattighieri, E; Ricchieri, F; Santagni, S; Simoncini, T, 2012)
"To further characterize hypothyroidemia with decreased serum concentrations of total triiodothyronine and total T4 in women with functional hypothalamic amenorrhea."3.69Altered binding of serum thyroid hormone to thyroxine-binding globulin in women with functional hypothalamic amenorrhea. ( Dominguez, CE; Laughlin, GA; Nelson, JC; Yen, SS, 1997)
" Serum levels of total 3,5,3'-triiodothyronine (T3) and total thyroxine (T4) as well as free T3 and T4 were significantly lower in patients with weight loss amenorrhea compared to normal cycling women."3.68A role for thyroid hormone in the induction of ovulation and corpus luteum function. ( Barnea, ER; Katayama, K; Maruo, T; Mochizuki, M, 1992)
"The effect of thyroxine treatment in cases of functional amenorrhea accompanied by low normally thyroid function was studied."3.66Amenorrhea with low normal thyroid function and thyroxine treatment. ( Kontula, K; Kujala, P; Ylöstalo, P, 1980)
"In order to determine the role of thyroid hormone in prolactin (PRL) secretion in patients with amenorrhea-galactorrhae, PRL response to 500 mug of iv thyrotropin-releasing hormone (TRH) was studied before and after the administration of triiodothyronine (T3) in 10 patients with amenorrhea-galactorrhea."3.65Effect of triiodothyronine treatment on prolactin secretion in patients with amenorrhea-galactorrhea. ( Aono, T; Kurachi, K; Miyai, K; Onishi, T; Shioji, T, 1977)
"A 32-year-old female with amenorrhea-galactorrhea due to primary hypothyroidism was treated with thyroid hormones, and serum levels of thyrotropin (TSH), prolactin (PRL), triiodothyronine (T3), thyroxin (T4), and T3 resin sponge uptake (RT3U) were measured throughout the course of treatment."3.65Pregnancy following thyroid hormone treatment in a patient with amenorrhea-galactorrhea due to primary hypothyroidism. ( Aono, T; Kurachi, H; Miyai, K; Onishi, T; Shioji, T, 1977)
"Thirteen subjects had a history of menstrual irregularity (HI)."1.30Decreased resting metabolic rate in ballet dancers with menstrual irregularity. ( Berman, C; Lambert, E; Myburgh, KH; Noakes, T; Novick, I, 1999)
"Galactorrhea has been associated with prior use of OCs, but this study gives no data due to the lack of reliable OC-use history by many of the patients."1.26The significance of galactorrhea in patients with normal menses, oligomenorrhea, and secondary amenorrhea. ( Davajan, V; Kletzky, O; March, CM; Mishell, DR; Roy, S, 1978)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-199015 (42.86)18.7374
1990's7 (20.00)18.2507
2000's5 (14.29)29.6817
2010's7 (20.00)24.3611
2020's1 (2.86)2.80

