trihexyphenidyl has been researched along with Cerebral Palsy in 19 studies
Trihexyphenidyl: One of the centrally acting MUSCARINIC ANTAGONISTS used for treatment of PARKINSONIAN DISORDERS and drug-induced extrapyramidal movement disorders and as an antispasmodic.
Cerebral Palsy: A heterogeneous group of nonprogressive motor disorders caused by chronic brain injuries that originate in the prenatal period, perinatal period, or first few years of life. The four major subtypes are spastic, athetoid, ataxic, and mixed cerebral palsy, with spastic forms being the most common. The motor disorder may range from difficulties with fine motor control to severe spasticity (see MUSCLE SPASTICITY) in all limbs. Spastic diplegia (Little disease) is the most common subtype, and is characterized by spasticity that is more prominent in the legs than in the arms. Pathologically, this condition may be associated with LEUKOMALACIA, PERIVENTRICULAR. (From Dev Med Child Neurol 1998 Aug;40(8):520-7)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Trihexyphenidyl alone is as effective as combination of gabapentin with trihexyphenidyl in decreasing the severity of dystonia at 12 wk." | 9.69 | Gabapentin as Add-on Therapy to Trihexyphenidyl in Children with Dyskinetic Cerebral Palsy: A Randomized, Controlled Trial. ( Dabla, S; Kumar, S; Shankar Kaushik, J; Verma, S, 2023) |
| "The aim of this study was to assess trihexyphenidyl in reducing overall dystonia, improving upper limb function, and achieving goals in children with dystonic cerebral palsy." | 9.14 | Pilot study on trihexyphenidyl in the treatment of dystonia in children with cerebral palsy. ( Rice, J; Waugh, MC, 2009) |
| "Although trihexyphenidyl is used clinically to treat both primary and secondary dystonia in children, limited evidence exists to support its effectiveness, particularly in dystonia secondary to disorders such as cerebral palsy." | 9.12 | Prospective open-label clinical trial of trihexyphenidyl in children with secondary dystonia due to cerebral palsy. ( Bastian, A; Brunstrom, J; Damiano, D; Delgado, M; Dure, L; Gaebler-Spira, D; Hoon, A; Mink, JW; Sanger, TD; Sherman-Levine, S; Welty, LJ, 2007) |
| "We included randomised controlled trials comparing oral trihexyphenidyl versus placebo for dystonia in cerebral palsy." | 8.98 | Trihexyphenidyl for dystonia in cerebral palsy. ( Baker, LB; Harvey, AR; Reddihough, DS; Scheinberg, A; Williams, K, 2018) |
| "Trihexyphenidyl significantly improved dystonia, motor function and development in children with dystonic cerebral palsy in this study." | 8.31 | Trihexyphenidyl in young children with dystonic cerebral palsy: A single arm study. ( Das, B; Juneja, M; Khanna, R; Khosla, M; Mishra, D; Rajkumar, L; Sairam, S; Ventatakrishnan, A, 2023) |
| " We report an unusual case of colonic pseudo-obstruction in an 8-year-old child with cerebral palsy and long-term hypomotility issues being treated for drooling with the anticholinergic medication trihexyphenidyl." | 7.81 | Acute colonic pseudo-obstruction in a child taking trihexyphenidyl for drooling: Prescribers beware. ( Begbie, F; Kubba, H; Sabharwal, A; Walker, G, 2015) |
| " This study sought to review the benefits and tolerability of trihexyphenidyl in children with cerebral palsy, treated for dystonia or sialorrhea or both in a pediatric tertiary care hospital, through a retrospective chart review." | 7.77 | Use of trihexyphenidyl in children with cerebral palsy. ( Carranza-del Rio, J; Clegg, NJ; Delgado, MR; Moore, A, 2011) |
