trifluridine has been researched along with Metastase in 54 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (1.85) | 29.6817 |
| 2010's | 29 (53.70) | 24.3611 |
| 2020's | 24 (44.44) | 2.80 |
| Authors | Studies |
|---|---|
| Barghout, V; Duh, MS; Germain, G; Jacques, P; Laliberté, F; Patel, AK; Yenikomshian, MA | 1 |
| Bekaii-Saab, T; Grothey, A; Marshall, JL | 1 |
| Li, J; Peng, Z; Shen, L; Wang, Q; Wang, X; Zhang, Q | 1 |
| Bando, H; Horasawa, S; Kaneko, A; Kawazoe, A; Kojima, T; Kotani, D; Kuboki, Y; Nakamura, Y; Shitara, K; Taniguchi, H; Tsuji, A; Yoshino, T | 1 |
| Amellal, NC; André, T; Falcone, A; Fougeray, R; Gandossi, E; Kanehisa, A; Saunders, M | 1 |
| Krogh, M; Möller, S; Petersen, LN; Pfeiffer, P; Poulsen, LØ; Qvortrup, C; Thomsen, KG; Winther, SB; Yilmaz, M; Zitnjak, D | 1 |
| Carter, AM; Iveson, T; Mullamitha, S; Shiu, KK; Spooner, C; Stevens, D | 1 |
| Borner, M; De Dosso, S; Meisel, A; Siebenhüner, A; Wagner, AD | 1 |
| Colaone, F; Hawkins, NS; Pollock, RF; Ross, PJ; Shergill, S; Walter, T | 1 |
| Bonetti, A; Giuliani, J | 1 |
| Funato, Y; Koyama, T; Muro, K; Ozawa, D; Tajiri, M; Uetake, H; Yamaguchi, Y; Yoshino, T | 1 |
| Kawakami, K; Nakashima, M; Takeuchi, M; Tanaka, S | 1 |
| Bendell, JC; Falchook, GS; Hamada, K; Makris, L; Patel, MR | 1 |
| Amellal, N; Ciardiello, F; Fakih, M; Fougeray, R; Leger, C; Prager, GW; Tabernero, J; Taieb, J; van Cutsem, E | 1 |
| Banzi, MC; Barone, CA; Bartolomeo, MD; Bergamo, F; Besse, MG; Blasi, L; Bordonaro, R; Costanzo, FD; Falcone, A; Frassineti, GL; Garufi, C; Giuliani, F; Latiano, TP; Martinelli, E; Personeni, N; Racca, P; Spione, M; Tamburini, E; Tonini, G; Zaniboni, A | 1 |
| Alsina, M; Ando, T; Arkenau, HT; Benhadji, KA; Beretta, GD; Cuffe, S; Doi, T; Dvorkin, M; Ilson, DH; Makris, L; Mansoor, W; Park, D; Shitara, K; Tabernero, J; Thuss-Patience, P; Van Cutsem, E; Van Den Eynde, M; Zaniboni, A | 1 |
| Ando, K; Fujimoto, Y; Kimura, Y; Kitao, H; Kotaka, M; Maehara, Y; Makiyama, A; Miyamoto, Y; Mori, M; Nakanishi, R; Oki, E; Qiu, S; Shimokawa, M | 1 |
| Enomoto, M; Ishizaki, T; Kasahara, K; Katsumata, K; Kawakita, H; Matsudo, T; Mazaki, J; Nagakawa, Y; Shigoka, M; Tsuchida, A | 1 |
| Denda, T; Esaki, T; Fukuoka, S; Hatachi, Y; Kajiwara, T; Kumekawa, Y; Makiyama, A; Masuishi, T; Moriwaki, T; Niisato, Y; Shimada, Y; Sugimoto, N; Suto, T; Takashima, A; Yamazaki, K | 1 |
| Ciardiello, F; Grothey, A; Marshall, JL | 1 |
| Marshall, JL | 1 |
| Bekaii-Saab, TS; Loupakis, F; Marshall, JL | 1 |
| Bekaii-Saab, TS; Grothey, A; Prager, GW; Yoshino, T | 1 |
| Ceribelli, A; Chilelli, MG; DE Marco, S; Gemma, D; Grande, R; Morandi, MG; Ruggeri, EM; Saltarelli, R; Signorelli, C; Sperduti, I; Spinelli, GP; Zoratto, F | 1 |
