trientine has been researched along with Alzheimer Disease in 7 studies
Trientine: An ethylenediamine derivative used as stabilizer for EPOXY RESINS, as ampholyte for ISOELECTRIC FOCUSING and as chelating agent for copper in HEPATOLENTICULAR DEGENERATION.
TETA : An azamacrocyle in which four nitrogen atoms at positions 1, 4, 8 and 11 of a fouteen-membered ring are each substituted with a carboxymethyl group.
2,2,2-tetramine : A polyazaalkane that is decane in which the carbon atoms at positions 1, 4, 7 and 10 are replaced by nitrogens.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Some of the implications are that Alzheimer's disease and other diseases of neurodegeneration and fibrotic, inflammatory, and autoimmune diseases may be treatable by lowering the availability of free copper." | 2.44 | The risks of free copper in the body and the development of useful anticopper drugs. ( Brewer, GJ, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 3 (42.86) | 2.80 |
| Authors | Studies |
|---|---|
| Li, LB | 1 |
| Fan, YG | 1 |
| Wu, WX | 1 |
| Bai, CY | 1 |
| Jia, MY | 1 |
| Hu, JP | 1 |
| Gao, HL | 1 |
| Wang, T | 2 |
| Zhong, ML | 1 |
| Huang, XS | 1 |
| Guo, C | 1 |
| Vasilopoulou, MA | 1 |
| Gioran, A | 1 |
| Theodoropoulou, M | 1 |
| Koutsaviti, A | 1 |
| Roussis, V | 1 |
| Ioannou, E | 1 |
| Chondrogianni, N | 1 |
| Guo, LX | 1 |
| Sun, B | 1 |
| Wang, CY | 1 |
| Xie, JW | 1 |
| Xu, Y | 1 |
| Cai, JH | 1 |
| Wang, X | 1 |
| Zhao, BL | 1 |
| An, L | 1 |
| Wang, ZY | 1 |
| Brewer, GJ | 1 |
| Cooper, GJ | 1 |
| Cherny, RA | 1 |
| Barnham, KJ | 1 |
| Lynch, T | 1 |
| Volitakis, I | 1 |
| Li, QX | 1 |
| McLean, CA | 1 |
| Multhaup, G | 1 |
| Beyreuther, K | 1 |
| Tanzi, RE | 1 |
| Masters, CL | 1 |
| Bush, AI | 1 |
2 reviews available for trientine and Alzheimer Disease
| Article | Year |
|---|---|
The risks of free copper in the body and the development of useful anticopper drugs.
Topics: Alzheimer Disease; Angiogenesis Inhibitors; Autoimmunity; Copper; Fibrosis; Hepatolenticular Degener | 2008 |
Therapeutic potential of copper chelation with triethylenetetramine in managing diabetes mellitus and Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Chelating Agents; Copper; Diabetes Complications; Diabetes Mellitus; Dru | 2011 |
5 other studies available for trientine and Alzheimer Disease
| Article | Year |
|---|---|
Novel melatonin-trientine conjugate as potential therapeutic agents for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Chelating A | 2022 |
Healthspan improvement and anti-aggregation effects induced by a marine-derived structural proteasome activator.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Caenorhabditis elegans; Caenorhabditis elegans Pr | 2022 |
N,N'-1,10-Bis(Naringin) Triethylenetetraamine, Synthesis and as a Cu(II) Chelator for Alzheimer's Disease Therapy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Cell Survival; Chelating Agents; Co | 2021 |
Trientine reduces BACE1 activity and mitigates amyloidosis via the AGE/RAGE/NF-κB pathway in a transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Amyloidosis; Animals; Aspartic Acid Endopep | 2013 |
Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Chelating Agents; Copper; Humans; Mice; Mi | 2000 |