trigonelline has been researched along with Disease Models, Animal in 16 studies
trigonelline: in hydra among other organisms; RN given refers to hydroxide inner salt; structure
N-methylnicotinic acid : A pyridinium ion consisting of nicotinic acid having a methyl substituent on the pyridine nitrogen.
N-methylnicotinate : An iminium betaine that is the conjugate base of N-methylnicotinic acid, arising from deprotonation of the carboxy group.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These findings suggest that trigonelline protects diabetic pregnancy partly by suppressing inflammation, regulating the secretion of adipocytokines, increasing β-cell mass, replication, and decreasing β-cell apoptosis." | 7.85 | Trigonelline Inhibits Inflammation and Protects β Cells to Prevent Fetal Growth Restriction during Pregnancy in a Mouse Model of Diabetes. ( Du, XH; Qian, GS; Zhang, Z; Zhou, JY, 2017) |
| "Stroke is devastating with a limited choice of intervention." | 5.51 | Trigonelline therapy confers neuroprotection by reduced glutathione mediated myeloperoxidase expression in animal model of ischemic stroke. ( Bhattacharya, P; Borah, A; Dave, KR; Kalia, K; Kaur, H; Pravalika, K; Saraf, J; Sarmah, D; Vats, K; Wanve, M; Yavagal, DR, 2019) |
| " Trigonelline showed significant improvement and prevent the progression of osteoporosis by enhancing the BMD, restoring bone physiology." | 3.96 | Trigonelline Demonstrated Ameliorative Effects in Dexamethasone Induced Osteoporotic Rats. ( Akhtar, M; Ishaq, M; Najmi, AK; Rathi, A, 2020) |
| "These findings suggest that trigonelline protects diabetic pregnancy partly by suppressing inflammation, regulating the secretion of adipocytokines, increasing β-cell mass, replication, and decreasing β-cell apoptosis." | 3.85 | Trigonelline Inhibits Inflammation and Protects β Cells to Prevent Fetal Growth Restriction during Pregnancy in a Mouse Model of Diabetes. ( Du, XH; Qian, GS; Zhang, Z; Zhou, JY, 2017) |
| "Trigonelline (TRG) is a pyridine alkaloid that has various pharmacological effects including hypoglycemic, neuroprotective and memory-improving properties." | 1.56 | Trigonelline through the Attenuation of Oxidative Stress Exerts Antidepressant- and Anxiolytic-Like Effects in a Mouse Model of Maternal Separation Stress. ( Amini-Khoei, H; Bijad, E; Habibian Dehkordi, S; Lorigooini, Z; Sadeghi Dehsahraei, K, 2020) |
| "Stroke is devastating with a limited choice of intervention." | 1.51 | Trigonelline therapy confers neuroprotection by reduced glutathione mediated myeloperoxidase expression in animal model of ischemic stroke. ( Bhattacharya, P; Borah, A; Dave, KR; Kalia, K; Kaur, H; Pravalika, K; Saraf, J; Sarmah, D; Vats, K; Wanve, M; Yavagal, DR, 2019) |