| "There are conflicting reports regarding the efficacy of trihexyphenidyl, an anticholinergic drug, for treatment of dystonia in cerebral palsy." | 7.77 | Trihexyphenidyl improves motor function in children with dystonic cerebral palsy: a retrospective analysis. ( Ben-Pazi, H, 2011) |
| "Trihexyphenidyl (Artane) is a centrally active muscarinic antagonist commonly used to treat patients with generalized dystonia." | 7.71 | Age-dependent effects of trihexyphenidyl in extrapyramidal cerebral palsy. ( Freese, PO; Harryman, SE; Hoon, AH; Johnston, MV; Lawrie, WT; Pidcock, FS; Reinhardt, EM; Wilson, MA, 2001) |
| "Trihexyphenidyl alone is as effective as combination of gabapentin with trihexyphenidyl in decreasing the severity of dystonia at 12 wk." | 5.69 | Gabapentin as Add-on Therapy to Trihexyphenidyl in Children with Dyskinetic Cerebral Palsy: A Randomized, Controlled Trial. ( Dabla, S; Kumar, S; Shankar Kaushik, J; Verma, S, 2023) |
| "The aim of this study was to assess trihexyphenidyl in reducing overall dystonia, improving upper limb function, and achieving goals in children with dystonic cerebral palsy." | 5.14 | Pilot study on trihexyphenidyl in the treatment of dystonia in children with cerebral palsy. ( Rice, J; Waugh, MC, 2009) |
| "Although trihexyphenidyl is used clinically to treat both primary and secondary dystonia in children, limited evidence exists to support its effectiveness, particularly in dystonia secondary to disorders such as cerebral palsy." | 5.12 | Prospective open-label clinical trial of trihexyphenidyl in children with secondary dystonia due to cerebral palsy. ( Bastian, A; Brunstrom, J; Damiano, D; Delgado, M; Dure, L; Gaebler-Spira, D; Hoon, A; Mink, JW; Sanger, TD; Sherman-Levine, S; Welty, LJ, 2007) |
| "We included randomised controlled trials comparing oral trihexyphenidyl versus placebo for dystonia in cerebral palsy." | 4.98 | Trihexyphenidyl for dystonia in cerebral palsy. ( Baker, LB; Harvey, AR; Reddihough, DS; Scheinberg, A; Williams, K, 2018) |
| "Trihexyphenidyl significantly improved dystonia, motor function and development in children with dystonic cerebral palsy in this study." | 4.31 | Trihexyphenidyl in young children with dystonic cerebral palsy: A single arm study. ( Das, B; Juneja, M; Khanna, R; Khosla, M; Mishra, D; Rajkumar, L; Sairam, S; Ventatakrishnan, A, 2023) |
| " We report an unusual case of colonic pseudo-obstruction in an 8-year-old child with cerebral palsy and long-term hypomotility issues being treated for drooling with the anticholinergic medication trihexyphenidyl." | 3.81 | Acute colonic pseudo-obstruction in a child taking trihexyphenidyl for drooling: Prescribers beware. ( Begbie, F; Kubba, H; Sabharwal, A; Walker, G, 2015) |
| "In this study we evaluated a cohort of 47 patients affected by dyskinetic cerebral palsy and treated with anticholinergic drug (trihexyphenidyl) over one year in order to verify the responsiveness of the new scale." | 3.80 | Responsiveness of the MD-childhood rating scale in dyskinetic cerebral palsy patients undergoing anticholinergic treatment. ( Battini, R; Casarano, M; Cioni, G; Di Pietro, R; Mercuri, E; Olivieri, I; Romeo, DM; Sgandurra, G, 2014) |
| " This study sought to review the benefits and tolerability of trihexyphenidyl in children with cerebral palsy, treated for dystonia or sialorrhea or both in a pediatric tertiary care hospital, through a retrospective chart review." | 3.77 | Use of trihexyphenidyl in children with cerebral palsy. ( Carranza-del Rio, J; Clegg, NJ; Delgado, MR; Moore, A, 2011) |
| "There are conflicting reports regarding the efficacy of trihexyphenidyl, an anticholinergic drug, for treatment of dystonia in cerebral palsy." | 3.77 | Trihexyphenidyl improves motor function in children with dystonic cerebral palsy: a retrospective analysis. ( Ben-Pazi, H, 2011) |
