triclosan and Gingivitis studies

Gingivitis: Inflammation of gum tissue (GINGIVA) without loss of connective tissue.

Research Excerpts

Excerpt	Relevance	Reference
"The aims of this study were to; 1) test susceptibility to bacteremia in subjects with moderate gingivitis, and 2) compare the effects of brushing with a fluoride toothpaste (control) as compared to a triclosan/copolymer toothpaste (test) on those susceptible to repeated bacteremia."	9.24	Reduction in bacteremia after brushing with a triclosan/copolymer dentifrice-A randomized clinical study. ( Fine, DH; Sreenivasan, PK; Tischio-Bereski, D, 2017)
"Triclosan reduced microbial levels during gingivitis development (ClinicalTrials."	9.22	Effects of triclosan on host response and microbial biomarkers during experimental gingivitis. ( Braun, TM; Giannobile, WV; Kinney, JS; Kott, D; Panagakos, FS; Pancer, BA; Sugai, JV; Teles, RP, 2016)
"To assess the effectiveness of three different mouthrinses--chlorhexidine, triclosan + sodium fluoride and chlorhexidine + triclosan + sodium fluoride + zinc chloride--on plaque, calculus, gingivitis and stains and to evaluate the occurrence of adverse effects with these three treatments."	9.17	Effectiveness of a mouthrinse containing active ingredients in addition to chlorhexidine and triclosan compared with chlorhexidine and triclosan rinses on plaque, gingivitis, supragingival calculus and extrinsic staining. ( Duraiswamy, P; Kulkarni, S; Kumar, S; Patel, S; Tadakamadla, J; Tibdewal, H, 2013)
"243% sodium fluoride provides a significant reduction in established supragingival plaque and gingivitis, as compared to a dentifrice containing 0."	9.14	Comparative investigation of the efficacy of triclosan/copolymer/sodium fluoride and stannous fluoride/sodium hexametaphosphate/zinc lactate dentifrices for the control of established supragingival plaque and gingivitis in a six-month clinical study. ( Aguilar, MM; Boneta, AE; DeVizio, W; Proskin, HM; Romeu, FL; Stewart, B, 2010)
"The aim of this pilot study was to evaluate the effectiveness of a mouthwash containing Triclosan and Gantrez in the reduction of bacterial biofilm and gingivitis."	9.14	Effectiveness of a mouthwash containing Triclosan and Gantrez in the reduction of biofilm and gingivitis: a clinical pilot study. ( Andrade Acevedo, R; Chávez, N; Machón, L, 2009)
"The objective of this study was to determine the effects of a triclosan/copolymer dentifrice on plaque formation, gingivitis and gingival bleeding in pregnant subjects."	9.12	Effects of a triclosan dentifrice on plaque formation, gingivitis and gingival bleeding in pregnant women: five-month clinical results. ( Amornchat, C; Kraivaphan, P; Triratana, T, 2007)
"3% triclosan/copolymer dentifrice on gingivitis, compared to a placebo dentifrice."	9.12	Clinical effect of a triclosan containing dentifrice on gingivitis during pregnancy and post-partum. ( Amornchat, C; Kraivaphan, P; Leethochawalit, U; Triratana, T, 2006)
"454% stannous fluoride/sodium hexametaphosphate dentifrice in reducing gingivitis compared to the triclosan/copolymer control in this partially supervised study."	9.11	The comparative efficacy of stabilized stannous fluoride/sodium hexametaphosphate dentifrice and sodium fluoride/triclosan/copolymer dentifrice for the control of gingivitis: a 6-month randomized clinical study. ( Archila, L; Bartizek, RD; Biesbrock, AR; He, T; McClanahan, SF; Winston, JL, 2004)
"15% triclosan and zinc chloride mouthwash against gingivitis development and supragingival plaque formation."	9.11	Influence of alcohol in mouthwashes containing triclosan and zinc: an experimental gingivitis study. ( Almerich, JM; Cabedo, B; Ortolá, JC; Poblet, J, 2005)
"Antimicrobial agents, such as stannous fluoride and triclosan, have been incorporated into dentifrice formulations and shown to be effective in the prevention and reduction of gingivitis."	9.11	Antigingivitis efficacy of a stabilized stannous fluoride/sodium hexametaphosphate dentifrice in subjects previously nonresponsive to a triclosan/copolymer dentifrice. ( Archila, L; Bartizek, RD; Biesbrock, AR; He, T; McClanahan, SF; Winston, JL, 2005)
"28% triclosan/5% pyrophosphate (with NaF/silica) dentifrice on dental plaque and gingivitis as compared to a NaF/silica negative control dentifrice."	9.10	Triclosan/pyrophosphate dentifrice: dental plaque and gingivitis effects in a 6-month randomized controlled clinical study. ( Bennett, S; Bollmer, BW; Court, LK; Grossman, E; Hou, L; McClanahan, SF; McClary, JM; Winston, JL, 2002)
" However, liquid varieties recently have become available The authors conducted a study to determine whether a fluoridated liquid product with added triclosan and a polyvinyl methyl ether/maleic acid, or PVM/MA, copolymer delivery system is efficacious for the control of supragingival plaque and gingivitis."	9.10	Clinical effect of a new liquid dentifrice containing triclosan/copolymer on existing plaque and gingivitis. ( DeVizio, W; Giniger, M; Petrone, M; Rustogi, KN; Triratana, T; Volpe, AR, 2002)
"A recently reported six-month gingivitis study demonstrated that in subjects with gingivitis, a triclosan/pyrophosphate dentifrice provided supragingival plaque control."	9.10	Experimental gingivitis studies: effects of triclosan and triclosan-containing dentifrices on dental plaque and gingivitis in three-week randomized controlled clinical trials. ( Bacca, L; Barlow, A; Bartizek, RD; Brennan, K; Lang, NP; McClanahan, SF; Sander, L; White, DJ, 2002)
"The data suggest that a dentifrice containing the combination of triclosan + pvm/ma + Zn + PPi should be formulated for dental plaque control."	9.09	Effect of 3 dentifrices containing triclosan and various additives. An experimental gingivitis study. ( Cury, JA; Nogueira-Filho, GR; Toledo, S, 2000)
"243% sodium fluoride on supragingival dental plaque and gingivitis."	9.08	Microbial alterations in supragingival dental plaque in response to a triclosan-containing dentifrice. ( Berta, R; Bonta, Y; DeVizio, W; Dunford, RG; Reynolds, HS; Tempro, JP; Volpe, AR; Zambon, JJ, 1995)
"3% triclosan and 2% of a copolymer of methoxyethylene and maleic acid on supragingival plaque formation and gingivitis, as compared to a placebo dentifrice."	9.07	Effect upon plaque formation and gingivitis of a triclosan/copolymer/fluoride dentifrice: a 6-month clinical study. ( Denepitiya, JL; DeVizio, W; Fine, D; Person, P; Singh, S; Volpe, AR, 1992)
"The aim of this study was to investigate the ability of Triclosan dentifrices to delay the development of gingivitis during a 21-day period without toothbrushing."	9.07	The effect of dentifrices containing Triclosan on the development of gingivitis in a 21-day experimental gingivitis study. ( Cummins, D; Huntington, E; Saxton, CA, 1993)
"In order to compare the antiplaque and antigingivitis activity of three commercially-available triclosan containing dentifrices with that of a placebo dentifrice without triclosan, a double-blind clinical study was conducted on 194 subjects over six months."	9.07	The effect of three commercially available dentifrices containing triclosan on supragingival plaque formation and gingivitis: a six month clinical study. ( DeVizio, W; McCool, J; Palomo, F; Sanchez, A; Volpe, AR; Wantland, L, 1994)
"8 per cent sodium monofluorophosphate/silica base on supragingival plaque, gingivitis and supragingival calculus formation, compared to a 0."	9.07	The effects of a silica dentifrice containing Triclosan and zinc citrate on supragingival plaque and calculus formation and the control of gingivitis. ( Cummins, D; Huntington, E; Saxton, CA; Svatun, B, 1993)
"A double blind, seven month clinical study was conducted to determine the effects of three Triclosan containing test dentifrices on supragingival plaque, gingivitis and supragingival calculus formation compared to a 0."	9.07	The effects of three silica dentifrices containing Triclosan on supragingival plaque and calculus formation and on gingivitis. ( Cummins, D; Huntington, E; Sadxton, CA; Svatun, B, 1993)
"The aim of the present clinical trial was to study the effect on existing plaque and gingivitis of an oral hygiene regimen which utilized a dentifrice which contained triclosan."	9.07	The effect of a triclosan-containing dentifrice on established plaque and gingivitis. ( Lindhe, J; Rosling, B; Socransky, SS; Volpe, AR, 1993)
"A partial mouth experimental gingivitis model was employed to establish the potential efficacy of a dentifrice containing a zinc salt and the antimicrobial agent Triclosan to prevent or delay the development of gingivitis over a period of 28 days."	9.06	The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. ( Saxton, CA; van der Ouderaa, FJ, 1989)
"3% triclosan and 2% of a copolymer of methoxyethylene and maleic acid on plaque formation and gingivitis, as compared to a placebo dentifrice."	9.06	Effect of a triclosan/copolymer/fluoride dentifrice on plaque formation and gingivitis: a 7-month clinical study. ( DeVizio, W; Ferlauto, RJ; Garcia-Godoy, F; Miller, JM; Volpe, AR, 1990)
"3% triclosan and 2% of a copolymer of methoxyethylene and maleic acid on plaque formation and gingivitis."	9.06	The effect of a dentifrice containing triclosan and a copolymer on plaque formation and gingivitis: a 14-week clinical study. ( Baines, E; Carter, W; DeVizio, W; Palomo, F; Sanchez, A; Wantland, L, 1989)
"454% highly bioavailable stannous fluoride dentifrice (SnF2) relative to a 0."	6.78	Evaluation of anti-gingivitis benefits of stannous fluoride dentifrice among triclosan dentifrice users. ( Amini, P; Barker, ML; Biesbrock, A; Goyal, CR; He, T; Miner, M; Qaqish, J, 2013)
"Triclosan is a broad-spectrum antimicrobial agent widely used in oral care products."	6.70	Effects of triclosan/copolymer dentifrice on dental plaque and gingivitis in a 3-month randomized controlled clinical trial: influence of baseline gingivitis on observed efficacy. ( Bartizek, RD; McClanahan, SF, 2002)
