triiodothyronine has been researched along with Abnormality, Heart in 37 studies
Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thyroid hormone, including total and free triiodothyronine levels at predetermined time points, potential side effects indicating hyperthyroidism, indicators of the thyroid-pituitary axis, and clinical endpoints." | 5.17 | Oral triiodothyronine normalizes triiodothyronine levels after surgery for pediatric congenital heart disease*. ( Boom, CE; Fakhri, D; Haas, NA; Kartini, A; Kekalih, A; Marwali, EM; Sakidjan, I; Santoso, A; Schwartz, SM, 2013) |
| "We tested the validity of low cardiac output syndrome (LCOS), derived using clinical parameters and laboratory data, by comparing the LCOS diagnosis with objective parameters commonly measured in a cardiac intensive care unit (CCU) setting." | 2.90 | Oral Triiodothyronine Supplementation Decreases Low Cardiac Output Syndrome After Pediatric Cardiac Surgery. ( Batubara, JRL; Caesa, P; Darmaputri, S; Djer, MM; Fakhri, D; Haas, NA; Marwali, EM; Munasir, ZM; Portman, MA; Roebiono, PS; Sani, AA; Satroasmoro, S, 2019) |
| " The calculated half-life of T(3) was 7 hours." | 2.69 | Pharmacokinetic evaluation of triiodothyronine supplementation in children after modified Fontan procedure. ( Acosta, M; Capparelli, E; Mainwaring, RD; Nelson, JC; Schell, K, 2000) |
| "Infants less than 1 year old undergoing ventricular septal defect or tetralogy of Fallot repair were randomized into 2 groups." | 2.69 | Triiodothyronine repletion in infants during cardiopulmonary bypass for congenital heart disease. ( Duncan, BW; Fearneyhough, C; Lupinetti, FM; Ning, XH; Portman, MA; Rosenthal, GL, 2000) |
| "Triiodothyronine is an important regulator of cellular metabolism and may have potential use as an inotropic agent." | 1.28 | The effects of cardiopulmonary bypass on thyroid function in infants weighing less than five kilograms. ( Donaghey, SF; Jamieson, MP; Logan, RW; Mitchell, IM; Paton, RD; Pollock, JC, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.70) | 18.7374 |
| 1990's | 7 (18.92) | 18.2507 |
| 2000's | 12 (32.43) | 29.6817 |
| 2010's | 13 (35.14) | 24.3611 |
| 2020's | 4 (10.81) | 2.80 |
| Authors | Studies |
|---|---|
| Portman, MA | 7 |
| Slee, AE | 1 |
| Roth, SJ | 2 |
| Radman, M | 1 |
| Olson, AK | 3 |
| Mainwaring, RD | 3 |
| Kamerkar, A | 1 |
| Nuri, M | 1 |
| Hastings, L | 2 |
| Lin, WH | 1 |
| Zhou, SJ | 1 |
| Chen, XH | 1 |
| Cao, H | 1 |
| Chen, Q | 1 |
| Iliopoulos, I | 1 |
| Cooper, DS | 1 |
| Kuwata, S | 1 |
| Takanashi, M | 1 |
| Hashimoto, M | 1 |
| Iwamoto, Y | 1 |
| Ishido, H | 1 |
| Masutani, S | 1 |
| Saiki, H | 1 |
| Sugamoto, K | 1 |
| Senzaki, H | 1 |
| Flores, S | 1 |
| Loomba, RS | 1 |
| Checchia, PA | 1 |
| Graham, EM | 1 |
| Bronicki, RA | 1 |
| Marwali, EM | 3 |
| Caesa, P | 1 |
| Darmaputri, S | 1 |
| Sani, AA | 1 |
| Roebiono, PS | 2 |
| Fakhri, D | 3 |
