triiodothyronine has been researched along with Alzheimer Disease in 31 studies
Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the effects of T3 treatment on the depression-like behavior in male transgenic 3xTg-AD mice." | 5.72 | Triiodothyronine Treatment reverses Depression-Like Behavior in a triple-transgenic animal model of Alzheimer's Disease. ( Britto, LRG; da Conceição, RR; da Silva, REC; de Souza, JS; de Souza, TJL; do Nascimento, BPP; Giannocco, G; Laureano-Melo, R; Maciel, RMB; Maglione, AV; Penatti, CAA; Ribeiro, MO; Sato, MA, 2022) |
| "Hypothyroidism and hyperthyroidism are commonly present conditions in adults, leading to neurological symptoms, affecting the central and peripheral nervous system, and to neurocognitive impairment." | 2.44 | Thyroid function, Alzheimer's disease and postoperative cognitive dysfunction: a tale of dangerous liaisons? ( Fodale, V; Mafrica, F, 2008) |
| "We investigated the effects of T3 treatment on the depression-like behavior in male transgenic 3xTg-AD mice." | 1.72 | Triiodothyronine Treatment reverses Depression-Like Behavior in a triple-transgenic animal model of Alzheimer's Disease. ( Britto, LRG; da Conceição, RR; da Silva, REC; de Souza, JS; de Souza, TJL; do Nascimento, BPP; Giannocco, G; Laureano-Melo, R; Maciel, RMB; Maglione, AV; Penatti, CAA; Ribeiro, MO; Sato, MA, 2022) |
| "Clinical hypothyroidism was prevalent (>20% of individuals studied) and was associated with cerebrovascular disease but not Alzheimer's disease-type neuropathology." | 1.48 | Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer's disease pathology in older adults. ( Brenowitz, WD; Han, F; Kukull, WA; Nelson, PT, 2018) |
| "The amyloid beta (Aβ) induced Alzheimer's disease (AD) is associated with formation the amyloid plaques, cognitive impairments and decline in spontaneous discharge of neurons." | 1.46 | Peripheral and central administration of T3 improved the histological changes, memory and the dentate gyrus electrophysiological activity in an animal model of Alzheimer's disease. ( Ahangarpour, A; Farbood, Y; Khorsandi, L; Mard, SA; Sarkaki, A; Shabani, S, 2017) |
| "These data suggest that autoimmune thyroiditis associated with a mild "subclinical" form of hypothyroidism is common in adult DS patients and more pronounced in patients with AD manifestations than in those without." | 1.28 | Autoimmune thyroiditis associated with mild "subclinical" hypothyroidism in adults with Down syndrome: a comparison of patients with and without manifestations of Alzheimer disease. ( Andrews, DF; Crapper McLachlan, DR; Dalton, AJ; Gera, E; Hummel, JT; Markovic, VD; Percy, ME; Rusk, AC; Somerville, MJ; Walfish, PG, 1990) |
| "Plasma ACTH in senile dementia of the Alzheimer's type was lower, but not significant as compared with that in normal controls." | 1.28 | High plasma levels of cortisol in patients with senile dementia of the Alzheimer's type. ( Kumahara, Y; Masugi, F; Morimoto, S; Nishide, M; Ogihara, T; Otsuka, A; Saeki, S; Sakaguchi, K; Tsuchiya, Y, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (12.90) | 18.7374 |
| 1990's | 1 (3.23) | 18.2507 |
| 2000's | 7 (22.58) | 29.6817 |
| 2010's | 12 (38.71) | 24.3611 |
| 2020's | 7 (22.58) | 2.80 |
| Authors | Studies |
|---|---|
| Ge, F | 1 |
| Dong, L | 1 |
| Zhu, D | 1 |
| Lin, X | 1 |
| Shi, J | 1 |
| Xiao, M | 1 |
| Quinlan, P | 3 |
| Horvath, A | 3 |
| Eckerström, C | 2 |
| Wallin, A | 4 |
| Svensson, J | 4 |
| Maglione, AV | 1 |
| do Nascimento, BPP | 1 |
