trihexyphenidyl has been researched along with Seizures in 10 studies
Trihexyphenidyl: One of the centrally acting MUSCARINIC ANTAGONISTS used for treatment of PARKINSONIAN DISORDERS and drug-induced extrapyramidal movement disorders and as an antispasmodic.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In contrast, benactyzine and trihexyphenidyl showed a third profile of activity: There was a smaller increase in drug dosage required for anticonvulsant activity as seizure duration increased, and both drugs could terminate seizures that had progressed for 40 min." | 5.29 | Pharmacological modulation of soman-induced seizures. ( McDonough, JH; Shih, TM, 1993) |
| "Preclinical studies have reported that, compared to the muscarinic receptor (mAChR) antagonist atropine, (R,S)-trihexyphenidyl (THP) more effectively counters the cholinergic crisis, seizures, and neuropathology triggered by organophosphorus (OP)-induced acetylcholinesterase (AChE) inhibition." | 4.31 | (R,S)-trihexyphenidyl, acting via a muscarinic receptor-independent mechanism, inhibits hippocampal glutamatergic and GABAergic synaptic transmissions: Potential relevance for treatment of organophosphorus intoxication. ( Albuquerque, EX; Aracava, Y; Pereira, EFR, 2023) |
| " In contrast, benactyzine and trihexyphenidyl showed a third profile of activity: There was a smaller increase in drug dosage required for anticonvulsant activity as seizure duration increased, and both drugs could terminate seizures that had progressed for 40 min." | 1.29 | Pharmacological modulation of soman-induced seizures. ( McDonough, JH; Shih, TM, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (50.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aracava, Y | 1 |
| Albuquerque, EX | 1 |
| Pereira, EFR | 1 |
| Bamford, A | 1 |
| Crowe, BH | 1 |
| Hacohen, Y | 1 |
| Lin, JP | 1 |
| Clarke, A | 1 |
| Tudor-Williams, G | 1 |
| Sancho-Shimizu, V | 1 |
| Vincent, A | 1 |
| Lim, M | 1 |
| Pullaperuma, SP | 1 |
| Cousse, H | 1 |
| Mouzin, G | 1 |
| Bonnaud, B | 1 |
| Charveron, M | 1 |
| Stenger, A | 1 |
| Morre, M | 1 |
| Lauressergues, H | 1 |
| McDonough, JH | 1 |
| Shih, TM | 1 |
| Urbańska, E | 1 |
| Dziki, M | 1 |
| Czuczwar, SJ | 1 |
| Kleinrok, Z | 1 |
| Turski, WA | 1 |
| Lim, DK | 1 |
| Hoskins, B | 1 |
| Ho, IK | 1 |
| Beleslin, DB | 1 |
| Stefanović-Denić, K | 1 |
| Samardzić, R | 1 |
| Ursillo, RC | 1 |
| McCulloch, JA | 1 |
| Millichap, JG | 1 |
| Pitchford, GL | 1 |
| Millichap, MG | 1 |
| Madill, HD | 1 |
| Stewart, WC | 1 |
| Savoie, ML | 1 |
10 other studies available for trihexyphenidyl and Seizures
| Article | Year |
|---|---|
(R,S)-trihexyphenidyl, acting via a muscarinic receptor-independent mechanism, inhibits hippocampal glutamatergic and GABAergic synaptic transmissions: Potential relevance for treatment of organophosphorus intoxication.
Topics: Acetylcholinesterase; Animals; Atropine Derivatives; Hippocampus; Rats; Rats, Sprague-Dawley; Recept | 2023 |
Pediatric Herpes Simplex Virus Encephalitis Complicated by N-Methyl-D-aspartate Receptor Antibody Encephalitis.
Topics: Acyclovir; Anti-N-Methyl-D-Aspartate Receptor Encephalitis; Antiviral Agents; Autoantibodies; Clonid | 2015 |
[Phenothiazine carboxamides that have anticholinergic properties].
Topics: Animals; Behavior, Animal; Convulsants; Dogs; Mice; Nicotine; Parasympatholytics; Pentylenetetrazole | 1980 |
Pharmacological modulation of soman-induced seizures.
Topics: Animals; Anticonvulsants; Atropine; Behavior, Animal; Benactyzine; Diazepam; Dizocilpine Maleate; El | 1993 |
Antiparkinsonian drugs memantine and trihexyphenidyl potentiate the anticonvulsant activity of valproate against maximal electroshock-induced seizures.
Topics: Animals; Anticonvulsants; Antiparkinson Agents; Avoidance Learning; Drug Synergism; Electroshock; Ma | 1992 |
Trihexyphenidyl enhances physostigmine prophylaxis against soman poisoning in guinea pigs.
Topics: Animals; Body Weight; Brain; Drinking; Drug Interactions; Guinea Pigs; Kinetics; Lethal Dose 50; Mal | 1991 |
Comparative behavioral effects of anticholinergic agents in cats: psychomotor stimulation and aggression.
Topics: Aggression; Animals; Atropine; Autonomic Nervous System; Carbachol; Cats; Dose-Response Relationship | 1986 |
The effect of elantrine, a new anti-Parkinsonism agent, on drug-induced tremor in mice.
Topics: Alkaloids; Animals; Antiparkinson Agents; Atropine; Benztropine; Body Temperature; Central Nervous S | 1972 |
Anticonvulsant activity of antiparkinsonism agents.
Topics: Animals; Anticonvulsants; Child; Child, Preschool; Electroshock; Female; Glaucoma; Humans; Infant; M | 1968 |
Central and peripheral anticholinergic potency of some drugs antagonistic to anticholinesterase poisoning.
Topics: Animals; Antidotes; Atropine; Bradycardia; Carbachol; Central Nervous System; Cholinesterase Inhibit | 1968 |