| Fukazawa, A; Hasegawa, S; Ihara, K; Ishibashi, K; Ishida, H; Kamiyama, H; Koda, K; Kosugi, C; Kuramochi, H; Matsuda, A; Sakamoto, K; Sonoda, H; Yamada, T; Yoshida, H; Yoshida, Y; Yoshimatsu, K | 1 |
| Hochster, HS; Larson, H; Minnella, A; White, T | 1 |
| Arnold, D; Hofheinz, RD; Kubicka, S; Vogel, A | 1 |
| Barzi, A; Berger, MD; Borelli, B; Cao, S; Dadduzio, V; Gopez, R; Lenz, HJ; Loupakis, F; Miyamoto, Y; Ning, Y; Okazaki, S; Pietrantonio, F; Salvatore, L; Schirripa, M; Suenaga, M; Yamaguchi, T; Yang, D; Zhang, W | 1 |
| Arnold, D; Moreno Vera, S; Mounedji, N; Prager, GW; Quintela, A; Stein, A; Taieb, J | 1 |
| Akiba, T; Ishida, K; Kawahara, H; Matsumoto, N; Mouri, T; Yanaga, K | 1 |
| Garcia-Carbonero, R; Martinez-Perez, J; Riesco-Martinez, MC | 1 |
| Aria, AB; Chen, L; Chon, SY; Glass, WF; Lahoti, A | 1 |
| Kimura, M; Teramachi, H; Usami, E; Yoshimura, T | 1 |
| Fukuoka, T; Hirakawa, K; Iseki, Y; Maeda, K; Matsutani, S; Nagahara, H; Ohira, M; Shibutani, M; Wang, EN | 1 |
| Candamio Folgar, S; Carmona Campos, M; Cousillas Castiñeiras, A; Covela Rúa, M; de la Cámara Gómez, J; Fernandez Montes, A; Gallardo Martín, E; García Gómez, J; Gonzalez Villarroel, P; Jorge Fernández, M; Martinez Lago, N; Méndez Méndez, JC; París Bouzas, L; Pellón Augusto, ML; Reboredo López, M; Salgado Fernández, M; Vazquez Rivera, F | 1 |
| Ahn, DH; Bekaii-Saab, T; Benkhadra, R; Firwana, B; Hubbard, JM; Mody, K; Murad, MH; Sonbol, MB; Walden, DJ; Wang, Z | 1 |
| Kawano, Y; Matsuda, A; Matsumoto, S; Sakurazawa, N; Sekiguchi, K; Shinozuka, E; Suzuki, H; Yamada, T; Yoshida, H | 1 |
| Benedetti, F; Boucher, E; Cleary, JM; Falcone, A; Garcia-Carbonero, R; Hochster, H; Ito, M; Komatsu, Y; Lenz, HJ; Makris, L; Mayer, RJ; Mizuguchi, H; Mizunuma, N; Ohtsu, A; Peeters, M; Prenen, H; Shimada, Y; Sobrero, A; Tabernero, J; Tran, B; Van Cutsem, E; Yamazaki, K; Yoshino, T; Zaniboni, A | 1 |
| Cleghorn, S | 1 |
| Boku, N; Doi, T; Fuse, N; Koizumi, W; Ohtsu, A; Shimada, K; Takinishi, Y; Yamazaki, K; Yoshino, T | 1 |
| Fujimoto, T; Katsube, T; Matsumoto, A; Nakayama, M; Naritaka, Y; Okayama, S; Sakuma, A; Satake, M; Shimakawa, T; Shiozawa, S; Usui, T; Yamaguchi, K; Yano, Y; Yokomizo, H; Yoshimatsu, K | 1 |
| Antoniotti, C; Cremolini, C; Falcone, A; Loupakis, F; Marmorino, F; Masi, G; Moretto, R; Rossini, D; Salvatore, L; Schirripa, M | 1 |
| Argiles, G; Elez, ME; Grasselli, J; Sanz-Garcia, E; Tabernero, J | 1 |
| Baba, H; Lenz, HJ; Miyamoto, Y | 1 |
| Goldberg, R | 1 |
| Falcone, A; Salvatore, L | 1 |
| Doki, Y; Haraguchi, N; Hata, T; Hayashi, T; Kudo, T; Mizushima, T; Mori, M; Nishimura, J; Sakai, D; Satoh, T; Sueda, T; Sugiura, T; Takahashi, H | 1 |
| Marshall, JL; Salem, ME; Weinberg, BA | 1 |
| Ando, M; Fukutomi, A; Hamauchi, S; Ishihara, M; Kadowaki, S; Kito, Y; Komori, A; Machida, N; Masuishi, T; Mori, K; Muro, K; Narita, Y; Onozawa, Y; Tajika, M; Tanaka, T; Taniguchi, H; Todaka, A; Tsushima, T; Ura, T; Yamazaki, K; Yasui, H; Yokota, T | 1 |
