trientine has been researched along with Diabetic Nephropathies in 3 studies
Trientine: An ethylenediamine derivative used as stabilizer for EPOXY RESINS, as ampholyte for ISOELECTRIC FOCUSING and as chelating agent for copper in HEPATOLENTICULAR DEGENERATION.
TETA : An azamacrocyle in which four nitrogen atoms at positions 1, 4, 8 and 11 of a fouteen-membered ring are each substituted with a carboxymethyl group.
2,2,2-tetramine : A polyazaalkane that is decane in which the carbon atoms at positions 1, 4, 7 and 10 are replaced by nitrogens.
Diabetic Nephropathies: KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aimed to identify new diabetic nephropathy (DN)-related proteins and renal targets of the copper(II)-selective chelator, triethylenetetramine (TETA) in streptozotocin-diabetic rats." | 1.35 | Quantitative proteomic profiling identifies new renal targets of copper(II)-selective chelation in the reversal of diabetic nephropathy in rats. ( Chen, X; Cooper, GJ; Gong, D; Huang, L; Lu, J; Middleditch, M; Phillips, AR; Reddy, S; Ruggiero, K; Vazhoor Amarsingh, G; Zhang, S, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gong, D | 2 |
| Lu, J | 2 |
| Chen, X | 2 |
| Reddy, S | 2 |
| Crossman, DJ | 1 |
| Glyn-Jones, S | 1 |
| Choong, YS | 1 |
| Kennedy, J | 1 |
| Barry, B | 1 |
| Zhang, S | 2 |
| Chan, YK | 1 |
| Ruggiero, K | 2 |
| Phillips, AR | 2 |
| Cooper, GJ | 2 |
| Middleditch, M | 1 |
| Huang, L | 1 |
| Vazhoor Amarsingh, G | 1 |
| Moya-Olano, L | 1 |
| Milne, HM | 1 |
| Robinson, JM | 1 |
| Hill, JV | 1 |
| Frampton, CM | 1 |
| Abbott, HF | 1 |
| Turner, R | 1 |
| Kettle, AJ | 1 |
| Endre, ZH | 1 |
3 other studies available for trientine and Diabetic Nephropathies
| Article | Year |
|---|---|
A copper(II)-selective chelator ameliorates diabetes-evoked renal fibrosis and albuminuria, and suppresses pathogenic TGF-beta activation in the kidneys of rats used as a model of diabetes.
Topics: Albuminuria; Animals; Chelating Agents; Copper; Diabetes Mellitus, Experimental; Diabetic Nephropath | 2008 |
Quantitative proteomic profiling identifies new renal targets of copper(II)-selective chelation in the reversal of diabetic nephropathy in rats.
Topics: Animals; Cations; Cell Adhesion Molecules; Chelating Agents; Collagen Type VI; Copper; Diabetes Mell | 2009 |
Trientine and renin-angiotensin system blockade ameliorate progression of glomerular morphology in hypertensive experimental diabetic nephropathy.
Topics: Allantoin; Animals; Chelating Agents; Copper; Creatinine; Diabetes Mellitus, Experimental; Diabetic | 2011 |