trientine has been researched along with Carcinoma, Hepatocellular in 3 studies
Trientine: An ethylenediamine derivative used as stabilizer for EPOXY RESINS, as ampholyte for ISOELECTRIC FOCUSING and as chelating agent for copper in HEPATOLENTICULAR DEGENERATION.
TETA : An azamacrocyle in which four nitrogen atoms at positions 1, 4, 8 and 11 of a fouteen-membered ring are each substituted with a carboxymethyl group.
2,2,2-tetramine : A polyazaalkane that is decane in which the carbon atoms at positions 1, 4, 7 and 10 are replaced by nitrogens.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We administered trientine hydrochloride, a drug used in the treatment of Wilson's disease, to patients with hepatocellular carcinoma after radical treatment with percutaneous ethanol injection or radiofrequency ablation, and examined its effect on the reduction of liver-tissue copper content." | 9.11 | Metal contents of liver parenchyma after percutaneous ethanol injection or radiofrequency ablation in patients with hepatocellular carcinoma before and after trientine hydrochloride therapy. ( Ebara, M; Fukuda, H; Kondo, F; Okabe, S; Saisho, H; Sugiura, N; Yoshikawa, M; Yukawa, M, 2004) |
| " We examined the antiangiogenic effect against hepatocellular carcinoma (HCC) of the copper chelator trientine, especially focusing on the relationship between copper and interleukin-8 (IL-8), a potent angiogenic factor produced by hepatoma cells." | 7.71 | The copper chelator trientine has an antiangiogenic effect against hepatocellular carcinoma, possibly through inhibition of interleukin-8 production. ( Kagawa, K; Katagishi, T; Kimura, H; Mitsumoto, Y; Moriguchi, M; Nakajima, T; Okanoue, T; Takashima, H; Watanabe, T, 2002) |
| "We administered trientine hydrochloride, a drug used in the treatment of Wilson's disease, to patients with hepatocellular carcinoma after radical treatment with percutaneous ethanol injection or radiofrequency ablation, and examined its effect on the reduction of liver-tissue copper content." | 5.11 | Metal contents of liver parenchyma after percutaneous ethanol injection or radiofrequency ablation in patients with hepatocellular carcinoma before and after trientine hydrochloride therapy. ( Ebara, M; Fukuda, H; Kondo, F; Okabe, S; Saisho, H; Sugiura, N; Yoshikawa, M; Yukawa, M, 2004) |
| " We examined the antiangiogenic effect against hepatocellular carcinoma (HCC) of the copper chelator trientine, especially focusing on the relationship between copper and interleukin-8 (IL-8), a potent angiogenic factor produced by hepatoma cells." | 3.71 | The copper chelator trientine has an antiangiogenic effect against hepatocellular carcinoma, possibly through inhibition of interleukin-8 production. ( Kagawa, K; Katagishi, T; Kimura, H; Mitsumoto, Y; Moriguchi, M; Nakajima, T; Okanoue, T; Takashima, H; Watanabe, T, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Harada, M | 1 |
| Honma, Y | 1 |
| Yoshizumi, T | 1 |
| Kumamoto, K | 1 |
| Oe, S | 1 |
| Harada, N | 1 |
| Tanimoto, A | 1 |
| Yabuki, K | 1 |
| Karasuyama, T | 1 |
| Yoneda, A | 1 |
| Shibata, M | 1 |
| Moriguchi, M | 1 |
| Nakajima, T | 1 |
| Kimura, H | 1 |
| Watanabe, T | 1 |
| Takashima, H | 1 |
| Mitsumoto, Y | 1 |
| Katagishi, T | 1 |
| Okanoue, T | 1 |
| Kagawa, K | 1 |
| Fukuda, H | 1 |
| Ebara, M | 1 |
| Okabe, S | 1 |
| Yoshikawa, M | 1 |
| Sugiura, N | 1 |
| Saisho, H | 1 |
| Kondo, F | 1 |
| Yukawa, M | 1 |
1 trial available for trientine and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Metal contents of liver parenchyma after percutaneous ethanol injection or radiofrequency ablation in patients with hepatocellular carcinoma before and after trientine hydrochloride therapy.
Topics: Aged; Carcinoma, Hepatocellular; Chelating Agents; Combined Modality Therapy; Copper; Ethanol; Femal | 2004 |
2 other studies available for trientine and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Idiopathic copper toxicosis: is abnormal copper metabolism a primary cause of this disease?
Topics: Carcinoma, Hepatocellular; Ceruloplasmin; Chelating Agents; Chemical and Drug Induced Liver Injury; | 2020 |
The copper chelator trientine has an antiangiogenic effect against hepatocellular carcinoma, possibly through inhibition of interleukin-8 production.
Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Division; Chelating Age | 2002 |