| Antonuzzo, L; Aprile, G; Baretti, M; Battaglin, F; Berenato, R; Beretta, G; Bozzarelli, S; Cinieri, S; Cremolini, C; de Braud, F; Falcone, A; Formica, V; Ghidini, M; Lonardi, S; Loupakis, F; Marmorino, F; Mennitto, A; Miceli, R; Morano, F; Mosconi, S; Petrelli, F; Pietrantonio, F; Rimassa, L; Rossini, D; Spada, D; Tamburini, E | 1 |
| Chu, E; Lee, JJ | 1 |
| Baba, H; Esaki, T; Hamada, C; Komatsu, Y; Mizunuma, N; Moriwaki, T; Muro, K; Nishina, T; Ohtsu, A; Sugimoto, N; Tanase, T; Tsuji, A; Tsuji, Y; Yamaguchi, K; Yamazaki, K; Yoshino, T | 1 |
| Emura, T; Fukushima, M; Kitazato, K; Murakami, Y; Nakagawa, F | 1 |
13 review(s) available for trifluridine and Metastase
| Article | Year |
|---|---|
Regorafenib, TAS-102, or fruquintinib for metastatic colorectal cancer: any difference in randomized trials?
Topics: Antineoplastic Agents; Benzofurans; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Disease Progression; Drug Combinations; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Network Meta-Analysis; Phenylurea Compounds; Progression-Free Survival; Pyridines; Pyrrolidines; Quinazolines; Randomized Controlled Trials as Topic; Thymine; Time Factors; Trifluridine; Uracil | 2020 |
Metastatic Colorectal Carcinoma after Second Progression and the Role of Trifluridine-Tipiracil (TAS-102) in Switzerland.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Disease Progression; Drug Combinations; Humans; Neoplasm Metastasis; Phenylurea Compounds; Pyridines; Pyrrolidines; Survival Rate; Switzerland; Thymine; Treatment Outcome; Trifluridine; Uracil | 2020 |
Systematic review and network meta-analyses of third-line treatments for metastatic colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; Colorectal Neoplasms; Double-Blind Method; Drug Combinations; Humans; Microspheres; Neoplasm Metastasis; Network Meta-Analysis; Palliative Care; Phenylurea Compounds; Progression-Free Survival; Pyridines; Pyrrolidines; Randomized Controlled Trials as Topic; Thymine; Trifluridine; Uracil; Yttrium Radioisotopes | 2020 |
Metastatic Colorectal Cancer: Management With Trifluridine/Tipiracil
.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Humans; Male; Middle Aged; Nausea; Neoplasm Metastasis; Trifluridine; Vomiting | 2017 |
Treatment decisions in metastatic colorectal cancer - Beyond first and second line combination therapies.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Disease-Free Survival; Female; Humans; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Staging; Phenylurea Compounds; Prognosis; Pyridines; Risk Assessment; Survival Analysis; Treatment Outcome; Trifluridine | 2017 |
Beyond second-line therapy in patients with metastatic colorectal cancer: a systematic review.
