trientine has been researched along with Alloxan Diabetes in 13 studies
Trientine: An ethylenediamine derivative used as stabilizer for EPOXY RESINS, as ampholyte for ISOELECTRIC FOCUSING and as chelating agent for copper in HEPATOLENTICULAR DEGENERATION.
TETA : An azamacrocyle in which four nitrogen atoms at positions 1, 4, 8 and 11 of a fouteen-membered ring are each substituted with a carboxymethyl group.
2,2,2-tetramine : A polyazaalkane that is decane in which the carbon atoms at positions 1, 4, 7 and 10 are replaced by nitrogens.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Trientine treatment significantly improved cardiac function in diabetic rats with substantive LV impairment." | 1.39 | Treatment with a copper-selective chelator causes substantive improvement in cardiac function of diabetic rats with left-ventricular impairment. ( Choong, SY; Cooper, GJ; Cowan, BR; Gamble, GD; Li, M; Lu, J; Phillips, AR; Pickup, S; Pontré, B; Xu, H; Young, AA, 2013) |
| "This study aimed to identify new diabetic nephropathy (DN)-related proteins and renal targets of the copper(II)-selective chelator, triethylenetetramine (TETA) in streptozotocin-diabetic rats." | 1.35 | Quantitative proteomic profiling identifies new renal targets of copper(II)-selective chelation in the reversal of diabetic nephropathy in rats. ( Chen, X; Cooper, GJ; Gong, D; Huang, L; Lu, J; Middleditch, M; Phillips, AR; Reddy, S; Ruggiero, K; Vazhoor Amarsingh, G; Zhang, S, 2009) |
| "Oral trientine treatment also caused elevated Cu excretion in humans with type 2 diabetes, in whom 6 months of treatment caused elevated left ventricular mass to decline significantly toward normal." | 1.32 | Regeneration of the heart in diabetes by selective copper chelation. ( Allen, GR; Baker, JR; Borg, TK; Boyd, PD; Brunton, DH; Chan, YK; Choong, SY; Cooper, GJ; Cowan, BR; Crossman, DJ; Dissanayake, AM; Doughty, RN; Gamble, GD; Keogh, GF; Leahy, FE; Leonard, BL; Occleshaw, CJ; Phillips, AR; Pope, AJ; Poppitt, SD; Saafi, 'L; Young, AA, 2004) |
| "Trientine treatment over the first 4 weeks gave 72% protection; intervention therapy over the final 4 weeks prevented deterioration and corrected the initial deficit by 68%." | 1.31 | Effects of trientine, a metal chelator, on defective endothelium-dependent relaxation in the mesenteric vasculature of diabetic rats. ( Cameron, NE; Cotter, MA; Inkster, ME, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 6 (46.15) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, L | 1 |
| Ward, ML | 1 |
| Phillips, AR | 6 |
| Zhang, S | 5 |
| Kennedy, J | 2 |
| Barry, B | 2 |
| Cannell, MB | 1 |
| Cooper, GJ | 7 |
| Rezaei, A | 1 |
| Heidarian, E | 1 |
| Brings, S | 1 |
| Choong, YS | 2 |
| Hogl, S | 1 |
| Middleditch, M | 2 |
| Kamalov, M | 1 |
| Brimble, MA | 1 |
| Gong, D | 4 |
| Lu, J | 4 |
| Chen, X | 3 |
| Reddy, S | 2 |
| Crossman, DJ | 2 |
| Glyn-Jones, S | 2 |
| Chan, YK | 3 |
| Ruggiero, K | 3 |
| Huang, L | 1 |
| Vazhoor Amarsingh, G | 1 |
| Choong, SY | 3 |
| Xu, H | 2 |
| Fitzpatrick, S | 1 |
| Nakamura, T | 1 |
| Obolonkin, V | 1 |
| Poppitt, SD | 2 |
| Moya-Olano, L | 1 |
| Milne, HM | 1 |
| Robinson, JM | 1 |
| Hill, JV | 1 |
| Frampton, CM | 1 |
| Abbott, HF | 1 |
| Turner, R | 1 |
| Kettle, AJ | 1 |
| Endre, ZH | 1 |
| Pontré, B | 1 |
| Pickup, S | 1 |
| Li, M | 1 |
| Gamble, GD | 2 |
| Cowan, BR | 2 |
| Young, AA | 2 |
| Inkster, ME | 1 |
| Cotter, MA | 4 |
| Cameron, NE | 4 |
| Leonard, BL | 1 |
| Brunton, DH | 1 |
| Saafi, 'L | 1 |
| Dissanayake, AM | 1 |
| Occleshaw, CJ | 1 |
| Leahy, FE | 1 |
| Keogh, GF | 1 |
| Allen, GR | 1 |
| Pope, AJ | 1 |
| Boyd, PD | 1 |
| Borg, TK | 1 |
| Doughty, RN | 1 |
| Baker, JR | 1 |
| Love, A | 1 |
| Keegan, A | 1 |
13 other studies available for trientine and Alloxan Diabetes
| Article | Year |
|---|---|
Protection of the heart by treatment with a divalent-copper-selective chelator reveals a novel mechanism underlying cardiomyopathy in diabetic rats.
