Compounds > triiodothyronine
Page last updated: 2024-11-08

triiodothyronine and Acromegaly

triiodothyronine has been researched along with Acromegaly in 46 studies

Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.

Acromegaly: A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)

Research Excerpts

ExcerptRelevanceReference
"All 7 patients had hyperthyroidism, elevated free thyroxine or triiodothyronine levels, and unsuppressed levels of TSH."3.72Clinical characteristics of patients with thyrotropin-secreting pituitary adenoma. ( Chang, HY; Chen, KW; Huang, YY; Jung, SM; Lin, JD; Wu, YY, 2003)
"To study whether high growth hormone (GH) milieu may counteract fasting-induced changes in thyroid hormone economy, we measured basal and TRH-stimulated TSH concentrations as well as thyroxine (total, TT4 and free, FT4), total triiodothyronine (TT3) and total reverse T3 (TrT3) before and after a 6-day fast in 6 healthy men and in 8 patients with acromegaly."3.68Fasting-induced changes in thyroid hormone economy in normal and acromegalic subjects. ( Barkan, A; Friberg, RD; Ho, PJ, 1992)
"In order to determine if acromegaly per se may be associated with abnormalities in thyroidal economy, serum thyroxine-binding globulin (TBG), resin T3 uptake, total and free T4, T3, and reverse T3 concentrations were measured in 21 patients with active acromegaly."3.66Parameters of thyroid function in patients with active acromegaly. ( Burman, KD; Corrigan, DF; Dimond, RC; Earll, JM; Rogers, JE; Schaaf, M; Wartofsky, L; Wright, FD, 1978)
"Two women had sporadic multiple endocrine neoplasia type 1-associated syndrome."1.32The changing spectrum of TSH-secreting pituitary adenomas: diagnosis and management in 43 patients. ( Beckers, A; Chanson, P; Delemer, B; Mockel, J; Rohmer, V; Socin, HV; Stevenaert, A; Tabarin, A, 2003)
" Increasing the dosage of Sandostatin LAR from 20 to 30 mg had no obvious additional effect on GH suppression, but provided a further decrease in IGF-I levels."1.30Sandostatin LAR in acromegalic patients: long-term treatment. ( Bakke, S; Bruns, C; Fløgstad, AK; Halse, J; Jervell, J; Lancranjan, I; Marbach, P, 1997)

Research

Studies (46)

