trifluoperazine has been researched along with Brain Edema in 4 studies
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Trifluoperazine (TFP) is a therapeutic agent for the treatment of psychiatric disorders that reduces edema of the central nervous system." | 1.91 | Trifluoperazine reduces apoptosis and inflammatory responses in traumatic brain injury by preventing the accumulation of Aquaporin4 on the surface of brain cells. ( Cheng, J; Li, S; Ma, H; Xing, R; Yu, J; Zhao, Y, 2023) |
| "However, the efficacy of CsA to protect cytotoxic brain edema in ALF is problematic because it poorly crosses the blood-brain barrier, which is relatively intact in ALF." | 1.35 | Inhibitors of the mitochondrial permeability transition reduce ammonia-induced cell swelling in cultured astrocytes. ( Norenberg, MD; Rama Rao, KV; Reddy, PV, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xing, R | 1 |
| Cheng, J | 1 |
| Yu, J | 1 |
| Li, S | 1 |
| Ma, H | 1 |
| Zhao, Y | 1 |
| Kitchen, P | 1 |
| Salman, MM | 1 |
| Halsey, AM | 1 |
| Clarke-Bland, C | 1 |
| MacDonald, JA | 1 |
| Ishida, H | 1 |
| Vogel, HJ | 1 |
| Almutiri, S | 1 |
| Logan, A | 1 |
| Kreida, S | 1 |
| Al-Jubair, T | 1 |
| Winkel Missel, J | 1 |
| Gourdon, P | 1 |
| Törnroth-Horsefield, S | 1 |
| Conner, MT | 1 |
| Ahmed, Z | 1 |
| Conner, AC | 1 |
| Bill, RM | 1 |
| Reddy, PV | 1 |
| Rama Rao, KV | 1 |
| Norenberg, MD | 1 |
| Sato, T | 1 |
| Morishima, Y | 1 |
| Shirasaki, Y | 1 |
4 other studies available for trifluoperazine and Brain Edema
| Article | Year |
|---|---|
Trifluoperazine reduces apoptosis and inflammatory responses in traumatic brain injury by preventing the accumulation of Aquaporin4 on the surface of brain cells.
Topics: Animals; Apoptosis; Aquaporin 4; Brain; Brain Edema; Brain Injuries, Traumatic; Inflammation; Rats; | 2023 |
Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema.
Topics: Animals; Aquaporin 4; Astrocytes; Brain; Brain Edema; Calmodulin; Central Nervous System; Edema; Mal | 2020 |
Inhibitors of the mitochondrial permeability transition reduce ammonia-induced cell swelling in cultured astrocytes.
Topics: Ammonia; Animals; Astrocytes; Blood-Brain Barrier; Brain; Brain Edema; Cell Size; Cells, Cultured; C | 2009 |
3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e), a novel calmodulin antagonist, reduces brain edema through the inhibition of enhanced blood-brain barrier perme
Topics: Animals; Blood-Brain Barrier; Brain Edema; Calmodulin; Cell Membrane Permeability; Disease Models, A | 2003 |