trigonelline has been researched along with Alloxan Diabetes in 13 studies
trigonelline: in hydra among other organisms; RN given refers to hydroxide inner salt; structure
N-methylnicotinic acid : A pyridinium ion consisting of nicotinic acid having a methyl substituent on the pyridine nitrogen.
N-methylnicotinate : An iminium betaine that is the conjugate base of N-methylnicotinic acid, arising from deprotonation of the carboxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These findings suggest that trigonelline protects diabetic pregnancy partly by suppressing inflammation, regulating the secretion of adipocytokines, increasing β-cell mass, replication, and decreasing β-cell apoptosis." | 7.85 | Trigonelline Inhibits Inflammation and Protects β Cells to Prevent Fetal Growth Restriction during Pregnancy in a Mouse Model of Diabetes. ( Du, XH; Qian, GS; Zhang, Z; Zhou, JY, 2017) |
| "These findings suggest that trigonelline protects diabetic pregnancy partly by suppressing inflammation, regulating the secretion of adipocytokines, increasing β-cell mass, replication, and decreasing β-cell apoptosis." | 3.85 | Trigonelline Inhibits Inflammation and Protects β Cells to Prevent Fetal Growth Restriction during Pregnancy in a Mouse Model of Diabetes. ( Du, XH; Qian, GS; Zhang, Z; Zhou, JY, 2017) |
| " However, to the best of our knowledge, no study has investigated the pharmacokinetic parameters of purified standardized T." | 1.72 | A novel UPLC-MS/MS method for simultaneous quantification of trigonelline, 4-hydroxyisoleucine, and diosgenin from Trigonella foenum-graecum extract: Application to pharmacokinetic study in healthy and type 2 diabetic rats. ( Banerjee, D; Dubey, SK; Katiyar, C; Krishna, KV; Narwaria, A; Taliyan, R; Tandon, N; Wadhwa, G; Yadav, SS, 2022) |
| "Trigonelline treatment restored the above mentioned parameters." | 1.48 | Trigonelline inhibits caspase 3 to protect β cells apoptosis in streptozotocin-induced type 1 diabetic mice. ( Du, X; Liu, L; Zhang, Z; Zhou, J, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 10 (76.92) | 24.3611 |
| 2020's | 2 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Wadhwa, G | 1 |
| Krishna, KV | 1 |
| Taliyan, R | 1 |
| Tandon, N | 1 |
| Yadav, SS | 1 |
| Banerjee, D | 1 |
| Narwaria, A | 1 |
| Katiyar, C | 1 |
| Dubey, SK | 1 |
| Gong, M | 1 |
| Guo, Y | 1 |
| Dong, H | 1 |
| Wu, W | 1 |
| Wu, F | 1 |
| Lu, F | 1 |
| Zhou, JY | 1 |
| Du, XH | 1 |
| Zhang, Z | 2 |
| Qian, GS | 1 |
| Vellai, RD | 1 |
| Chandiran, S | 1 |
| Pillai, SS | 1 |
| Castañeda, R | 1 |
| Rodriguez, I | 1 |
| Nam, YH | 1 |
| Hong, BN | 2 |
| Kang, TH | 2 |
| Liu, L | 1 |
| Du, X | 1 |
| Zhou, J | 2 |
| Hamden, K | 1 |
| Bengara, A | 1 |
| Amri, Z | 1 |
| Elfeki, A | 1 |
| Tharaheswari, M | 1 |
| Jayachandra Reddy, N | 1 |
| Kumar, R | 1 |
| Varshney, KC | 1 |
| Kannan, M | 1 |
| Sudha Rani, S | 1 |
| Folwarczna, J | 1 |
| Janas, A | 1 |
| Pytlik, M | 1 |
| Cegieła, U | 1 |
| Śliwiński, L | 1 |
| Krivošíková, Z | 1 |
| Štefíková, K | 1 |
| Gajdoš, M | 1 |
| Aldakinah, AA | 1 |
| Al-Shorbagy, MY | 1 |
| Abdallah, DM | 1 |
| El-Abhar, HS | 1 |
| Yi, TH | 1 |
| Park, R | 1 |
| Kim, SY | 1 |
| Zhou, S | 1 |
| Zeng, S | 1 |
| Ghule, AE | 1 |
| Jadhav, SS | 1 |
| Bodhankar, SL | 1 |
13 other studies available for trigonelline and Alloxan Diabetes
| Article | Year |
|---|---|
A novel UPLC-MS/MS method for simultaneous quantification of trigonelline, 4-hydroxyisoleucine, and diosgenin from Trigonella foenum-graecum extract: Application to pharmacokinetic study in healthy and type 2 diabetic rats.
Topics: Alkaloids; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diosgenin; Female; I | 2022 |
Trigonelline inhibits tubular epithelial-mesenchymal transformation in diabetic kidney disease via targeting Smad7.
Topics: Alkaloids; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Epithelial-Mesenchymal | 2023 |
Trigonelline Inhibits Inflammation and Protects β Cells to Prevent Fetal Growth Restriction during Pregnancy in a Mouse Model of Diabetes.
Topics: Alkaloids; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; | 2017 |
GTF-231, a Mixture of Gymnemic Acid, Trigonelline and Ferulic Acid Significantly Ameliorates Oxidative Stress in Experimental Type 2 Diabetes in Rats.
Topics: Alkaloids; Animals; Antioxidants; Blood Glucose; Coumaric Acids; Cytokines; Diabetes Mellitus, Exper | 2018 |
Trigonelline promotes auditory function through nerve growth factor signaling on diabetic animal models.
Topics: Alkaloids; Animals; Auditory Threshold; Carbazoles; Catalytic Domain; Computer Simulation; Diabetes | 2017 |
Trigonelline inhibits caspase 3 to protect β cells apoptosis in streptozotocin-induced type 1 diabetic mice.
Topics: Alkaloids; Animals; Blood Glucose; Body Weight; Caspase 3; Caspase Inhibitors; Cytoprotection; Diabe | 2018 |
Experimental diabetes treated with trigonelline: effect on key enzymes related to diabetes and hypertension, β-cell and liver function.
Topics: Alkaloids; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Glycated | 2013 |
Trigonelline and diosgenin attenuate ER stress, oxidative stress-mediated damage in pancreas and enhance adipose tissue PPARγ activity in type 2 diabetic rats.
Topics: Adipose Tissue; Alkaloids; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet | 2014 |
Effects of Trigonelline, an Alkaloid Present in Coffee, on Diabetes-Induced Disorders in the Rat Skeletal System.
Topics: Alkaloids; Animals; Biomarkers; Bone Density; Coffea; Diabetes Complications; Diabetes Mellitus, Exp | 2016 |
Trigonelline and vildagliptin antidiabetic effect: improvement of insulin signalling pathway.
Topics: Adamantane; Alkaloids; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabet | 2017 |
Coffee improves auditory neuropathy in diabetic mice.
Topics: Acoustic Stimulation; Alkaloids; Animals; Auditory Pathways; Auditory Threshold; Caffeine; Cochlear | 2008 |
Experimental diabetes treated with trigonelline: effect on β cell and pancreatic oxidative parameters.
Topics: Alkaloids; Animals; Antioxidants; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Diabe | 2013 |
Trigonelline ameliorates diabetic hypertensive nephropathy by suppression of oxidative stress in kidney and reduction in renal cell apoptosis and fibrosis in streptozotocin induced neonatal diabetic (nSTZ) rats.
Topics: Alkaloids; Animals; Animals, Newborn; Apoptosis; Blood Glucose; Diabetes Mellitus, Experimental; Dia | 2012 |