Topics: Colorectal Neoplasms; Disease Progression; Drug Combinations; Drugs, Investigational; Humans; Neoplasm Metastasis; Neoplasm Recurrence, Local; Phenylurea Compounds; Pyridines; Pyrrolidines; Thymine; Trifluridine; Uracil | 2018 |
The safety of trifluridine and tipiracil for the treatment of metastatic colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease-Free Survival; Drug Combinations; Humans; Molecular Targeted Therapy; Neoplasm Metastasis; Pyrrolidines; Survival Rate; Thymine; Treatment Outcome; Trifluridine; Uracil | 2018 |
A Systematic Review and Network Meta-Analysis of Regorafenib and TAS-102 in Refractory Metastatic Colorectal Cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Combinations; Drug Resistance, Neoplasm; Humans; Neoplasm Metastasis; Phenylurea Compounds; Pyridines; Pyrrolidines; Randomized Controlled Trials as Topic; Survival Rate; Thymine; Treatment Outcome; Trifluridine; Uracil | 2019 |
TAS-102 for the treatment of metastatic colorectal cancer.
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Combinations; Humans; Neoplasm Metastasis; Prognosis; Pyrrolidines; Survival Rate; Thymine; Trifluridine; Uracil | 2015 |
Current and advancing treatments for metastatic colorectal cancer.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Camptothecin; Colorectal Neoplasms; Drug Combinations; ErbB Receptors; Humans; Irinotecan; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Panitumumab; Pyrrolidines; Ramucirumab; Receptors, Vascular Endothelial Growth Factor; Recombinant Fusion Proteins; Therapies, Investigational; Thymine; Trifluridine; Uracil; Vascular Endothelial Growth Factor A | 2016 |
A novel antimetabolite: TAS-102 for metastatic colorectal cancer.
Topics: Animals; Antineoplastic Agents; Colorectal Neoplasms; Disease-Free Survival; Drug Combinations; Humans; Neoplasm Metastasis; Pyrrolidines; Randomized Controlled Trials as Topic; Survival Rate; Thymine; Trifluridine; Uracil | 2016 |
Trifluridine/tipiracil and regorafenib: new weapons in the war against metastatic colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colorectal Neoplasms; Humans; Neoplasm Metastasis; Phenylurea Compounds; Pyridines; Treatment Outcome; Trifluridine | 2016 |
Adherence, Dosing, and Managing Toxicities With Trifluridine/Tipiracil (TAS-102).
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Combinations; Humans; Medication Adherence; Neoplasm Metastasis; Pyrrolidines; Thymine; Trifluridine; Uracil | 2017 |
14 trial(s) available for trifluridine and Metastase
| Article | Year |
|---|---|
Retrospective cohort study of trifluridine/tipiracil (TAS-102) plus bevacizumab versus trifluridine/tipiracil monotherapy for metastatic colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Colorectal Neoplasms; Disease-Free Survival; Drug Combinations; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Pyrrolidines; Retrospective Studies; Thymine; Trifluridine; Uracil; Young Adult | 2019 |
First-line trifluridine/tipiracil plus bevacizumab for unresectable metastatic colorectal cancer: SOLSTICE study design.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Clinical Protocols; Colorectal Neoplasms; Drug Combinations; Female; Humans; Male; Neoplasm Metastasis; Neoplasm Staging; Pyrrolidines; Research Design; Thymine; Trifluridine; Uracil | 2020 |
TAS-102 with or without bevacizumab in patients with chemorefractory metastatic colorectal cancer: an investigator-initiated, open-label, randomised, phase 2 trial.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Colorectal Neoplasms; Drug Combinations; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Prognosis; Pyrrolidines; Salvage Therapy; Survival Rate; Thymine; Trifluridine; Uracil | 2020 |
A phase 2 trial of trifluridine/tipiracil plus nivolumab in patients with heavily pretreated microsatellite-stable metastatic colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Combinations; Drug Resistance, Neoplasm; Female; Humans; Male; Microsatellite Repeats; Middle Aged; Neoplasm Metastasis; Nivolumab; Pyrrolidines; Survival Rate; Thymine; Trifluridine | 2021 |
Trifluridine/tipiracil plus bevacizumab for third-line management of metastatic colorectal cancer: SUNLIGHT study design.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Drug Combinations; Female; Humans; Male; Middle Aged; Multicenter Studies as Topic; Neoplasm Metastasis; Pyrrolidines; Randomized Controlled Trials as Topic; Thymine; Trifluridine; Young Adult | 2021 |
Italian results of the PRECONNECT study: safety and efficacy of trifluridine/tipiracil in metastatic colorectal cancer.
