trihexyphenidyl has been researched along with Drug Withdrawal Symptoms in 18 studies
Trihexyphenidyl: One of the centrally acting MUSCARINIC ANTAGONISTS used for treatment of PARKINSONIAN DISORDERS and drug-induced extrapyramidal movement disorders and as an antispasmodic.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 64-year-old woman with blepharospasm, sustained clenching of the jaw, antecollis, and a strained, high-pitched phonation continued chronic trihexyphenidyl therapy despite the lack of any obvious benefit." | 7.67 | Life-threatening cranial dystonia following trihexyphenidyl withdrawal. ( Giménez-Roldán, S; Martín, M; Mateo, D, 1989) |
| "A 64-year-old woman with blepharospasm, sustained clenching of the jaw, antecollis, and a strained, high-pitched phonation continued chronic trihexyphenidyl therapy despite the lack of any obvious benefit." | 3.67 | Life-threatening cranial dystonia following trihexyphenidyl withdrawal. ( Giménez-Roldán, S; Martín, M; Mateo, D, 1989) |
| "Acute withdrawal is therefore unjustified, but occasional revision of dosage of anti-Parkinsonian drugs is advisable." | 2.64 | Benzhexol and side effects with long-acting fluphenazine therapy. ( Crammer, JL; Grove, L, 1972) |
| " Hence we would advise that if for any reason anticholinergic drugs are to be withdrawn in patients receiving a stable dosage of levodopa this must be done slowly." | 2.64 | Levodopa in Parkinsonism: the effects of withdrawal of anticholinergic drugs. ( Hughes, RC; Polgar, JG; Walton, JN; Weightman, D, 1971) |
| " In a between-groups dosing design, five separate groups of rats received vehicle, clozapine 1." | 1.30 | Similarities and differences between the subchronic and withdrawal effects of clozapine and olanzapine on forelimb force steadiness. ( Fowler, SC; Stanford, JA, 1997) |
| "Development of neuroleptic malignant syndrome (NMS) following discontinuation of high-dose and high-potency neuroleptic agents is described." | 1.28 | Neuroleptic malignant syndrome during abrupt reduction of neuroleptic treatment. ( Hermesh, H; Munitz, H; Spivak, B; Tyano, S; Weizman, A; Wolovick, L, 1990) |
| " Of 24 placebo patients 9 left the study early because of adverse effects; none of the 8 patients in the antiparkinsonian group did so." | 1.26 | Adverse effects of antiparkinson drug withdrawal. ( Cole, JO; Gardos, G; Jellinek, T, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (66.67) | 18.7374 |
| 1990's | 5 (27.78) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guru, S | 1 |
| Vanamoorthy, U | 1 |
| Loganathan, S | 1 |
| Varghese, M | 1 |
| MUCKLOW, ES | 1 |
| METZ, HT | 1 |
| Jellinek, T | 1 |
| Gardos, G | 1 |
| Cole, JO | 1 |
| McInnis, M | 2 |
| Petursson, H | 2 |
| de Leon, J | 1 |
| Stanilla, JK | 1 |
| White, AO | 1 |
| Simpson, GM | 1 |
| Spivak, B | 2 |
| Gonen, N | 1 |
| Mester, R | 1 |
| Averbuch, E | 1 |
| Adlersberg, S | 1 |
| Weizman, A | 2 |
| Johkura, K | 1 |
| Matsumoto, S | 1 |
| Hasegawa, O | 1 |
| Kuroiwa, Y | 1 |
| Stanford, JA | 1 |
| Fowler, SC | 1 |
| Alpert, M | 1 |
| Diamond, F | 1 |
| Laski, EM | 1 |
| Wolovick, L | 1 |
| Hermesh, H | 1 |
| Tyano, S | 1 |
| Munitz, H | 1 |
| Giménez-Roldán, S | 1 |
| Mateo, D | 1 |
| Martín, M | 1 |
| Fisch, RZ | 1 |
| Keshavan, MS | 1 |
| Burton, S | 1 |
| Murphy, M | 1 |
| Checkley, SA | 1 |
| Crammer, JL | 2 |
| Grove, L | 1 |
| Pecknold, JC | 1 |
| Ananth, JV | 1 |
| Ban, TA | 1 |
| Lehmann, HE | 1 |
| Hughes, RC | 1 |
| Polgar, JG | 1 |
| Weightman, D | 1 |
| Walton, JN | 1 |
| Dusek, K | 1 |
| Janík, A | 1 |
3 trials available for trihexyphenidyl and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Withdrawal of trihexyphenidyl.
