trifluoperazine has been researched along with Glial Cell Tumors in 13 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " Previously, we reported that trifluoperazine (TFP), a well-known antipsychotic, has anti-glioma activity through the modulation of intracellular calcium levels." | 8.12 | COX-2 Acts as a Key Mediator of Trifluoperazine-induced Cell Death in U87MG Glioma Cells. ( Jeong, JY; Kang, SS; Park, J, 2022) |
| " We report that radiation induces a glioma-initiating cell phenotype, and we have identified trifluoperazine (TFP) as a compound that interferes with this phenotype conversion." | 7.96 | The dopamine receptor antagonist trifluoperazine prevents phenotype conversion and improves survival in mouse models of glioblastoma. ( Alli, C; Bhat, K; Cheng, F; Cloughesy, TF; Damoiseaux, R; Duhachek-Muggy, S; He, L; Kornblum, HI; Liau, LM; Medina, P; Nghiemphu, PL; Pajonk, F; Pellegrini, M; Saki, M; Vlashi, E; Yu, G; Zemke, NR, 2020) |
| " Ectopic expression of Egr-1 enhanced the TFP-induced antiproliferative activity and downregulated cyclin D1 level in U87MG glioma cells." | 7.72 | Implication of Egr-1 in trifluoperazine-induced growth inhibition in human U87MG glioma cells. ( Hong, DD; Kim, CG; Kim, JH; Lee, YH; Shin, SY, 2004) |
| " Previously, we reported that trifluoperazine (TFP), a well-known antipsychotic, has anti-glioma activity through the modulation of intracellular calcium levels." | 4.12 | COX-2 Acts as a Key Mediator of Trifluoperazine-induced Cell Death in U87MG Glioma Cells. ( Jeong, JY; Kang, SS; Park, J, 2022) |
| " We report that radiation induces a glioma-initiating cell phenotype, and we have identified trifluoperazine (TFP) as a compound that interferes with this phenotype conversion." | 3.96 | The dopamine receptor antagonist trifluoperazine prevents phenotype conversion and improves survival in mouse models of glioblastoma. ( Alli, C; Bhat, K; Cheng, F; Cloughesy, TF; Damoiseaux, R; Duhachek-Muggy, S; He, L; Kornblum, HI; Liau, LM; Medina, P; Nghiemphu, PL; Pajonk, F; Pellegrini, M; Saki, M; Vlashi, E; Yu, G; Zemke, NR, 2020) |
| " Ectopic expression of Egr-1 enhanced the TFP-induced antiproliferative activity and downregulated cyclin D1 level in U87MG glioma cells." | 3.72 | Implication of Egr-1 in trifluoperazine-induced growth inhibition in human U87MG glioma cells. ( Hong, DD; Kim, CG; Kim, JH; Lee, YH; Shin, SY, 2004) |
| "Membrane-modifying agents such as reserpine, calcium antagonists (nicardipine, verapamil) and calmodulin inhibitor (trifluoperazine) were found to enhance the cytotoxicity of ACNU in vitro and in vivo in ACNU-resistant C 6 (C 6/ACNU) glioma." | 3.67 | [Possibility of overcoming of ACNU resistance in an ACNU-resistant subline of C6 rat glioma]. ( Mogami, H; Sakamoto, Y; Shimizu, K; Ushio, Y; Yoshida, T, 1986) |
| "A calmodulin inhibitor, trifluoperazine, was found to enhance the cytotoxic action of ACNU in C6, especially in ACNU-resistant (C6/ACNU) glioma cells in vitro." | 3.67 | [Overcoming of ACNU resistance in an ACNU-resistant subline of rat C6 glioma in vivo through enhanced effect of ACNU by calmodulin inhibitor]. ( Egawa, T; Hayakawa, T; Mogami, H; Sakamoto, Y; Shimizu, K; Yoshida, T, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (30.77) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 2 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Park, J | 3 |
| Jeong, JY | 3 |
| Kang, SS | 3 |
| Bhat, K | 1 |
| Saki, M | 1 |
| Vlashi, E | 1 |
| Cheng, F | 1 |
| Duhachek-Muggy, S | 1 |
| Alli, C | 1 |
| Yu, G | 1 |
| Medina, P | 1 |
| He, L | 1 |
| Damoiseaux, R | 1 |
| Pellegrini, M | 1 |
| Zemke, NR | 1 |
| Nghiemphu, PL | 1 |
| Cloughesy, TF | 1 |
| Liau, LM | 1 |
| Kornblum, HI | 1 |
| Pajonk, F | 1 |
| Wen, Y | 1 |
| Zhang, Y | 1 |
| Li, J | 1 |
| Luo, F | 1 |
| Huang, Z | 1 |
| Liu, K | 1 |
| Chen, X | 1 |
| Luo, X | 1 |
| Cheng, Y | 1 |
| Shin, SY | 1 |
| Kim, CG | 1 |
| Hong, DD | 1 |
| Kim, JH | 1 |
| Lee, YH | 1 |
| Brostrom, MA | 2 |
| Brostrom, CO | 2 |
| Huang, SC | 1 |
| Wolff, DJ | 2 |
| Brotman, LA | 1 |
| Lee, C | 1 |
| Geller, HM | 1 |
| Bagaglio, DM | 1 |
| Cheng, EH | 1 |
| Gorelick, FS | 1 |
| Mitsui, K | 1 |
| Nairn, AC | 1 |
| Hait, WN | 1 |
| Lin, WW | 1 |
| Tjalkens, RB | 1 |
| Ewing, MM | 1 |
| Philbert, MA | 1 |
| Zhang, L | 1 |
| Tardy, M | 1 |
| Berry, JP | 1 |
| Escaig, F | 1 |
| Galle, P | 1 |
| Yoshida, T | 2 |
| Shimizu, K | 2 |
| Ushio, Y | 1 |
| Mogami, H | 2 |
| Sakamoto, Y | 2 |
| Hayakawa, T | 1 |
| Egawa, T | 1 |
13 other studies available for trifluoperazine and Glial Cell Tumors
| Article | Year |
|---|---|
COX-2 Acts as a Key Mediator of Trifluoperazine-induced Cell Death in U87MG Glioma Cells.