Authors

AuthorsStudies
Strock, NCA1
Koltun, KJ1
Southmayd, EA2
Williams, NI4
De Souza, MJ3
Tornberg, ÅB1
Melin, A1
Koivula, FM1
Johansson, A1
Skouby, S1
Faber, J1
Sjödin, A1
Heikura, IA1
Uusitalo, ALT1
Stellingwerff, T1
Bergland, D1
Mero, AA1
Burke, LM1
Michopoulos, V1
Mancini, F1
Loucks, TL1
Berga, SL1
Koehler, K1
Mallinson, RJ1
Allaway, HC1
Goswami, D1
Arif, A1
Saxena, A1
Batra, S1
Bruni, V2
Dei, M2
Morelli, C1
Schettino, MT1
Balzi, D2
Nuvolone, D1
Genazzani, AD3
Meczekalski, B1
Podfigurna-Stopa, A1
Santagni, S1
Rattighieri, E1
Ricchieri, F1
Chierchia, E1
Simoncini, T1
Filicetti, MF1
Pasqua, A1
Lujan, ME1
Krzemien, AA1
Reid, RL1
Van Vugt, DA1
Hontscharuk, R1
Olmsted, M1
Kerr, G1
Ylöstalo, P1
Kujala, P1
Kontula, K1
Van Gaal, L1
Abs, R1
De Leeuw, I1
Bekaert, J1
Nakazawa, T1
Okada, Y1
Onishi, T3
Azukizawa, M1
Kumahara, Y1
Stephan, F1
Schlienger, JL1
Blickle, JF1
de Laharpe, F1
Baer, JT1
Dominguez, CE1
Laughlin, GA1
Nelson, JC1
Yen, SS1
Zanker, CL1
Swaine, IL1
Harber, VJ1
Petersen, SR1
Chilibeck, PD1
Gamba, O1
Petraglia, F2
Myburgh, KH1
Berman, C1
Novick, I1
Noakes, T1
Lambert, E1
Strucchi, C1
Malavasi, B1
Tortolani, F1
Vecchi, F1
Luisi, S1
Helmreich, DL1
Parfitt, DB1
Caston-Balderrama, A1
Cameron, JL1
Wakeling, A1
de Souza, VF1
Gore, MB1
Sabur, M1
Kingstone, D1
Boss, AM1
Aono, T2
Shioji, T2
Miyai, K2
Kurachi, K1
Davajan, V1
Kletzky, O1
March, CM1
Roy, S1
Mishell, DR1
Thomson, JE1
Baird, SG1
Thomson, JA1
Keye, WR1
Yuen, BH1
Knopf, RF1
Jaffe, RB1
Kurachi, H1
Maruo, T1
Katayama, K1
Barnea, ER1
Mochizuki, M1
Berezin, M1
Ohry, A1
Shemesh, Y1
Zeilig, G1
Brooks, ME1
Shi, YF1
Liu, ZM1
Moltz, L1
Trapp, M1
Bispink, G1
Leidenberger, F1
Gual, C1
Kastin, AJ1
Schally, AV1
Seki, A1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pathogenesis of Functional Hypothalamic Amenorrhea[NCT01674426]17 participants (Actual)Interventional1997-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for triiodothyronine and Amenorrhea

ArticleYear
Clinical experience with hypothalamic releasing hormones. 1. Thyrotropin-releasing hormone.
    Recent progress in hormone research, 1972, Volume: 28

    Topics: Acromegaly; Adult; Amenorrhea; Craniopharyngioma; Dwarfism, Pituitary; Female; Humans; Hyperthyroidi

1972

Trials

2 trials available for triiodothyronine and Amenorrhea

ArticleYear
Neuroendocrine recovery initiated by cognitive behavioral therapy in women with functional hypothalamic amenorrhea: a randomized, controlled trial.
    Fertility and sterility, 2013, Volume: 99, Issue:7

    Topics: Academic Medical Centers; Amenorrhea; Analysis of Variance; Cognitive Behavioral Therapy; Female; Hu

2013
Estriol administration modulates luteinizing hormone secretion in women with functional hypothalamic amenorrhea.
    Fertility and sterility, 2012, Volume: 97, Issue:2

    Topics: 17-alpha-Hydroxyprogesterone; Adult; Amenorrhea; Analysis of Variance; Androstenedione; Estradiol; E

2012

Other Studies

32 other studies available for triiodothyronine and Amenorrhea

ArticleYear
Indices of Resting Metabolic Rate Accurately Reflect Energy Deficiency in Exercising Women.
    International journal of sport nutrition and exercise metabolism, 2020, Jan-01, Volume: 30, Issue:1

    Topics: Absorptiometry, Photon; Adolescent; Adult; Amenorrhea; Basal Metabolism; Biomarkers; Body Mass Index

2020
Reduced Neuromuscular Performance in Amenorrheic Elite Endurance Athletes.
    Medicine and science in sports and exercise, 2017, Volume: 49, Issue:12

    Topics: Adolescent; Adult; Amenorrhea; Blood Glucose; Body Mass Index; Body Weight; Energy Metabolism; Estro

2017
Low Energy Availability Is Difficult to Assess but Outcomes Have Large Impact on Bone Injury Rates in Elite Distance Athletes.
    International journal of sport nutrition and exercise metabolism, 2018, Jul-01, Volume: 28, Issue:4

    Topics: Adult; Amenorrhea; Athletes; Athletic Injuries; Bone and Bones; Bone Density; Cross-Sectional Studie

2018
Low resting metabolic rate in exercise-associated amenorrhea is not due to a reduced proportion of highly active metabolic tissue compartments.
    American journal of physiology. Endocrinology and metabolism, 2016, 08-01, Volume: 311, Issue:2

    Topics: Absorptiometry, Photon; Adaptation, Physiological; Adipose Tissue; Adult; Amenorrhea; Basal Metaboli

2016
Idiopathic primary ovarian insufficiency: a study of serial hormonal profiles to assess ovarian follicular activity.
    Human reproduction (Oxford, England), 2011, Volume: 26, Issue:8