| Djer, MM | 1 |
| Munasir, ZM | 1 |
| Batubara, JRL | 1 |
| Satroasmoro, S | 1 |
| Haas, NA | 5 |
| Boom, CE | 2 |
| Sakidjan, I | 1 |
| Santoso, A | 2 |
| Kartini, A | 1 |
| Kekalih, A | 1 |
| Schwartz, SM | 1 |
| Srinivasan, V | 1 |
| Mittnacht, J | 1 |
| Choukair, D | 1 |
| Kneppo, C | 1 |
| Brunner, R | 1 |
| Parzer, P | 1 |
| Gorenflo, M | 1 |
| Bettendorf, M | 2 |
| Deladoëy, J | 1 |
| Harrington, K | 1 |
| Dechant, MJ | 1 |
| van der Werf-Grohmann, N | 1 |
| Neumann, E | 1 |
| Spiekerkoetter, U | 1 |
| Stiller, B | 1 |
| Grohmann, J | 1 |
| Budiwardhana, N | 1 |
| Sastroasmoro, S | 1 |
| Slee, A | 3 |
| Cohen, G | 2 |
| Karl, T | 1 |
| Tong, E | 2 |
| Patel, H | 1 |
| Reinhartz, O | 1 |
| Mott, AR | 1 |
| Mainwaring, R | 1 |
| Linam, J | 1 |
| Danzi, S | 1 |
| Akçevin, A | 1 |
| Alkan-Bozkaya, T | 1 |
| Qiu, F | 1 |
| Undar, A | 1 |
| Mishra, P | 1 |
| Samanta, L | 1 |
| Priest, JR | 1 |
| Ledee, D | 1 |
| Morrish, F | 1 |
| van Veenendaal, NR | 1 |
| Ulmer, B | 1 |
| Boskovski, MT | 1 |
| Fang, X | 1 |
| Khokha, MK | 1 |
| Wendler, CC | 1 |
| Blum, M | 1 |
| Rivkees, SA | 1 |
| Klemperer, JD | 1 |
| Bartkowski, R | 1 |
| Wojtalik, M | 1 |
| Korman, E | 1 |
| Sharma, G | 1 |
| Henschke, J | 1 |
| Mrówczyński, W | 1 |
| McMahon, CK | 1 |
| Klein, I | 3 |
| Ojamaa, K | 3 |
| Fearneyhough, C | 2 |
| Karl, TR | 1 |
| Seidel, K | 1 |
| Mott, A | 1 |
| Tacy, T | 1 |
| Lewin, M | 1 |
| Permut, L | 1 |
| Schlater, M | 1 |
| Azakie, A | 1 |
| Plumpton, K | 1 |
| Mackie, AS | 1 |
| Booth, KL | 1 |
| Newburger, JW | 1 |
| Gauvreau, K | 1 |
| Huang, SA | 1 |
| Laussen, PC | 1 |
| DiNardo, JA | 1 |
| del Nido, PJ | 1 |
| Mayer, JE | 1 |
| Jonas, RA | 1 |
| McGrath, E | 1 |
| Elder, J | 1 |
| Camphausen, CK | 2 |
| Manson, JM | 1 |
| Murzi, B | 1 |
| Iervasi, G | 1 |
| Masini, S | 1 |
| Moschetti, R | 1 |
| Vanini, V | 1 |
| Zucchelli, G | 1 |
| Biagini, A | 1 |
| Lamberti, JJ | 1 |
| Carter, TL | 1 |
| Nelson, JC | 2 |
| Saatvedt, K | 1 |
| Lindberg, H | 1 |
| Brogan, TV | 1 |
| Bratton, SL | 1 |
| Lynn, AM | 1 |
| Bialkowski, J | 1 |
| Chowdhury, D | 2 |
| Parnell, VA | 2 |
| Boxer, R | 1 |
| Cooper, R | 1 |
| Capparelli, E | 1 |
| Schell, K | 1 |
| Acosta, M | 1 |
| Schmidt, KG | 1 |
| Grulich-Henn, J | 1 |
| Ulmer, HE | 1 |
| Heinrich, UE | 1 |
| Ning, XH | 1 |
| Duncan, BW | 1 |
| Rosenthal, GL | 1 |
| Lupinetti, FM | 1 |
| McMahon, C | 1 |
| Sison, CP | 1 |
| Mitchell, IM | 1 |
| Pollock, JC | 1 |
| Jamieson, MP | 1 |
| Donaghey, SF | 1 |
| Paton, RD | 1 |
| Logan, RW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Tetronine (Sodium Liothyronine) for Infants & Children Undergoing Cardiopulmonary Bypass in a Middle Income Nation (OTICC Study)[NCT02222532] | Phase 3 | 224 participants (Actual) | Interventional | 2013-06-30 | Completed | ||