| "Trihexyphenidyl (Artane) is a centrally active muscarinic antagonist commonly used to treat patients with generalized dystonia." | 3.71 | Age-dependent effects of trihexyphenidyl in extrapyramidal cerebral palsy. ( Freese, PO; Harryman, SE; Hoon, AH; Johnston, MV; Lawrie, WT; Pidcock, FS; Reinhardt, EM; Wilson, MA, 2001) |
| "Isolated dystonia or spasticity was infrequently seen, with a mixed picture of dystonia and spasticity ± choreoathetosis identified in 194/275 (70." | 1.51 | Pharmacological management of abnormal tone and movement in cerebral palsy. ( Amin, S; Basu, A; Cadwgan, J; Crowe, B; DeAlwis, Y; Devlin, A; Kumar, R; Lodh, R; Lumsden, DE; Lundy, CT; Mordekar, SR; Smith, M, 2019) |
| "Drooling is a common dysfunction in children with cerebral palsy and may also affect neurologically unimpaired children." | 1.35 | An evidence-based approach to the child who drools saliva. ( Hussain, SS; Kubba, H; Little, SA, 2009) |
| " Drooling was measured before treatment and then repeatedly until an optimal dosage of benzhexol hydrochloride was attained." | 1.28 | Use of benzhexol hydrochloride to control drooling of children with cerebral palsy. ( Exarchos, H; Hudson, I; Johnson, H; Reddihough, D; Staples, M, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.53) | 18.7374 |
| 1990's | 2 (10.53) | 18.2507 |
| 2000's | 5 (26.32) | 29.6817 |
| 2010's | 7 (36.84) | 24.3611 |
| 2020's | 3 (15.79) | 2.80 |
| Authors | Studies |
|---|---|
| Kumar, S | 1 |
| Shankar Kaushik, J | 1 |
| Verma, S | 1 |
| Dabla, S | 1 |
| Rajkumar, L | 1 |
| Ventatakrishnan, A | 1 |
| Sairam, S | 1 |
| Khosla, M | 1 |
| Khanna, R | 1 |
| Das, B | 1 |
| Mishra, D | 1 |
| Juneja, M | 1 |
| Bohn, E | 1 |
| Goren, K | 1 |
| Switzer, L | 1 |
| Falck-Ytter, Y | 1 |
| Fehlings, D | 1 |
| Harvey, AR | 1 |
| Baker, LB | 1 |
| Reddihough, DS | 1 |
| Scheinberg, A | 1 |
| Williams, K | 1 |
| Lumsden, DE | 1 |
| Crowe, B | 1 |
| Basu, A | 1 |
| Amin, S | 1 |
| Devlin, A | 1 |
| DeAlwis, Y | 1 |
| Kumar, R | 1 |
| Lodh, R | 1 |
| Lundy, CT | 1 |
| Mordekar, SR | 1 |
| Smith, M | 1 |
| Cadwgan, J | 1 |
| Battini, R | 1 |
| Casarano, M | 1 |
| Sgandurra, G | 1 |
| Olivieri, I | 1 |
| Di Pietro, R | 1 |
| Romeo, DM | 1 |
| Mercuri, E | 1 |
| Cioni, G | 1 |
| Begbie, F | 1 |
| Walker, G | 1 |
| Kubba, H | 2 |
| Sabharwal, A | 1 |
| Appendino, JP | 1 |
| Soman, T | 1 |
| Rice, J | 1 |
| Waugh, MC | 1 |
| Little, SA | 1 |
| Hussain, SS | 1 |
| De Rinaldis, M | 1 |
| Gennaro, L | 1 |
| Losito, L | 1 |
| Trabacca, A | 1 |
| Carranza-del Rio, J | 1 |
| Clegg, NJ | 1 |
| Moore, A | 1 |
| Delgado, MR | 1 |
| Ben-Pazi, H | 1 |
| LORBER, J | 1 |
| MELIN, KA | 1 |
| HERRLIN, KM | 1 |
| Sanger, TD | 1 |
| Bastian, A | 1 |
| Brunstrom, J | 1 |
| Damiano, D | 1 |
| Delgado, M | 1 |
| Dure, L | 1 |
| Gaebler-Spira, D | 1 |
| Hoon, A | 1 |
| Mink, JW | 1 |
| Sherman-Levine, S | 1 |
| Welty, LJ | 1 |
| Hoon, AH | 1 |
| Freese, PO | 1 |
| Reinhardt, EM | 1 |
| Wilson, MA | 1 |
| Lawrie, WT | 1 |
| Harryman, SE | 1 |
| Pidcock, FS | 1 |
| Johnston, MV | 1 |
| Deutsch, A | 1 |
| Eyma, J | 1 |
| Reddihough, D | 1 |
| Johnson, H | 1 |
| Staples, M | 1 |
| Hudson, I | 1 |
| Exarchos, H | 1 |
2 reviews available for trihexyphenidyl and Cerebral Palsy
| Article | Year |
|---|---|
Pharmacological and neurosurgical interventions for individuals with cerebral palsy and dystonia: a systematic review update and meta-analysis.
Topics: Baclofen; Botulinum Toxins; Cerebral Palsy; Clonidine; Deep Brain Stimulation; Dystonia; Humans; Inj | 2021 |
Trihexyphenidyl for dystonia in cerebral palsy.
