Page last updated: 2024-11-08

triiodothyronine and Alcoholism

triiodothyronine has been researched along with Alcoholism in 42 studies

Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.

Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)

Research Excerpts

ExcerptRelevanceReference
" The presence of starvation was supported by the finding of subnormal plasma triiodothyronine levels (less than 90 micrograms/dl) in six of seven ketotic patients (average 60 micrograms/dl for all seven)."3.67Alcoholic ketosis. ( Ben-Ezra, J; Bock, J; Fulop, M, 1986)
"Post-traumatic stress disorder (PTSD) is a relatively new psychiatric disorder with three clusters of symptoms: trauma re-experiencing, avoidance, and increased arousal."2.71Increase of serum triiodothyronine concentration in soldiers with combat-related chronic post-traumatic stress disorder with or without alcohol dependence. ( Karlović, D; Martinac, M; Marusić, S, 2004)
"Vitamin D deficiency was defined as serum concentrations of the main circulating vitamin D, 25-hydroxy vitamin D [25(OH)D], below 50 nmol/L."1.91Relationship between serum vitamin D and thyroid hormone profiles in male patients with alcohol dependence. ( Liu, Y; Pang, L; Wang, Y; Xu, Y; Zhang, X, 2023)
" In plantaris muscle, the fractional rate of protein synthesis (ks, %/day) did not fall 20 min after dosage but was reduced after 1 hr by 23% (p < 0."1.30Studies on the time-course of ethanol's acute effects on skeletal muscle protein synthesis: comparison with acute changes in proteolytic activity. ( Jones, J; Mantle, D; Peters, TJ; Preedy, VR; Reilly, ME; Richardson, PJ; Salisbury, J, 1997)
"After 4-wk of treatment, the body weight of the ethanol group was 7% and of the pair-fed rats 19% lower than that of the absolute controls."1.30Chronic ethanol drinking and food deprivation affect rat hypothalamic-pituitary-thyroid axis and TRH in septum. ( Benický, J; Brtko, J; Nikodémová, M; Strbák, V, 1998)
" These results suggest that chronic administration of ethanol affects intracellular thyroid hormone metabolism in both rat CNS and liver in the highly complex manner."1.29Hypothalamic-pituitary-thyroid axis in chronic alcoholism. II. Deiodinase activities and thyroid hormone concentrations in brain and peripheral tissues of rats chronically exposed to ethanol. ( Baumgartner, A; Campos-Barros, A; Heyne, A; Köhler, R; Meinhold, H; Müller, F; Rommelspacher, H; Wolffgramm, J, 1994)
" It is suggested that alcohol may have a toxic effect on the thyroid gland independent of the degree of liver damage."1.27Independent effects of liver disease and chronic alcoholism on thyroid function and size: the possibility of a toxic effect of alcohol on the thyroid gland. ( Aldershvile, J; Hegedüs, L; Kastrup, J; Krogsgaard, K; Rasmussen, N; Ravn, V, 1988)

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-199024 (57.14)18.7374
1990's12 (28.57)18.2507
2000's4 (9.52)29.6817
2010's1 (2.38)24.3611
2020's1 (2.38)2.80