"One hundred twenty subjects previously treated for chronic periodontitis were included in the study."	6.70	Effect of a toothpaste containing triclosan on dental plaque, gingivitis, and bleeding on probing--an investigation in periodontitis patients over 28 weeks. ( Brecx, M; Bruhn, G; Hoffmann, T; Netuschil, L; Richter, S, 2002)
" Pharmacokinetic data demonstrate that approximately 30% of the zinc and Triclosan dosed is retained immediately after brushing."	6.38	Zinc citrate/Triclosan: a new anti-plaque system for the control of plaque and the prevention of gingivitis: short-term clinical and mode of action studies. ( Cummins, D, 1991)
"Subjects brushing with a newly formulated stannous fluoride dentifrice had statistically significantly fewer bleeding sites and less gingivitis than those using a positive control triclosan dentifrice after two months."	5.24	Assessment of the Effects of a Novel Stabilized Stannous Fluoride Dentifrice on Gingivitis in a Two-Month Positive-Controlled Clinical Study. ( Eusebio, R; Goyal, CR; He, T; Qaqish, JG, 2017)
"Aloe vera-containing toothpaste was effective in reducing plaque, gingivitis, and overall candidal counts compared to triclosan."	5.24	Antiplaque, Antifungal Effectiveness of Aloevera Among Intellectually Disabled Adolescents: Pilot Study. ( Acharya, S; Khatri, SG; Patil, ST; Samuel, SR, 2017)
"The aims of this study were to; 1) test susceptibility to bacteremia in subjects with moderate gingivitis, and 2) compare the effects of brushing with a fluoride toothpaste (control) as compared to a triclosan/copolymer toothpaste (test) on those susceptible to repeated bacteremia."	5.24	Reduction in bacteremia after brushing with a triclosan/copolymer dentifrice-A randomized clinical study. ( Fine, DH; Sreenivasan, PK; Tischio-Bereski, D, 2017)
"Triclosan reduced microbial levels during gingivitis development (ClinicalTrials."	5.22	Effects of triclosan on host response and microbial biomarkers during experimental gingivitis. ( Braun, TM; Giannobile, WV; Kinney, JS; Kott, D; Panagakos, FS; Pancer, BA; Sugai, JV; Teles, RP, 2016)
"To assess the effectiveness of three different mouthrinses--chlorhexidine, triclosan + sodium fluoride and chlorhexidine + triclosan + sodium fluoride + zinc chloride--on plaque, calculus, gingivitis and stains and to evaluate the occurrence of adverse effects with these three treatments."	5.17	Effectiveness of a mouthrinse containing active ingredients in addition to chlorhexidine and triclosan compared with chlorhexidine and triclosan rinses on plaque, gingivitis, supragingival calculus and extrinsic staining. ( Duraiswamy, P; Kulkarni, S; Kumar, S; Patel, S; Tadakamadla, J; Tibdewal, H, 2013)
"Ninety patients diagnosed with chronic generalized gingivitis were selected and randomly divided into three groups: group 1, placebo toothpaste; group 2, toothpaste containing aloe vera; and group 3, toothpaste with polymer and fluoride containing triclosan."	5.16	Clinical and microbiologic effects of commercially available dentifrice containing aloe vera: a randomized controlled clinical trial. ( Agarwal, E; Naik, SB; Pradeep, AR, 2012)
"Subjects in the triclosan/copolymer group demonstrated significantly lower levels of dental plaque, gingivitis, and bleeding on probing at 3 and 6 months at both the implant and contra-lateral tooth compared with the fluoride group (p<0."	5.15	A 6-month study of the effects of 0.3% triclosan/copolymer dentifrice on dental implants. ( da Silva, MP; De Vizio, W; Haraszthy, VI; Kolog, H; Mann, J; Sreenivasan, PK; Steinberg, D; Vered, Y; Zambon, JJ; Zini, A, 2011)
"The aim of this pilot study was to evaluate the effectiveness of a mouthwash containing Triclosan and Gantrez in the reduction of bacterial biofilm and gingivitis."	5.14	Effectiveness of a mouthwash containing Triclosan and Gantrez in the reduction of biofilm and gingivitis: a clinical pilot study. ( Andrade Acevedo, R; Chávez, N; Machón, L, 2009)
"Statistical analysis indicates that CT significantly decreased the levels of inosine, lysine, putrescine, and xanthine at the gingivitis sites as early as week 1."	5.14	Assessment of the effects of dentifrice on periodontal disease biomarkers in gingival crevicular fluid. ( Barnes, VM; Devizio, W; Guo, L; Lee, DP; Milburn, MV; Mitchell, MW; Teles, R; Trivedi, HM; Wulff, JE; Xu, T, 2010)
"243% sodium fluoride is efficacious for the control of established gingivitis and supragingival plaque as compared to a regular fluoride dentifrice, and that it provides a greater level of efficacy for the control of gingivitis and supragingival plaque than does a dentifrice containing 0."	5.14	A clinical investigation of the efficacy of three commercially available dentifrices for controlling established gingivitis and supragingival plaque. ( Chaknis, P; DeVizio, W; Panagakos, FS; Petrone, M; Proskin, HM; Singh, S, 2010)
"243% sodium fluoride provides a significant reduction in established supragingival plaque and gingivitis, as compared to a dentifrice containing 0."	5.14	Comparative investigation of the efficacy of triclosan/copolymer/sodium fluoride and stannous fluoride/sodium hexametaphosphate/zinc lactate dentifrices for the control of established supragingival plaque and gingivitis in a six-month clinical study. ( Aguilar, MM; Boneta, AE; DeVizio, W; Proskin, HM; Romeu, FL; Stewart, B, 2010)
"243% sodium fluoride in a 17% dual silica base is efficacious for the control of established supragingival plaque and gingivitis."	5.13	A clinical investigation of the efficacy of two dentifrices for controlling established supragingival plaque and gingivitis. ( Boneta, AE; DeVizio, W; Mateu, FA; Proskin, HM; Stewart, B, 2008)
"The results of this clinical study support the conclusion that the use of Colgate Total Toothpaste, both with and without the use of dental floss, provided statistically significant improvements over the sodium fluoride toothpaste plus flossing regimen with respect to the control of gingivitis and supragingival plaque formation."	5.12	A clinical investigation of the efficacy of three different treatment regimens for the control of plaque and gingivitis. ( DeVizio, W; Petrone, M; Proskin, HM; Schiff, T; Zhang, YP, 2006)
" Triclosan appears to attenuate the causal association between supragingival plaque and gingival bleeding in gingivitis."	5.12	Effect of triclosan/copolymer-containing toothpaste on the association between plaque and gingival bleeding: a randomized controlled clinical trial. ( Barrieshi-Nusair, KM; Könönen, E; Müller, HP; Yang, M, 2006)
"The objective of this study was to determine the effects of a triclosan/copolymer dentifrice on plaque formation, gingivitis and gingival bleeding in pregnant subjects."	5.12	Effects of a triclosan dentifrice on plaque formation, gingivitis and gingival bleeding in pregnant women: five-month clinical results. ( Amornchat, C; Kraivaphan, P; Triratana, T, 2007)
"15% triclosan and zinc chloride mouthwash against gingivitis development and supragingival plaque formation."	5.11	Influence of alcohol in mouthwashes containing triclosan and zinc: an experimental gingivitis study. ( Almerich, JM; Cabedo, B; Ortolá, JC; Poblet, J, 2005)
"45% SnF2 gel significantly inhibited the onset of gingivitis compared to Triclosan/sodium fluoride/copolymer (Colgate Total)."	5.11	An experimental gingivitis study to evaluate the clinical effects of a stannous fluoride dentifrice. ( Anton, E; Gabriel, Y; He, T; Lang, NP; Pjetursson, BE; Salvi, GE; Winston, JL, 2004)
"Antimicrobial agents, such as stannous fluoride and triclosan, have been incorporated into dentifrice formulations and shown to be effective in the prevention and reduction of gingivitis."	5.11	Antigingivitis efficacy of a stabilized stannous fluoride/sodium hexametaphosphate dentifrice in subjects previously nonresponsive to a triclosan/copolymer dentifrice. ( Archila, L; Bartizek, RD; Biesbrock, AR; He, T; McClanahan, SF; Winston, JL, 2005)
"28% triclosan/5% pyrophosphate (with NaF/silica) dentifrice on dental plaque and gingivitis as compared to a NaF/silica negative control dentifrice."	5.10	Triclosan/pyrophosphate dentifrice: dental plaque and gingivitis effects in a 6-month randomized controlled clinical study. ( Bennett, S; Bollmer, BW; Court, LK; Grossman, E; Hou, L; McClanahan, SF; McClary, JM; Winston, JL, 2002)
" However, liquid varieties recently have become available The authors conducted a study to determine whether a fluoridated liquid product with added triclosan and a polyvinyl methyl ether/maleic acid, or PVM/MA, copolymer delivery system is efficacious for the control of supragingival plaque and gingivitis."	5.10	Clinical effect of a new liquid dentifrice containing triclosan/copolymer on existing plaque and gingivitis. ( DeVizio, W; Giniger, M; Petrone, M; Rustogi, KN; Triratana, T; Volpe, AR, 2002)
" Colgate Total Fresh Stripe Toothpaste as a control, and a placebo dentifrice without triclosan and the copolymer, for the control of supragingival dental plaque and gingivitis."	5.10	The clinical efficacy of Colgate Total Plus Whitening Toothpaste containing a special grade of silica and Colgate Total Fresh Stripe Toothpaste in the control of plaque and gingivitis: a six-month clinical study. ( Allen, DR; Battista, GW; Chaknis, P; DeVizio, W; Petrone, DM; Petrone, ME; Volpe, AR, 2002)
"Although the Listerine Antiseptic and Colgate Total antiplaque/antigingivitis products produced similar, clinically significant reductions in gingivitis (as measured by MGI and BI), Listerine, when used in conjunction with a fluoride dentifrice and usual oral hygiene, provided a greater benefit in reducing plaque."	5.09	Comparative efficacy of an antiseptic mouthrinse and an antiplaque/antigingivitis dentifrice. A six-month clinical trial. ( Charles, CH; Galustians, HJ; McGuire, JA; Qaqish, J; Sharma, NC; Vincent, JW, 2001)