Topics: Aged; Colorectal Neoplasms; Drug Combinations; Female; Follow-Up Studies; Humans; International Agencies; Italy; Male; Middle Aged; Neoplasm Metastasis; Prognosis; Pyrrolidines; Quality of Life; Survival Rate; Thymine; Trifluridine | 2021 |
Trifluridine/tipiracil in patients with metastatic gastroesophageal junction cancer: a subgroup analysis from the phase 3 TAGS study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Esophagogastric Junction; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Proportional Hazards Models; Pyrrolidines; Stomach Neoplasms; Survival Rate; Thymine; Treatment Outcome; Trifluridine; Young Adult | 2021 |
Monitoring FTD in the peripheral blood mononuclear cells of elderly patients with metastatic colorectal cancer administered FTD plus bevacizumab as first-line treatment.
Topics: Administration, Intravenous; Administration, Oral; Aged; Aged, 80 and over; Bevacizumab; Colorectal Neoplasms; DNA, Neoplasm; Drug Administration Schedule; Drug Combinations; Female; Humans; Leukocytes, Mononuclear; Male; Neoplasm Metastasis; Pyrrolidines; ROC Curve; Thymine; Trifluridine | 2021 |
Prospective Multicenter Phase II Study of Biweekly TAS-102 and Bevacizumab for Metastatic Colorectal Cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Chemotherapy-Induced Febrile Neutropenia; Colorectal Neoplasms; Drug Administration Schedule; Drug Combinations; Female; Humans; Japan; Male; Middle Aged; Neoplasm Metastasis; Pyrrolidines; Survival Analysis; Thymine; Treatment Outcome; Trifluridine | 2021 |
Randomized trial of TAS-102 for refractory metastatic colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Double-Blind Method; Drug Combinations; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Proportional Hazards Models; Pyrrolidines; Survival Analysis; Thymine; Trifluridine; Uracil | 2015 |
TAS-102 for metastatic refractory colorectal cancer.
Topics: Colorectal Neoplasms; Disease-Free Survival; Drug Combinations; Female; Humans; Male; Neoplasm Metastasis; Neoplasm Staging; Prognosis; Pyrrolidines; Risk Assessment; Survival Analysis; Thymine; Treatment Outcome; Trifluridine; Uracil | 2015 |
Phase I study of TAS-102 and irinotecan combination therapy in Japanese patients with advanced colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Camptothecin; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Combinations; Female; Glucuronosyltransferase; Humans; Irinotecan; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Metastasis; Polymorphism, Genetic; Proto-Oncogene Proteins p21(ras); Pyrrolidines; Thymine; Trifluridine; Uracil | 2015 |
Estimating 12-week death probability in patients with refractory metastatic colorectal cancer: the Colon Life nomogram.
Topics: Aged; Colon; Colorectal Neoplasms; Cost-Benefit Analysis; Disease-Free Survival; Drug Combinations; Female; Humans; Logistic Models; Male; Middle Aged; Neoplasm Metastasis; Nomograms; Phenylurea Compounds; Prognosis; Proportional Hazards Models; Pyridines; Pyrrolidines; Thymine; Trifluridine; Uracil | 2017 |
TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial.