    Topics: Adolescent; Adult; Amenorrhea; Estradiol; Female; Follicle Stimulating Hormone; Humans; India; Iodid

2011
Body composition variables and leptin levels in functional hypothalamic amenorrhea and amenorrhea related to eating disorders.
    Journal of pediatric and adolescent gynecology, 2011, Volume: 24, Issue:6

    Topics: Absorptiometry, Photon; Adaptation, Psychological; Adiposity; Adolescent; Adult; Amenorrhea; Body Co

2011
Predictors of bone loss in young women with restrictive eating disorders.
    Pediatric endocrinology reviews : PER, 2006, Volume: 3 Suppl 1

    Topics: Adolescent; Adult; Amenorrhea; Body Composition; Body Mass Index; Bone Density; Dehydroepiandrostero

2006
Effect of leptin administration on ovulation in food-restricted rhesus monkeys.
    Neuroendocrinology, 2006, Volume: 84, Issue:2

    Topics: Adaptation, Physiological; Amenorrhea; Analysis of Variance; Animals; Anovulation; Caloric Restricti

2006
Drive for thinness score is a proxy indicator of energy deficiency in exercising women.
    Appetite, 2007, Volume: 48, Issue:3

    Topics: Adaptation, Physiological; Adult; Amenorrhea; Basal Metabolism; Biomarkers; Energy Intake; Energy Me

2007
Amenorrhea with low normal thyroid function and thyroxine treatment.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 1980, Volume: 18, Issue:3

    Topics: Adult; Amenorrhea; Estradiol; Female; Follicle Stimulating Hormone; Humans; Hypothyroidism; Luteiniz

1980
Hypothyroidism and prolactin.
    European journal of obstetrics, gynecology, and reproductive biology, 1981, Volume: 12, Issue:5

    Topics: Adolescent; Adult; Aged; Amenorrhea; Female; Humans; Hypothyroidism; Male; Middle Aged; Prolactin; T

1981
Hyperalimentation in treatment of anorexia nervosa.
    Endocrinologia japonica, 1982, Volume: 29, Issue:1

    Topics: Adolescent; Adult; Amenorrhea; Anorexia Nervosa; Body Weight; Creatinine; Female; Humans; Length of

1982
[Hormonal adaptation to chronic self-starvation in patients with anorexia nervosa (author's transl)].
    La Nouvelle presse medicale, 1982, Mar-27, Volume: 11, Issue:14

    Topics: Adolescent; Adult; Amenorrhea; Anorexia Nervosa; Blood Glucose; Body Weight; Fatty Acids, Nonesterif

1982
Endocrine parameters in amenorrheic and eumenorrheic adolescent female runners.
    International journal of sports medicine, 1993, Volume: 14, Issue:4

    Topics: Adolescent; Amenorrhea; Body Composition; Body Weight; Eating; Estradiol; Female; Follicle Stimulati

1993
Altered binding of serum thyroid hormone to thyroxine-binding globulin in women with functional hypothalamic amenorrhea.
    Fertility and sterility, 1997, Volume: 68, Issue:6

    Topics: Adult; Amenorrhea; Cohort Studies; Electrophoresis; Female; Follicular Phase; Humans; Hypothalamic D

1997
The relationship between serum oestradiol concentration and energy balance in young women distance runners.
    International journal of sports medicine, 1998, Volume: 19, Issue:2

    Topics: Adipose Tissue; Adult; Amenorrhea; Body Mass Index; Diet; Energy Intake; Energy Metabolism; Estradio

1998
Thyroid hormone concentrations and muscle metabolism in amenorrheic and eumenorrheic athletes.
    Canadian journal of applied physiology = Revue canadienne de physiologie appliquee, 1998, Volume: 23, Issue:3

    Topics: Adult; Amenorrhea; Cross-Sectional Studies; Female; Humans; Magnetic Resonance Spectroscopy; Muscle,

1998
Estrogen replacement therapy modulates spontaneous GH secretion but does not affect GH-RH-induced GH response and low T3 syndrome in women with hypothalamic amenorrhea associated to weight-loss.
    Journal of endocrinological investigation, 1998, Volume: 21, Issue:6

    Topics: Administration, Cutaneous; Adult; Amenorrhea; Body Mass Index; Estradiol; Estrogen Replacement Thera

1998
Decreased resting metabolic rate in ballet dancers with menstrual irregularity.
    International journal of sport nutrition, 1999, Volume: 9, Issue:3