"The aim of the study was to assess the effect on existing plaque and gingivitis of an oral hygiene regimen which utilizes triclosan/copolymer and to compare it with a regimen which uses interdental cleaning devices to control the interdental inflammation."	5.09	Resolution of interdental inflammation with 2 different modes of plaque control. ( Kocher, T; Sawaf, H; Warncke, M; Welk, A, 2000)
"The purpose of this work was to assess the in vitro antibacterial effectiveness of three dentifrices containing antimicrobial agents and to test the in vivo anti plaque and anti gingivitis effect of a toothpaste containing triclosan (CAOLA)."	5.09	[Laboratory and clinical investigation of multifunctional dentifrices. Clinical study of a new triclosan-containing toothpaste]. ( Dóri, F; Gera, I; Keglevich, T; Nagy, E; Szabó, G, 1999)
"The data suggest that a dentifrice containing the combination of triclosan + pvm/ma + Zn + PPi should be formulated for dental plaque control."	5.09	Effect of 3 dentifrices containing triclosan and various additives. An experimental gingivitis study. ( Cury, JA; Nogueira-Filho, GR; Toledo, S, 2000)
"243% sodium fluoride on supragingival dental plaque and gingivitis."	5.08	Microbial alterations in supragingival dental plaque in response to a triclosan-containing dentifrice. ( Berta, R; Bonta, Y; DeVizio, W; Dunford, RG; Reynolds, HS; Tempro, JP; Volpe, AR; Zambon, JJ, 1995)
"Some triclosan and stannous fluoride toothpastes have been shown effective in reducing plaque and more particularly gingivitis in home use studies."	5.08	A comparison of triclosan and stannous fluoride toothpastes for inhibition of plaque regrowth. A crossover study designed to assess carry over. ( Addy, M; Binney, A; Faulkner, J; Owens, J, 1997)
"In order to compare the antiplaque and antigingivitis activity of three commercially-available triclosan containing dentifrices with that of a placebo dentifrice without triclosan, a double-blind clinical study was conducted on 194 subjects over six months."	5.07	The effect of three commercially available dentifrices containing triclosan on supragingival plaque formation and gingivitis: a six month clinical study. ( DeVizio, W; McCool, J; Palomo, F; Sanchez, A; Volpe, AR; Wantland, L, 1994)
"The aim of the present clinical trial was to study the effect on existing plaque and gingivitis of an oral hygiene regimen which utilized a dentifrice which contained triclosan."	5.07	The effect of a triclosan-containing dentifrice on established plaque and gingivitis. ( Lindhe, J; Rosling, B; Socransky, SS; Volpe, AR, 1993)
"8 per cent sodium monofluorophosphate/silica base on supragingival plaque, gingivitis and supragingival calculus formation, compared to a 0."	5.07	The effects of a silica dentifrice containing Triclosan and zinc citrate on supragingival plaque and calculus formation and the control of gingivitis. ( Cummins, D; Huntington, E; Saxton, CA; Svatun, B, 1993)
"The aim of this study was to investigate the ability of Triclosan dentifrices to delay the development of gingivitis during a 21-day period without toothbrushing."	5.07	The effect of dentifrices containing Triclosan on the development of gingivitis in a 21-day experimental gingivitis study. ( Cummins, D; Huntington, E; Saxton, CA, 1993)
"A double blind, seven month clinical study was conducted to determine the effects of three Triclosan containing test dentifrices on supragingival plaque, gingivitis and supragingival calculus formation compared to a 0."	5.07	The effects of three silica dentifrices containing Triclosan on supragingival plaque and calculus formation and on gingivitis. ( Cummins, D; Huntington, E; Sadxton, CA; Svatun, B, 1993)
"3% triclosan and 2% of a copolymer of methoxyethylene and maleic acid on supragingival plaque formation and gingivitis, as compared to a placebo dentifrice."	5.07	Effect upon plaque formation and gingivitis of a triclosan/copolymer/fluoride dentifrice: a 6-month clinical study. ( Denepitiya, JL; DeVizio, W; Fine, D; Person, P; Singh, S; Volpe, AR, 1992)
"3% triclosan and 2% of a copolymer of methoxyethylene and maleic acid on plaque formation and gingivitis, as compared to a placebo dentifrice."	5.06	Effect of a triclosan/copolymer/fluoride dentifrice on plaque formation and gingivitis: a 7-month clinical study. ( DeVizio, W; Ferlauto, RJ; Garcia-Godoy, F; Miller, JM; Volpe, AR, 1990)
"A partial mouth experimental gingivitis model was employed to establish the potential efficacy of a dentifrice containing a zinc salt and the antimicrobial agent Triclosan to prevent or delay the development of gingivitis over a period of 28 days."	5.06	The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. ( Saxton, CA; van der Ouderaa, FJ, 1989)
"3% triclosan and 2% of a copolymer of methoxyethylene and maleic acid on plaque formation and gingivitis."	5.06	The effect of a dentifrice containing triclosan and a copolymer on plaque formation and gingivitis: a 14-week clinical study. ( Baines, E; Carter, W; DeVizio, W; Palomo, F; Sanchez, A; Wantland, L, 1989)
"To systematically review the literature to compare the efficacy of triclosan (Tcs) and stannous fluoride (SnF) dentifrices on parameters of gingivitis and plaque scores."	4.91	Comparison of triclosan and stannous fluoride dentifrices on parameters of gingival inflammation and plaque scores: a systematic review and meta-analysis. ( Dörfer, CE; Sälzer, S; Slot, DE; Van der Weijden, GA, 2015)
"To assess the effects of triclosan/copolymer containing fluoride toothpastes, compared with fluoride toothpastes, for the long-term control of caries, plaque and gingivitis in children and adults."	4.89	Triclosan/copolymer containing toothpastes for oral health. ( Lamont, T; Riley, P, 2013)
"This systematic review indicates, based on studies >or=6 months of duration in adults with gingivitis, that the effectiveness of self-performed mechanical plaque control with a triclosan-containing dentifrice, had a significant albeit small positive effect on the reduction of plaque and gingivitis."	4.82	The effectiveness of self-performed mechanical plaque control with triclosan containing dentifrices. ( Hioe, KP; van der Weijden, GA, 2005)
" The results from these studies conclusively demonstrate that long-term use of oral care formulations with well-known antiplaque biocides such as chlorhexidine and triclosan reduce supragingival plaque and gingivitis."	4.81	Antiplaque biocides and bacterial resistance: a review. ( Gaffar, A; Sreenivasan, P, 2002)
"This paper provides an overview and summary of the data that demonstrate the effectiveness of a dentifrice containing triclosan/copolymer/fluoride in significantly reducing plaque, calculus, gingivitis, and the onset and progression of periodontitis."	3.72	Rationale for the daily use of a dentifrice containing triclosan in the maintenance of oral health. ( Davies, R; DeVizio, W, 2004)
"454% highly bioavailable stannous fluoride dentifrice (SnF2) relative to a 0."	2.78	Evaluation of anti-gingivitis benefits of stannous fluoride dentifrice among triclosan dentifrice users. ( Amini, P; Barker, ML; Biesbrock, A; Goyal, CR; He, T; Miner, M; Qaqish, J, 2013)
"At baseline, pre-treatment gingivitis levels were assessed with both the Lobene Modified Gingival Index (MGI) and the Gingival Bleeding Index (GBI)."	2.77	Anti-gingivitis effects of a novel 0.454% stabilized stannous fluoride dentifrice relative to a positive control. ( Barker, ML; Biesbrock, AR; Goyal, CR; He, T, 2012)
"One hundred twenty subjects previously treated for chronic periodontitis were included in the study."	2.70	Effect of a toothpaste containing triclosan on dental plaque, gingivitis, and bleeding on probing--an investigation in periodontitis patients over 28 weeks. ( Brecx, M; Bruhn, G; Hoffmann, T; Netuschil, L; Richter, S, 2002)
"Triclosan is a broad-spectrum antimicrobial agent widely used in oral care products."	2.70	Effects of triclosan/copolymer dentifrice on dental plaque and gingivitis in a 3-month randomized controlled clinical trial: influence of baseline gingivitis on observed efficacy. ( Bartizek, RD; McClanahan, SF, 2002)
"Triclosan is a lipid-soluble, antibacterial substance which is added to toothpastes and mouthwashes to inhibit plaque."	2.67	Experiments with a toothpaste containing polydimethylsiloxan/triclosan. ( Ellingsen, JE; Gaare, D; Rölla, G, 1993)
"The retention of triclosan in dental plaque was significantly higher with Total as compared with other dentifrices 2 hours post brushing."	2.67	Recent advances in plaque, gingivitis, tartar and caries prevention technology. ( Afflitto, J; Gaffar, A; Herles, S; Kruger, I; Nabi, N; Olsen, S, 1994)
"Triclosan is a broad-spectrum antibacterial agent, marketed for use in oral products."	2.43	Advanced oral antibacterial/anti-inflammatory technology: A comprehensive review of the clinical benefits of a triclosan/copolymer/fluoride dentifrice. ( Davies, RM; DeVizio, W; Panagakos, FS; Petrone, ME; Proskin, HM; Volpe, AR, 2005)
"Triclosan is a broad spectrum antimicrobial agent, with additional anti-metabolic and anti-inflammatory properties."	2.42	The role of Triclosan in dentifrice formulations, with particular reference to a new 0.3% Triclosan calcium carbonate-based system. ( Beasley, T; Brading, MG; Cromwell, VJ; DeBrabander, S; Green, AK; Marsh, PD, 2004)
"Periodontal diseases are a group of related inflammatory disorders, initiated by dental plaque and causing destruction of the supporting structures of the teeth."	2.39	Mouthrinses as adjuncts in periodontal therapy. ( Walsh, TF, 1996)
" Pharmacokinetic data demonstrate that approximately 30% of the zinc and Triclosan dosed is retained immediately after brushing."	2.38	Zinc citrate/Triclosan: a new anti-plaque system for the control of plaque and the prevention of gingivitis: short-term clinical and mode of action studies. ( Cummins, D, 1991)
"Pre-treatment with triclosan before SLS exposure had a slight effect whereas treatment after exposure showed a significant effect."	1.29	Triclosan protects the skin against dermatitis caused by sodium lauryl sulphate exposure. ( Barkvoll, P; Rølla, G, 1994)