| Thiamine Influenced on Substrate Energy Effectiveness in Indonesian Children Undergoing Congenital Heart Disease Surgery With Cardiopulmonary Bypass Procedure and Oral Thyroid Supplementation[NCT04453761] | Phase 4 | 50 participants (Actual) | Interventional | 2018-07-01 | Active, not recruiting | ||
| Triostat in Children During CardioPulmonary Bypass (CPB)[NCT00027417] | Phase 3 | 195 participants (Actual) | Interventional | 2001-04-30 | Completed | ||
| Oral Triiodothyronine Normalizes T3 Levels After Surgery For Pediatric Congenital Heart Disease[NCT01780584] | Phase 2 | 45 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Specific symptoms of hyperthyroidism included cardiac dysrhythmia requiring medical or electrical treatment, hypertension (mean systolic or diastolic blood pressure more than 2 standard deviation above normal for age) and hyperthermia (>37.5 degree Celsius). One patient in low dose group had hypertension directly after surgery due to unrecognized coarctation of the aorta and this patient was withdrawal from the protocol. (NCT01780584)
Timeframe: Since the first dose of oral T3 until 7 days after surgery
| Intervention | participants (Number) |
|---|---|
| Placebo | 0 |
| Oral T3 Low Dose | 1 |
| Oral T3 High Dose | 0 |
(NCT01780584)
Timeframe: up to 3 month after surgery
| Intervention | days (Median) |
|---|---|
| Placebo | 6 |
| Oral T3 Low Dose | 17.5 |
| Oral T3 High Dose | 10 |
(NCT01780584)
Timeframe: up to 3 months after surgery
| Intervention | hours (Median) |
|---|---|
| Placebo | 48.5 |
| Oral T3 Low Dose | 109.5 |
| Oral T3 High Dose | 87 |
Postoperative time to extubation is length of time on ventilator. (NCT01780584)
Timeframe: up to 3 months after surgery
| Intervention | hours (Median) |
|---|---|
| Placebo | 23 |
| Oral T3 Low Dose | 36.5 |
| Oral T3 High Dose | 17 |
Free T3 levels were measured up to 36 hours after cross-clamp removal (NCT01780584)
Timeframe: during the first 36 hours after cross clamp removal
| Intervention | pg/ml (Mean) | ||||
|---|---|---|---|---|---|
| hour 0 | hour 1 | hour 6 | hour 18 | hour 36 | |
| Oral T3 High Dose | 3.9 | 4.3 | 3.7 | 3.8 | 4.4 |
| Oral T3 Low Dose | 4.5 | 4.1 | 3.3 | 2.6 | 2.1 |
| Placebo | 3.6 | 3.6 | 2.9 | 2.4 | 1.6 |
4 reviews available for triiodothyronine and Abnormality, Heart
| Article | Year |
|---|---|
Thyroid Hormone (Triiodothyronine) Therapy in Children After Congenital Heart Surgery: A Meta-Analysis.
Topics: Age Factors; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Female; Heart Defects, Congenital; | 2020 |
Oxidative stress and heart failure in altered thyroid States.
Topics: Animals; Atherosclerosis; Cardiomyopathies; Coronary Artery Disease; Heart Defects, Congenital; Hear | 2012 |
Thyroid hormone and cardiac surgery.
Topics: Animals; Cardiac Output; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Clinical Trials as Top | 2002 |
Mechanism of environmental agents by class associated with adverse female reproductive outcome.