Authors

AuthorsStudies
Liu, Y1
Xu, Y1
Wang, Y1
Pang, L1
Zhang, X1
Sinai, C1
Hirvikoski, T1
Nordström, AL1
Nordström, P1
Nilsonne, Å1
Wilczek, A1
Åsberg, M1
Jokinen, J1
Leggio, L1
Ferrulli, A1
Cardone, S1
Malandrino, N1
Mirijello, A1
D'Angelo, C1
Vonghia, L1
Miceli, A1
Capristo, E1
Kenna, GA1
Gasbarrini, G1
Swift, RM1
Addolorato, G1
Hermann, D1
Heinz, A1
Mann, K1
NEWMAN, H1
SMITH, ME1
Goldberg, M1
Hehir, R1
Hurowitz, M1
SATTERFIELD, JH1
GUZE, SB1
BOWMAN, KM1
MOORHEAD, HH1
MCKINLEY, RA1
Rasmussen, DD1
Karlović, D1
Marusić, S1
Martinac, M1
Dackis, CA1
Pottash, AL1
Bailey, J1
Stuckey, RF1
Extein, IL1
Gold, MS1
Loosen, PT5
Wilson, IC1
Dew, BW2
Tipermas, A1
Prange, AJ3
Geurts, J1
Demeester-Mirkine, N1
Glinoer, D1
Prigogine, T1
Fernandez-Deville, M1
Corvilain, J1
Melander, A1
Thorell, J1
Wadstein, J1
Majumdar, SK1
Shaw, GK1
Thomson, AD1
Sudha, S1
Balasubramanian, K1
Arunakaran, J1
Govindarajulu, P1
Baumgartner, A1
Heyne, A1
Campos-Barros, A1
Köhler, R1
Müller, F1
Meinhold, H1
Rommelspacher, H1
Wolffgramm, J1
Garbutt, JC2
Miller, LP1
Karnitschnig, JS1
Mason, GA3
Pienaar, WP1
Roberts, MC1
Emsley, RA1
Aalbers, C1
Taljaard, FJ1
Kaptein, EM1
Reilly, ME1
Mantle, D1
Richardson, PJ1
Salisbury, J1
Jones, J1
Peters, TJ1
Preedy, VR1
Nikodémová, M1
Benický, J1
Brtko, J1
Strbák, V1
van Thiel, DH1
Lester, R1
Bleich, HL1
Boro, ES1
Nomura, S1
Pittman, CS1
Chambers, JB1
Buck, MW1
Shimizu, T1
McDavid, J1
Quade, D1
Adinoff, B2
Nemeroff, CB2
Bissette, G2
Martin, PR1
Linnoila, M3
Roy, A1
DeJong, J1
Ravitz, B1
Knudsen, GM1
Christensen, H1
Berild, D1
Melgaard, B1
Kirkegaard, C1
Hasselbalch, H1
Moss, HB1
Guthrie, S1
Marciniak, R1
Thadani, K1
Stanley, DA1
Walker, CH1
Hashimoto, H1
Noonan, LR1
Hegedüs, L1
Rasmussen, N1
Ravn, V1
Kastrup, J1
Krogsgaard, K1
Aldershvile, J1
Fulop, M1
Ben-Ezra, J1
Bock, J1
Borodulin, VG1
Avdienko, VN1
Tolkaeva, MV1
Bunout, D1
del Pino, D1
Iturriaga, H1
Barrera, R1
Pérez, C1
Ugarte, G1
Nordkild, P1
Kromann-Andersen, H1
Pamenter, RW1
Boyden, TW1
Chopra, IJ1
Solomon, DH1
Chopra, U1
Young, RT1
Chua Teco, GN1

Reviews

3 reviews available for triiodothyronine and Alcoholism

ArticleYear
Dysregulation of the hypothalamic-pituitary-thyroid axis in alcoholism.
    Addiction (Abingdon, England), 2002, Volume: 97, Issue:11

    Topics: Alcoholism; Humans; Hypothalamo-Hypophyseal System; Hypothyroidism; Substance Withdrawal Syndrome; T

2002
ALCOHOLISM.
    The American journal of psychiatry, 1964, Volume: 120

    Topics: Alcoholism; Ethanol; Humans; Learning; Psychotherapy; Succinylcholine; Triiodothyronine

1964
ALCOHOLISM.
    Progress in neurology and psychiatry, 1963, Volume: 18

    Topics: Alcoholism; Chlordiazepoxide; Chlormethiazole; Chlorpropamide; Culture; Lysergic Acid Diethylamide;

1963

Trials

2 trials available for triiodothyronine and Alcoholism

ArticleYear
Increase of serum triiodothyronine concentration in soldiers with combat-related chronic post-traumatic stress disorder with or without alcohol dependence.
    Wiener klinische Wochenschrift, 2004, Jun-30, Volume: 116, Issue:11-12

    Topics: Adult; Alcoholism; Combat Disorders; Comorbidity; Croatia; Educational Status; Humans; Male; Marital