Topics: Animals; Calcium; Cardiotonic Agents; Chelating Agents; Copper; Diabetes Mellitus, Experimental; Dia | 2013 |
Co-administration of trientine and flaxseed oil on oxidative stress, serum lipids and heart structure in diabetic rats.
Topics: Animals; Antioxidants; Chelating Agents; Cholesterol; Copper; Diabetes Mellitus, Experimental; Drug | 2013 |
Diabetes-induced alterations in tissue collagen and carboxymethyllysine in rat kidneys: Association with increased collagen-degrading proteinases and amelioration by Cu(II)-selective chelation.
Topics: Animals; Chelating Agents; Collagen; Copper; Diabetes Mellitus, Experimental; Kidney; Lysine; Male; | 2015 |
A copper(II)-selective chelator ameliorates diabetes-evoked renal fibrosis and albuminuria, and suppresses pathogenic TGF-beta activation in the kidneys of rats used as a model of diabetes.
Topics: Albuminuria; Animals; Chelating Agents; Copper; Diabetes Mellitus, Experimental; Diabetic Nephropath | 2008 |
Quantitative proteomic profiling identifies new renal targets of copper(II)-selective chelation in the reversal of diabetic nephropathy in rats.
Topics: Animals; Cations; Cell Adhesion Molecules; Chelating Agents; Collagen Type VI; Copper; Diabetes Mell | 2009 |
Copper(II)-selective chelation improves function and antioxidant defences in cardiovascular tissues of rats as a model of diabetes: comparisons between triethylenetetramine and three less copper-selective transition-metal-targeted treatments.
Topics: Adult; Aged; Analysis of Variance; Animals; Aorta; Chelating Agents; Deferiprone; Diabetes Mellitus, | 2010 |
Trientine and renin-angiotensin system blockade ameliorate progression of glomerular morphology in hypertensive experimental diabetic nephropathy.
Topics: Allantoin; Animals; Chelating Agents; Copper; Creatinine; Diabetes Mellitus, Experimental; Diabetic | 2011 |
Treatment with a copper-selective chelator causes substantive improvement in cardiac function of diabetic rats with left-ventricular impairment.
Topics: Animals; Chelating Agents; Copper; Diabetes Mellitus, Experimental; Heart; Heart Function Tests; Mal | 2013 |
Effects of trientine, a metal chelator, on defective endothelium-dependent relaxation in the mesenteric vasculature of diabetic rats.
Topics: Acetylcholine; Animals; Biological Factors; Chelating Agents; Diabetes Mellitus, Experimental; Endot | 2002 |
Regeneration of the heart in diabetes by selective copper chelation.
Topics: Animals; Chelating Agents; Copper; Coronary Vessels; Diabetes Mellitus, Experimental; Diabetic Angio | 2004 |
Neurovascular dysfunction in diabetic rats. Potential contribution of autoxidation and free radicals examined using transition metal chelating agents.
Topics: Animals; Cell Hypoxia; Chelating Agents; Chelation Therapy; Deferoxamine; Diabetes Mellitus, Experim | 1995 |
Nerve function and regeneration in diabetic and galactosaemic rats: antioxidant and metal chelator effects.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Butylated Hydroxytoluene; Chelating Agents; Diabe | 1996 |
Effects of chelator treatment on aorta and corpus cavernosum from diabetic rats.
Topics: Acetylcholine; Animals; Aorta; Blood Glucose; Chelating Agents; Diabetes Mellitus, Experimental; Ele | 1999 |