| Ribeiro, MO | 1 |
| de Souza, TJL | 1 |
| da Silva, REC | 1 |
| Sato, MA | 1 |
| Penatti, CAA | 1 |
| Britto, LRG | 1 |
| de Souza, JS | 1 |
| Maciel, RMB | 1 |
| da Conceição, RR | 1 |
| Laureano-Melo, R | 1 |
| Giannocco, G | 1 |
| Dolatshahi, M | 1 |
| Salehipour, A | 1 |
| Saghazadeh, A | 1 |
| Sanjeari Moghaddam, H | 1 |
| Aghamollaii, V | 1 |
| Fotouhi, A | 1 |
| Tafakhori, A | 1 |
| Qiu, M | 3 |
| Luo, F | 3 |
| Du, L | 3 |
| Li, LX | 1 |
| Yang, T | 1 |
| Guo, L | 1 |
| Wang, DY | 1 |
| Tang, CH | 1 |
| Li, Q | 1 |
| Yang, HM | 1 |
| Zhu, J | 1 |
| Zhang, LL | 1 |
| Chiaravalloti, A | 1 |
| Ursini, F | 1 |
| Fiorentini, A | 1 |
| Barbagallo, G | 1 |
| Martorana, A | 1 |
| Koch, G | 1 |
| Tavolozza, M | 1 |
| Schillaci, O | 1 |
| Brenowitz, WD | 1 |
| Han, F | 1 |
| Kukull, WA | 2 |
| Nelson, PT | 2 |
| Chang, YS | 1 |
| Wu, YH | 1 |
| Wang, CJ | 1 |
| Tang, SH | 1 |
| Chen, HL | 1 |
| Chen, JM | 1 |
| Huang, CQ | 1 |
| Ai, M | 1 |
| Kuang, L | 1 |
| Accorroni, A | 1 |
| Giorgi, FS | 1 |
| Donzelli, R | 1 |
| Lorenzini, L | 1 |
| Prontera, C | 1 |
| Saba, A | 1 |
| Vergallo, A | 1 |
| Tognoni, G | 1 |
| Siciliano, G | 1 |
| Baldacci, F | 1 |
| Bonuccelli, U | 1 |
| Clerico, A | 1 |
| Zucchi, R | 1 |
| Katsumata, Y | 1 |
| Nho, K | 1 |
| Artiushin, SC | 1 |
| Jicha, GA | 1 |
| Wang, WX | 1 |
| Abner, EL | 1 |
| Saykin, AJ | 1 |
| Fardo, DW | 1 |
| Farbood, Y | 1 |
| Shabani, S | 1 |
| Sarkaki, A | 1 |
| Mard, SA | 1 |
| Ahangarpour, A | 1 |
| Khorsandi, L | 1 |
| Mafrica, F | 1 |
| Fodale, V | 1 |
| Cuesta, A | 1 |
| Zambrano, A | 1 |
| López, E | 1 |
| Pascual, A | 1 |
| Davis, JD | 1 |
| Podolanczuk, A | 1 |
| Donahue, JE | 1 |
| Stopa, E | 1 |
| Hennessey, JV | 1 |
| Luo, LG | 1 |
| Lim, YP | 1 |
| Stern, RA | 1 |
| Belakavadi, M | 1 |
| Dell, J | 1 |
| Grover, GJ | 1 |
| Fondell, JD | 1 |
| Zhang, N | 1 |
| Du, HJ | 1 |
| Wang, JH | 1 |
| Cheng, Y | 1 |
| Johansson, P | 1 |
| Almqvist, EG | 1 |
| Johansson, JO | 1 |
| Mattsson, N | 1 |
| Hansson, O | 1 |
| Blennow, K | 1 |
| Zetterberg, H | 1 |
| Yong-Hong, L | 1 |
| Xiao-Dong, P | 1 |
| Chang-Quan, H | 1 |
| Bo, Y | 1 |
| Qing-Xiu, L | 1 |
| Döbert, N | 1 |
| Hamscho, N | 1 |
| Menzel, C | 1 |
| Peters, J | 1 |
| Frölich, L | 1 |
| Tsolakis, A | 1 |
| Zaplatnikov, K | 1 |
| Kratzsch, T | 1 |
| Diener, J | 1 |
| Maurer, K | 1 |
| Grünwald, F | 1 |
| Sampaolo, S | 1 |
| Campos-Barros, A | 1 |
| Mazziotti, G | 1 |
| Carlomagno, S | 1 |
| Sannino, V | 1 |
| Amato, G | 1 |
| Carella, C | 1 |
| Di Iorio, G | 1 |
| de Jong, FJ | 2 |
| den Heijer, T | 2 |
| Visser, TJ | 2 |
| de Rijke, YB | 1 |
| Drexhage, HA | 1 |
| Hofman, A | 2 |
| Breteler, MM | 2 |
| Peeters, RP | 1 |
| van der Deure, WM | 1 |
| Uitterlinden, AG | 1 |
| Percy, ME | 1 |
| Dalton, AJ | 1 |
| Markovic, VD | 1 |
| Crapper McLachlan, DR | 1 |
| Gera, E | 1 |
| Hummel, JT | 1 |
| Rusk, AC | 1 |
| Somerville, MJ | 1 |
| Andrews, DF | 1 |
| Walfish, PG | 1 |
| Thomas, R | 1 |
| Williams, P | 1 |
| John, R | 2 |
| Scanlon, M | 1 |
| Masugi, F | 1 |
| Ogihara, T | 1 |
| Sakaguchi, K | 1 |
| Otsuka, A | 1 |
| Tsuchiya, Y | 1 |
| Morimoto, S | 1 |
| Kumahara, Y | 1 |
| Saeki, S | 1 |
| Nishide, M | 1 |
| Bilikiewicz, A | 1 |
| Bidzan, L | 1 |
| Thomas, DR | 1 |
| Hailwood, R | 1 |
| Harris, B | 1 |
| Williams, PA | 1 |
| Scanlon, MF | 1 |
2 reviews available for triiodothyronine and Alzheimer Disease
| Article | Year |
|---|---|
Thyroid hormone levels in Alzheimer disease: a systematic review and meta-analysis.
