triethyltin has been researched along with Central-Nervous-System-Diseases* in 3 studies
3 other study(ies) available for triethyltin and Central-Nervous-System-Diseases
Article | Year |
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Central nervous system demyelinating diseases and increased release of cholesterol into the urinary system of rats.
The question of what happens to cholesterol in the adult central nervous system during its slow turnover has been addressed using rats with brain and spinal cord labeled with [4-14C]cholesterol upon intracerebral injection of labeled cholesterol into rats at 10-12 days of age. At six months after injection, 14C was found only in the brain and spinal cord and was slowly released via the rat's urine. When labeled rats were given demyelinating agents (triethyl tin chloride, hexachlorophene, sodium cyanide) and when experimental allergic encephalomyelitis was induced, a measurable increase in urinary 14C label above control levels was found. It was concluded that there is a direct relationship between the experimental demyelination induced and the increased release of cholesterol metabolites into urine. The study suggests that a clinical method could be developed to determine the rate of central nervous system demyelination by measuring the amount of urinary cholesterol metabolites. Topics: Animals; Carbon Radioisotopes; Central Nervous System Diseases; Cholesterol; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Hexachlorophene; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Sodium Cyanide; Starvation; Triethyltin Compounds | 1994 |
Organometal-induced antinociception: a time- and dose-response comparison of triethyl and trimethyl lead and tin.
Recent reports have demonstrated that organolead and -tin compounds can alter behavioral reactivity to noxious stimuli. To further define the dose response and temporal characteristics of these neurobehavioral effects, male Fischer 344 rats were injected sc with either one-fourth, one-half, or three-fourths the acute LD50 of triethyl lead (TEL), triethyl tin (TET), trimethyl lead (TML), trimethyl tin (TMT), or distilled water and tested on a 57.5 degrees C hot plate 1, 7, 14, 21, and 28 days after dosing. All four organometals altered hot plate latencies, but the magnitude and time course of these effects differed among the compounds. TEL produced a dose-related increase in latencies which was maximal 1 and 7 days postdosing and had dissipated by 28 days. In contrast, the group administered TML (3/4 LD50) exhibited a late developing antinocioception which became evident 14 days after dosing and persisted throughout the period of testing. The intermediate dose of TMT (1/2 LD50) also produced a delayed increase in response times which was observed 21 and 28 days post-treatment. The 3/4 LD50 dose of TMT produced increased hot plate latencies on all post-treatment test days except Day 14. TET (1/2 LD50) produced increased hot plate latencies 1, 7, 14, and 21 days postdosing and also induced a reversible ataxia and akinesia. Higher doses of TET proved lethal to 80% of the animals and lower doses failed to alter response times in the hot plate. These data demonstrate that trialkyl lead and tin compounds can produce time- and dose-related increases in hot plate latencies. Topics: Animals; Central Nervous System Diseases; Dose-Response Relationship, Drug; Lead; Lead Poisoning; Lethal Dose 50; Male; Organometallic Compounds; Organotin Compounds; Pain; Rats; Rats, Inbred F344; Reaction Time; Tetraethyl Lead; Time Factors; Triethyltin Compounds; Trimethyltin Compounds | 1984 |
FURTHER OBSERVATIONS ON TRIETHYLTIN EDEMA.
Topics: Animals; Brain Diseases; Central Nervous System Diseases; Edema; Metabolism; Potassium; Rabbits; Research; Sodium; Spinal Cord; Sulfates; Tin; Toxicology; Triethyltin Compounds | 1963 |