trifluoperazine has been researched along with Glioma in 13 studies
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Previously, we reported that trifluoperazine (TFP), a well-known antipsychotic, has anti-glioma activity through the modulation of intracellular calcium levels." | 8.12 | COX-2 Acts as a Key Mediator of Trifluoperazine-induced Cell Death in U87MG Glioma Cells. ( Jeong, JY; Kang, SS; Park, J, 2022) |
| " We report that radiation induces a glioma-initiating cell phenotype, and we have identified trifluoperazine (TFP) as a compound that interferes with this phenotype conversion." | 7.96 | The dopamine receptor antagonist trifluoperazine prevents phenotype conversion and improves survival in mouse models of glioblastoma. ( Alli, C; Bhat, K; Cheng, F; Cloughesy, TF; Damoiseaux, R; Duhachek-Muggy, S; He, L; Kornblum, HI; Liau, LM; Medina, P; Nghiemphu, PL; Pajonk, F; Pellegrini, M; Saki, M; Vlashi, E; Yu, G; Zemke, NR, 2020) |
| " Ectopic expression of Egr-1 enhanced the TFP-induced antiproliferative activity and downregulated cyclin D1 level in U87MG glioma cells." | 7.72 | Implication of Egr-1 in trifluoperazine-induced growth inhibition in human U87MG glioma cells. ( Hong, DD; Kim, CG; Kim, JH; Lee, YH; Shin, SY, 2004) |
| " Previously, we reported that trifluoperazine (TFP), a well-known antipsychotic, has anti-glioma activity through the modulation of intracellular calcium levels." | 4.12 | COX-2 Acts as a Key Mediator of Trifluoperazine-induced Cell Death in U87MG Glioma Cells. ( Jeong, JY; Kang, SS; Park, J, 2022) |
| " We report that radiation induces a glioma-initiating cell phenotype, and we have identified trifluoperazine (TFP) as a compound that interferes with this phenotype conversion." | 3.96 | The dopamine receptor antagonist trifluoperazine prevents phenotype conversion and improves survival in mouse models of glioblastoma. ( Alli, C; Bhat, K; Cheng, F; Cloughesy, TF; Damoiseaux, R; Duhachek-Muggy, S; He, L; Kornblum, HI; Liau, LM; Medina, P; Nghiemphu, PL; Pajonk, F; Pellegrini, M; Saki, M; Vlashi, E; Yu, G; Zemke, NR, 2020) |
| " Ectopic expression of Egr-1 enhanced the TFP-induced antiproliferative activity and downregulated cyclin D1 level in U87MG glioma cells." | 3.72 | Implication of Egr-1 in trifluoperazine-induced growth inhibition in human U87MG glioma cells. ( Hong, DD; Kim, CG; Kim, JH; Lee, YH; Shin, SY, 2004) |
| "Membrane-modifying agents such as reserpine, calcium antagonists (nicardipine, verapamil) and calmodulin inhibitor (trifluoperazine) were found to enhance the cytotoxicity of ACNU in vitro and in vivo in ACNU-resistant C 6 (C 6/ACNU) glioma." | 3.67 | [Possibility of overcoming of ACNU resistance in an ACNU-resistant subline of C6 rat glioma]. ( Mogami, H; Sakamoto, Y; Shimizu, K; Ushio, Y; Yoshida, T, 1986) |
| "A calmodulin inhibitor, trifluoperazine, was found to enhance the cytotoxic action of ACNU in C6, especially in ACNU-resistant (C6/ACNU) glioma cells in vitro." | 3.67 | [Overcoming of ACNU resistance in an ACNU-resistant subline of rat C6 glioma in vivo through enhanced effect of ACNU by calmodulin inhibitor]. ( Egawa, T; Hayakawa, T; Mogami, H; Sakamoto, Y; Shimizu, K; Yoshida, T, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (30.77) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 2 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Park, J | 3 |
| Jeong, JY | 3 |
| Kang, SS | 3 |
| Bhat, K | 1 |
| Saki, M | 1 |
| Vlashi, E | 1 |
| Cheng, F | 1 |
| Duhachek-Muggy, S | 1 |
| Alli, C | 1 |
| Yu, G | 1 |
| Medina, P | 1 |
| He, L | 1 |
| Damoiseaux, R | 1 |
| Pellegrini, M | 1 |
| Zemke, NR | 1 |
| Nghiemphu, PL | 1 |
| Cloughesy, TF | 1 |
| Liau, LM | 1 |
| Kornblum, HI | 1 |
| Pajonk, F | 1 |
| Wen, Y | 1 |
| Zhang, Y | 1 |
| Li, J | 1 |
| Luo, F | 1 |
| Huang, Z | 1 |
| Liu, K | 1 |
| Chen, X | 1 |
| Luo, X | 1 |
| Cheng, Y | 1 |
| Shin, SY | 1 |
| Kim, CG | 1 |
| Hong, DD | 1 |
| Kim, JH | 1 |
| Lee, YH | 1 |
| Brostrom, MA | 2 |
| Brostrom, CO | 2 |
| Huang, SC | 1 |
| Wolff, DJ | 2 |
| Brotman, LA | 1 |
| Lee, C | 1 |
| Geller, HM | 1 |
| Bagaglio, DM | 1 |
| Cheng, EH | 1 |
| Gorelick, FS | 1 |
| Mitsui, K | 1 |
| Nairn, AC | 1 |
| Hait, WN | 1 |
| Lin, WW | 1 |
| Tjalkens, RB | 1 |
| Ewing, MM | 1 |
| Philbert, MA | 1 |
| Zhang, L | 1 |
| Tardy, M | 1 |
| Berry, JP | 1 |
| Escaig, F | 1 |
| Galle, P | 1 |
| Yoshida, T | 2 |
| Shimizu, K | 2 |
| Ushio, Y | 1 |
| Mogami, H | 2 |
| Sakamoto, Y | 2 |
| Hayakawa, T | 1 |
| Egawa, T | 1 |
13 other studies available for trifluoperazine and Glioma
| Article | Year |
|---|---|
COX-2 Acts as a Key Mediator of Trifluoperazine-induced Cell Death in U87MG Glioma Cells.