Topics: Abnormalities, Drug-Induced; Animals; Biotransformation; Bone and Bones; Female; Gestational Age; He | 1984 |
15 trials available for triiodothyronine and Abnormality, Heart
| Article | Year |
|---|---|
Triiodothyronine Supplementation in Infants Undergoing Cardiopulmonary Bypass: A Randomized Controlled Trial.
Topics: Cardiopulmonary Bypass; Dietary Supplements; Heart Defects, Congenital; Humans; Infant; Treatment Ou | 2023 |
Oral Triiodothyronine Supplementation Decreases Low Cardiac Output Syndrome After Pediatric Cardiac Surgery.
Topics: Cardiac Output; Cardiac Output, Low; Cardiopulmonary Bypass; Child; Female; Heart Defects, Congenita | 2019 |
Oral triiodothyronine normalizes triiodothyronine levels after surgery for pediatric congenital heart disease*.
Topics: Cardiopulmonary Bypass; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heart Defects | 2013 |
Oral triiodothyronine normalizes triiodothyronine levels after surgery for pediatric congenital heart disease*.
Topics: Cardiopulmonary Bypass; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heart Defects | 2013 |
Oral triiodothyronine normalizes triiodothyronine levels after surgery for pediatric congenital heart disease*.
Topics: Cardiopulmonary Bypass; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heart Defects | 2013 |
Oral triiodothyronine normalizes triiodothyronine levels after surgery for pediatric congenital heart disease*.
Topics: Cardiopulmonary Bypass; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heart Defects | 2013 |
Long-Term Neurodevelopmental Outcome of Children Treated with Tri-Iodothyronine after Cardiac Surgery: Follow-Up of a Double-Blind, Randomized, Placebo-Controlled Study.
Topics: Adolescent; Cardiopulmonary Bypass; Child; Child Development; Cognition; Double-Blind Method; Female | 2015 |
Oral Triiodothyronine for Infants and Children Undergoing Cardiopulmonary Bypass.
Topics: Administration, Oral; Cardiopulmonary Bypass; Child, Preschool; Dose-Response Relationship, Drug; Do | 2017 |
Triiodothyronine Supplementation in Infants and Children Undergoing Cardiopulmonary Bypass (TRICC): a multicenter placebo-controlled randomized trial: age analysis.
Topics: Age Factors; Arrhythmias, Cardiac; Cardiopulmonary Bypass; Child, Preschool; Double-Blind Method; Fe | 2010 |
Triiodothyronine Supplementation in Infants and Children Undergoing Cardiopulmonary Bypass (TRICC): a multicenter placebo-controlled randomized trial: age analysis.
Topics: Age Factors; Arrhythmias, Cardiac; Cardiopulmonary Bypass; Child, Preschool; Double-Blind Method; Fe | 2010 |
Triiodothyronine Supplementation in Infants and Children Undergoing Cardiopulmonary Bypass (TRICC): a multicenter placebo-controlled randomized trial: age analysis.
Topics: Age Factors; Arrhythmias, Cardiac; Cardiopulmonary Bypass; Child, Preschool; Double-Blind Method; Fe | 2010 |
Triiodothyronine Supplementation in Infants and Children Undergoing Cardiopulmonary Bypass (TRICC): a multicenter placebo-controlled randomized trial: age analysis.
Topics: Age Factors; Arrhythmias, Cardiac; Cardiopulmonary Bypass; Child, Preschool; Double-Blind Method; Fe | 2010 |
Triiodothyronine Supplementation in Infants and Children Undergoing Cardiopulmonary Bypass (TRICC): a multicenter placebo-controlled randomized trial: age analysis.
Topics: Age Factors; Arrhythmias, Cardiac; Cardiopulmonary Bypass; Child, Preschool; Double-Blind Method; Fe | 2010 |
Triiodothyronine Supplementation in Infants and Children Undergoing Cardiopulmonary Bypass (TRICC): a multicenter placebo-controlled randomized trial: age analysis.
