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trifluoperazine and Subarachnoid Hemorrhage

trifluoperazine has been researched along with Subarachnoid Hemorrhage in 2 studies

Subarachnoid Hemorrhage: Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.

Research Excerpts

ExcerptRelevanceReference
" The prophylactic and therapeutic effectiveness of a potent calmodulin antagonist, the phenothiazine compound trifluoperazine (TFP), was investigated in vivo over a wide range of doses in the well-documented "double-subarachnoid hemorrhage" canine model of cerebral vasospasm."7.67The calmodulin antagonist trifluoperazine provides mild prophylactic protection against cerebral vasospasm after subarachnoid hemorrhage, but no therapeutic value. ( Candia, G; Peterson, JW; Spanos, AJ; Zervas, NT, 1989)
" The prophylactic and therapeutic effectiveness of a potent calmodulin antagonist, the phenothiazine compound trifluoperazine (TFP), was investigated in vivo over a wide range of doses in the well-documented "double-subarachnoid hemorrhage" canine model of cerebral vasospasm."3.67The calmodulin antagonist trifluoperazine provides mild prophylactic protection against cerebral vasospasm after subarachnoid hemorrhage, but no therapeutic value. ( Candia, G; Peterson, JW; Spanos, AJ; Zervas, NT, 1989)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19901 (50.00)18.7374
1990's1 (50.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nishizawa, S1
Peterson, JW2
Shimoyama, I1
Uemura, K1
Candia, G1
Spanos, AJ1
Zervas, NT1

Other Studies

2 other studies available for trifluoperazine and Subarachnoid Hemorrhage

ArticleYear
Relation between protein kinase C and calmodulin systems in cerebrovascular contraction: investigation of the pathogenesis of vasospasm after subarachnoid hemorrhage.
    Neurosurgery, 1992, Volume: 31, Issue:4

    Topics: Animals; Basilar Artery; Brain; Calmodulin; Chlorpromazine; Dogs; Dose-Response Relationship, Drug;

1992
The calmodulin antagonist trifluoperazine provides mild prophylactic protection against cerebral vasospasm after subarachnoid hemorrhage, but no therapeutic value.
    Neurosurgery, 1989, Volume: 25, Issue:6

    Topics: Animals; Dogs; Ischemic Attack, Transient; Subarachnoid Hemorrhage; Trifluoperazine

1989