2004
Preliminary study of androgen, thyroid & adrenal status in alcoholic men during deaddiction.
    The Indian journal of medical research, 1995, Volume: 101

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex; Adult; Alcoholism; Estradiol; Estrone; H

1995

Other Studies

37 other studies available for triiodothyronine and Alcoholism

ArticleYear
Relationship between serum vitamin D and thyroid hormone profiles in male patients with alcohol dependence.
    BMC psychiatry, 2023, 10-24, Volume: 23, Issue:1

    Topics: Alcoholism; Humans; Male; Thyroid Hormones; Thyrotropin; Thyroxine; Triiodothyronine; Vitamin D; Vit

2023
Thyroid hormones and adult interpersonal violence among women with borderline personality disorder.
    Psychiatry research, 2015, Jun-30, Volume: 227, Issue:2-3

    Topics: Adult; Aggression; Alcoholism; Biomarkers; Borderline Personality Disorder; Case-Control Studies; Fe

2015
Relationship between the hypothalamic-pituitary-thyroid axis and alcohol craving in alcohol-dependent patients: a longitudinal study.
    Alcoholism, clinical and experimental research, 2008, Volume: 32, Issue:12

    Topics: Adult; Alcohol Drinking; Alcoholism; Baclofen; Behavior, Addictive; Female; Humans; Hypothalamo-Hypo

2008
Triiodothyronine in acute alcoholic intoxication.
    Nature, 1959, Mar-07, Volume: 183, Issue:4662

    Topics: Alcoholic Intoxication; Alcoholism; Triiodothyronine

1959
Intravenous tri-iodothyronine in acute alcoholic intoxication. Preliminary report.
    The New England journal of medicine, 1960, 12-29, Volume: 263

    Topics: Alcoholic Intoxication; Alcoholism; Humans; Thyronines; Triiodothyronine

1960
Treatment of alcoholic patients with triiodothyronine.
    Diseases of the nervous system, 1961, Volume: 22

    Topics: Alcoholism; Triiodothyronine

1961
Chronic daily ethanol and withdrawal: 5. Diurnal effects on plasma thyroid hormone levels.
    Endocrine, 2003, Volume: 22, Issue:3

    Topics: Alcoholism; Animals; Circadian Rhythm; Ethanol; Male; Rats; Rats, Sprague-Dawley; Substance Withdraw

2003
The specificity of the thyrotropin-releasing hormone (TRH) test and dexamethasone suppression test (DST) for major depressive illness in alcoholics.
    NIDA research monograph, 1983, Volume: 43

    Topics: Adult; Alcoholism; Depressive Disorder; Dexamethasone; Female; Humans; Male; Middle Aged; Thyrotropi

1983
Thyrotropin-releasing hormone (TRH) in abstinent alcoholic men.
    The American journal of psychiatry, 1983, Volume: 140, Issue:9

    Topics: Adult; Aged; Alcohol Drinking; Alcoholism; Depressive Disorder; Growth Hormone; Humans; Male; Middle

1983
Thyrotropin releasing hormone (TRH): a useful tool for psychoneuroendocrine investigation.
    Psychoneuroendocrinology, 1980, Volume: 5, Issue:1

    Topics: Adult; Alcoholism; Depression; Endocrine Glands; Female; Growth Hormone; Humans; Male; Middle Aged;

1980
Alterations in circulating thyroid hormones and thyroxine binding globulin in chronic alcoholism.
    Clinical endocrinology, 1981, Volume: 14, Issue:2

    Topics: Adult; Alcoholism; Female; Humans; Male; Middle Aged; Thyroid Function Tests; Thyroxine; Thyroxine-B

1981
Alteration of thyroid hormone economy during alcohol withdrawal in alcoholics.
    Drug-nutrient interactions, 1982, Volume: 1, Issue:2

    Topics: Alcohol Withdrawal Delirium; Alcoholism; Humans; Substance Withdrawal Syndrome; Thyroid Hormones; Th

