trifluoperazine has been researched along with Astrocytoma in 4 studies
Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In human astrocytoma cells (1321N1), trifluoperazine potently inhibited histamine-induced phosphoinositide hydrolysis, while it slightly inhibited carbachol-induced phosphoinositide hydrolysis." | 3.68 | Trifluoperazine inhibits phosphoinositide hydrolysis as a histamine H1-receptor antagonist. ( Ishimoto, H; Kurita, M; Nakahata, N; Ohmori, K; Takahashi, A, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Weiss, B | 2 |
| Nakahata, N | 1 |
| Ishimoto, H | 1 |
| Takahashi, A | 1 |
| Ohmori, K | 1 |
| Kurita, M | 1 |
| Lee, GL | 1 |
| Hait, WN | 1 |
| Uzunov, P | 1 |
| Shein, HM | 1 |
1 review available for trifluoperazine and Astrocytoma
| Article | Year |
|---|---|
Differential activation and inhibition of the multiple forms of cyclic nucleotide phosphodiesterase.
Topics: Adenylyl Cyclases; Animals; Astrocytoma; Brain; Cyclic AMP; Cyclic GMP; Enzyme Activation; Isoenzyme | 1975 |
3 other studies available for trifluoperazine and Astrocytoma
| Article | Year |
|---|---|
Trifluoperazine inhibits phosphoinositide hydrolysis as a histamine H1-receptor antagonist.
Topics: Astrocytoma; Carbachol; Enzyme Activation; Histamine; Histamine H1 Antagonists; Humans; Hydrolysis; | 1991 |
Inhibition of growth of C6 astrocytoma cells by inhibitors of calmodulin.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Astrocytoma; Calmodulin; Cell Division; Cell Line; Chl | 1985 |
Multiple forms of cyclic 3',5'-AMP phosphodiesterase of rat cerebrum and cloned astrocytoma and neuroblastoma cells.
Topics: Animals; Astrocytoma; Brain; Brain Neoplasms; Cattle; Clone Cells; Cyclic AMP; Dialysis; Drug Stabil | 1974 |