Topics: Cell Death; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Glioma; Humans; PPAR gamma; Trifluoperazi | 2022 |
COX-2 Acts as a Key Mediator of Trifluoperazine-induced Cell Death in U87MG Glioma Cells.
Topics: Cell Death; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Glioma; Humans; PPAR gamma; Trifluoperazi | 2022 |
COX-2 Acts as a Key Mediator of Trifluoperazine-induced Cell Death in U87MG Glioma Cells.
Topics: Cell Death; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Glioma; Humans; PPAR gamma; Trifluoperazi | 2022 |
COX-2 Acts as a Key Mediator of Trifluoperazine-induced Cell Death in U87MG Glioma Cells.
Topics: Cell Death; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Glioma; Humans; PPAR gamma; Trifluoperazi | 2022 |
The dopamine receptor antagonist trifluoperazine prevents phenotype conversion and improves survival in mouse models of glioblastoma.
Topics: Animals; beta Catenin; Brain Neoplasms; Disease Models, Animal; Dopamine Antagonists; Gene Expressio | 2020 |
Low concentration trifluoperazine promotes proliferation and reduces calcium-dependent apoptosis in glioma cells.
Topics: Animals; Antidepressive Agents; Apoptosis; Biomarkers, Tumor; Brain Neoplasms; Calcium; Cell Cycle; | 2018 |
Trifluoperazine prevents FOXO1 nuclear excretion and reverses doxorubicin-resistance in the SHG44/DOX drug-resistant glioma cell line.
Topics: Animals; Apoptosis; Caspase 3; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Doxorubicin; | 2018 |
Implication of Egr-1 in trifluoperazine-induced growth inhibition in human U87MG glioma cells.
Topics: Cell Cycle; Cell Proliferation; Cyclin D1; DNA-Binding Proteins; Early Growth Response Protein 1; Ge | 2004 |
Cholera toxin-stimulated cyclic AMP accumulation in glial tumor cells: modulation by Ca2+.
Topics: Adenylyl Cyclases; Animals; Calcium; Calmodulin; Cell Line; Cholera Toxin; Cyclic AMP; Glioma; Neopl | 1981 |
Alterations of glial tumor cell Ca2+ metabolism and Ca2+-dependent cAMP accumulation by phorbol myristate acetate.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Biological Transport, Active; Calci | 1982 |
Phosphorylation of elongation factor 2 in normal and malignant rat glial cells.
Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cell Division; Cells, Cu | 1993 |
Potentiation of stimulus-induced phosphoinositide breakdown by calmodulin antagonists in C6 glioma cells.
Topics: Adenosine Triphosphate; Calcimycin; Calmodulin; Digitonin; Dose-Response Relationship, Drug; Enzyme | 1995 |
Differential cellular regulation of the mitochondrial permeability transition in an in vitro model of 1,3-dinitrobenzene-induced encephalopathy.
Topics: Adenosine Triphosphate; Antioxidants; bcl-2-Associated X Protein; bcl-X Protein; Brain Diseases; Cal | 2000 |
[Localization of two neurotropic molecules in cultured glial cells by ion microscopy].
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Astrocytes; Flunitrazepam; Flurazepam; Glioma; M | 1992 |
[Possibility of overcoming of ACNU resistance in an ACNU-resistant subline of C6 rat glioma].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line; Cells, Cultured; Drug Resistance; Drug T | 1986 |
[Overcoming of ACNU resistance in an ACNU-resistant subline of rat C6 glioma in vivo through enhanced effect of ACNU by calmodulin inhibitor].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Calmodulin; Drug Resistance; Glioma; Male; Nimustin | 1987 |