trientine has been researched along with Amyotrophic Lateral Sclerosis in 3 studies
Trientine: An ethylenediamine derivative used as stabilizer for EPOXY RESINS, as ampholyte for ISOELECTRIC FOCUSING and as chelating agent for copper in HEPATOLENTICULAR DEGENERATION.
TETA : An azamacrocyle in which four nitrogen atoms at positions 1, 4, 8 and 11 of a fouteen-membered ring are each substituted with a carboxymethyl group.
2,2,2-tetramine : A polyazaalkane that is decane in which the carbon atoms at positions 1, 4, 7 and 10 are replaced by nitrogens.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nagano, S | 2 |
| Fujii, Y | 1 |
| Yamamoto, T | 1 |
| Taniyama, M | 1 |
| Fukada, K | 1 |
| Yanagihara, T | 2 |
| Sakoda, S | 2 |
| Ogawa, Y | 1 |
| Andreassen, OA | 1 |
| Dedeoglu, A | 1 |
| Friedlich, A | 1 |
| Ferrante, KL | 1 |
| Hughes, D | 1 |
| Szabo, C | 1 |
| Beal, MF | 1 |
3 other studies available for trientine and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
The efficacy of trientine or ascorbate alone compared to that of the combined treatment with these two agents in familial amyotrophic lateral sclerosis model mice.
Topics: Amyotrophic Lateral Sclerosis; Animals; Antioxidants; Ascorbic Acid; Chelating Agents; Disease Model | 2003 |
Benefit of a combined treatment with trientine and ascorbate in familial amyotrophic lateral sclerosis model mice.
Topics: Amyotrophic Lateral Sclerosis; Animals; Ascorbic Acid; Chelating Agents; Copper; Disease Models, Ani | 1999 |
Effects of an inhibitor of poly(ADP-ribose) polymerase, desmethylselegiline, trientine, and lipoic acid in transgenic ALS mice.
Topics: Amphetamines; Amyotrophic Lateral Sclerosis; Animals; Female; Male; Mice; Mice, Transgenic; Motor Sk | 2001 |