Research

Studies (128)

Authors

Clinical Trials (16)

Trial Overview

Trial Outcomes

Dental Plaque Score

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (4.69)	18.7374
1990's	46 (35.94)	18.2507
2000's	46 (35.94)	29.6817
2010's	29 (22.66)	24.3611
2020's	1 (0.78)	2.80

Authors	Studies
He, T	9
Zou, Y	2
DiGennaro, J	2
Biesbrock, AR	6
Sreenivasan, PK	2
Tischio-Bereski, D	1
Fine, DH	2
Eusebio, R	1
Goyal, CR	4
Qaqish, JG	1
Khatri, SG	1
Samuel, SR	1
Acharya, S	1
Patil, ST	1
Figuero, E	2
Herrera, D	2
Tobías, A	2
Serrano, J	2
Roldán, S	2
Escribano, M	2
Martín, C	2
Trombelli, L	1
Farina, R	1
Riley, P	1
Lamont, T	1
Barker, ML	3
Biesbrock, A	1
Miner, M	1
Amini, P	1
Qaqish, J	3
Sälzer, S	1
Slot, DE	1
Dörfer, CE	1
Van der Weijden, GA	2
Rover, JA	1
Leu-Wai-See, P	1
Cagetti, MG	1
Strohmenger, L	1
Basile, V	1
Abati, S	1
Mastroberardino, S	1
Campus, G	1
Hernandez, M	1
Kumar, S	2
Triratana, T	5
Kraivaphan, P	4
Amornchat, C	4
Mateo, LR	1
Morrison, BM	1
Dibart, S	2
Zhang, YP	3
Pancer, BA	1
Kott, D	1
Sugai, JV	1
Panagakos, FS	5
Braun, TM	1
Teles, RP	2
Giannobile, WV	1
Kinney, JS	1
Davies, RM	4
DeVizio, W	21
Mateu, FA	1
Boneta, AE	2
Stewart, B	2
Proskin, HM	7
Blinkhorn, A	1
Bartold, PM	1
Cullinan, MP	1
Madden, TE	1
Marshall, RI	1
Raphael, SL	1
Seymour, GJ	1
Teles, FR	1
Andrade Acevedo, R	1
Machón, L	1
Chávez, N	1
Barnes, VM	2
Teles, R	1
Trivedi, HM	2
Xu, T	2
Lee, DP	1
Mitchell, MW	1
Wulff, JE	1
Milburn, MV	1
Guo, L	1
Vervelle, A	1
Mouhyi, J	1
Del Corso, M	1
Hippolyte, MP	1
Sammartino, G	1
Dohan Ehrenfest, DM	1
Vered, Y	1
Zini, A	1
Mann, J	1
Kolog, H	1
Steinberg, D	1
Zambon, JJ	4
Haraszthy, VI	1
da Silva, MP	1
De Vizio, W	2
Ciancio, S	1
Singh, S	2
Chaknis, P	5
Petrone, M	5
Aguilar, MM	1
Romeu, FL	1
Pradeep, AR	1
Agarwal, E	1
Naik, SB	1
García-Godoy, F	3
Mankodi, S	3
Patel, S	1
Tadakamadla, J	1
Tibdewal, H	1
Duraiswamy, P	1
Kulkarni, S	1
Biesbock, AR	1
Sharma, NC	2
Grossman, E	1
Hou, L	1
Bollmer, BW	1
Court, LK	1
McClary, JM	1
Bennett, S	1
Winston, JL	5
McClanahan, SF	7
Lang, NP	2
Sander, L	1
Barlow, A	1
Brennan, K	1
White, DJ	2
Bacca, L	2
Bartizek, RD	7
Bruhn, G	1
Netuschil, L	1
Richter, S	1
Brecx, M	1
Hoffmann, T	1
Yates, R	1
Shearer, BH	1
Huntington, E	4
Addy, M	5
Sreenivasan, P	1
Gaffar, A	6
Nogueira-Filho, GR	2
Duarte, PM	1
Toledo, S	2
Tabchoury, CP	1
Cury, JA	2
Rosin, M	1
Kramer, A	1
Bradtke, D	1
Richter, G	1
Kocher, T	2
Lopez, M	1
Smith, I	1
Petrone, DM	2
Petrone, ME	7
Mau, MS	1
Beiswanger, BB	2
Sköld-Larsson, K	1
Yucel-Lindberg, T	1
Twetman, S	1
Modéer, T	2
Hoang, TQ	1
Brading, MG	1
Cromwell, VJ	1
Green, AK	1
DeBrabander, S	1
Beasley, T	1
Marsh, PD	2
Peter, S	1
Nayak, DG	1
Philip, P	1
Bijlani, NS	1
Wara-aswapati, N	1
Krongnawakul, D	1
Jiraviboon, D	1
Adulyanon, S	1
Karimbux, N	1
Pitiphat, W	1
Deshmukh, M	1
Cummins, D	7
Davies, R	1
Archila, L	2
Almerich, JM	1
Cabedo, B	1
Ortolá, JC	1
Poblet, J	1
Shearer, B	1
Hall, P	1
Clarke, P	1
Marshall, G	1
Kinane, DF	1
Anton, E	1
Gabriel, Y	1
Salvi, GE	1
Pjetursson, BE	1
Paraskevas, S	1
Hioe, KP	1
Volpe, AR	18
Müller, HP	1
Barrieshi-Nusair, KM	1
Könönen, E	1
Yang, M	1
Leethochawalit, U	1
Gunsolley, JC	1
Schiff, T	1
Luan, Q	1
Desta, T	1
Chehab, L	1
Sanders, VJ	1
Plattner, J	1
Graves, DT	1
Gerlach, RW	1
Terézhalmy, GT	1
Ramberg, P	3
Furuichi, Y	3
Sherl, D	1
Nabi, N	3
Lindhe, J	5
Scherl, D	1
Afflitto, J	3
Coleman, EJ	1
Renvert, S	1
Birkhed, D	1
Kanchanakamol, U	1
Umpriwan, R	1
Jotikasthira, N	1
Srisilapanan, P	1
Tuongratanaphan, S	1
Sholitkul, W	1
Chat-Uthai, T	1
Barkvoll, P	1
Rølla, G	2
Ellingsen, JE	2
Gaare, D	2
Ayad, F	2
Berta, R	2
Volpe, A	1
Simard, F	1
Landry, RG	1
Herles, S	1
Kruger, I	1
Olsen, S	1
Palomo, F	2
Wantland, L	2
Sanchez, A	2
McCool, J	1
Schaeken, MJ	2
van der Hoeven, JS	2
Saxton, CA	11
Worthington, HV	1
Blinkhorn, AS	1
Svatun, B	4
Sadxton, CA	1
Rölla, G	4
Yiu, CK	1
Wei, SH	1
Rosling, B	1
Socransky, SS	1
Reynolds, HS	1
Dunford, RG	2
Tempro, JP	1
Bonta, Y	2
Rustogi, K	1
Petrone, MP	1
Bengtsson, A	1
Walsh, TF	1
Binney, A	2
Owens, J	3
Faulkner, J	3
McKeown, S	1
Everatt, L	1
Lanzalaco, AC	1
Krok, L	1
Jackson, RJ	1
Moran, JM	1
Dóri, F	1
Gera, I	1
Szabó, G	1
Keglevich, T	1
Nagy, E	1
Furgang, D	1
Reynolds, H	1
Sawaf, H	1
Warncke, M	1
Welk, A	1
Charles, CH	1
Galustians, HJ	1
McGuire, JA	1
Vincent, JW	1
Hu, D	1
Zhang, J	1
Wan, H	1
Zhang, Y	1
Prencipe, M	1
Allen, DR	1
Battista, GW	1
Rustogi, KN	1
Giniger, M	1
Angelillo, IF	1
Nobile, CG	1
Pavia, M	1
Denepitiya, JL	1
Fine, D	1
Person, P	1
Bolden, TE	1
Sowinski, J	1
McCool, JJ	1
Cubells, AB	1
Dalmau, LB	1
Ferlauto, RJ	1
Miller, JM	1
Jones, CL	2
Ritchie, JA	2
Stephen, KW	1
Morrison, T	1
Moran, J	1
Newcombe, R	1
van der Ouderaa, FJ	1
Carter, W	1
Baines, E	1
van der Ouderaa, F	2
Lane, RM	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Effects of a Toothpaste Containing 0.3% Triclosan in the Maintenance Phase of Peri-implantitis Treatment.[NCT03191721]	Phase 3	102 participants (Actual)	Interventional	2010-06-30	Completed
The Clinical Investigation of Colgate Total Toothpaste as Compared to Parodontax Toothpaste and Colgate Cavity Protection Toothpaste in Controlling Established Plaque and Gingivitis. (A Six Month Study)[NCT02080273]	Phase 4	135 participants (Actual)	Interventional	2013-03-31	Completed
Study of the Anti-Inflammatory Effects of Colgate Total® During an Experimental Gingivitis Model[NCT01799226]		32 participants (Actual)	Interventional	2013-03-31	Completed
Evaluation of Synergistic Anti-plaque Activity of Salvadora Persica L. and Green Tea: A Clinical Comparative Study[NCT02624336]	Phase 2	14 participants (Actual)	Interventional	2015-02-28	Completed
Clinical Evaluation of a Mouthwash Containing Malva Sylvestris Extract and Its Role in Reducing Oral Biofilm and Gingival Inflammation. A Randomized, Triple Masked Clinical Trial.[NCT05138484]	Phase 3	54 participants (Actual)	Interventional	2017-10-20	Completed
Efficiency of Flurbiprofen 2.5% in Comparison to 98% Aloe Vera Gel as an Adjunctive Therapy to Scaling and Root Planning in the Initial Treatment of Stage III Chronic Periodontitis in Smoking Patients[NCT06041178]	Phase 4	60 participants (Actual)	Interventional	2022-09-30	Completed
Efficacy of a Commercial Dentifrice Containing Ilex Rotunda Thunb Extract for Dental Plaque and Gingivitis: A 3-month Clinical Study in Adults in China[NCT02313558]		100 participants (Actual)	Interventional	2013-03-31	Completed
Efficacy of a Rinse Containing Sea Salt and Lysozyme on Biofilm and Gingival Health in a Group of Young Adults: A Pilot Study.[NCT03329105]		30 participants (Actual)	Interventional	2016-11-07	Completed
A Prospective, Randomized, Blinded, Clinical Study to Evaluate Effects of an Oral Rinse on Plaque and Gingivitis[NCT03421145]		200 participants (Actual)	Interventional	2017-12-17	Completed
Imaging-based Assessment of Oral Biofilm and Gingival Health[NCT05470023]		275 participants (Anticipated)	Interventional	2022-09-01	Recruiting
Twelve Week Clinical Efficacy of Virtually Supervised Mouth Rinse and Flossing: Effect on Plaque and Gingivitis[NCT04750005]	Phase 4	209 participants (Actual)	Interventional	2020-10-23	Completed
Twelve Week Clinical Efficacy of Virtually Supervised Mouth Rinse and Flossing: Effect on Plaque, Gingivitis, and Microbiome[NCT05600231]	Phase 4	284 participants (Actual)	Interventional	2022-04-18	Completed
Six Month Clinical Efficacy of Virtually Supervised Mouthwash and Interdental Brushes: Effect on Plaque, Gingivitis and Oral Microbiome[NCT05756673]	Phase 4	292 participants (Actual)	Interventional	2023-02-09	Completed
Twelve Week Safety/Clinical/Microbiological Efficacy of Experimental Mouthwashes[NCT05121909]	Phase 4	274 participants (Actual)	Interventional	2021-11-15	Completed
Effectiveness of Metronidazole Gel and Mobile Telephone Short- Message Service Reminders on Gingivitis in Orthodontic Patients: A Randomized Controlled Trial[NCT03508999]	Phase 4	63 participants (Actual)	Interventional	2018-05-23	Completed
Twelve Week Safety and Clinical Efficacy of Experimental Mouth Rinses[NCT05120141]	Phase 4	300 participants (Actual)	Interventional	2021-03-29	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Dental Plaque (Quigley-Hein, Turesky Modification Index) Units on a scale 0 to 5 (0 = no plaque, 1 = separate flecks of plaque on the tooth, 2 = a thin continuous band of plaque, 3 = a band of plaque up to one-third of the tooth, 4 = plaque covering up to two thirds of the of the tooth, 5 = plaque covering two-thirds or more of the crown of the tooth) (NCT02080273)
Timeframe: 3 months post treatment use

Dental Plaque Score

Intervention	units on a scale (Mean)
Colgate Cavity Protection Toothpaste	3.31
Colgate Total Toothpaste	2.45
Parodontax	3.45

Intervention	units on a scale (Mean)
Colgate Cavity Protection Toothpaste	3.46
Colgate Total Toothpaste	2.98
Parodontax	3.50

Intervention	units on a scale (Mean)
Colgate Cavity Protection Toothpaste	3.40
Colgate Total Toothpaste	1.65
Parodontax	3.23

Gingivitis Scores

Intervention	units on a scale (Mean)
Colgate Cavity Protection Toothpaste	3.53
Colgate Total Toothpaste	3.55
Parodontax	3.59

Gingivitis scale (Loe & Silness Gingival Index) Units on a scale 0 to 3 (0 = no inflammation, 1 = Mild inflammation-slight change in color and little change in texture 2 = Moderate inflammation-moderate glazing, redness, edema and hypertrophy. Tendency to bleed upon probing. 3 = Severe inflammation-marked redness and hypertrophy. Tendency to spontaneous bleeding) (NCT02080273)
Timeframe: 3 months post treatment use

Gingivitis Scores

Intervention	units on a scale (Mean)
Colgate Cavity Protection Toothpaste	1.63
Colgate Total Toothpaste	1.27
Parodontax	1.67

Intervention	units on a scale (Mean)
Colgate Cavity Protection Toothpaste	1.76
Colgate Total Toothpaste	1.65
Parodontax	1.67

Intervention	units on a scale (Mean)
Colgate Cavity Protection Toothpaste	1.57
Colgate Total Toothpaste	0.95
Parodontax	1.47