TimeframeStudies, this research(%)All Research%
pre-199033 (71.74)18.7374
1990's7 (15.22)18.2507
2000's5 (10.87)29.6817
2010's1 (2.17)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yamauchi, I1
Sakane, Y1
Yamashita, T1
Hirota, K1
Ueda, Y1
Kanai, Y1
Yamashita, Y1
Kondo, E1
Fujii, T1
Taura, D1
Sone, M1
Yasoda, A1
Inagaki, N1
Socin, HV1
Chanson, P1
Delemer, B1
Tabarin, A1
Rohmer, V1
Mockel, J1
Stevenaert, A1
Beckers, A1
Wu, YY1
Chang, HY1
Lin, JD1
Chen, KW1
Huang, YY1
Jung, SM1
Hubina, E1
Kovács, L1
Görömbey, Z1
Szabolcs, I1
Czirják, S1
Góth, MI1
Lamberg, BA1
Pelkonen, R1
Gordin, A1
Haltia, M1
Wahlström, T1
Paetau, A1
Leppäluoto, J1
Carmina, E1
Rosato, F1
Pirronello, S1
Jannì, A1
Lamberts, SW2
Oosterom, R1
Verleun, T1
Krenning, EP1
Assies, H1
Tsuchiya, H1
Onishi, T1
Mori, S1
Lee, S1
Kohno, H1
Imanaka, S1
Saitoh, Y1
Mogami, H1
Uozumi, T1
Kumahara, Y1
Ferrari, C2
Boghen, M1
Paracchi, A1
Rampini, P1
Raiteri, F1
Benco, R1
Romussi, M1
Codecasa, F1
Mucci, M1
Bianco, M1
Shalet, SM1
Price, DA1
Beardwell, CG1
Mindel, A1
MacFarlane, IA1
Klijn, JG1
Docter, R1
De Jong, FH1
Van Dongen, KJ1
Birkenhager, JC1
Heberling, HJ1
Heilmann, W1
Ulrich, FE1
Schneyer, U1
Marek, J1
Límanová, Z1
Srámková, J1
Felt, V4
Nedvídková, J3
Thieriot-Prévost, G1
Schimpff, RM1
Fløgstad, AK1
Halse, J1
Bakke, S1
Lancranjan, I1
Marbach, P1
Bruns, C1
Jervell, J1
Junik, R1
Sawicka, J1
Kozak, W1
Gembicki, M1
Ozawa, Y1
Kameya, T1
Kasuga, A1
Naritaka, H1
Kanda, N1
Maruyama, H1
Saruta, T1
Hasan, W1
Cowen, T1
Barnett, PS1
Elliot, E1
Coskeran, P1
Bouloux, PM1
De Marinis, L1
Mancini, A1
Bianchi, A1
Gentilella, R1
Valle, D1
Giampietro, A1
Zuppi, P1
Anile, C1
Maira, G1
Giustina, A1
Smallridge, RC1
Wartofsky, L2
Dimond, RC2
Shameti, H1
Kasafírek, E1
Mulaisho, C1
Utiger, RD1
Lindholm, J1
Dige-Petersen, H1
Hummer, L1
Rasmussen, P1
Korsgaard, O1
Corrigan, DF1
Schaaf, M1
Earll, JM1
Rogers, JE1
Wright, FD1
Burman, KD1
Stahl, TJ1
Sandler, R1
Christensen, SE1
Weeke, J1
Kaal, A1
Harris, AG2
Orskov, H1
Ho, PJ1
Friberg, RD1
Barkan, A1
Roelfsema, F4
Frölich, M3
de Boer, H2
Losa, M1
Alba-Roth, J1
Sobieszczyk, S1
Schopohl, J1
Müller, OA1
von Werder, K1
Geelhoed-Duijvestijn, PH1
Bussemaker, JK1
Shigemasa, C1
Abe, K1
Taniguchi, S1
Mitani, Y1
Ueta, Y1
Adachi, T1
Urabe, K1
Tanaka, T1
Yoshida, A1
Hori, T1
Eskildsen, PC1
Faber, J1
Siersbaek-Nielsen, K1
Faglia, G1
Beck-Peccoz, P1
Travaglini, P1
Ambrosi, B1
Spada, A1
AvRuskin, TW1
Sau, K1
Tang, S1
Juan, C1
Samaan, NA1
Leavens, ME1
Jesse, RH1
Strasek, J1
Bednár, J1
Irie, M1
Tsushima, T1
Gual, C1
Kastin, AJ1
Schally, AV1
Lederer, J1
Szybiński, Z1
Sieradzki, J1
Freychet, P1
Rosselin, G1
Dolais, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Observational, Cross-sectional, Longitudinal, Multi-center, Diagnostic Study to Evaluate the Influence of Acromegaly on Glucose Tolerance and to Evaluate the Changes of Impaired Glucose Tolerance During Standard Treatment of Acromegaly.[NCT00663000]138 participants (Actual)Observational2008-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for triiodothyronine and Acromegaly

ArticleYear
Clinical experience with hypothalamic releasing hormones. 1. Thyrotropin-releasing hormone.
    Recent progress in hormone research, 1972, Volume: 28

    Topics: Acromegaly; Adult; Amenorrhea; Craniopharyngioma; Dwarfism, Pituitary; Female; Humans; Hyperthyroidi

1972

Trials

1 trial available for triiodothyronine and Acromegaly

ArticleYear
The sweating apparatus in growth hormone deficiency, following treatment with r-hGH and in acromegaly.
    Autonomic neuroscience : basic & clinical, 2001, Jun-20, Volume: 89, Issue:1-2

    Topics: Acetylcholinesterase; Acromegaly; Adult; Antigens, Differentiation; Biopsy; Female; Growth Disorders

2001

Other Studies

44 other studies available for triiodothyronine and Acromegaly

ArticleYear
Effects of growth hormone on thyroid function are mediated by type 2 iodothyronine deiodinase in humans.
    Endocrine, 2018, Volume: 59, Issue:2

    Topics: Acromegaly; Adult; Cell Line; Dwarfism, Pituitary; Female; Gene Expression Regulation; Hormone Repla

2018
The changing spectrum of TSH-secreting pituitary adenomas: diagnosis and management in 43 patients.
    European journal of endocrinology, 2003, Volume: 148, Issue:4

    Topics: Acromegaly; Adenoma; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Belgium; Femal

2003
Clinical characteristics of patients with thyrotropin-secreting pituitary adenoma.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2003, Volume: 102, Issue:3

    Topics: Acromegaly; Adenoma; Adult; Aged; Female; Human Growth Hormone; Humans; Hyperthyroidism; Hyperthyrox

2003
Thyrotropin secretion during oral glucose tolerance test in acromegalic patients and control subjects.
    Endocrine, 2003, Volume: 22, Issue:2