Topics: Adult; Anxiety; Basal Ganglia Diseases; Double-Blind Method; Female; Humans; Male; Middle Aged; Psyc | 1985 |
Benzhexol and side effects with long-acting fluphenazine therapy.
Topics: Administration, Oral; Adult; Aged; Basal Ganglia Diseases; Clinical Trials as Topic; Female; Fluphen | 1972 |
Levodopa in Parkinsonism: the effects of withdrawal of anticholinergic drugs.
Topics: Dihydroxyphenylalanine; Drug Synergism; Drug Tolerance; Female; Humans; Male; Methods; Neurologic Ma | 1971 |
15 other studies available for trihexyphenidyl and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Neuroleptic malignant syndrome following abrupt anti-cholinergic withdrawal: a case report.
Topics: Antipsychotic Agents; Cholinergic Antagonists; Female; Humans; Lorazepam; Neuroleptic Malignant Synd | 2014 |
REMARKABLE RESPONSE TO BENZHEXOL HYDRO-CHLORIDE (ARTANE) IN CHILDREN WITH AN UNUSUAL PROGRESSIVE STRIATAL SYNDROME: A REPORT ON 3 CASES.
Topics: Adolescent; Athetosis; Central Nervous System Diseases; Child; Corpus Striatum; Drug Therapy; Extrap | 1964 |
Adverse effects of antiparkinson drug withdrawal.
Topics: Antiparkinson Agents; Antipsychotic Agents; Benztropine; Biperiden; Double-Blind Method; Drug Therap | 1981 |
Trihexyphenidyl dependence.
Topics: Adult; Anxiety; Female; Humans; Male; Parkinson Disease, Secondary; Substance Withdrawal Syndrome; S | 1984 |
Anticholinergics to treat clozapine withdrawal.
Topics: Adult; Clozapine; Female; Humans; Male; Schizophrenia; Substance Withdrawal Syndrome; Trihexyphenidy | 1994 |
Neuroleptic malignant syndrome associated with abrupt withdrawal of anticholinergic agents.
Topics: Adult; Antipsychotic Agents; Delayed-Action Preparations; Fluphenazine; Humans; Male; Muscarinic Ant | 1996 |
Trihexyphenidyl withdrawal encephalopathy.
Topics: Brain; Brain Diseases; Electroencephalography; Female; Humans; Middle Aged; Substance Withdrawal Syn | 1997 |
Similarities and differences between the subchronic and withdrawal effects of clozapine and olanzapine on forelimb force steadiness.
Topics: Animals; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Benzodiazepines; Clozapine; | 1997 |
Anticholinergic exacerbation of phenothiazine-induced extrapyramidal syndrome.
Topics: Adult; Basal Ganglia Diseases; Chlorpromazine; Humans; Substance Withdrawal Syndrome; Trifluoperazin | 1976 |
Neuroleptic malignant syndrome during abrupt reduction of neuroleptic treatment.
Topics: Adolescent; Antipsychotic Agents; Chlorpromazine; Dose-Response Relationship, Drug; Drug Therapy, Co | 1990 |
Life-threatening cranial dystonia following trihexyphenidyl withdrawal.
Topics: Aged; Airway Obstruction; Blepharospasm; Deglutition Disorders; Dystonia; Female; Humans; Substance | 1989 |
Trihexyphenidyl abuse: therapeutic implications for negative symptoms of schizophrenia?
Topics: Adult; Borderline Personality Disorder; Dose-Response Relationship, Drug; Female; Hallucinations; Hu | 1987 |
Benzhexol withdrawal and cholinergic mechanisms in depression.
Topics: Adult; Cholinergic Fibers; Depression; Hallucinations; Humans; Male; Memory; Recurrence; Sleep Wake | 1985 |
Lack of indication for use of antiparkinson medication. A follow-up study.
Topics: Adolescent; Adult; Female; Follow-Up Studies; Humans; Intellectual Disability; Male; Mental Disorder | 1971 |
[Forms of dependency on psychopharmaceutic drugs and sleep disorders].
Topics: Humans; Mental Disorders; Sleep Wake Disorders; Substance Withdrawal Syndrome; Substance-Related Dis | 1968 |