Topics: Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Double-Blind Method; Drug Combinations; Female; Humans; Male; Middle Aged; Mutation; Neoplasm Metastasis; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Pyrrolidines; ras Proteins; Thymine; Trifluridine; Uracil | 2012 |
27 other study(ies) available for trifluridine and Metastase
| Article | Year |
|---|---|
Real-World Adherence in Patients with Metastatic Colorectal Cancer Treated with Trifluridine plus Tipiracil or Regorafenib.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cohort Studies; Colorectal Neoplasms; Drug Combinations; Female; Humans; Longitudinal Studies; Male; Medication Adherence; Middle Aged; Neoplasm Metastasis; Phenylurea Compounds; Pyridines; Pyrrolidines; Retrospective Studies; Thymine; Trifluridine | 2020 |
Sequencing beyond the second-line setting in metastatic colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Combinations; Humans; Neoplasm Metastasis; Phenylurea Compounds; Prognosis; Pyridines; Pyrrolidines; Salvage Therapy; Survival Rate; Thymine; Trifluridine; Uracil | 2019 |
Review of metastatic colorectal cancer treatment pathways and early clinical experience of trifluridine/tipiracil in the UK named patient programme.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Disease Progression; Drug Combinations; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Organoplatinum Compounds; Pyrrolidines; Thymine; Treatment Outcome; Trifluridine; United Kingdom; Uracil | 2020 |
Trifluridine/Tipiracil in heavily pretreated metastatic gastric cancer. A perspective based on pharmacological costs.
Topics: Drug Combinations; Drug Costs; Humans; Neoplasm Metastasis; Pyrrolidines; Stomach Neoplasms; Thymine; Trifluridine | 2020 |
Post-marketing surveillance study of trifluridine/tipiracil in patients with metastatic colorectal cancer.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Combinations; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Product Surveillance, Postmarketing; Pyrrolidines; Thymine; Trifluridine; Young Adult | 2021 |
Salvage Therapy After Regorafenib or Trifluridine/Tipiracil Treatment of Metastatic Colorectal Cancer: A Conditional Landmark Analysis.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Combinations; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Phenylurea Compounds; Pyridines; Pyrrolidines; Retrospective Studies; Salvage Therapy; Survival Analysis; Thymine; Treatment Outcome; Trifluridine | 2021 |
Clinical Outcomes Following Trifluridine/Tipiracil Treatment for Patients With Metastatic Colorectal Cancer Ineligible for Regorafenib Treatment.
Topics: Adenocarcinoma; Adult; Aged; Colorectal Neoplasms; Comorbidity; Drug Combinations; Female; Humans; Japan; Male; Middle Aged; Neoplasm Metastasis; Patient Selection; Phenylurea Compounds; Progression-Free Survival; Pyridines; Pyrrolidines; Retrospective Studies; Salvage Therapy; Survival Analysis; Thymine; Treatment Outcome; Trifluridine | 2021 |
How to incorporate a chemo-free interval into the management of metastatic colorectal cancer.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; COVID-19; Disease Management; Drug Combinations; Humans; Neoplasm Metastasis; Phenylurea Compounds; Pyridines; Pyrrolidines; Quality of Life; Thymine; Time Factors; Trifluridine | 2020 |
Third-line treatments for the management of metastatic colorectal cancer: why to change the mechanism of action after frontline chemotherapy, and insights into management during the COVID-19 pandemic.