    Topics: Acromegaly; Adult; Aged; Blood Glucose; Case-Control Studies; Female; Glucose Tolerance Test; Human

2003
Hyperthyroidism and acromegaly caused by a pituitary TSH- and GH-secreting tumour.
    Acta endocrinologica, 1983, Volume: 103, Issue:1

    Topics: Acromegaly; Adenoma, Acidophil; Female; Follow-Up Studies; Growth Hormone; Humans; Hyperthyroidism;

1983
Hypothalamic-pituitary-thyroid axis in acromegaly.
    Journal of endocrinological investigation, 1983, Volume: 6, Issue:4

    Topics: Acromegaly; Adult; Female; Humans; Hypothalamo-Hypophyseal System; Male; Middle Aged; Thyroid Functi

1983
Regulation of hormone release by cultured cells from a thyrotropin-growth hormone-secreting pituitary tumor. Direct inhibiting effects of 3,5,3'-triiodothyronine and dexamethasone on thyrotropin secretion.
    Journal of endocrinological investigation, 1984, Volume: 7, Issue:4

    Topics: Acromegaly; Adult; Bromocriptine; Cells, Cultured; Dexamethasone; Gonadotropin-Releasing Hormone; Gr

1984
Normalization of thyroid stimulating hormone levels in acromegalic patients after selective adenomectomy.
    Endocrinologia japonica, 1984, Volume: 31, Issue:6

    Topics: Acromegaly; Adenoma; Adult; Female; Growth Hormone; Humans; Male; Middle Aged; Pituitary Neoplasms;

1984
Thyroid autoimmunity in hyperprolactinaemic disorders.
    Acta endocrinologica, 1983, Volume: 104, Issue:1

    Topics: Acromegaly; Adolescent; Adult; Aged; Autoantibodies; Child; Empty Sella Syndrome; Female; Humans; Hy

1983
Growth hormone and somatomedin levels in acromegalics treated with bromocriptine.
    Hormone research, 1980, Volume: 12, Issue:3

    Topics: Acromegaly; Bromocriptine; Female; Follicle Stimulating Hormone; Growth Hormone; Humans; Luteinizing

1980
The function of the pituitary-thyroidal axis in acromegalic patients v. patients with hyperprolactinaemia and a pituitary tumour.
    Clinical endocrinology, 1980, Volume: 13, Issue:6

    Topics: Acromegaly; Adolescent; Adult; Aged; Female; Humans; Male; Middle Aged; Pituitary Gland; Pituitary N

1980
[Peripheral thyroid function and TRH-TSH test in patients with acromegaly].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1981, Apr-15, Volume: 36, Issue:8

    Topics: Acromegaly; Growth Hormone; Humans; Thyroid Gland; Thyrotropin; Thyrotropin-Releasing Hormone; Thyro

1981
Oral thyrotropin-releasing hormone (TRH) test in acromegaly.
    Endokrinologie, 1981, Volume: 78, Issue:1

    Topics: Acromegaly; Administration, Oral; Adult; Aged; Female; Growth Hormone; Humans; Injections, Intraveno

1981
Growth hormone and changes in the secretion of thyrotropic hormone after thyrotropin-releasing hormone (TRH): ineffectiveness of dopaminergic stimulation.
    Endokrinologie, 1982, Volume: 80, Issue:2

    Topics: Acromegaly; Adult; Bromocriptine; Ergolines; Female; Growth Hormone; Humans; Lisuride; Male; Middle

1982
A hormonally controlled serum factor stimulating the thymidine uptake into lectin-activated lymphocytes.
    Acta endocrinologica, 1981, Volume: 98, Issue:3

    Topics: Acromegaly; Adolescent; Adult; Blood; Child; Child, Preschool; Dwarfism; Dwarfism, Pituitary; Female

1981
Sandostatin LAR in acromegalic patients: long-term treatment.
    The Journal of clinical endocrinology and metabolism, 1997, Volume: 82, Issue:1

    Topics: Acromegaly; Adult; Aged; Antineoplastic Agents; Blood Glucose; Delayed-Action Preparations; Female;

1997
Thyroid volume and function in patients with acromegaly living in iodine deficient areas.
    Journal of endocrinological investigation, 1997, Volume: 20, Issue:3

    Topics: Acromegaly; Adult; Aged; Female; Human Growth Hormone; Humans; Iodine; Male; Middle Aged; Organ Size

1997
A functional thyrotropin- and growth hormone-secreting pituitary adenoma with a ultrastructurally monomorphic feature: a case study.
    Endocrine journal, 1998, Volume: 45, Issue:2

