trientine has been researched along with Nervous System Diseases in 9 studies
Trientine: An ethylenediamine derivative used as stabilizer for EPOXY RESINS, as ampholyte for ISOELECTRIC FOCUSING and as chelating agent for copper in HEPATOLENTICULAR DEGENERATION.
TETA : An azamacrocyle in which four nitrogen atoms at positions 1, 4, 8 and 11 of a fouteen-membered ring are each substituted with a carboxymethyl group.
2,2,2-tetramine : A polyazaalkane that is decane in which the carbon atoms at positions 1, 4, 7 and 10 are replaced by nitrogens.
Nervous System Diseases: Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Wilson's disease is a rare autosomal recessive disease of copper accumulation and copper toxicity, due to mutations in the ATP7B gene, which leads to a failure of copper excretion in the bile." | 2.43 | Neurologically presenting Wilson's disease: epidemiology, pathophysiology and treatment. ( Brewer, GJ, 2005) |
| "Wilson disease is an autosomal recessive disease that produces a copper accumulation in many organs, initially in the liver, progressing to liver cirrhosis, and in the brain, with different neurologic symptoms." | 1.38 | [Diagnosis and care of Wilson disease with neurological revelation]. ( Bost, M; Broussolle, E; Brunet, AS; Des Portes, V; Lachaux, A; Lion-François, L; Wagner, S, 2012) |
| "In patients with Wilson's disease and neurological manifestations, treatment with D-penicillamine can cause worsening of neurological symptoms, usually in the first few weeks of treatment." | 1.32 | [Wilson's disease with severe neurological manifestations: response to trientine plus zinc therapy]. ( Amorós, I; Aragó, M; García, M; Merino, C; Primo, J; Serra, B, 2004) |
| "The progression of Wilson disease (WD), a disorder of copper metabolism, can be arrested by chelation therapy." | 1.32 | Clinical correlation of brain MRI and MRS abnormalities in patients with Wilson disease. ( Davie, CA; Lees, AJ; MacManus, D; Miller, DH; Miszkiel, KA; Page, RA; Schapira, AH; Walshe, JM, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Antos, A | 1 |
| Członkowska, A | 1 |
| Smolinski, L | 1 |
| Bembenek, J | 1 |
| Przybyłkowski, A | 1 |
| Skowrońska, M | 1 |
| Kurkowska-Jastrzębska, I | 1 |
| Litwin, T | 1 |
| Teodoro, T | 1 |
| Neutel, D | 1 |
| Lobo, P | 1 |
| Geraldo, AF | 1 |
| Conceição, I | 1 |
| Rosa, MM | 1 |
| Albuquerque, L | 1 |
| Ferreira, JJ | 1 |
| Wagner, S | 1 |
| Brunet, AS | 1 |
| Bost, M | 1 |
| Lachaux, A | 1 |
| Broussolle, E | 1 |
| Des Portes, V | 1 |
| Lion-François, L | 1 |
| Kim, B | 1 |
| Chung, SJ | 1 |
| Shin, HW | 1 |
| Hermann, W | 1 |
| Villmann, T | 1 |
| Wagner, A | 1 |
| Serra, B | 1 |
| Primo, J | 1 |
| García, M | 1 |
| Amorós, I | 1 |
| Aragó, M | 1 |
| Merino, C | 1 |
| Page, RA | 1 |
| Davie, CA | 1 |
| MacManus, D | 1 |
| Miszkiel, KA | 1 |
| Walshe, JM | 1 |
| Miller, DH | 1 |
| Lees, AJ | 1 |
| Schapira, AH | 1 |
| Brewer, GJ | 1 |
| Ede, RJ | 1 |
| Mowat, AP | 1 |
2 reviews available for trientine and Nervous System Diseases
| Article | Year |
|---|---|
Early neurological deterioration in Wilson's disease: a systematic literature review and meta-analysis.
Topics: Copper; Hepatolenticular Degeneration; Humans; Nervous System Diseases; Penicillamine; Trientine | 2023 |
Neurologically presenting Wilson's disease: epidemiology, pathophysiology and treatment.
Topics: Behavior; Chelating Agents; Enzyme Inhibitors; Hepatolenticular Degeneration; Humans; Molybdenum; Ne | 2005 |
7 other studies available for trientine and Nervous System Diseases
| Article | Year |
|---|---|
Recovery after copper-deficiency myeloneuropathy in Wilson's disease.
Topics: Adult; Copper; Deficiency Diseases; Hepatolenticular Degeneration; Humans; Male; Nervous System Dise | 2013 |
[Diagnosis and care of Wilson disease with neurological revelation].
Topics: Adolescent; Brain; Chelating Agents; Female; Hepatolenticular Degeneration; Humans; Liver Transplant | 2012 |
Trientine-induced neurological deterioration in a patient with Wilson's disease.
Topics: Brain; Chelating Agents; Copper; Dystonia; Gait Disorders, Neurologic; Hepatolenticular Degeneration | 2013 |
[Electrophysiological impairment profile of patients with Wilson's disease].
Topics: Autonomic Nervous System Diseases; Basal Ganglia Diseases; Cerebral Cortex; Chelating Agents; Diagno | 2003 |
[Wilson's disease with severe neurological manifestations: response to trientine plus zinc therapy].
Topics: Adolescent; Chelating Agents; Hepatolenticular Degeneration; Humans; Male; Nervous System Diseases; | 2004 |
Clinical correlation of brain MRI and MRS abnormalities in patients with Wilson disease.
Topics: Adult; Aged; Aspartic Acid; Atrophy; Brain; Brain Chemistry; Chelation Therapy; Copper; Dipeptides; | 2004 |
Wilson's disease: a 1984 perspective.
Topics: Adolescent; Adult; Bone and Bones; Ceruloplasmin; Child; Child, Preschool; Copper; Diagnosis, Differ | 1984 |