| "Trigonelline is an alkaloid found in medicinal plants such as fenugreek seeds and coffee beans with neuroprotective potential and according to existing evidences, a favorable agent for treatment of neurodegenerative disorders." | 1.51 | Trigonelline protects hippocampus against intracerebral Aβ(1-40) as a model of Alzheimer's disease in the rat: insights into underlying mechanisms. ( Baluchnejadmojarad, T; Fahanik-Babaei, J; Nikbakht, F; Roghani, M, 2019) |
| "Trigonelline is an alkaloid with several therapeutic potential properties." | 1.51 | Inflammatory responses bridge comorbid cardiac disorder in experimental model of IBD induced by DSS: protective effect of the trigonelline. ( Amini-Khoei, H; Balali-Dehkordi, S; Lorigooini, Z; Omidi-Ardali, H; Soltani, A, 2019) |
| "Trigonelline (TRG) is a naturally occurring alkaloid, commonly isolated from fenugreek and coffee beans." | 1.48 | Trigonelline insulates against oxidative stress, proinflammatory cytokines and restores BDNF levels in lipopolysaccharide induced cognitive impairment in adult mice. ( Chowdhury, AA; Gawali, NB; Juvekar, AR; Munshi, R, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 10 (62.50) | 24.3611 |
| 2020's | 5 (31.25) | 2.80 |
| Authors | Studies |
|---|---|
| Zeng, WY | 1 |
| Tan, L | 1 |
| Han, C | 1 |
| Zheng, ZY | 1 |
| Wu, GS | 1 |
| Luo, HR | 1 |
| Li, SL | 1 |
| Lorigooini, Z | 2 |
| Sadeghi Dehsahraei, K | 1 |
| Bijad, E | 1 |
| Habibian Dehkordi, S | 1 |
| Amini-Khoei, H | 2 |
| Costa, MC | 1 |
| Lima, TFO | 1 |
| Arcaro, CA | 1 |
| Inacio, MD | 1 |
| Batista-Duharte, A | 1 |
| Carlos, IZ | 1 |
| Spolidorio, LC | 1 |
| Assis, RP | 1 |
| Brunetti, IL | 1 |
| Baviera, AM | 1 |
| Rathi, A | 1 |
| Ishaq, M | 1 |
| Najmi, AK | 1 |
| Akhtar, M | 1 |
| Farid, MM | 1 |
| Yang, X | 1 |
| Kuboyama, T | 1 |
| Tohda, C | 1 |
| Zhou, JY | 1 |
| Du, XH | 1 |
| Zhang, Z | 1 |
| Qian, GS | 1 |
| Mohamadi, N | 1 |
| Sharififar, F | 1 |
| Pournamdari, M | 1 |
| Ansari, M | 1 |
| Chowdhury, AA | 2 |
| Gawali, NB | 2 |
| Munshi, R | 1 |
| Juvekar, AR | 2 |
| Bulani, VD | 1 |
| Kothavade, PS | 1 |
| Mestry, SN | 1 |
| Deshpande, PS | 1 |
| Pravalika, K | 1 |
| Sarmah, D | 1 |
| Kaur, H | 1 |
| Vats, K | 1 |
| Saraf, J | 1 |
| Wanve, M | 1 |
| Kalia, K | 1 |
| Borah, A | 1 |
| Yavagal, DR | 1 |
| Dave, KR | 1 |
| Bhattacharya, P | 1 |
| Fahanik-Babaei, J | 1 |
| Baluchnejadmojarad, T | 1 |
| Nikbakht, F | 1 |
| Roghani, M | 1 |
| Omidi-Ardali, H | 1 |
| Soltani, A | 1 |
| Balali-Dehkordi, S | 1 |
| Ludwig, IA | 1 |
| Clifford, MN | 1 |
| Lean, ME | 1 |
| Ashihara, H | 1 |
| Crozier, A | 1 |
| Afifi, NA | 1 |
| Ramadan, A | 1 |
| Erian, EY | 1 |
| Saleh, DO | 1 |
| Sedik, AA | 1 |
| Badawi, M | 1 |
| El Hotaby, W | 1 |
| Hong, BN | 1 |
| Yi, TH | 1 |
| Park, R | 1 |
| Kim, SY | 1 |
| Kang, TH | 1 |
| Gaur, V | 1 |
| Bodhankar, SL | 1 |
| Mohan, V | 1 |
| Thakurdesai, PA | 1 |
2 reviews available for trigonelline and Disease Models, Animal
| Article | Year |
|---|---|
A Review on Biosynthesis, Analytical Techniques, and Pharmacological Activities of Trigonelline as a Plant Alkaloid.
