triiodothyronine has been researched along with Acute Respiratory Distress Syndrome in 5 studies
Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Triiodothyronine treatment abolished the sepsis-induced decrease in free T3 levels (S = 68 +/- 5 ng/dL, CLP < 15 ng/dL, CLP/T3 = 91 +/- 20 ng/dL)." | 5.29 | Pulmonary biophysical effects of triiodothyronine augmentation during sepsis-induced hypothyroidism. ( Dulchavsky, SA; Dutta, S; Hendrick, SR, 1993) |
| "Subacute thyroiditis, autoimmune thyroiditis and an atypical form of thyroiditis are complications of COVID-19." | 2.72 | Thyroid complications of SARS and coronavirus disease 2019 (COVID-19). ( Somogyi, P; Speer, G, 2021) |
| "73 µg T3 in 300 µl for 5 consecutive days had no clinically relevant T3-related adverse clinical, histopathologic, or clinical pathology findings." | 1.62 | A Preclinical Safety Study of Thyroid Hormone Instilled into the Lungs of Healthy Rats-an Investigational Therapy for ARDS. ( Coicou, LG; Flory, CM; Ingbar, DH; Koniar, BL; Larson, NA; Mysz, MA; Norris, BJ; Rich, TP; Schumacher, RJ, 2021) |
| "Triiodothyronine treatment abolished the sepsis-induced decrease in free T3 levels (S = 68 +/- 5 ng/dL, CLP < 15 ng/dL, CLP/T3 = 91 +/- 20 ng/dL)." | 1.29 | Pulmonary biophysical effects of triiodothyronine augmentation during sepsis-induced hypothyroidism. ( Dulchavsky, SA; Dutta, S; Hendrick, SR, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 3 (60.00) | 2.80 |
| Authors | Studies |
|---|---|
| Flory, CM | 1 |
| Norris, BJ | 1 |
| Larson, NA | 1 |
| Coicou, LG | 1 |
| Koniar, BL | 1 |
| Mysz, MA | 1 |
| Rich, TP | 1 |
| Ingbar, DH | 2 |
| Schumacher, RJ | 1 |
| Speer, G | 1 |
| Somogyi, P | 1 |
| Baldelli, R | 1 |
| Nicastri, E | 1 |
| Petrosillo, N | 1 |
| Marchioni, L | 1 |
| Gubbiotti, A | 1 |
| Sperduti, I | 1 |
| Di Giacinto, P | 1 |
| Rizza, L | 1 |
| Rota, F | 1 |
| Franco, M | 1 |
| Lania, A | 1 |
| Aimaretti, G | 1 |
| Ippolito, G | 1 |
| Zuppi, P | 1 |
| Bhargava, M | 1 |
| Runyon, MR | 1 |
| Smirnov, D | 1 |
| Lei, J | 1 |
| Groppoli, TJ | 1 |
| Mariash, CN | 1 |
| Wangensteen, OD | 1 |
| Dulchavsky, SA | 1 |
| Hendrick, SR | 1 |
| Dutta, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| PHASE II RANDOMIZED, INTERVENTION VERSUS NON- INTERVENTION, MULTI- CENTER STUDY OF THE EFFECTS OF THYROID HORMONE (T3) ON SAFETY/TOLERABILITY AND OXYGENATION IN SUBJECTS WITH ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS)[NCT04115514] | Phase 2 | 68 participants (Anticipated) | Interventional | 2019-10-21 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for triiodothyronine and Acute Respiratory Distress Syndrome
| Article | Year |
|---|---|
Thyroid complications of SARS and coronavirus disease 2019 (COVID-19).
Topics: Angiotensin-Converting Enzyme 2; COVID-19; Graves Disease; Humans; Hypothyroidism; Mortality; Progno | 2021 |
4 other studies available for triiodothyronine and Acute Respiratory Distress Syndrome
| Article | Year |
|---|---|
A Preclinical Safety Study of Thyroid Hormone Instilled into the Lungs of Healthy Rats-an Investigational Therapy for ARDS.
Topics: Animals; Drug Evaluation, Preclinical; Female; Instillation, Drug; Intubation, Intratracheal; Lung; | 2021 |
Thyroid dysfunction in COVID-19 patients.
Topics: Adult; Aged; Aged, 80 and over; COVID-19; Critical Care; Euthyroid Sick Syndromes; Female; Hospitali | 2021 |
Triiodo-L-thyronine rapidly stimulates alveolar fluid clearance in normal and hyperoxia-injured lungs.
Topics: Animals; Cells, Cultured; Injections, Intraperitoneal; Male; Pulmonary Edema; Rats; Rats, Sprague-Da | 2008 |
Pulmonary biophysical effects of triiodothyronine augmentation during sepsis-induced hypothyroidism.
Topics: Animals; Hypothyroidism; Infections; Lung; Lung Compliance; Male; Pulmonary Gas Exchange; Rats; Rats | 1993 |