    Topics: Adolescent; Adult; Amenorrhea; Basal Metabolism; Body Composition; Calorimetry, Indirect; Dancing; E

1999
Effects of cyproheptadine clorhydrate, a serotonin receptor antagonist, on endocrine parameters in weight-loss related amenorrhea.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2001, Volume: 15, Issue:4

    Topics: Amenorrhea; Cyproheptadine; Estradiol; Female; Follicle Stimulating Hormone; Gonadotropins; Growth H

2001
Evidence for a causal role of low energy availability in the induction of menstrual cycle disturbances during strenuous exercise training.
    The Journal of clinical endocrinology and metabolism, 2001, Volume: 86, Issue:11

    Topics: Amenorrhea; Animals; Body Weight; Diet; Eating; Energy Metabolism; Estrogens; Female; Macaca fascicu

2001
Amenorrhoea, body weight and serum hormone concentrations, with particular reference to prolactin and thyroid hormones in anorexia nervosa.
    Psychological medicine, 1979, Volume: 9, Issue:2

    Topics: Adolescent; Adult; Amenorrhea; Anorexia Nervosa; Body Weight; Estradiol; Female; Follicle Stimulatin

1979
Effect of triiodothyronine treatment on prolactin secretion in patients with amenorrhea-galactorrhea.
    The Journal of clinical endocrinology and metabolism, 1977, Volume: 44, Issue:1

    Topics: Adult; Amenorrhea; Female; Galactorrhea; Humans; Hypothyroidism; Lactation Disorders; Pregnancy; Pro

1977
The significance of galactorrhea in patients with normal menses, oligomenorrhea, and secondary amenorrhea.
    American journal of obstetrics and gynecology, 1978, Apr-15, Volume: 130, Issue:8

    Topics: Adolescent; Adult; Amenorrhea; Female; Follicle Stimulating Hormone; Galactorrhea; Humans; Hypothyro

1978
Thyroid function in dietary amenorrhoea.
    Clinical endocrinology, 1977, Volume: 7, Issue:5

    Topics: Adolescent; Adult; Amenorrhea; Female; Humans; Nutrition Disorders; Thyroid Gland; Thyrotropin; Thyr

1977
Amenorrhea, hyperprolactinemia and pituitary enlargement secondary to primary hypothyroidism. Successful treatment with thyroid replacement.
    Obstetrics and gynecology, 1976, Volume: 48, Issue:6

    Topics: Adult; Amenorrhea; Female; Growth Hormone; Humans; Hypertrophy; Hypothyroidism; Insulin; Levodopa; P

1976
Pregnancy following thyroid hormone treatment in a patient with amenorrhea-galactorrhea due to primary hypothyroidism.
    Fertility and sterility, 1977, Volume: 28, Issue:8

    Topics: Adolescent; Adult; Amenorrhea; Female; Follicle Stimulating Hormone; Galactorrhea; Humans; Hypothyro

1977
A role for thyroid hormone in the induction of ovulation and corpus luteum function.
    Hormone research, 1992, Volume: 37 Suppl 1

    Topics: Adolescent; Adult; Amenorrhea; Clomiphene; Corpus Luteum; Estrogens; Female; Humans; Hypothyroidism;

1992
Hyperprolactinemia, galactorrhea and amenorrhea in women with a spinal cord injury.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 1989, Volume: 3, Issue:2

    Topics: Adult; Amenorrhea; Female; Follicle Stimulating Hormone; Galactorrhea; Growth Hormone; Humans; Hydro

1989
[The clinical manifestations and endocrine changes of anorexia nervosa].
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 1989, Volume: 11, Issue:3

    Topics: Adolescent; Adult; Amenorrhea; Anorexia Nervosa; Female; Follicle Stimulating Hormone; Humans; Hydro

1989
[Rational hormonal diagnosis of secondary amenorrhea].
    Geburtshilfe und Frauenheilkunde, 1987, Volume: 47, Issue:4

    Topics: Adolescent; Adult; Amenorrhea; Dehydroepiandrosterone; Endocrine System Diseases; Estradiol; Female;

1987
[Effects of thyroidectomy, L-thyroxine, triiodothyronine and methylthiouracil on gonadotropin secretion].
    Nihon Sanka Fujinka Gakkai zasshi, 1970, Volume: 22, Issue:3

    Topics: Amenorrhea; Animals; Female; Gonadotropins, Pituitary; Humans; Methylthiouracil; Organ Size; Rats; T

1970