Topics: Antineoplastic Agents; Clinical Trials as Topic; Colorectal Neoplasms; COVID-19; Disease Management; Drug Combinations; ErbB Receptors; Humans; Neoplasm Metastasis; Phenylurea Compounds; Protein Kinase Inhibitors; Pyridines; Pyrrolidines; Thymine; Trifluridine | 2020 |
Transitioning from second-line to third-line therapy in metastatic colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Decision-Making; Colorectal Neoplasms; Disease Management; Drug Combinations; Humans; Neoplasm Metastasis; Palliative Care; Phenylurea Compounds; Pyridines; Pyrrolidines; Thymine; Trifluridine | 2021 |
Optimizing the treatment sequence from second-line to third-line therapy in patients with metastatic colorectal cancer.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease Management; Disease Progression; Drug Combinations; Humans; Neoplasm Metastasis; Phenylurea Compounds; Progression-Free Survival; Pyridines; Pyrrolidines; Thymine; Trifluridine | 2020 |
Regorafenib-to-trifluridine/tipiracil Versus the Reverse Sequence for Refractory Metastatic Colorectal Cancer Patients: A Multicenter Retrospective Real-life Experience.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Administration Schedule; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Metastasis; Phenylurea Compounds; Progression-Free Survival; Pyridines; Pyrrolidines; Thymine; Trifluridine | 2021 |
The Pre-treatment Lymphocyte-to-Monocyte Ratio Predicts Efficacy in Metastatic Colorectal Cancer Treated With TAS-102 and Bevacizumab.
Topics: Aged; Antineoplastic Agents, Immunological; Bevacizumab; Colorectal Neoplasms; Drug Combinations; Female; Humans; Lymphocytes; Male; Middle Aged; Monocytes; Neoplasm Metastasis; Pyrrolidines; Thymine; Trifluridine | 2021 |
Potential role of polymorphisms in the transporter genes ENT1 and MATE1/OCT2 in predicting TAS-102 efficacy and toxicity in patients with refractory metastatic colorectal cancer.
Topics: Antineoplastic Agents; California; Colorectal Neoplasms; Disease-Free Survival; Drug Combinations; Equilibrative Nucleoside Transporter 1; Female; Gene Frequency; Genotype; Humans; Italy; Japan; Male; Neoplasm Metastasis; Organic Cation Transport Proteins; Organic Cation Transporter 2; Pharmacogenetics; Pharmacogenomic Testing; Pharmacogenomic Variants; Phenotype; Polymorphism, Single Nucleotide; Predictive Value of Tests; Pyrrolidines; Retrospective Studies; Thymine; Treatment Outcome; Trifluridine; Uracil | 2017 |
Usefulness of TAS-102 as Third-line Chemotherapy for Metastatic Colorectal Cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Drug Combinations; Feasibility Studies; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Pyrrolidines; Retrospective Studies; Salvage Therapy; Survival Analysis; Thymine; Treatment Outcome; Trifluridine; Uracil | 2018 |
Leukocytoclastic vasculitis with late-onset Henoch-Schönlein purpura after trifluridine/tipiracil treatment.
Topics: Adult; Appendiceal Neoplasms; Fatal Outcome; Glomerulonephritis; Humans; IgA Vasculitis; Kidney Failure, Chronic; Male; Neoplasm Metastasis; Pyrrolidines; Thymine; Trifluridine; Vasculitis, Leukocytoclastic, Cutaneous | 2018 |
Evaluation of Tolerability of Trifluridine/Tipiracil Combination Tablet in Patients With Advanced/Recurrent Colorectal Cancer.
Topics: Adult; Aged; Aged, 80 and over; Anemia; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Combinations; Female; Humans; Male; Middle Aged; Nausea; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neutropenia; Pyrrolidines; Retrospective Studies; Tablets; Thymine; Treatment Outcome; Trifluridine; Uracil | 2019 |
Prognostic Significance of the C-Reactive Protein-to-Albumin Ratio in Patients With Metastatic Colorectal Cancer Treated With Trifluridine/Thymidine Phosphorylase Inhibitor as Later-line Chemotherapy.
Topics: Aged; Albumins; Antineoplastic Agents; C-Reactive Protein; Colorectal Neoplasms; Disease Progression; Disease-Free Survival; Female; Humans; Inflammation; Kaplan-Meier Estimate; L-Lactate Dehydrogenase; Male; Middle Aged; Neoplasm Metastasis; Prognosis; Retrospective Studies; ROC Curve; Sensitivity and Specificity; Thymidine Phosphorylase; Treatment Outcome; Trifluridine | 2019 |
Efficacy and safety of trifluridine/tipiracil in third-line and beyond for the treatment of patients with metastatic colorectal cancer in routine clinical practice: patterns of use and prognostic nomogram.