Change From Baseline in Gingival Index (Loe & Silness 1963) to Day 35

Intervention	units on a scale (Mean)
Colgate Cavity Protection Toothpaste	1.77
Colgate Total Toothpaste	1.78
Parodontax	1.77

Loe & Silness 1963 is a score of 0-3 with 0 = Absence of inflammation, 1 = Mild inflammation, slight change in color and texture, 2 = Moderate inflammation, glazing, redness, edema and hypertrophy, 3 = Severe inflammation, redness and hypertrophy, ulceration. This index was used at days 0, 14, 21 and 35. (NCT01799226)
Timeframe: Baseline to 35 Days

Change From Baseline in Plaque Index (Silness & Loe 1964) to Day 35

Intervention	units on a scale (Mean)
	Gingival index Baseline	Gingival index Day 14	Gingival index Day 21	Gingival index Day 35
Control Arm	0.25	1.33	1.56	0.39
Test Arm	0.32	1.38	1.52	0.47

Silness & Loe 1964 is a score of 0-3 with 0 = No plaque, 1 = A film of plaque adhering to free gingival margin and adjacent area of tooth. The plaque may be seen in situ only after application of disclosing solution or by using the probe on the tooth surface, 2 = Moderate accumulation of soft deposits within the gingival pocket, or on the tooth and gingival margin, which can be seen with the naked eye, 3 = Abundance of soft matter within the gingival pocket and/or on the tooth and gingival margin. This index was used at days 0, 14, 21 and 35. (NCT01799226)
Timeframe: Baseline to 35 Days

Gingivitis Assessment After 12 Weeks of Dentifrice Use

Intervention	units on a scale (Mean)
	Plaque index Baseline	Plaque index Day 14	Plaque index Day 21	Plaque index Day 35
Control Arm	0.37	1.24	1.84	0.45
Test Arm	0.44	1.49	1.81	0.57

"After 12 weeks gingivitis was scored according to the Löe-Silness Gingival Index. Each tooth was scored on facial and lingual surfaces. Third molars and those teeth with cervical restorations or prosthetic crowns were excluded from the scoring procedure. The gingiva adjacent to each tooth surface was scored as follows: 0 = Absence of inflammation; 1 = Mild inflammation: slight change in color and little change in texture; 2 = Moderate inflammation: moderate glazing, redness, edema, hypertrophy. Tendency to bleed upon probing; 3 = Severe inflammation: marked redness and hypertrophy. Tendency for spontaneous bleeding.~Whole-mouth mean scores were obtained by averaging the values obtained over all scoreable surfaces in the mouth." (NCT02313558)
Timeframe: 12 weeks after dentifrice use

Gingivitis Assessment After 6 Weeks of Dentifrice Use

Intervention	units on a scale (Mean)
Dentifrice Containing Ilex Rotunda Thunb	1.13
Control Dentifrice	1.30

After 6 weeks gingivitis was scored according to the Löe-Silness Gingival Index. Each tooth was scored on facial and lingual surfaces. Third molars and those teeth with cervical restorations or prosthetic crowns were excluded from the scoring procedure. The gingiva adjacent to each tooth surface was scored as follows: 0 = Absence of inflammation; 1 = Mild inflammation: slight change in color and little change in texture; 2 = Moderate inflammation: moderate glazing, redness, edema, hypertrophy. Tendency to bleed upon probing; 3 = Severe inflammation: marked redness and hypertrophy. Tendency for spontaneous bleeding. (NCT02313558)
Timeframe: 6 weeks after dentifrice use

Plaque Assessment After 12 Weeks of Dentifrice Use

Intervention	units on a scale (Mean)
Dentifrice Containing Ilex Rotunda Thunb	1.22
Control Dentifrice	1.30

"After 12 weeks supra-gingival plaque on the facial and lingual surfaces of each tooth was scored according to the Turesky modification of the Quigley-Hein Plaque Index. Third molars and those teeth with cervical restorations or prosthetic crowns were excluded from the scoring procedure. Plaque was disclosed and scored on each tooth surface according to the following criteria: 0 = No plaque; 1 = Separate flecks of plaque at the cervical margin of the tooth; 2 = A thin, continuous band of plaque (up to 1 mm) at the cervical margin of the tooth; 3 = A band of plaque wider than 1 mm, but covering less than 1/3 of the side of the crown of the tooth; 4 = Plaque covering at least 1/3, but less than 2/3 of the side of the crown of the tooth; 5 = Plaque covering 2/3 or more of the side of the crown of the tooth.~Whole-mouth mean scores were obtained by averaging the values obtained over all scoreable surfaces in the mouth." (NCT02313558)
Timeframe: 12 weeks after dentifrice use

Plaque Assessment After 6 Weeks of Dentifrice Use

Intervention	units on a scale (Mean)
Dentifrice Containing Ilex Rotunda Thunb	2.53
Control Dentifrice	2.93

"After 6 weeks supra-gingival plaque on the facial and lingual surfaces of each tooth was scored according to the Turesky modification of the Quigley-Hein Plaque Index. Third molars and those teeth with cervical restorations or prosthetic crowns were excluded from the scoring procedure. Plaque was disclosed and scored on each tooth surface according to the following criteria: 0 = No plaque; 1 = Separate flecks of plaque at the cervical margin of the tooth; 2 = A thin, continuous band of plaque (up to 1 mm) at the cervical margin of the tooth; 3 = A band of plaque wider than 1 mm, but covering less than 1/3 of the side of the crown of the tooth; 4 = Plaque covering at least 1/3, but less than 2/3 of the side of the crown of the tooth; 5 = Plaque covering 2/3 or more of the side of the crown of the tooth.~Whole-mouth mean scores were obtained by averaging the values obtained over all scoreable surfaces in the mouth." (NCT02313558)
Timeframe: 6 weeks after dentifrice use

Bleeding Assessment Per Participant at 6 Months

Intervention	units on a scale (Mean)
Dentifrice Containing Ilex Rotunda Thunb	2.98
Control Dentifrice	3.04

"Eastman Interdental Bleeding Index 0 = Absence of bleeding.~1 = Presence of bleeding The interdental cleaner is inserted between two teeth from the facial aspect, depressing the interdental tissues 1 to 2 mm. This is repeated four times and the presence or absence of bleeding within 15 seconds is recorded. The absence or presence of bleeding will be recorded for each examined site (between two teeth), and a score will be calculated as the number of bleeding sites out of the number of examined sites for each evaluation on a subject." (NCT03421145)
Timeframe: 6 months

Bleeding Index Per Participant at 3 Months

Intervention	score on a scale (Mean)
3M™ Oral Rinse	0.28
Vehicle Control Oral Rinse	0.42
PerioShield™ Oral Health Rinse	0.28
Water	0.43

Gingivitis Index Per Participant at 3 Months

Intervention	score on a scale (Mean)
3M™ Oral Rinse	0.34
Vehicle Control Oral Rinse	0.40
PerioShield™ Oral Health Rinse	0.33
Water	0.40

"Löe-Silness Gingival Index~0 = Absence of inflammation.~= Mild inflammation: slight change in color and little change in texture.~= Moderate inflammation: moderate glazing, redness, edema, hypertrophy. Tendency to bleed upon probing.~= Severe inflammation: marked redness and hypertrophy. Tendency to spontaneous bleeding.~The gingival surface surrounding each tooth (all natural teeth) will be scored on six surfaces: 1) mesio-facial; 2) mid-facial; 3) disto-facial; 4) mesio-lingual; 5) mid-lingual; and 6) disto-lingual. Third molars and those teeth with cervical restorations or prosthetic crowns will be excluded from the scoring procedure. The GI score of the individual can be obtained by adding the scores of all surfaces and dividing by the number of surfaces examined." (NCT03421145)
Timeframe: 3 months

Gingivitis Index Score Per Participant at 6 Months

Intervention	score on a scale (Mean)
3M™ Oral Rinse	1.17
Vehicle Control Oral Rinse	1.27
PerioShield™ Oral Health Rinse	1.19
Water	1.30

Plaque Index Score Per Participant at 3 Months

Intervention	score on a scale (Mean)
3M™ Oral Rinse	1.09
Vehicle Control Oral Rinse	1.29
PerioShield™ Oral Health Rinse	1.11
Water	1.32

"Modified Quigley-Hein Plaque Index 0 = No plaque~= Separate flecks of plaque at the cervical margin of the tooth~= A thin, continuous band of plaque (up to one mm) at the cervical margin of the tooth.~= A band of plaque wider than 1 mm, but covering less than 1/3 of the crown of the tooth.~= Plaque covering at least 1/3, but less than 2/3 of the crown of the tooth.~= Plaque covering 2/3 or more of the crown of the tooth. Each tooth is scored for supragingival plaque on six surfaces: 1) mesio-facial; 2) mid-facial; 3) disto-facial; 4) mesio-lingual; 5) mid-lingual; and 6) disto-lingual. Third molars and those teeth with cervical restorations or prosthetic crowns will be excluded from the scoring procedure. The PI score of the individual can be obtained by adding the scores of all surfaces and dividing by the number of surfaces examined." (NCT03421145)
Timeframe: 3 months

Plaque Index Score Per Participant at 6 Months

Intervention	score on a scale (Mean)
3M™ Oral Rinse	2.43
Vehicle Control Oral Rinse	2.79
PerioShield™ Oral Health Rinse	2.49
Water	2.85

"Modified Quigley-Hein Plaque Index 0 = No plaque~= Separate flecks of plaque at the cervical margin of the tooth~= A thin, continuous band of plaque (up to one mm) at the cervical margin of the tooth.~= A band of plaque wider than 1 mm, but covering less than 1/3 of the crown of the tooth.~= Plaque covering at least 1/3, but less than 2/3 of the crown of the tooth.~= Plaque covering 2/3 or more of the crown of the tooth. Each tooth is scored for supragingival plaque on six surfaces: 1) mesio-facial; 2) mid-facial; 3) disto-facial; 4) mesio-lingual; 5) mid-lingual; and 6) disto-lingual. Third molars and those teeth with cervical restorations or prosthetic crowns will be excluded from the scoring procedure.~The PI score of the individual can be obtained by adding the scores of all surfaces and dividing by the number of surfaces examined." (NCT03421145)
Timeframe: 6 months