1982
Thyroid status in chronic alcoholics.
    Drug and alcohol dependence, 1981, Volume: 7, Issue:1

    Topics: Adult; Alcoholism; Female; Humans; Male; Middle Aged; Thyroid Gland; Thyrotropin; Thyroxine; Triiodo

1981
Hypothalamic-pituitary-thyroid axis in chronic alcoholism. II. Deiodinase activities and thyroid hormone concentrations in brain and peripheral tissues of rats chronically exposed to ethanol.
    Alcoholism, clinical and experimental research, 1994, Volume: 18, Issue:2

    Topics: Alcoholism; Animals; Brain; Hypothalamo-Hypophyseal System; Iodide Peroxidase; Isoenzymes; Male; Rat

1994
Thyrotropin response to thyrotropin-releasing hormone in young men at high or low risk for alcoholism.
    Annals of the New York Academy of Sciences, 1994, Feb-28, Volume: 708

    Topics: Adult; Alcohol Drinking; Alcoholism; Cocaine; Humans; Hydrocortisone; Male; Marijuana Abuse; Prolact

1994
The thyrotropin releasing hormone stimulation test in alcoholism.
    Alcohol and alcoholism (Oxford, Oxfordshire), 1995, Volume: 30, Issue:5

    Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Female; Gonadotropin-Releasing Hormone; Humans; Hydr

1995
Hormone-specific alterations of T4, T3, and reverse T3 metabolism with recent ethanol abstinence in humans.
    The American journal of physiology, 1997, Volume: 272, Issue:2 Pt 1

    Topics: Adult; Alcoholism; Ethanol; Female; Humans; Male; Middle Aged; Models, Biological; Reference Values;

1997
Studies on the time-course of ethanol's acute effects on skeletal muscle protein synthesis: comparison with acute changes in proteolytic activity.
    Alcoholism, clinical and experimental research, 1997, Volume: 21, Issue:5

    Topics: Alcoholism; Aminopeptidases; Animals; CD13 Antigens; Corticosterone; Dipeptidyl-Peptidases and Tripe

1997
Chronic ethanol drinking and food deprivation affect rat hypothalamic-pituitary-thyroid axis and TRH in septum.
    Endocrine, 1998, Volume: 9, Issue:2

    Topics: Alcoholism; Animals; Body Weight; Ethanol; Food Deprivation; Hypothalamus; Iodide Peroxidase; Liver;

1998
Further evidence for hypothalamic-pituitary dysfunction in alcoholic men.
    Alcoholism, clinical and experimental research, 1978, Volume: 2, Issue:3

    Topics: Adolescent; Adult; Alcoholism; Gonadotropin-Releasing Hormone; Humans; Hypothalamo-Hypophyseal Syste

1978
Metabolic and hepatic effects of alcohol.
    The New England journal of medicine, 1977, Mar-17, Volume: 296, Issue:11

    Topics: Acidosis; Alcohol Oxidoreductases; Alcoholism; Amino Acids; Animals; Carbohydrate Metabolism; Chemic

1977
Reduced peripheral conversion of thyroxine to triiodothyronine in patients with hepatic cirrhosis.
    The Journal of clinical investigation, 1975, Volume: 56, Issue:3

    Topics: Adult; Aged; Alcoholism; Humans; Kinetics; Liver; Liver Cirrhosis; Liver Function Tests; Male; Metab

1975
Evidence for normal feedback inhibition of triiodothyronine on the thyrotropin (TSH) response to thyrotropin-releasing hormone (TRH) in abstinent male alcoholics.
    Alcoholism, clinical and experimental research, 1992, Volume: 16, Issue:5

    Topics: Adult; Alcoholism; Feedback; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Male; Middle Ag

1992
Inverse relationship between CSF TRH concentrations and the TSH response to TRH in abstinent alcohol-dependent patients.
    The American journal of psychiatry, 1991, Volume: 148, Issue:11

    Topics: Adult; Alcoholism; Down-Regulation; Humans; Male; Middle Aged; Pituitary Gland, Anterior; Receptors,

1991
Cerebrospinal fluid thyrotropin-releasing hormone concentrations in alcoholics and normal controls.
    Biological psychiatry, 1990, Nov-01, Volume: 28, Issue:9