Topics: Cell Death; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Glioma; Humans; PPAR gamma; Trifluoperazi | 2022 |
COX-2 Acts as a Key Mediator of Trifluoperazine-induced Cell Death in U87MG Glioma Cells.
Topics: Cell Death; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Glioma; Humans; PPAR gamma; Trifluoperazi | 2022 |
COX-2 Acts as a Key Mediator of Trifluoperazine-induced Cell Death in U87MG Glioma Cells.
Topics: Cell Death; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Glioma; Humans; PPAR gamma; Trifluoperazi | 2022 |
COX-2 Acts as a Key Mediator of Trifluoperazine-induced Cell Death in U87MG Glioma Cells.
Topics: Cell Death; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Glioma; Humans; PPAR gamma; Trifluoperazi | 2022 |
The dopamine receptor antagonist trifluoperazine prevents phenotype conversion and improves survival in mouse models of glioblastoma.
Topics: Animals; beta Catenin; Brain Neoplasms; Disease Models, Animal; Dopamine Antagonists; Gene Expressio | 2020 |
Low concentration trifluoperazine promotes proliferation and reduces calcium-dependent apoptosis in glioma cells.
Topics: Animals; Antidepressive Agents; Apoptosis; Biomarkers, Tumor; Brain Neoplasms; Calcium; Cell Cycle; | 2018 |
Trifluoperazine prevents FOXO1 nuclear excretion and reverses doxorubicin-resistance in the SHG44/DOX drug-resistant glioma cell line.
Topics: Animals; Apoptosis; Caspase 3; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Doxorubicin; | 2018 |
Implication of Egr-1 in trifluoperazine-induced growth inhibition in human U87MG glioma cells.
Topics: Cell Cycle; Cell Proliferation; Cyclin D1; DNA-Binding Proteins; Early Growth Response Protein 1; Ge | 2004 |
Cholera toxin-stimulated cyclic AMP accumulation in glial tumor cells: modulation by Ca2+.
Topics: Adenylyl Cyclases; Animals; Calcium; Calmodulin; Cell Line; Cholera Toxin; Cyclic AMP; Glioma; Neopl | 1981 |
Alterations of glial tumor cell Ca2+ metabolism and Ca2+-dependent cAMP accumulation by phorbol myristate acetate.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Biological Transport, Active; Calci | 1982 |
Phosphorylation of elongation factor 2 in normal and malignant rat glial cells.
Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cell Division; Cells, Cu | 1993 |
Potentiation of stimulus-induced phosphoinositide breakdown by calmodulin antagonists in C6 glioma cells.
Topics: Adenosine Triphosphate; Calcimycin; Calmodulin; Digitonin; Dose-Response Relationship, Drug; Enzyme | 1995 |
Differential cellular regulation of the mitochondrial permeability transition in an in vitro model of 1,3-dinitrobenzene-induced encephalopathy.
Topics: Adenosine Triphosphate; Antioxidants; bcl-2-Associated X Protein; bcl-X Protein; Brain Diseases; Cal | 2000 |
[Localization of two neurotropic molecules in cultured glial cells by ion microscopy].
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Astrocytes; Flunitrazepam; Flurazepam; Glioma; M | 1992 |
[Possibility of overcoming of ACNU resistance in an ACNU-resistant subline of C6 rat glioma].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line; Cells, Cultured; Drug Resistance; Drug T | 1986 |
[Overcoming of ACNU resistance in an ACNU-resistant subline of rat C6 glioma in vivo through enhanced effect of ACNU by calmodulin inhibitor].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Calmodulin; Drug Resistance; Glioma; Male; Nimustin | 1987 |