Article	Year
Efficacy of adjunctive anti-plaque chemical agents in managing gingivitis: A systematic review and network meta-analyses. Journal of clinical periodontology, 2019, Volume: 46, Issue:7 Topics: Anti-Infective Agents, Local; Dental Plaque; Dental Plaque Index; Dentifrices; Double-Blind Method;	2019
Efficacy of triclosan-based toothpastes in the prevention and treatment of plaque-induced periodontal and peri-implant diseases. Minerva stomatologica, 2013, Volume: 62, Issue:3 Topics: Adolescent; Adult; Clinical Trials as Topic; Dental Implants; Dental Plaque; Drug Evaluation; Fluori	2013
Triclosan/copolymer containing toothpastes for oral health. The Cochrane database of systematic reviews, 2013, Dec-05, Issue:12 Topics: Anti-Infective Agents, Local; Dental Calculus; Dental Caries; Dental Plaque; Gingivitis; Humans; Ora	2013
Comparison of triclosan and stannous fluoride dentifrices on parameters of gingival inflammation and plaque scores: a systematic review and meta-analysis. International journal of dental hygiene, 2015, Volume: 13, Issue:1 Topics: Anti-Infective Agents, Local; Cariostatic Agents; Dental Plaque; Dental Plaque Index; Dentifrices; G	2015
Efficacy of adjunctive anti-plaque chemical agents: a systematic review and network meta-analyses of the Turesky modification of the Quigley and Hein plaque index. Journal of clinical periodontology, 2016, Volume: 43, Issue:12 Topics: Anti-Infective Agents, Local; Dental Plaque; Dental Plaque Index; Dentifrices; Double-Blind Method;	2016
The delivery of superior oral health benefits with dentifrices containing triclosan: a review. Refu'at ha-peh veha-shinayim (1993), 2008, Volume: 25, Issue:3 Topics: Anti-Infective Agents, Local; Dental Calculus; Dental Plaque; Dentifrices; Diphosphates; Drug Combin	2008
Is there a role for triclosan/copolymer toothpaste in the management of periodontal disease? British dental journal, 2009, Aug-08, Volume: 207, Issue:3 Topics: Adult; Anti-Infective Agents, Local; Delayed-Action Preparations; Dental Plaque; Gingivitis; Humans;	2009
Antimicrobial agents used in the control of periodontal biofilms: effective adjuncts to mechanical plaque control? Brazilian oral research, 2009, Volume: 23 Suppl 1 Topics: Anti-Infective Agents, Local; Biofilms; Dental Plaque; Dentifrices; Gingivitis; Humans; Meta-Analysi	2009
Antimicrobial agents used in the control of periodontal biofilms: effective adjuncts to mechanical plaque control? Brazilian oral research, 2009, Volume: 23 Suppl 1 Topics: Anti-Infective Agents, Local; Biofilms; Dental Plaque; Dentifrices; Gingivitis; Humans; Meta-Analysi	2009
Antimicrobial agents used in the control of periodontal biofilms: effective adjuncts to mechanical plaque control? Brazilian oral research, 2009, Volume: 23 Suppl 1 Topics: Anti-Infective Agents, Local; Biofilms; Dental Plaque; Dentifrices; Gingivitis; Humans; Meta-Analysi	2009
Antimicrobial agents used in the control of periodontal biofilms: effective adjuncts to mechanical plaque control? Brazilian oral research, 2009, Volume: 23 Suppl 1 Topics: Anti-Infective Agents, Local; Biofilms; Dental Plaque; Dentifrices; Gingivitis; Humans; Meta-Analysi	2009
Antiplaque biocides and bacterial resistance: a review. Journal of clinical periodontology, 2002, Volume: 29, Issue:11 Topics: Anti-Infective Agents, Local; Bacteria; Biofilms; Chemistry, Pharmaceutical; Chlorhexidine; Clinical	2002
The use of triclosan in supportive treatment of gingivitis and periodontitis. The Journal of the Western Society of Periodontology/Periodontal abstracts, 2000, Volume: 48, Issue:4 Topics: Anti-Infective Agents, Local; Dental Plaque; Drug Resistance, Bacterial; Gingivitis; Humans; Periodo	2000
The role of Triclosan in dentifrice formulations, with particular reference to a new 0.3% Triclosan calcium carbonate-based system. International dental journal, 2004, Volume: 54, Issue:5 Suppl 1 Topics: Anti-Infective Agents, Local; Calcium Carbonate; Chemistry, Pharmaceutical; Dental Plaque; Dentifric	2004
Randomized controlled clinical trials on agents used for chemical plaque control. International journal of dental hygiene, 2005, Volume: 3, Issue:4 Topics: Alkaloids; Anti-Infective Agents, Local; Benzophenanthridines; Cetylpyridinium; Chlorhexidine; Denta	2005
The effectiveness of self-performed mechanical plaque control with triclosan containing dentifrices. International journal of dental hygiene, 2005, Volume: 3, Issue:4 Topics: Anti-Infective Agents, Local; Dental Plaque; Dentifrices; Gingivitis; Humans; Oral Hygiene; Randomiz	2005
Advanced oral antibacterial/anti-inflammatory technology: A comprehensive review of the clinical benefits of a triclosan/copolymer/fluoride dentifrice. The Journal of clinical dentistry, 2005, Volume: 16 Suppl Topics: Anti-Infective Agents, Local; Anti-Inflammatory Agents, Non-Steroidal; Bacteria; Clinical Trials as	2005
A meta-analysis of six-month studies of antiplaque and antigingivitis agents. Journal of the American Dental Association (1939), 2006, Volume: 137, Issue:12 Topics: Anti-Infective Agents, Local; Cetylpyridinium; Chlorhexidine; Dental Plaque; Dentifrices; Drug Combi	2006
Polydimethylsiloxane as a tooth surface-bound carrier of triclosan: a new concept in chemical plaque inhibition. Advances in dental research, 1994, Volume: 8, Issue:2 Topics: Adolescent; Clinical Trials as Topic; Dental Plaque; Dimethylpolysiloxanes; Drug Carriers; Female; G	1994
Mouthrinses as an antibacterial adjunct in periodontal treatment. Journal (Canadian Dental Association), 1994, Volume: 60, Issue:10 Topics: Alkaloids; Benzoates; Benzophenanthridines; Benzydamine; Cetylpyridinium; Chlorhexidine; Dental Plaq	1994
Clinical efficacy of dentifrices in the control of calculus, plaque, and gingivitis. Quintessence international (Berlin, Germany : 1985), 1993, Volume: 24, Issue:3 Topics: Alkaloids; Benzophenanthridines; Chlorhexidine; Clinical Trials as Topic; Dental Calculus; Dental Pl	1993
A review of plaque, gingivitis, calculus and caries clinical efficacy studies with a dentifrice containing triclosan and PVM/MA Copolymer. The Journal of clinical dentistry, 1993, Volume: 4 Spec No Topics: Adult; Clinical Trials as Topic; Dental Calculus; Dental Caries; Dental Plaque; Dentifrices; Double-	1993
Mouthrinses as adjuncts in periodontal therapy. Dental update, 1996, Volume: 23, Issue:4 Topics: Adult; Anti-Infective Agents, Local; Cetylpyridinium; Child; Child, Preschool; Chlorhexidine; Chlori	1996
Chemical agents for the control of plaque and plaque microflora: an overview. European journal of oral sciences, 1997, Volume: 105, Issue:5 Pt 2 Topics: Anti-Infective Agents, Local; Bacteria; Bacterial Adhesion; Cariostatic Agents; Cations; Chemopreven	1997
Metal salts, essential oils and phenols--old or new? Periodontology 2000, 1997, Volume: 15 Topics: Anti-Infective Agents, Local; Dental Plaque; Dentifrices; Gingivitis; Humans; Mouthwashes; Oils, Vol	1997
Chemical plaque control--prevention for the masses. Periodontology 2000, 1997, Volume: 15 Topics: Anti-Infective Agents, Local; Dental Plaque; Dentifrices; Gingivitis; Humans; Patient Care Planning;	1997
The efficacy of a dentifrice with caries, plaque, gingivitis, tooth whitening and oral malodor benefits. The Journal of clinical dentistry, 2002, Volume: 13, Issue:2 Topics: Cariostatic Agents; Complex Mixtures; Dental Caries; Dental Plaque; Dentifrices; Fluorides; Gingivit	2002
Evaluation of the effectiveness of a pre-brushing rinse in plaque removal: a meta-analysis. Journal of clinical periodontology, 2002, Volume: 29, Issue:4 Topics: Anti-Infective Agents, Local; Benzoates; Confidence Intervals; Dental Plaque; Dental Plaque Index; D	2002
Zinc citrate/Triclosan: a new anti-plaque system for the control of plaque and the prevention of gingivitis: short-term clinical and mode of action studies. Journal of clinical periodontology, 1991, Volume: 18, Issue:6 Topics: Anti-Infective Agents; Citrates; Citric Acid; Dental Plaque; Drug Combinations; Gingivitis; Humans;	1991

