trifluoperazine has been researched along with Subarachnoid Hemorrhage in 2 studies
Subarachnoid Hemorrhage: Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The prophylactic and therapeutic effectiveness of a potent calmodulin antagonist, the phenothiazine compound trifluoperazine (TFP), was investigated in vivo over a wide range of doses in the well-documented "double-subarachnoid hemorrhage" canine model of cerebral vasospasm." | 7.67 | The calmodulin antagonist trifluoperazine provides mild prophylactic protection against cerebral vasospasm after subarachnoid hemorrhage, but no therapeutic value. ( Candia, G; Peterson, JW; Spanos, AJ; Zervas, NT, 1989) |
| " The prophylactic and therapeutic effectiveness of a potent calmodulin antagonist, the phenothiazine compound trifluoperazine (TFP), was investigated in vivo over a wide range of doses in the well-documented "double-subarachnoid hemorrhage" canine model of cerebral vasospasm." | 3.67 | The calmodulin antagonist trifluoperazine provides mild prophylactic protection against cerebral vasospasm after subarachnoid hemorrhage, but no therapeutic value. ( Candia, G; Peterson, JW; Spanos, AJ; Zervas, NT, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nishizawa, S | 1 |
| Peterson, JW | 2 |
| Shimoyama, I | 1 |
| Uemura, K | 1 |
| Candia, G | 1 |
| Spanos, AJ | 1 |
| Zervas, NT | 1 |
2 other studies available for trifluoperazine and Subarachnoid Hemorrhage
| Article | Year |
|---|---|
Relation between protein kinase C and calmodulin systems in cerebrovascular contraction: investigation of the pathogenesis of vasospasm after subarachnoid hemorrhage.
Topics: Animals; Basilar Artery; Brain; Calmodulin; Chlorpromazine; Dogs; Dose-Response Relationship, Drug; | 1992 |
The calmodulin antagonist trifluoperazine provides mild prophylactic protection against cerebral vasospasm after subarachnoid hemorrhage, but no therapeutic value.
Topics: Animals; Dogs; Ischemic Attack, Transient; Subarachnoid Hemorrhage; Trifluoperazine | 1989 |