Topics: Alkaloids; Animals; Anti-Infective Agents; Anticarcinogenic Agents; Antioxidants; Cardiovascular Dis | 2018 |
Coffee: biochemistry and potential impact on health.
Topics: Alkaloids; Animals; Antioxidants; Caffeine; Cardiovascular Diseases; Chlorogenic Acid; Coffee; Diabe | 2014 |
14 other studies available for trigonelline and Disease Models, Animal
| Article | Year |
|---|---|
Trigonelline Extends the Lifespan of
Topics: Aging; Alkaloids; AMP-Activated Protein Kinases; Animals; Animals, Genetically Modified; Caenorhabdi | 2021 |
Trigonelline through the Attenuation of Oxidative Stress Exerts Antidepressant- and Anxiolytic-Like Effects in a Mouse Model of Maternal Separation Stress.
Topics: Alkaloids; Animals; Anti-Anxiety Agents; Antidepressive Agents; Antioxidants; Anxiety; Behavior, Ani | 2020 |
Trigonelline and curcumin alone, but not in combination, counteract oxidative stress and inflammation and increase glycation product detoxification in the liver and kidney of mice with high-fat diet-induced obesity.
Topics: Alkaloids; Animals; Antioxidants; Biomarkers; Blood Glucose; Body Weight; Curcumin; Diet, High-Fat; | 2020 |
Trigonelline Demonstrated Ameliorative Effects in Dexamethasone Induced Osteoporotic Rats.
Topics: Alkaloids; Animals; Bone Density; Dexamethasone; Disease Models, Animal; Femur; Humans; Osteoporosis | 2020 |
Trigonelline recovers memory function in Alzheimer's disease model mice: evidence of brain penetration and target molecule.
Topics: Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Atroph | 2020 |
Trigonelline Inhibits Inflammation and Protects β Cells to Prevent Fetal Growth Restriction during Pregnancy in a Mouse Model of Diabetes.
Topics: Alkaloids; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; | 2017 |
Trigonelline insulates against oxidative stress, proinflammatory cytokines and restores BDNF levels in lipopolysaccharide induced cognitive impairment in adult mice.
Topics: Alkaloids; Animals; Antioxidants; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Cytokine | 2018 |
In vitro antiglycating effect and in vivo neuroprotective activity of Trigonelline in d-galactose induced cognitive impairment.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Br | 2018 |
Trigonelline therapy confers neuroprotection by reduced glutathione mediated myeloperoxidase expression in animal model of ischemic stroke.
Topics: Alkaloids; Aniline Compounds; Animals; Antioxidants; Blotting, Western; Brain Ischemia; Cerebral Inf | 2019 |
Trigonelline protects hippocampus against intracerebral Aβ(1-40) as a model of Alzheimer's disease in the rat: insights into underlying mechanisms.
Topics: Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Cytokines; Disease Model | 2019 |
Inflammatory responses bridge comorbid cardiac disorder in experimental model of IBD induced by DSS: protective effect of the trigonelline.
Topics: Alkaloids; Animals; Antioxidants; Colon; Comorbidity; Dextran Sulfate; Disease Models, Animal; Heart | 2019 |
Trigonelline attenuates hepatic complications and molecular alterations in high-fat high-fructose diet-induced insulin resistance in rats.
Topics: Alkaloids; Animals; Antioxidants; Biomarkers; Blood Glucose; Cytokines; Diet, Carbohydrate Loading; | 2017 |
Coffee improves auditory neuropathy in diabetic mice.
Topics: Acoustic Stimulation; Alkaloids; Animals; Auditory Pathways; Auditory Threshold; Caffeine; Cochlear | 2008 |
Neurobehavioral assessment of hydroalcoholic extract of Trigonella foenum-graecum seeds in rodent models of Parkinson's disease.
Topics: Administration, Oral; Alkaloids; Animals; Antiparkinson Agents; Chromatography, High Pressure Liquid | 2013 |