Article	Year
Reduction in bacteremia after brushing with a triclosan/copolymer dentifrice-A randomized clinical study. Journal of clinical periodontology, 2017, Volume: 44, Issue:10 Topics: Adult; Anti-Infective Agents, Local; Bacteremia; Cariostatic Agents; Complex Mixtures; Cross-Over St	2017
Assessment of the Effects of a Novel Stabilized Stannous Fluoride Dentifrice on Gingivitis in a Two-Month Positive-Controlled Clinical Study. The Journal of clinical dentistry, 2017, Volume: 28, Issue:4 Spec No Topics: Adult; Analysis of Variance; Dental Plaque; Dentifrices; Double-Blind Method; Gingivitis; Humans; Pe	2017
Antiplaque, Antifungal Effectiveness of Aloevera Among Intellectually Disabled Adolescents: Pilot Study. Pediatric dentistry, 2017, Nov-01, Volume: 39, Issue:7 Topics: Adolescent; Aloe; Anti-Infective Agents, Local; Candidiasis, Oral; Child; Dental Care for Disabled;	2017
Evaluation of anti-gingivitis benefits of stannous fluoride dentifrice among triclosan dentifrice users. American journal of dentistry, 2013, Volume: 26, Issue:4 Topics: Adult; Aged; Anti-Infective Agents, Local; Biological Availability; Dentifrices; Double-Blind Method	2013
Role of Colgate Total toothpaste in helping control plaque and gingivitis. American journal of dentistry, 2014, Volume: 27, Issue:3 Topics: Adolescent; Adult; Aged; Anti-Infective Agents, Local; Cariostatic Agents; Dental Plaque; Dental Pla	2014
Effect of a toothpaste containing triclosan, cetylpyridinium chloride, and essential oils on gingival status in schoolchildren: a randomized clinical pilot study. Quintessence international (Berlin, Germany : 1985), 2015, Volume: 46, Issue:5 Topics: Anti-Infective Agents, Local; Cetylpyridinium; Child; Dental Plaque Index; Double-Blind Method; Fluo	2015
Comparing three toothpastes in controlling plaque and gingivitis: A 6-month clinical study. American journal of dentistry, 2015, Volume: 28, Issue:2 Topics: Adolescent; Adult; Aged; Anti-Infective Agents, Local; Dental Plaque; Dental Plaque Index; Dentifric	2015
Effects of triclosan on host response and microbial biomarkers during experimental gingivitis. Journal of clinical periodontology, 2016, Volume: 43, Issue:5 Topics: Anti-Infective Agents, Local; Biomarkers; Dental Plaque; Dental Plaque Index; Dentifrices; Double-Bl	2016
A clinical investigation of the efficacy of two dentifrices for controlling established supragingival plaque and gingivitis. The Journal of clinical dentistry, 2008, Volume: 19, Issue:3 Topics: Adult; Aged; Analysis of Variance; Complex Mixtures; Dental Plaque; Dentifrices; Double-Blind Method	2008
Effectiveness of a mouthwash containing Triclosan and Gantrez in the reduction of biofilm and gingivitis: a clinical pilot study. The journal of contemporary dental practice, 2009, Nov-01, Volume: 10, Issue:6 Topics: Adolescent; Adult; Analysis of Variance; Anti-Infective Agents, Local; Benzoates; Biofilms; Delayed-	2009
Assessment of the effects of dentifrice on periodontal disease biomarkers in gingival crevicular fluid. Journal of periodontology, 2010, Volume: 81, Issue:9 Topics: Adult; Aged; Biomarkers; Chronic Periodontitis; Double-Blind Method; Female; Gingival Crevicular Flu	2010
A 6-month study of the effects of 0.3% triclosan/copolymer dentifrice on dental implants. Journal of clinical periodontology, 2011, Volume: 38, Issue:1 Topics: Adult; Aged; Analysis of Variance; Bacteria; Biofilms; Colony Count, Microbial; Dental Implants; Den	2011
A clinical investigation of the efficacy of three commercially available dentifrices for controlling established gingivitis and supragingival plaque. The Journal of clinical dentistry, 2010, Volume: 21, Issue:4 Topics: Adolescent; Adult; Aged; Analysis of Variance; Chi-Square Distribution; Dental Plaque; Dental Plaque	2010
Comparative investigation of the efficacy of triclosan/copolymer/sodium fluoride and stannous fluoride/sodium hexametaphosphate/zinc lactate dentifrices for the control of established supragingival plaque and gingivitis in a six-month clinical study. The Journal of clinical dentistry, 2010, Volume: 21, Issue:4 Topics: Adult; Aged; Analysis of Variance; Chi-Square Distribution; Dental Plaque; Dental Plaque Index; Dent	2010
Clinical and microbiologic effects of commercially available dentifrice containing aloe vera: a randomized controlled clinical trial. Journal of periodontology, 2012, Volume: 83, Issue:6 Topics: Actinomyces; Actinomyces viscosus; Adult; Aloe; Anti-Infective Agents, Local; Bacterial Load; Carios	2012
Comparative investigation of a dentifrice containing triclosan/copolymer/sodium fluoride and specially-designed silica and a dentifrice containing 0.243% sodium fluoride in a silica base for the control of established supra-gingival plaque and gingivitis: American journal of dentistry, 2011, Volume: 24 Spec No A Topics: Adult; Aged; Analysis of Variance; Dental Plaque; Dental Plaque Index; Double-Blind Method; Female;	2011
Effectiveness of a mouthrinse containing active ingredients in addition to chlorhexidine and triclosan compared with chlorhexidine and triclosan rinses on plaque, gingivitis, supragingival calculus and extrinsic staining. International journal of dental hygiene, 2013, Volume: 11, Issue:1 Topics: Anti-Infective Agents, Local; Cariostatic Agents; Chlorhexidine; Chlorides; Dental Calculus; Dental	2013
Anti-gingivitis effects of a novel 0.454% stabilized stannous fluoride dentifrice relative to a positive control. American journal of dentistry, 2012, Volume: 25, Issue:3 Topics: Adult; Dentifrices; Double-Blind Method; Gingivitis; Humans; Periodontal Index; Tin Fluorides; Tricl	2012
Assessment of the effects of a stannous fluoride dentifrice on gingivitis in a two-month positive-controlled clinical study. The Journal of clinical dentistry, 2012, Volume: 23, Issue:3 Topics: Adolescent; Adult; Aged; Analysis of Variance; Dentifrices; Double-Blind Method; Drug Combinations;	2012
Triclosan/pyrophosphate dentifrice: dental plaque and gingivitis effects in a 6-month randomized controlled clinical study. The Journal of clinical dentistry, 2002, Volume: 13, Issue:4 Topics: Adolescent; Adult; Aged; Analysis of Variance; Anti-Infective Agents, Local; Dental Plaque; Dental P	2002
Experimental gingivitis studies: effects of triclosan and triclosan-containing dentifrices on dental plaque and gingivitis in three-week randomized controlled clinical trials. The Journal of clinical dentistry, 2002, Volume: 13, Issue:4 Topics: Adolescent; Adult; Analysis of Variance; Anti-Infective Agents, Local; Dental Plaque; Dentifrices; D	2002
Effects of triclosan/copolymer dentifrice on dental plaque and gingivitis in a 3-month randomized controlled clinical trial: influence of baseline gingivitis on observed efficacy. The Journal of clinical dentistry, 2002, Volume: 13, Issue:4 Topics: Adult; Aged; Analysis of Variance; Anti-Infective Agents, Local; Dental Plaque; Dentifrices; Double-	2002
Effect of a toothpaste containing triclosan on dental plaque, gingivitis, and bleeding on probing--an investigation in periodontitis patients over 28 weeks. Clinical oral investigations, 2002, Volume: 6, Issue:2 Topics: Adult; Aged; Anti-Infective Agents, Local; Cariostatic Agents; Chronic Disease; Dental Plaque; Denta	2002
A method to compare four mouthrinses: time to gingivitis level as the primary outcome variable. Journal of clinical periodontology, 2002, Volume: 29, Issue:6 Topics: Adult; Analysis of Variance; Anti-Infective Agents, Local; Cariostatic Agents; Cetylpyridinium; Chlo	2002
Effect of triclosan dentifrices on mouth volatile sulphur compounds and dental plaque trypsin-like activity during experimental gingivitis development. Journal of clinical periodontology, 2002, Volume: 29, Issue:12 Topics: Adult; Analysis of Variance; Anti-Infective Agents; Benzoylarginine Nitroanilide; Breath Tests; Cros	2002
The effect of a SCN-/H2O2 toothpaste compared to a commercially available triclosan-containing toothpaste on oral hygiene and gingival health -- a 6-month home-use study. Journal of clinical periodontology, 2002, Volume: 29, Issue:12 Topics: Adult; Analysis of Variance; Anti-Infective Agents, Local; Carbamide Peroxide; Complex Mixtures; Den	2002
Comparison of two dentifrices with respect to efficacy for the control of plaque and gingivitis, and with respect to extrinsic tooth staining: a six-month clinical study on adults. The Journal of clinical dentistry, 2002, Volume: 13, Issue:6 Topics: Adult; Aged; Analysis of Variance; Case-Control Studies; Complex Mixtures; Dental Plaque; Dental Pla	2002
A clinical methods study of the effects of triclosan dentifrices on gingivitis over six months. The Journal of clinical dentistry, 2002, Volume: 13, Issue:6 Topics: Adult; Analysis of Variance; Anti-Infective Agents, Local; Cariostatic Agents; Complex Mixtures; Den	2002
Listerine and Colgate Total directly compared. Dentistry today, 2002, Volume: 21, Issue:2 Topics: Adult; Complex Mixtures; Dental Plaque; Dental Plaque Index; Dentifrices; Drug Combinations; Fluorid	2002
Effect of a triclosan-containing dental gel on the levels of prostaglandin I2 and interleukin-1beta in gingival crevicular fluid from adolescents with fixed orthodontic appliances. Acta odontologica Scandinavica, 2003, Volume: 61, Issue:4 Topics: Adolescent; Analysis of Variance; Anti-Infective Agents, Local; Double-Blind Method; Epoprostenol; F	2003
Antiplaque and antigingivitis efficacy of toothpastes containing Triclosan and fluoride. International dental journal, 2004, Volume: 54, Issue:5 Suppl 1 Topics: Adolescent; Adult; Anti-Infective Agents, Local; Calcium Carbonate; Cariostatic Agents; Dental Plaqu	2004
The effect of a new toothpaste containing potassium nitrate and triclosan on gingival health, plaque formation and dentine hypersensitivity. Journal of clinical periodontology, 2005, Volume: 32, Issue:1 Topics: Adult; Anti-Inflammatory Agents; Dental Plaque; Dentin; Dentin Sensitivity; Female; Gingivitis; Huma	2005
The comparative efficacy of stabilized stannous fluoride/sodium hexametaphosphate dentifrice and sodium fluoride/triclosan/copolymer dentifrice for the control of gingivitis: a 6-month randomized clinical study. Journal of periodontology, 2004, Volume: 75, Issue:12 Topics: Adolescent; Adult; Aged; Analysis of Variance; Anti-Infective Agents, Local; Dentifrices; Double-Bli	2004
Influence of alcohol in mouthwashes containing triclosan and zinc: an experimental gingivitis study. Journal of clinical periodontology, 2005, Volume: 32, Issue:6 Topics: Adolescent; Adult; Dental Plaque; Epidemiologic Methods; Ethanol; Female; Gingivitis; Humans; Male;	2005
Reducing variability and choosing ideal subjects for experimental gingivitis studies. Journal of clinical periodontology, 2005, Volume: 32, Issue:7 Topics: Adult; Anti-Infective Agents, Local; Citric Acid; Dental Plaque; Dental Plaque Index; Gingivitis; Hu	2005
An experimental gingivitis study to evaluate the clinical effects of a stannous fluoride dentifrice. Oral health & preventive dentistry, 2004, Volume: 2, Issue:4 Topics: Adult; Complex Mixtures; Dental Plaque; Dental Plaque Index; Dentifrices; Double-Blind Method; Femal	2004
Effect of triclosan/copolymer-containing toothpaste on the association between plaque and gingival bleeding: a randomized controlled clinical trial. Journal of clinical periodontology, 2006, Volume: 33, Issue:11 Topics: Adult; Anti-Infective Agents, Local; Cariostatic Agents; Dental Calculus; Dental Plaque; Dental Plaq	2006
Antigingivitis efficacy of a stabilized stannous fluoride/sodium hexametaphosphate dentifrice in subjects previously nonresponsive to a triclosan/copolymer dentifrice. Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 2005, Volume: 26, Issue:9 Suppl 1 Topics: Adult; Anti-Infective Agents, Local; Female; Gingivitis; Humans; Longitudinal Studies; Male; Middle	2005
Clinical effect of a triclosan containing dentifrice on gingivitis during pregnancy and post-partum. The Southeast Asian journal of tropical medicine and public health, 2006, Volume: 37, Issue:4 Topics: Adult; Dentifrices; Double-Blind Method; Female; Gingivitis; Humans; Pregnancy; Thailand; Time Facto	2006
