trifluoperazine has been researched along with Adenocarcinoma of Lung in 2 studies
Adenocarcinoma of Lung: A carcinoma originating in the lung and the most common lung cancer type in never-smokers. Malignant cells exhibit distinct features such as glandular epithelial, or tubular morphology. Mutations in KRAS, EGFR, BRAF, and ERBB2 genes are associated with this cancer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Trifluoperazine (TFP), which is an antipsychotic drug, has the ability to bind to NUPR1 and mimic NUPR1 deficiency in cancer cells." | 5.56 | Combination of AAV‑mediated NUPR1 knockdown and trifluoperazine induces premature senescence in human lung adenocarcinoma A549 cells in nude mice. ( Cui, B; Li, Y; Liu, Z; Ma, J; Ma, Z; Sun, Y; Yan, X; Yang, J; Yin, Y; Zhang, Y; Zhou, R, 2020) |
| " Furthermore, the use of the FDA-approved drug trifluoperazine hydrochloride (TFP), which has been shown to inhibit FOXO1 nuclear export, restored sensitivity to AKT-driven erlotinib resistance through modulation of the KLF6/FOXO1 signaling cascade in both cell culture and xenograft models of lung adenocarcinoma." | 3.78 | Targeting the FOXO1/KLF6 axis regulates EGFR signaling and treatment response. ( Albano, T; Arnovitz, P; Burstein, D; Dhawan, NS; Difeo, A; Farrington, C; Galsky, M; Izadmehr, S; Katz, S; Mazhar, S; Melville, H; Narla, G; Ohlmeyer, M; Okrent, R; Politi, K; Rana, H; Sangodkar, J; Singh, VJ; Yuan, E; Zhang, D, 2012) |
| "Trifluoperazine (TFP), which is an antipsychotic drug, has the ability to bind to NUPR1 and mimic NUPR1 deficiency in cancer cells." | 1.56 | Combination of AAV‑mediated NUPR1 knockdown and trifluoperazine induces premature senescence in human lung adenocarcinoma A549 cells in nude mice. ( Cui, B; Li, Y; Liu, Z; Ma, J; Ma, Z; Sun, Y; Yan, X; Yang, J; Yin, Y; Zhang, Y; Zhou, R, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, Y | 1 |
| Yin, Y | 1 |
| Ma, J | 1 |
| Sun, Y | 1 |
| Zhou, R | 1 |
| Cui, B | 1 |
| Zhang, Y | 1 |
| Yang, J | 1 |
| Yan, X | 1 |
| Liu, Z | 1 |
| Ma, Z | 1 |
| Sangodkar, J | 1 |
| Dhawan, NS | 1 |
| Melville, H | 1 |
| Singh, VJ | 1 |
| Yuan, E | 1 |
| Rana, H | 1 |
| Izadmehr, S | 1 |
| Farrington, C | 1 |
| Mazhar, S | 1 |
| Katz, S | 1 |
| Albano, T | 1 |
| Arnovitz, P | 1 |
| Okrent, R | 1 |
| Ohlmeyer, M | 1 |
| Galsky, M | 1 |
| Burstein, D | 1 |
| Zhang, D | 1 |
| Politi, K | 1 |
| Difeo, A | 1 |
| Narla, G | 1 |
2 other studies available for trifluoperazine and Adenocarcinoma of Lung
| Article | Year |
|---|---|
Combination of AAV‑mediated NUPR1 knockdown and trifluoperazine induces premature senescence in human lung adenocarcinoma A549 cells in nude mice.
Topics: A549 Cells; Adenocarcinoma of Lung; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Surv | 2020 |
Targeting the FOXO1/KLF6 axis regulates EGFR signaling and treatment response.
Topics: Active Transport, Cell Nucleus; Adenocarcinoma; Adenocarcinoma of Lung; Animals; Antineoplastic Agen | 2012 |