Topics: Alzheimer Disease; Humans; Hypothyroidism; Thyroid Function Tests; Thyroid Hormones; Thyroxine; Trii | 2023 |
Thyroid function, Alzheimer's disease and postoperative cognitive dysfunction: a tale of dangerous liaisons?
Topics: Aged; Alzheimer Disease; Brain; Cholinergic Fibers; Cognition Disorders; Delirium; Euthyroid Sick Sy | 2008 |
29 other studies available for triiodothyronine and Alzheimer Disease
| Article | Year |
|---|---|
Comparison of Serum Triiodothyronine with Biomarkers for Alzheimer's Disease Continuum in Euthyroid Subjects.
Topics: Aged; Alzheimer Disease; Biomarkers; Cognitive Dysfunction; Cross-Sectional Studies; Female; Humans; | 2022 |
Higher thyroid function is associated with accelerated hippocampal volume loss in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Hippocampus; Humans; Prospective Studies; Thyroid Function Tests; Thyroid G | 2022 |
Triiodothyronine Treatment reverses Depression-Like Behavior in a triple-transgenic animal model of Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; Depression; Disease Models, Animal; Glycogen Synthase Kinase 3; Male; Mi | 2022 |
Serum total and free T3 and CSF total T3 levels are significantly lower in Alzheimer Disease?
Topics: Alzheimer Disease; Humans; Thyroid Function Tests; Thyroxine; Triiodothyronine | 2023 |
Serum total and free T3 and CSF total T3 levels are significantly lower in Alzheimer Disease?
Topics: Alzheimer Disease; Humans; Thyroid Function Tests; Thyroxine; Triiodothyronine | 2023 |
Serum total and free T3 and CSF total T3 levels are significantly lower in Alzheimer Disease?
Topics: Alzheimer Disease; Humans; Thyroid Function Tests; Thyroxine; Triiodothyronine | 2023 |
Serum total and free T3 and CSF total T3 levels are significantly lower in Alzheimer Disease?
Topics: Alzheimer Disease; Humans; Thyroid Function Tests; Thyroxine; Triiodothyronine | 2023 |
Serum total and free T3 and CSF total T3 levels are significantly lower in Alzheimer Disease?
Topics: Alzheimer Disease; Humans; Thyroid Function Tests; Thyroxine; Triiodothyronine | 2023 |
Serum total and free T3 and CSF total T3 levels are significantly lower in Alzheimer Disease?
Topics: Alzheimer Disease; Humans; Thyroid Function Tests; Thyroxine; Triiodothyronine | 2023 |
Serum total and free T3 and CSF total T3 levels are significantly lower in Alzheimer Disease?
Topics: Alzheimer Disease; Humans; Thyroid Function Tests; Thyroxine; Triiodothyronine | 2023 |
Serum total and free T3 and CSF total T3 levels are significantly lower in Alzheimer Disease?
Topics: Alzheimer Disease; Humans; Thyroid Function Tests; Thyroxine; Triiodothyronine | 2023 |
Serum total and free T3 and CSF total T3 levels are significantly lower in Alzheimer Disease?
Topics: Alzheimer Disease; Humans; Thyroid Function Tests; Thyroxine; Triiodothyronine | 2023 |
Serum tau levels are increased in patients with hyperthyroidism.
Topics: Adult; Alzheimer Disease; Cognitive Dysfunction; Female; Humans; Hyperthyroidism; Male; Middle Aged; | 2020 |
Altered thyroid hormone profile in patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Biomarkers; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Thy | 2020 |
Functional correlates of TSH, fT3 and fT4 in Alzheimer disease: a F-18 FDG PET/CT study.
