trifluoperazine has been researched along with Pancreatic Neoplasms in 14 studies
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diarrhea in a patient with pancreatic cholera syndrome caused by a vasoactive intestinal polypeptide producing pancreatic islet-cell carcinoma responded rapidly and dramatically to the phenothiazine trifluoperazine." | 7.66 | Trifluoperazine reversal of secretory diarrhea in pancreatic cholera. ( Bloom, SR; Donowitz, M; Elta, G; Nathanson, L, 1980) |
| " A significant potentiation of the P-30 protein-induced cell growth inhibition by tamoxifen as well as trifluoroperazine (Stelazine) in both the human A-549 lung carcinoma and the ASPC-1 pancreatic adenocarcinoma systems at wide ranges of drug concentrations was observed." | 3.68 | Tamoxifen and trifluoroperazine (Stelazine) potentiate cytostatic/cytotoxic effects of P-30 protein, a novel protein possessing anti-tumor activity. ( Ardelt, W; Menduke, H; Mikulski, SM; Shogen, K; Viera, A, 1990) |
| "Diarrhea in a patient with pancreatic cholera syndrome caused by a vasoactive intestinal polypeptide producing pancreatic islet-cell carcinoma responded rapidly and dramatically to the phenothiazine trifluoperazine." | 3.66 | Trifluoperazine reversal of secretory diarrhea in pancreatic cholera. ( Bloom, SR; Donowitz, M; Elta, G; Nathanson, L, 1980) |
| "The pharmacodynamic interactions among trifluoperazine (TFP), gemcitabine (GEM), and paclitaxel (PTX) were assessed in pancreatic cancer cells (PANC-1)." | 1.48 | Assessment of Three-Drug Combination Pharmacodynamic Interactions in Pancreatic Cancer Cells. ( Jusko, WJ; Molins, EAG, 2018) |
| "Pancreatic cancer is highly malignant with limited therapy and a poor prognosis." | 1.42 | Calmodulin antagonists promote TRA-8 therapy of resistant pancreatic cancer. ( Chen, Y; McDonald, JM; Xu, F; Yong, S; Yuan, K; Zhou, T, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (42.86) | 18.7374 |
| 1990's | 5 (35.71) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Molins, EAG | 1 |
| Jusko, WJ | 1 |
| Yuan, K | 1 |
| Yong, S | 1 |
| Xu, F | 1 |
| Zhou, T | 1 |
| McDonald, JM | 1 |
| Chen, Y | 1 |
| Neira, JL | 1 |
| Bintz, J | 1 |
| Arruebo, M | 1 |
| Rizzuti, B | 1 |
| Bonacci, T | 1 |
| Vega, S | 1 |
| Lanas, A | 1 |
| Velázquez-Campoy, A | 1 |
| Iovanna, JL | 1 |
| Abián, O | 1 |
| Sopwith, AM | 2 |
| Hutton, JC | 3 |
| Naber, SP | 1 |
| Chick, WL | 1 |
| Hales, CN | 2 |
| Schubart, UK | 2 |
| Erlichman, J | 2 |
| Fleischer, N | 2 |
| Donowitz, M | 1 |
| Elta, G | 1 |
| Bloom, SR | 1 |
| Nathanson, L | 1 |
| Penn, EJ | 1 |
| Brocklehurst, KW | 2 |
| Abad, A | 1 |
| Masuti, B | 1 |
| Camps, C | 1 |
| Font, A | 1 |
| Balañá, C | 1 |
| Vicent, JM | 1 |
| Sánchez, JJ | 1 |
| Safayhi, H | 1 |
| Anazodo, MI | 1 |
| Ammon, HP | 1 |
| Hoenig, M | 2 |
| Culberson, LH | 1 |
| Ferguson, DC | 2 |
| Lee, RJ | 1 |
| Mikulski, SM | 1 |
| Viera, A | 1 |
| Ardelt, W | 1 |
| Menduke, H | 1 |
| Shogen, K | 1 |
14 other studies available for trifluoperazine and Pancreatic Neoplasms
| Article | Year |
|---|---|
Assessment of Three-Drug Combination Pharmacodynamic Interactions in Pancreatic Cancer Cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; | 2018 |
Calmodulin antagonists promote TRA-8 therapy of resistant pancreatic cancer.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Binding Sites; Calmodulin; Caspas | 2015 |
Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma.
Topics: Animals; Antineoplastic Agents; Basic Helix-Loop-Helix Transcription Factors; Carcinoma, Ductal; Cel | 2017 |
Insulin secretion by a transplantable rat islet cell tumour.
Topics: Adenoma, Islet Cell; Animals; Colchicine; Epinephrine; Glucagon; Glucose; Insulin; Insulin Secretion | 1981 |
The role of calmodulin in the regulation of protein phosphorylation and insulin release in hamster insulinoma cells.
Topics: Adenoma, Islet Cell; Animals; Calcium; Calcium-Binding Proteins; Calmodulin; Cricetinae; Cytosol; In | 1980 |
Trifluoperazine reversal of secretory diarrhea in pancreatic cholera.
Topics: Adenoma, Islet Cell; Diarrhea; Female; Humans; Middle Aged; Pancreatic Neoplasms; Syndrome; Trifluop | 1980 |
Ca2+-dependent protein phosphorylation and insulin release in intact hamster insulinoma cells. Inhibition by trifluoperazine.
Topics: Adenoma, Islet Cell; Animals; Calcium; Cricetinae; Insulin; Insulin Secretion; Kinetics; Molecular W | 1980 |
Ca2+--Calmodulin dependent myosin light-chain phosphorylating activity in insulin-secreting tissues.
Topics: Adenoma, Islet Cell; Animals; Calcium; Calcium-Binding Proteins; Calmodulin; Chromatography, Affinit | 1982 |
Ca2+-dependent binding of cytosolic components to insulin-secretory granules results in Ca2+-dependent protein phosphorylation.
Topics: Adenoma, Islet Cell; Animals; Calcium; Calmodulin; Cytoplasmic Granules; Cytosol; Electrophoresis, P | 1983 |
Epirubicin plus a calmodulin inhibitor (trifluoperazine) activity in advanced pancreatic adenocarcinoma. T.T.D. Cooperative Spanish Group.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Drug Resistance, Multiple; Epirubici | 1994 |
Calmodulin- and Ca2(+)-insensitive fatty acid methyltransferase from RINm5F cells. Inhibition by trifluoperazine and W7.
Topics: Animals; Benzimidazoles; Calcium; Calmodulin; Egtazic Acid; Hot Temperature; Insulinoma; Methylation | 1991 |
Calcium transport by plasma membranes from a glucose-responsive rat insulinoma.
Topics: Animals; Biological Transport; Calcium; Cell Membrane; Dose-Response Relationship, Drug; Glucose; In | 1991 |
Glucose inhibits the high-affinity (Ca2+ + Mg2+)-ATPase in the plasma membrane of a glucose-responsive insulinoma.
Topics: Adenoma, Islet Cell; Adenosine Triphosphate; Animals; Ca(2+) Mg(2+)-ATPase; Calcium; Calcium-Transpo | 1990 |
Tamoxifen and trifluoroperazine (Stelazine) potentiate cytostatic/cytotoxic effects of P-30 protein, a novel protein possessing anti-tumor activity.
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Division; Drug Synergism; Humans; Lung Neoplasms; Pancre | 1990 |