    Topics: Adult; Alcoholism; Depressive Disorder; Female; Humans; Hydroxyindoleacetic Acid; Hypothalamo-Hypoph

1990
Long-term predictors of outcome in abstinent alcoholic men.
    The American journal of psychiatry, 1990, Volume: 147, Issue:12

    Topics: Adult; Aged; Alcoholism; Comorbidity; Depressive Disorder; Follow-Up Studies; Growth Hormone; Humans

1990
Hypothalamic-pituitary and thyroid function in chronic alcoholics with neurological complications.
    Alcoholism, clinical and experimental research, 1990, Volume: 14, Issue:3

    Topics: Adult; Alcohol Amnestic Disorder; Alcoholism; Blood Glucose; Gonadotropin-Releasing Hormone; Growth

1990
Enhanced thyrotropin response to thyrotropin releasing hormone in boys at risk for development of alcoholism. Preliminary findings.
    Archives of general psychiatry, 1986, Volume: 43, Issue:12

    Topics: Adolescent; Alcoholism; Child; Female; Growth Hormone; Humans; Male; Prolactin; Risk; Sex Factors; T

1986
TRH-induced TSH response in healthy volunteers: relationship to psychiatric history.
    The American journal of psychiatry, 1987, Volume: 144, Issue:4

    Topics: Adult; Alcoholism; Depressive Disorder; Female; Humans; Male; Sex Factors; Thyrotropin; Thyrotropin-

1987
Chronic alcohol ingestion decreases pituitary-thyroid axis measures in Fischer-344 rats.
    Alcoholism, clinical and experimental research, 1988, Volume: 12, Issue:6

    Topics: Alcoholism; Animals; Hypothalamo-Hypophyseal System; Male; Rats; Rats, Inbred F344; Thyroid Gland; T

1988
Independent effects of liver disease and chronic alcoholism on thyroid function and size: the possibility of a toxic effect of alcohol on the thyroid gland.
    Metabolism: clinical and experimental, 1988, Volume: 37, Issue:3

    Topics: Adult; Aged; Alcoholism; Chronic Disease; Ethanol; Female; Humans; Liver Diseases; Male; Middle Aged

1988
Alcoholic ketosis.
    Alcoholism, clinical and experimental research, 1986, Volume: 10, Issue:6

    Topics: Acidosis; Acidosis, Lactic; Adult; Aged; Alcoholism; Ethanol; Female; Humans; Insulin; Ketosis; Male

1986
[Hypophyseal-thyroid system in chronic alcoholism].
    Meditsinskaia radiologiia, 1986, Volume: 31, Issue:10

    Topics: Adult; Alcoholism; Female; Humans; Iodine Radioisotopes; Liver; Male; Middle Aged; Pituitary Gland;

1986
[Serum levels of thyroid hormones in alcoholic subjects without hepatic insufficiency].
    Revista medica de Chile, 1985, Volume: 113, Issue:8

    Topics: Alcoholism; Ethanol; Humans; Male; Thyroid Hormones; Triiodothyronine

1985
[Transient hypothyroxinemia in a beer-drinker with hyponatremia].
    Ugeskrift for laeger, 1985, Mar-11, Volume: 147, Issue:11

    Topics: Aged; Alcoholism; Beer; Humans; Hyponatremia; Male; Thyroxine; Triiodothyronine

1985
One year of ethanol feeding increases circulating thyroid hormones in the dog.
    The Journal of laboratory and clinical medicine, 1985, Volume: 106, Issue:2

    Topics: Alcoholism; Analysis of Variance; Animals; Blood Proteins; Dogs; Humans; Liver Diseases, Alcoholic;

1985
Alterations in circulating thyroid hormones and thyrotropin in hepatic cirrhosis: evidence for euthyroidism despite subnormal serum triiodothyronine.
    The Journal of clinical endocrinology and metabolism, 1974, Volume: 39, Issue:3

    Topics: Achilles Tendon; Adult; Aged; Alcoholism; Blood; Female; Humans; Infant, Newborn; Injections, Intrav

1974