Topics: Adolescent; Anti-Dyskinesia Agents; Cerebral Palsy; Child; Child, Preschool; Dystonia; Female; Human | 2018 |
3 trials available for trihexyphenidyl and Cerebral Palsy
| Article | Year |
|---|---|
Gabapentin as Add-on Therapy to Trihexyphenidyl in Children with Dyskinetic Cerebral Palsy: A Randomized, Controlled Trial.
Topics: Adolescent; Cerebral Palsy; Dystonia; Gabapentin; Humans; Trihexyphenidyl | 2023 |
Pilot study on trihexyphenidyl in the treatment of dystonia in children with cerebral palsy.
Topics: Adolescent; Cerebral Palsy; Child; Child, Preschool; Cross-Over Studies; Double-Blind Method; Dyston | 2009 |
Prospective open-label clinical trial of trihexyphenidyl in children with secondary dystonia due to cerebral palsy.
Topics: Adolescent; Cerebral Palsy; Child; Child, Preschool; Clinical Protocols; Dystonia; Female; Humans; M | 2007 |
14 other studies available for trihexyphenidyl and Cerebral Palsy
| Article | Year |
|---|---|
Trihexyphenidyl in young children with dystonic cerebral palsy: A single arm study.
Topics: Cerebral Palsy; Child; Child, Preschool; Dystonia; Dystonic Disorders; Humans; Infant; Motor Skills; | 2023 |
Pharmacological management of abnormal tone and movement in cerebral palsy.
Topics: Adolescent; Baclofen; Botulinum Toxins; Cerebral Palsy; Child; Child Health Services; Child, Prescho | 2019 |
Responsiveness of the MD-childhood rating scale in dyskinetic cerebral palsy patients undergoing anticholinergic treatment.
Topics: Adolescent; Age Factors; Analysis of Variance; Cerebral Palsy; Child; Child, Preschool; Cholinergic | 2014 |
Acute colonic pseudo-obstruction in a child taking trihexyphenidyl for drooling: Prescribers beware.
Topics: Cerebral Palsy; Child; Colonic Pseudo-Obstruction; Humans; Male; Muscarinic Antagonists; Sialorrhea; | 2015 |
Correspondence on "Prospective open-label clinical trial of trihexyphenidyl in children with secondary dystonia due to cerebral palsy".
Topics: Adolescent; Cerebral Palsy; Child; Child, Preschool; Clinical Trials as Topic; Dystonia; Humans; Ker | 2008 |
An evidence-based approach to the child who drools saliva.
Topics: Botulinum Toxins, Type A; Cerebral Palsy; Child; Cholinergic Antagonists; Evidence-Based Medicine; H | 2009 |
Drug-to-drug interaction between sodium valproate and trihexyphenidyl in a child with extrapyramidal cerebral palsy and epilepsy.
Topics: Anticonvulsants; Cerebral Palsy; Child, Preschool; Dose-Response Relationship, Drug; Drug Interactio | 2011 |
Use of trihexyphenidyl in children with cerebral palsy.
Topics: Adolescent; Age Factors; Cerebral Palsy; Child; Child, Preschool; Dystonia; Female; Humans; Infant; | 2011 |
Trihexyphenidyl improves motor function in children with dystonic cerebral palsy: a retrospective analysis.
Topics: Adolescent; Cerebral Palsy; Child; Child, Preschool; Female; Humans; Infant; Male; Motor Activity; M | 2011 |
A controlled investigation of artane in cerebral palsy.
Topics: Cerebral Palsy; Humans; Trihexyphenidyl | 1955 |
[Parpanit and artane as pediatric antispasmodics].
Topics: Cardiovascular Agents; Cerebral Palsy; Cyclopentanes; Muscle Relaxants, Central; Parasympatholytics; | 1952 |
Age-dependent effects of trihexyphenidyl in extrapyramidal cerebral palsy.
Topics: Age Factors; Arm; Cerebral Palsy; Child; Child, Preschool; Dystonia; Female; Humans; Infant; Linear | 2001 |
Massive ingestion of trihexyphenidyl.
Topics: Administration, Oral; Adult; Cerebral Palsy; Depressive Disorder; Drug Tolerance; Female; Humans; Se | 1992 |
Use of benzhexol hydrochloride to control drooling of children with cerebral palsy.
Topics: Cerebral Palsy; Child; Child, Preschool; Dose-Response Relationship, Drug; Education, Special; Femal | 1990 |