Topics: Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Drug Combinations; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Nomograms; Prognosis; Progression-Free Survival; Pyrrolidines; Response Evaluation Criteria in Solid Tumors; Retrospective Studies; Spain; Survival Rate; Thymine; Trifluridine; Uracil | 2020 |
Pretreatment Neutrophil-to-Lymphocyte Ratio Predicts Survival After TAS-102 Treatment of Patients With Metastatic Colorectal Cancer.
Topics: Aged; Aged, 80 and over; Biomarkers, Tumor; Colorectal Neoplasms; Drug Combinations; Female; Humans; Leukocyte Count; Lymphocyte Count; Lymphocytes; Male; Middle Aged; Neoplasm Metastasis; Neutrophils; Platelet Count; Prognosis; Progression-Free Survival; Pyrrolidines; Retrospective Studies; Thymine; Trifluridine; Uracil | 2019 |
[Short-Term Outcome of TAS-102 for Refractory Metastatic Colorectal Cancer].
Topics: Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Drug Combinations; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Pyrrolidines; Retrospective Studies; Salvage Therapy; Thymine; Treatment Outcome; Trifluridine; Uracil | 2015 |
Emerging phase 3 data in relapsed/refractory metastatic colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Drug Combinations; Drug Resistance, Neoplasm; Humans; Molecular Targeted Therapy; Neoplasm Metastasis; Neoplasm Recurrence, Local; Phenylurea Compounds; Pyridines; Pyrrolidines; Retreatment; Thymine; Treatment Outcome; Trifluridine; Uracil | 2016 |
In brief: trifluridine/tipiracil (Lonsurf) for metastatic colorectal cancer.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Combinations; Enzyme Inhibitors; Humans; Neoplasm Metastasis; Pyrrolidines; Thymidine Phosphorylase; Thymine; Treatment Outcome; Trifluridine; Uracil | 2016 |
An interview with Alfredo Falcone and Lisa Salvatore: RECOURSE and trifluridine/tipiracil in metastatic colorectal cancer.
Topics: Achievement; Antineoplastic Combined Chemotherapy Protocols; Career Choice; Clinical Trials as Topic; Colorectal Neoplasms; Disease Management; Drug Discovery; Humans; Neoplasm Metastasis; Neoplasm Staging; Pyrrolidines; Research; Thymine; Treatment Outcome; Trifluridine | 2016 |
Efficacy and Safety of Regorafenib or TAS-102 in Patients with Metastatic Colorectal Cancer Refractory to Standard Therapies.
Topics: Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Disease-Free Survival; Drug Combinations; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Phenylurea Compounds; Pyridines; Pyrrolidines; Randomized Controlled Trials as Topic; Thymine; Treatment Outcome; Trifluridine; Uracil | 2016 |
Regorafenib Versus Trifluridine/Tipiracil for Refractory Metastatic Colorectal Cancer: A Retrospective Comparison.
Topics: Aged; Antineoplastic Agents; Cohort Studies; Colorectal Neoplasms; Disease-Free Survival; Drug Combinations; Female; Humans; Japan; Male; Middle Aged; Neoplasm Metastasis; Phenylurea Compounds; Pyridines; Pyrrolidines; Retrospective Studies; Survival Rate; Thymine; Treatment Outcome; Trifluridine; Uracil | 2017 |
A novel antimetabolite, TAS-102 retains its effect on FU-related resistant cancer cells.
Topics: Animals; Antimetabolites; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colorectal Neoplasms; Coloring Agents; Drug Combinations; Drug Resistance, Neoplasm; Fluorouracil; Globins; Humans; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Models, Chemical; Neoplasm Metastasis; Neoplasm Transplantation; Polymerase Chain Reaction; Pyrrolidines; Sensitivity and Specificity; Tetrazolium Salts; Thiazoles; Thymidine Phosphorylase; Thymine; Trifluridine; Uracil | 2004 |