Topics: Aged; Alzheimer Disease; Brain; Case-Control Studies; Female; Fluorodeoxyglucose F18; Glucose; Human | 2017 |
Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer's disease pathology in older adults.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Atherosclerosis; Cerebrovascular Disorders; Drug Combina | 2018 |
Higher levels of thyroxine may predict a favorable response to donepezil treatment in patients with Alzheimer disease: a prospective, case-control study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Cholinesterase Inhibitors; Cogniti | 2018 |
Low serum concentration of free triiodothyronine (FT3) is associated with increased risk of Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Cognitive Dysfunction; Dementia; Dementia, Vascular; Female; Follow-Up Stud | 2019 |
Circadian rhythm of TSH levels in subjects with Alzheimer's disease (AD).
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Circadian Rhythm; Female; Humans; | 2013 |
Thyroid hormone levels in the cerebrospinal fluid correlate with disease severity in euthyroid patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Chromatography, High Pressure Liquid; Female; Humans; Male; Mass Spectromet | 2017 |
Genomics and CSF analyses implicate thyroid hormone in hippocampal sclerosis of aging.
Topics: Aged, 80 and over; Aging; Alzheimer Disease; Chromosomes, Human, Pair 12; Cohort Studies; Enzyme-Lin | 2016 |
Peripheral and central administration of T3 improved the histological changes, memory and the dentate gyrus electrophysiological activity in an animal model of Alzheimer's disease.
Topics: Action Potentials; Alzheimer Disease; Animals; Dentate Gyrus; Disease Models, Animal; Injections, In | 2017 |
Thyroid hormones reverse the UV-induced repression of APP in neuroblastoma cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cell Line, Tumor; | 2009 |
Thyroid hormone levels in the prefrontal cortex of post-mortem brains of Alzheimer's disease patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Autopsy; Case-Control Studies; Female; Humans; Male; Mid | 2008 |
Thyroid hormone suppression of β-amyloid precursor protein gene expression in the brain involves multiple epigenetic regulatory events.
Topics: Acetylation; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Cell Line, Tumor; Ep | 2011 |
A pilot study on the relationship between thyroid status and neuropsychiatric symptoms in patients with Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognition; Female; Humans; Male; Middle Aged; Multivaria | 2012 |
Reduced cerebrospinal fluid level of thyroxine in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognitive Dysfunction; Female; Humans; Male; Neuropsycho | 2013 |
Hypothalamic-pituitary-thyroid axis in patients with Alzheimer disease (AD).
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Fasting; Female; Humans; Hypothala | 2013 |
Subclinical hyperthyroidism in dementia and correlation of the metabolic index in FDG-PET.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Basal Metabolism; Brain; Female; Fluorodeoxyglucose F18; | 2003 |
Increased cerebrospinal fluid levels of 3,3',5'-triiodothyronine in patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Female; Humans; Male; Middle Aged; Thyroid Hormones; Triiodothyronine | 2005 |
Thyroid hormones, dementia, and atrophy of the medial temporal lobe.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amygdala; Atrophy; Cohort Studies; Dementia; Follow-Up S | 2006 |
The association of polymorphisms in the type 1 and 2 deiodinase genes with circulating thyroid hormone parameters and atrophy of the medial temporal lobe.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amygdala; Atrophy; Early Diagnosis; Female; Genet | 2007 |
Autoimmune thyroiditis associated with mild "subclinical" hypothyroidism in adults with Down syndrome: a comparison of patients with and without manifestations of Alzheimer disease.
Topics: Adult; Aged; Alzheimer Disease; Antibodies; Down Syndrome; Female; Humans; Hypothyroidism; Male; Mic | 1990 |
Growth hormone responses to growth hormone releasing factor in primary degenerative dementia.
Topics: Aged; Alzheimer Disease; Female; Growth Hormone; Growth Hormone-Releasing Hormone; Humans; Male; Pro | 1989 |
High plasma levels of cortisol in patients with senile dementia of the Alzheimer's type.
Topics: Adrenocorticotropic Hormone; Aged; Alzheimer Disease; Blood Pressure; Cognition Disorders; Humans; H | 1989 |
[Changes in thyroid function in primary degenerative dementia processes].
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Female; Humans; Hydrocortisone; Male; Middle Aged; Neuro | 1989 |
Thyroid status in senile dementia of the Alzheimer type (SDAT).
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Female; Growth Hormone; Humans; Male; Prolactin; Thyroid | 1987 |