trientine has been researched along with Disease Models, Animal in 8 studies
Trientine: An ethylenediamine derivative used as stabilizer for EPOXY RESINS, as ampholyte for ISOELECTRIC FOCUSING and as chelating agent for copper in HEPATOLENTICULAR DEGENERATION.
TETA : An azamacrocyle in which four nitrogen atoms at positions 1, 4, 8 and 11 of a fouteen-membered ring are each substituted with a carboxymethyl group.
2,2,2-tetramine : A polyazaalkane that is decane in which the carbon atoms at positions 1, 4, 7 and 10 are replaced by nitrogens.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Trientine (TETA), a copper (Cu) chelator, is capable of replenishing Cu in the heart, and Cu repletion reduces cardiac fibrosis in a rodent model of cardiac hypertrophy." | 3.88 | Copper-induced reduction in myocardial fibrosis is associated with increased matrix metalloproteins in a rat model of cardiac hypertrophy. ( Feng, L; Kang, YJ; Liu, J; Liu, Y; Xiao, Y, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Li, LB | 1 |
| Fan, YG | 1 |
| Wu, WX | 1 |
| Bai, CY | 1 |
| Jia, MY | 1 |
| Hu, JP | 1 |
| Gao, HL | 1 |
| Wang, T | 1 |
| Zhong, ML | 1 |
| Huang, XS | 1 |
| Guo, C | 1 |
| Liu, Y | 1 |
| Xiao, Y | 1 |
| Liu, J | 1 |
| Feng, L | 1 |
| Kang, YJ | 1 |
| Gong, D | 1 |
| Lu, J | 1 |
| Chen, X | 1 |
| Reddy, S | 1 |
| Crossman, DJ | 1 |
| Glyn-Jones, S | 1 |
| Choong, YS | 1 |
| Kennedy, J | 1 |
| Barry, B | 1 |
| Zhang, S | 1 |
| Chan, YK | 1 |
| Ruggiero, K | 1 |
| Phillips, AR | 1 |
| Cooper, GJ | 1 |
| Moya-Olano, L | 1 |
| Milne, HM | 1 |
| Robinson, JM | 1 |
| Hill, JV | 1 |
| Frampton, CM | 1 |
| Abbott, HF | 1 |
| Turner, R | 1 |
| Kettle, AJ | 1 |
| Endre, ZH | 1 |
| Nagano, S | 2 |
| Fujii, Y | 1 |
| Yamamoto, T | 1 |
| Taniyama, M | 1 |
| Fukada, K | 1 |
| Yanagihara, T | 2 |
| Sakoda, S | 2 |
| Ogawa, Y | 1 |
| Iseki, K | 1 |
| Kobayashi, M | 1 |
| Ohba, A | 1 |
| Miyazaki, K | 1 |
| Li, Y | 1 |
| Togashi, Y | 1 |
| Takeichi, N | 1 |
8 other studies available for trientine and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Novel melatonin-trientine conjugate as potential therapeutic agents for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Chelating A | 2022 |
Copper-induced reduction in myocardial fibrosis is associated with increased matrix metalloproteins in a rat model of cardiac hypertrophy.
Topics: Animals; Cardiomegaly; Cardiomyopathies; Copper; Disease Models, Animal; Fibrosis; Gene Expression R | 2018 |
A copper(II)-selective chelator ameliorates diabetes-evoked renal fibrosis and albuminuria, and suppresses pathogenic TGF-beta activation in the kidneys of rats used as a model of diabetes.
Topics: Albuminuria; Animals; Chelating Agents; Copper; Diabetes Mellitus, Experimental; Diabetic Nephropath | 2008 |
Trientine and renin-angiotensin system blockade ameliorate progression of glomerular morphology in hypertensive experimental diabetic nephropathy.
Topics: Allantoin; Animals; Chelating Agents; Copper; Creatinine; Diabetes Mellitus, Experimental; Diabetic | 2011 |
The efficacy of trientine or ascorbate alone compared to that of the combined treatment with these two agents in familial amyotrophic lateral sclerosis model mice.
Topics: Amyotrophic Lateral Sclerosis; Animals; Antioxidants; Ascorbic Acid; Chelating Agents; Disease Model | 2003 |
Benefit of a combined treatment with trientine and ascorbate in familial amyotrophic lateral sclerosis model mice.
Topics: Amyotrophic Lateral Sclerosis; Animals; Ascorbic Acid; Chelating Agents; Copper; Disease Models, Ani | 1999 |
Comparison of disposition behavior and de-coppering effect of triethylenetetramine in animal model for Wilson's disease (Long-Evans Cinnamon rat) with normal Wistar rat.
Topics: Animals; Copper; Disease Models, Animal; Hepatolenticular Degeneration; In Vitro Techniques; Liver; | 1992 |