Topics: Age Factors; Arrhythmias, Cardiac; Cardiopulmonary Bypass; Child, Preschool; Double-Blind Method; Fe | 2010 |
Triiodothyronine Supplementation in Infants and Children Undergoing Cardiopulmonary Bypass (TRICC): a multicenter placebo-controlled randomized trial: age analysis.
Topics: Age Factors; Arrhythmias, Cardiac; Cardiopulmonary Bypass; Child, Preschool; Double-Blind Method; Fe | 2010 |
Triiodothyronine Supplementation in Infants and Children Undergoing Cardiopulmonary Bypass (TRICC): a multicenter placebo-controlled randomized trial: age analysis.
Topics: Age Factors; Arrhythmias, Cardiac; Cardiopulmonary Bypass; Child, Preschool; Double-Blind Method; Fe | 2010 |
Triiodothyronine Supplementation in Infants and Children Undergoing Cardiopulmonary Bypass (TRICC): a multicenter placebo-controlled randomized trial: age analysis.
Topics: Age Factors; Arrhythmias, Cardiac; Cardiopulmonary Bypass; Child, Preschool; Double-Blind Method; Fe | 2010 |
Evaluation of perfusion modes on vital organ recovery and thyroid hormone homeostasis in pediatric patients undergoing cardiopulmonary bypass.
Topics: Adolescent; Biomarkers; Cardiopulmonary Bypass; Cardiovascular Agents; Chi-Square Distribution; Chil | 2010 |
Triiodothyronine supplementation and cytokines during cardiopulmonary bypass in infants and children.
Topics: Age Factors; Airway Extubation; Analysis of Variance; Biomarkers; Cardiopulmonary Bypass; Cytokines; | 2012 |
The Triiodothyronine for Infants and Children Undergoing Cardiopulmonary Bypass (TRICC) study: design and rationale.
Topics: Cardiopulmonary Bypass; Double-Blind Method; Female; Heart Defects, Congenital; Humans; Infant; Male | 2004 |
A randomized, double-blind, placebo-controlled pilot trial of triiodothyronine in neonatal heart surgery.
Topics: Aorta, Thoracic; Cardiac Output; Cardiac Surgical Procedures; Double-Blind Method; Female; Heart Def | 2005 |
Thyroid function in infants following cardiac surgery: comparative effects of iodinated and noniodinated topical antiseptics.
Topics: Anti-Infective Agents, Local; Cardiopulmonary Bypass; Chlorhexidine; Female; Heart Defects, Congenit | 1997 |
Pharmacokinetic evaluation of triiodothyronine supplementation in children after modified Fontan procedure.
Topics: Cardiac Output; Child, Preschool; Fontan Procedure; Half-Life; Heart Defects, Congenital; Humans; In | 2000 |
Tri-iodothyronine treatment in children after cardiac surgery: a double-blind, randomised, placebo-controlled study.
Topics: Cardiac Output; Cardiopulmonary Bypass; Cardiotonic Agents; Child; Child, Preschool; Double-Blind Me | 2000 |
Triiodothyronine repletion in infants during cardiopulmonary bypass for congenital heart disease.
Topics: Cardiopulmonary Bypass; Heart Defects, Congenital; Heart Septal Defects, Ventricular; Hemodynamics; | 2000 |
A prospective randomized clinical study of thyroid hormone treatment after operations for complex congenital heart disease.
Topics: Child, Preschool; Female; Heart Defects, Congenital; Humans; Infant; Infant, Newborn; Infusions, Int | 2001 |
18 other studies available for triiodothyronine and Abnormality, Heart
| Article | Year |
|---|---|
Changes of serum TSH, FT3, and FT4 levels in infants received surgical correction of congenital heart disease under cardiopulmonary bypass.
Topics: Cardiopulmonary Bypass; Heart Defects, Congenital; Humans; Infant; Retrospective Studies; Thyroid Ho | 2023 |
Commentary: Thyroid Hormone (T3) Replacement After Congenital Heart Surgery: "I'll Be Back"… But Still Not Work.