    Topics: Acromegaly; Adenoma; Adult; Cytoplasm; Female; Glycoprotein Hormones, alpha Subunit; Human Growth Ho

1998
Preoperative growth hormone response to thyrotropin-releasing hormone and oral glucose tolerance test in acromegaly: a retrospective evaluation of 50 patients.
    Metabolism: clinical and experimental, 2002, Volume: 51, Issue:5

    Topics: Acromegaly; Adenoma; Adult; Female; Glucose Tolerance Test; Human Growth Hormone; Humans; Hydrocorti

2002
Inappropriate secretion of thyrotropin: discordance between the suppressive effects of corticosteroids and thyroid hormone.
    The Journal of clinical endocrinology and metabolism, 1979, Volume: 48, Issue:4

    Topics: Acromegaly; Female; Growth Hormone; Humans; Hyperthyroidism; Menopause; Methimazole; Middle Aged; Pr

1979
[The use of thyreoliberin VUFB in the diagnosis of acromegaly (author's transl)].
    Casopis lekaru ceskych, 1979, Feb-23, Volume: 118, Issue:8

    Topics: Acromegaly; Administration, Oral; Adult; Aged; Female; Growth Hormone; Humans; Male; Middle Aged; Th

1979
Serum thyroxine-binding globulin: determination by competitive ligand-binding assay in thyroid disease and pregnancy.
    Acta endocrinologica, 1977, Volume: 85, Issue:2

    Topics: Acromegaly; Adult; Aged; Binding, Competitive; Female; Humans; Hyperthyroidism; Hypothyroidism; Male

1977
Effect of thyrotrophin releasing hormone (TRH) in patients with pituitary disorders.
    Acta endocrinologica, 1977, Volume: 85, Issue:3

    Topics: Acromegaly; Adenoma, Chromophobe; Adult; Female; Humans; Hypophysectomy; Male; Middle Aged; Pituitar

1977
Parameters of thyroid function in patients with active acromegaly.
    Metabolism: clinical and experimental, 1978, Volume: 27, Issue:2

    Topics: Acromegaly; Adult; Female; Growth Hormone; Humans; Male; Middle Aged; Postoperative Complications; T

1978
Radioimmunoassay and the hormones of thyroid function.
    Seminars in nuclear medicine, 1975, Volume: 5, Issue:3

    Topics: Acromegaly; Adenoma, Chromophobe; Blood; Calcitonin; Choriocarcinoma; Female; Glucocorticoids; Goite

1975
Recurrent hyperthyroidism in an acromegalic patient previously treated with proton beam irradiation: Graves' disease as probable etiology based on follow-up observations.
    The Journal of clinical endocrinology and metabolism, 1976, Volume: 42, Issue:1

    Topics: Acromegaly; Female; Follow-Up Studies; Graves Disease; Humans; Hyperthyroidism; Middle Aged; Thyrotr

1976
Serum levels of thyrotropin, prolactin, growth hormone, triiodothyronine and thyroxine after oral administration of thyrotropin releasing hormone in hypothyroid and hyperthyroid patients.
    Endokrinologie, 1976, Volume: 68, Issue:2

    Topics: Acromegaly; Adolescent; Adult; Aged; Growth Hormone; Humans; Hyperthyroidism; Hypothyroidism; Middle

1976
SMS 201-995 and thyroid function in acromegaly: acute, intermediate and long-term effects.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1992, Volume: 24, Issue:5

    Topics: Acromegaly; Adult; Humans; Male; Middle Aged; Octreotide; Radioimmunoassay; Thyroid Function Tests;

1992
Fasting-induced changes in thyroid hormone economy in normal and acromegalic subjects.
    Thyroid : official journal of the American Thyroid Association, 1992,Spring, Volume: 2, Issue:1

    Topics: Acromegaly; Fasting; Growth Hormone; Humans; Male; Thyroid Function Tests; Thyroid Hormones; Thyrotr

1992
Octreotide treatment in acromegaly: a comparison between pen-treated and pump-treated patients in a cross-over study.
    Acta endocrinologica, 1991, Volume: 125, Issue:1

    Topics: Acromegaly; Adult; Aged; Blood Glucose; Female; Glucose Tolerance Test; Growth Hormone; Humans; Infu

1991
Pulsatile thyrotropin release and thyroid function in acromegalics before and during subcutaneous octreotide infusion.
    The Journal of clinical endocrinology and metabolism, 1991, Volume: 72, Issue:1

