trihexyphenidyl has been researched along with Childhood Torsion Disease in 14 studies
Trihexyphenidyl: One of the centrally acting MUSCARINIC ANTAGONISTS used for treatment of PARKINSONIAN DISORDERS and drug-induced extrapyramidal movement disorders and as an antispasmodic.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Trihexyphenidyl was less effective at enhancing dopamine release in Dyt1 mice relative to controls ex vivo (mean increase WT: 65% vs Dyt1: 35%)." | 1.51 | Trihexyphenidyl rescues the deficit in dopamine neurotransmission in a mouse model of DYT1 dystonia. ( Donsante, C; Downs, AM; Fan, X; Hess, EJ; Jinnah, HA, 2019) |
| "DYT1 early-onset generalized torsion dystonia is an inherited movement disorder associated with mutations in DYT1 that codes for torsinA protein." | 1.38 | An anticholinergic reverses motor control and corticostriatal LTD deficits in Dyt1 ΔGAG knock-in mice. ( Cheetham, CC; Dang, MT; Li, Y; Lovinger, DM; Lu, J; Vo, V; Yokoi, F, 2012) |
| "DYTI dystonia (DYT1-D, early-onset torsion dystonia) is caused by a GAG deletion in the DYTI gene." | 1.35 | [Case of DYT1 dystonia (early-onset torsion dystonia) showing long-term focal dystonia in the arm]. ( Hachimori, K; Hayashi, M; Kimura, K; Nagao, Y; Nomura, Y; Segawa, M, 2008) |
| "In older patients hemidystonia appeared within 6 months after injury." | 1.27 | Hemidystonia: a report of 22 patients and a review of the literature. ( Jankovic, J; Pettigrew, LC, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (64.29) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Downs, AM | 1 |
| Fan, X | 1 |
| Donsante, C | 1 |
| Jinnah, HA | 1 |
| Hess, EJ | 1 |
| Hayashi, M | 1 |
| Nagao, Y | 1 |
| Kimura, K | 1 |
| Hachimori, K | 1 |
| Nomura, Y | 1 |
| Segawa, M | 1 |
| Dang, MT | 1 |
| Yokoi, F | 1 |
| Cheetham, CC | 1 |
| Lu, J | 1 |
| Vo, V | 1 |
| Lovinger, DM | 1 |
| Li, Y | 1 |
| BURNS, C | 1 |
| CORNER, BD | 1 |
| Marsden, CD | 3 |
| Marion, MH | 1 |
| Quinn, N | 1 |
| Klostermann, W | 1 |
| Vieregge, P | 1 |
| Kömpf, D | 1 |
| Barbero-Aguirre, P | 1 |
| Allen, N | 1 |
| Knopp, W | 1 |
| Burke, RE | 2 |
| Fahn, S | 2 |
| Pettigrew, LC | 1 |
| Jankovic, J | 1 |
| Harrison, MJ | 1 |
| Guggenheim, MA | 1 |
| Dodge, PR | 1 |
1 trial available for trihexyphenidyl and Childhood Torsion Disease
| Article | Year |
|---|---|
Torsion dystonia: a double-blind, prospective trial of high-dosage trihexyphenidyl.
Topics: Adolescent; Adult; Child; Clinical Trials as Topic; Double-Blind Method; Dystonia Musculorum Deforma | 1986 |
13 other studies available for trihexyphenidyl and Childhood Torsion Disease
| Article | Year |
|---|---|
Trihexyphenidyl rescues the deficit in dopamine neurotransmission in a mouse model of DYT1 dystonia.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dystonia Musculorum Deformans; Gene Knoc | 2019 |
[Case of DYT1 dystonia (early-onset torsion dystonia) showing long-term focal dystonia in the arm].
Topics: Child; Drug Therapy, Combination; Dystonia Musculorum Deformans; Female; Gene Deletion; Genes, Domin | 2008 |
An anticholinergic reverses motor control and corticostriatal LTD deficits in Dyt1 ΔGAG knock-in mice.
Topics: Animals; Calcium Channel Agonists; Corpus Striatum; Disease Models, Animal; Dystonia Musculorum Defo | 2012 |
Clumsy children.
Topics: Child; Conversion Disorder; Dystonia Musculorum Deformans; Dystonic Disorders; Genetic Diseases, X-L | 1963 |
Dystonia musculorum deformans in siblings; treated with artane (trihexyphenidyl).
Topics: Dystonia Musculorum Deformans; Dystonic Disorders; Genetic Diseases, X-Linked; Humans; Siblings; Tri | 1952 |
The treatment of severe dystonia in children and adults.
Topics: Adolescent; Adult; Age Factors; Child; Drug Therapy, Combination; Dystonia Musculorum Deformans; Fem | 1984 |
Apraxia of eyelid opening after bilateral stereotaxic subthalamotomy.
Topics: Adult; Antiparkinson Agents; Apraxias; Blinking; Dystonia Musculorum Deformans; Eyelid Diseases; Hum | 1997 |
[Movement disorders: dystonias which are apparently psychosomatic. Torsion dystonias].
Topics: Antiparkinson Agents; Child; Diagnosis, Differential; Dystonia Musculorum Deformans; Humans; Levodop | 1999 |
Hereditary Parkinsonism-dystonia with sustained control by L-DOPA and anticholinergic medication.
Topics: Adolescent; Adult; Aged; Dopamine beta-Hydroxylase; Dystonia Musculorum Deformans; Female; Growth Ho | 1976 |
Serum trihexyphenidyl levels in the treatment of torsion dystonia.
Topics: Animals; Dystonia Musculorum Deformans; Male; Rats; Rats, Inbred Strains; Trihexyphenidyl | 1985 |
Hemidystonia: a report of 22 patients and a review of the literature.
Topics: Adolescent; Adult; Aged; Basal Ganglia Diseases; Brain Damage, Chronic; Brain Diseases; Brain Injuri | 1985 |
Idiopathic torsion dystonia (dystonia musculorum deformans). A review of forty-two patients.
Topics: Adolescent; Adult; Child; Child, Preschool; Chlorpromazine; Diagnostic Errors; Diazepam; Disability | 1974 |
Unusual arm movements with onset in childhood--a nosologic entity?
Topics: Child; Diagnosis, Differential; Diazepam; Dihydroxyphenylalanine; Diphenhydramine; Dystonia Musculor | 1970 |