Topics: Child; Heart Defects, Congenital; Humans; Replantation; Thyroid Hormones; Triiodothyronine | 2020 |
Thyroid Function in Patients With a Fontan Circulation.
Topics: Cardiac Catheterization; Child; Female; Follow-Up Studies; Fontan Procedure; Heart Defects, Congenit | 2019 |
Thyroid hormone supplementation following pediatric cardiac surgery: all "routes" lead to rome!*.
Topics: Cardiopulmonary Bypass; Female; Heart Defects, Congenital; Humans; Male; Triiodothyronine | 2013 |
Has Triiodothyronine Treatment of Children after Cardiopulmonary Bypass Surgery Any Long-Term Effects?
Topics: Cardiopulmonary Bypass; Child Development; Female; Heart Defects, Congenital; Humans; Male; Nervous | 2015 |
Thyroidal response following iodine excess for cardiac catheterisation and intervention in early infancy.
Topics: Cardiac Catheterization; Contrast Media; Female; Germany; Heart Defects, Congenital; Humans; Hypothy | 2016 |
Embryonic exposure to propylthiouracil disrupts left-right patterning in Xenopus embryos.
Topics: Animals; Antithyroid Agents; Body Patterning; Cilia; Digestive System Abnormalities; Female; Gene Ex | 2013 |
Thyroid hormones levels in infants during and after cardiopulmonary bypass with ultrafiltration.
Topics: Cardiopulmonary Bypass; Critical Care; Heart Defects, Congenital; Humans; Infant; Infant, Newborn; I | 2002 |
Interleukin-6 and thyroid hormone metabolism in pediatric cardiac surgery patients.
Topics: Aortic Valve; Cardiopulmonary Bypass; Female; Heart Defects, Congenital; Humans; Infant; Infant, New | 2003 |
Identifying infants at risk of marked thyroid suppression post-cardiopulmonary bypass.
Topics: Cardiopulmonary Bypass; Female; Heart Defects, Congenital; Humans; Infant; Intensive Care Units, Ped | 2005 |
Triiodothyronine in neonatal heart surgery: Looking for an answer.
Topics: Cardiac Output, Low; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cardiotonic Agents; Heart | 2006 |
Fenoldapam after pediatric cardiac surgery: what is conventional diuretic therapy?
Topics: Aminophylline; Diuretics; Dopamine Agonists; Drug Therapy, Combination; Fenoldopam; Furosemide; Hear | 2006 |
Thyroid hormones homeostasis in pediatric patients during and after cardiopulmonary bypass.
Topics: Adolescent; Cardiopulmonary Bypass; Child; Child, Preschool; Female; Heart Defects, Congenital; Home | 1995 |
Reduction in triiodothyronine levels following modified Fontan procedure.
Topics: Atrial Function; Blood Pressure; Cardiopulmonary Bypass; Child, Preschool; Female; Follow-Up Studies | 1994 |
Depressed thyroid function following paediatric cardiopulmonary bypass: association with interleukin-6 release?
Topics: Anesthesia, Intravenous; Cardiopulmonary Bypass; Child, Preschool; Elective Surgical Procedures; Ext | 1996 |
Use of thyroid hormones after cardiopulmonary bypass in children.
Topics: Female; Heart Defects, Congenital; Humans; Infant; Infant, Newborn; Male; Thyroid Hormones; Thyroxin | 1998 |
Usefulness of triiodothyronine (T3) treatment after surgery for complex congenital heart disease in infants and children.
Topics: Child, Preschool; Female; Heart Defects, Congenital; Hemodynamics; Humans; Infant; Infant, Newborn; | 1999 |
The effects of cardiopulmonary bypass on thyroid function in infants weighing less than five kilograms.
Topics: Body Weight; Cardiopulmonary Bypass; Female; Heart Defects, Congenital; Humans; Hypothyroidism; Infa | 1992 |