    Topics: Acromegaly; Circadian Rhythm; Female; Growth Hormone; Humans; Insulin-Like Growth Factor I; Male; Mi

1991
Effects of repetitive administration of thyrotropin-releasing hormone at short intervals in acromegaly.
    Acta endocrinologica, 1989, Volume: 120, Issue:3

    Topics: Acromegaly; Adult; Aged; Female; Growth Hormone; Humans; Male; Middle Aged; Prolactin; Thyrotropin;

1989
Changes in basal and stimulated TSH and other parameters of thyroid function in acromegaly after transsphenoidal surgery.
    Acta endocrinologica, 1989, Volume: 121, Issue:2

    Topics: Acromegaly; Adult; Aged; Female; Follow-Up Studies; Humans; Insulin-Like Growth Factor I; Male; Midd

1989
Circadian and pulsatile thyrotropin release in treated acromegalics.
    Journal of endocrinological investigation, 1989, Volume: 12, Issue:10

    Topics: Acromegaly; Adult; Circadian Rhythm; Growth Hormone; Humans; Hypothalamus; Insulin-Like Growth Facto

1989
The influence of diabetes mellitus on thyrotropin response to thyrotropin-releasing hormone in untreated acromegalic patients.
    Journal of endocrinological investigation, 1988, Volume: 11, Issue:4

    Topics: Acromegaly; Adenoma; Adult; Aged; Diabetes Mellitus; Female; Humans; Insulin; Male; Middle Aged; Pit

1988
Renal handling of iodothyronines in acromegaly.
    Scandinavian journal of clinical and laboratory investigation, 1987, Volume: 47, Issue:1

    Topics: Acromegaly; Adult; Aged; Diiodothyronines; Female; Humans; Kidney; Male; Middle Aged; Thyronines; Th

1987
Plasma growth hormone response to thyrotropin-releasing hormone in patients with active acromegaly.
    The Journal of clinical endocrinology and metabolism, 1973, Volume: 36, Issue:6

    Topics: Acromegaly; Adult; Arginine; Female; Glucose; Growth Hormone; Humans; Insulin; Male; Middle Aged; Ra

1973
Childhood acromegaly: successful therapy with conventional radiation and effects of chlorpromazine on growth hormone and prolactin secretion.
    The Journal of clinical endocrinology and metabolism, 1973, Volume: 37, Issue:3

    Topics: Acromegaly; Adolescent; Antigens; Arginine; Blood Glucose; Child; Chlorpromazine; Female; Glucagon;

1973
Serum growth hormone and prolactin response to thyrotropin-releasing hormone in patients with acromegaly before and after surgery.
    The Journal of clinical endocrinology and metabolism, 1974, Volume: 38, Issue:6

    Topics: Acromegaly; Adult; Arginine; Female; Glucose Tolerance Test; Growth Hormone; Humans; Hydrocortisone;

1974
[Changes in indexes of nonbound thyroxine and of blood metabolites following administration of antiandrogens (Cyproterone), dehydroepiandrosterone, prednisone, L-triiodothyronine, D-thyroxine and in acromegaly].
    Vnitrni lekarstvi, 1972, Volume: 18, Issue:6

    Topics: 17-Hydroxycorticosteroids; Acromegaly; Adult; Binding Sites; Dehydroepiandrosterone; Female; Humans;

1972
Increase of serum growth hormone concentration following thyrotropin-releasing hormone injection in patients with acromegaly or gigantism.
    The Journal of clinical endocrinology and metabolism, 1972, Volume: 35, Issue:1

    Topics: Acromegaly; Adolescent; Adult; Female; Gigantism; Growth Hormone; Humans; Iodine Isotopes; Male; Mid

1972
[Thyroid gland in acromegaly].
    Actualites endocrinologiques, 1973, Volume: 13, Issue:0

    Topics: Acromegaly; Adenoma; Adult; Female; Humans; Hyperplasia; Hyperthyroidism; Iodine; Iodine Radioisotop

1973
[Evaluation of the pituitary-thyroid axis by the triiodothyronine test].
    Polskie Archiwum Medycyny Wewnetrznej, 1973, Volume: 50, Issue:11

    Topics: Acromegaly; Adult; Graves Disease; Humans; Hypopituitarism; Middle Aged; Pituitary Function Tests; P

1973
[Radioimmunoassay of thyrotropin (TSH) in human plasma].
    La Presse medicale, 1969, Jan-04, Volume: 77, Issue:1

    Topics: Acromegaly; Adult; Aged; Antigen-Antibody Reactions; Chorionic Gonadotropin; Chromatography; Chromat

1969