A clinical investigation of the efficacy of three different treatment regimens for the control of plaque and gingivitis. The Journal of clinical dentistry, 2006, Volume: 17, Issue:5 Topics: Adolescent; Adult; Aged; Cariostatic Agents; Complex Mixtures; Dental Devices, Home Care; Dental Pla	2006
Effects of a triclosan dentifrice on plaque formation, gingivitis and gingival bleeding in pregnant women: five-month clinical results. The Southeast Asian journal of tropical medicine and public health, 2007, Volume: 38, Issue:3 Topics: Adult; Anti-Infective Agents, Local; Dental Plaque; Dentifrices; Female; Gingivitis; Humans; Placebo	2007
Oral hygiene regimens, plaque control, and gingival health: a two-month clinical trial with antimicrobial agents. The Journal of clinical dentistry, 2007, Volume: 18, Issue:4 Topics: Adolescent; Adult; Aged; Analysis of Variance; Anti-Infective Agents, Local; Complex Mixtures; Denta	2007
The effect of triclosan on developing gingivitis. Journal of clinical periodontology, 1995, Volume: 22, Issue:6 Topics: Adult; Anti-Infective Agents, Local; Anti-Inflammatory Agents, Non-Steroidal; Bacteria; Chemoprevent	1995
Comparison between 3 triclosan dentifrices on plaque, gingivitis and salivary microflora. Journal of clinical periodontology, 1995, Volume: 22, Issue:1 Topics: Adolescent; Adult; Analysis of Variance; Citrates; Citric Acid; Colony Count, Microbial; Cross-Secti	1995
Reduction of plaque formation and gingivitis by a dentifrice containing triclosan and copolymer. Journal of periodontology, 1995, Volume: 66, Issue:2 Topics: Adolescent; Adult; Analysis of Variance; Dental Plaque; Dental Plaque Index; Dentifrices; Drug Combi	1995
Effect on plaque removal and gingivitis of a triclosan-copolymer pre-brush rinse: a six-month clinical study in Canada. Journal (Canadian Dental Association), 1995, Volume: 61, Issue:1 Topics: Adult; Dental Plaque; Dental Plaque Index; Double-Blind Method; Drug Combinations; Female; Gingiviti	1995
Recent advances in plaque, gingivitis, tartar and caries prevention technology. International dental journal, 1994, Volume: 44, Issue:1 Suppl 1 Topics: Adsorption; Animals; Dental Calculus; Dental Caries; Dental Plaque; Dentifrices; Double-Blind Method	1994
The effect of three commercially available dentifrices containing triclosan on supragingival plaque formation and gingivitis: a six month clinical study. International dental journal, 1994, Volume: 44, Issue:1 Suppl 1 Topics: Adolescent; Adult; Citrates; Citric Acid; Dental Plaque; Dental Plaque Index; Dentifrices; Diphospha	1994
The effect of mouthrinses containing zinc and triclosan on plaque accumulation and development of gingivitis in a 3-week clinical test. Journal of clinical periodontology, 1994, Volume: 21, Issue:5 Topics: Adult; Analysis of Variance; Dental Plaque; Dental Plaque Index; Double-Blind Method; Ethanol; Femal	1994
A six-month clinical study of the effect of a pre-brush rinse on plaque removal and gingivitis. British dental journal, 1993, Nov-06, Volume: 175, Issue:9 Topics: Adolescent; Adult; Aged; Benzoates; Dental Plaque; Dental Plaque Index; Double-Blind Method; Female;	1993
The effect of dentifrices containing Triclosan on the development of gingivitis in a 21-day experimental gingivitis study. International dental journal, 1993, Volume: 43, Issue:4 Suppl 1 Topics: Adult; Citrates; Citric Acid; Dental Plaque; Dentifrices; Drug Combinations; Gingival Hemorrhage; Gi	1993
The effects of a silica dentifrice containing Triclosan and zinc citrate on supragingival plaque and calculus formation and the control of gingivitis. International dental journal, 1993, Volume: 43, Issue:4 Suppl 1 Topics: Adult; Citrates; Citric Acid; Dental Calculus; Dental Plaque; Dental Plaque Index; Dentifrices; Doub	1993
The effects of three silica dentifrices containing Triclosan on supragingival plaque and calculus formation and on gingivitis. International dental journal, 1993, Volume: 43, Issue:4 Suppl 1 Topics: Adult; Citrates; Citric Acid; Dental Calculus; Dental Plaque; Dental Plaque Index; Dentifrices; Diph	1993
Experiments with a toothpaste containing polydimethylsiloxan/triclosan. Scandinavian journal of dental research, 1993, Volume: 101, Issue:3 Topics: Adolescent; Adsorption; Anti-Infective Agents; Dental Plaque; Dimethylpolysiloxanes; Female; Gingiva	1993
The effect of a triclosan-containing dentifrice on established plaque and gingivitis. Journal of clinical periodontology, 1993, Volume: 20, Issue:5 Topics: Adult; Analysis of Variance; Dental Plaque; Dental Plaque Index; Dentifrices; Gingivitis; Humans; Mi	1993
Microbial alterations in supragingival dental plaque in response to a triclosan-containing dentifrice. Oral microbiology and immunology, 1995, Volume: 10, Issue:4 Topics: Actinomyces; Adolescent; Adult; Aged; Aggregatibacter actinomycetemcomitans; Analysis of Variance; A	1995
Effect of a triclosan/copolymer pre-brush mouthrinse on established plaque formation and gingivitis: a six-month clinical study in Thailand. The Journal of clinical dentistry, 1995, Volume: 6, Issue:2 Topics: Adult; Anti-Infective Agents, Local; Benzoates; Dental Plaque; Dental Plaque Index; Double-Blind Met	1995
The effects of antimicrobial mouthrinses on de novo plaque formation at sites with healthy and inflamed gingivae. Journal of clinical periodontology, 1996, Volume: 23, Issue:1 Topics: Adult; Anti-Infective Agents, Local; Chlorhexidine; Cross-Over Studies; Dental Plaque; Dental Prophy	1996
The effect of mouthrinses containing zinc and triclosan on plaque accumulation, development of gingivitis and formation of calculus in a 28-week clinical test. Journal of clinical periodontology, 1996, Volume: 23, Issue:5 Topics: Analysis of Variance; Anti-Infective Agents, Local; Colony Count, Microbial; Dental Calculus; Dental	1996
A 3-month home use study comparing the oral hygiene and gingival health benefits of triclosan and conventional fluoride toothpastes. Journal of clinical periodontology, 1996, Volume: 23, Issue:11 Topics: Adolescent; Adult; Aged; Analysis of Variance; Anti-Infective Agents, Local; Dental Plaque; Dental P	1996
A comparison of triclosan and stannous fluoride toothpastes for inhibition of plaque regrowth. A crossover study designed to assess carry over. Journal of clinical periodontology, 1997, Volume: 24, Issue:3 Topics: Adult; Anti-Infective Agents, Local; Citric Acid; Cross-Over Studies; Dental Plaque; Female; Fluorid	1997
A comparison of stabilized stannous fluoride dentifrice and triclosan/copolymer dentifrice for efficacy in the reduction of gingivitis and gingival bleeding: six-month clinical results. The Journal of clinical dentistry, 1997, Volume: 8, Issue:2 Spec No Topics: Adult; Aged; Analysis of Variance; Anti-Infective Agents, Local; Dental Plaque; Dental Plaque Index;	1997
Short-term effects of triclosan on healing following subgingival scaling. Journal of clinical periodontology, 1997, Volume: 24, Issue:10 Topics: Anti-Infective Agents, Local; Bacteria; Dental Plaque Index; Dental Scaling; Dentifrices; Evaluation	1997
An 18-week home-use study comparing the oral hygiene and gingival health benefits of triclosan and fluoride toothpastes. Journal of clinical periodontology, 1997, Volume: 24, Issue:9 Pt 1 Topics: Adolescent; Adult; Anti-Infective Agents, Local; Cariostatic Agents; Citrates; Dental Plaque; Dental	1997
[Laboratory and clinical investigation of multifunctional dentifrices. Clinical study of a new triclosan-containing toothpaste]. Fogorvosi szemle, 1999, Volume: 92, Issue:3 Topics: Anti-Infective Agents, Local; Dental Plaque; Dental Plaque Index; Gingivitis; Humans; Oral Hygiene I	1999
Efficacy of a triclosan/NaF dentifrice in the control of plaque and gingivitis and concurrent oral microflora monitoring. American journal of dentistry, 1998, Volume: 11, Issue:6 Topics: Adolescent; Adult; Analysis of Variance; Anti-Infective Agents, Local; Bacteria; Dental Plaque; Dent	1998
Effect of 3 dentifrices containing triclosan and various additives. An experimental gingivitis study. Journal of clinical periodontology, 2000, Volume: 27, Issue:7 Topics: Adolescent; Adult; Anti-Infective Agents, Local; Complex Mixtures; Cross-Over Studies; Dental Plaque	2000
Resolution of interdental inflammation with 2 different modes of plaque control. Journal of clinical periodontology, 2000, Volume: 27, Issue:12 Topics: Adult; Anti-Infective Agents, Local; Complex Mixtures; Dental Devices, Home Care; Dental Plaque; Den	2000
Comparative efficacy of an antiseptic mouthrinse and an antiplaque/antigingivitis dentifrice. A six-month clinical trial. Journal of the American Dental Association (1939), 2001, Volume: 132, Issue:5 Topics: Adolescent; Adult; Aged; Analysis of Variance; Anti-Infective Agents, Local; Cariostatic Agents; Chi	2001
[Efficacy of a triclosan/copolymer dentifrice in the control of plaque and gingivitis: a six-month study in China]. Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 1997, Volume: 15, Issue:4 Topics: Adult; Anti-Infective Agents, Local; Dental Plaque; Double-Blind Method; Female; Gingivitis; Humans;	1997
The clinical efficacy of Colgate Total Plus Whitening Toothpaste containing a special grade of silica and Colgate Total Fresh Stripe Toothpaste in the control of plaque and gingivitis: a six-month clinical study. The Journal of clinical dentistry, 2002, Volume: 13, Issue:2 Topics: Adult; Analysis of Variance; Complex Mixtures; Dental Plaque; Dental Plaque Index; Dentifrices; Doub	2002
Clinical effect of a new liquid dentifrice containing triclosan/copolymer on existing plaque and gingivitis. Journal of the American Dental Association (1939), 2002, Volume: 133, Issue:2 Topics: Adult; Analysis of Variance; Anti-Infective Agents, Local; Cariostatic Agents; Delayed-Action Prepar	2002
Effect upon plaque formation and gingivitis of a triclosan/copolymer/fluoride dentifrice: a 6-month clinical study. American journal of dentistry, 1992, Volume: 5, Issue:6 Topics: Adolescent; Adult; Dental Plaque; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gin	1992
The clinical effect of a dentifrice containing triclosan and a copolymer in a sodium fluoride/silica base on plaque formation and gingivitis: a six-month clinical study. The Journal of clinical dentistry, 1992, Volume: 3, Issue:4 Topics: Adolescent; Adult; Analysis of Variance; Dental Plaque; Dental Plaque Index; Dentifrices; Double-Bli	1992
The effect of A Triclosan/copolymer/fluoride dentifrice on plaque formation and gingivitis: a six-month clinical study. The Journal of clinical dentistry, 1991, Volume: 2, Issue:3 Topics: Adolescent; Adult; Analysis of Variance; Dental Plaque; Dental Plaque Index; Dentifrices; Double-Bli	1991
Effect of a triclosan/copolymer/fluoride dentifrice on plaque formation and gingivitis: a 7-month clinical study. American journal of dentistry, 1990, Volume: 3 Spec No Topics: Adult; Analysis of Variance; Dental Plaque; Dental Plaque Index; Dentifrices; Double-Blind Method; F	1990
Microbiological and clinical effects of a dentifrice containing zinc citrate and Triclosan in the human experimental gingivitis model. Journal of clinical periodontology, 1990, Volume: 17, Issue:8 Topics: Actinomyces; Adolescent; Adult; Bacteria; Citrates; Citric Acid; Dental Plaque; Dentifrices; Female;	1990
Control of gingivitis and calculus by a dentifrice containing a zinc salt and triclosan. Journal of periodontology, 1990, Volume: 61, Issue:11 Topics: Adolescent; Adult; Bacteria; Citrates; Citric Acid; Dental Calculus; Dental Plaque; Dentifrices; Dou	1990
Six-month study of the effect of a dentifrice containing zinc citrate and triclosan on plaque, gingival health, and calculus. Scandinavian journal of dental research, 1990, Volume: 98, Issue:4 Topics: Adult; Citrates; Citric Acid; Dental Calculus; Dental Plaque; Dentifrices; Double-Blind Method; Fema	1990
Comparison of the effect of toothpastes containing enzymes or antimicrobial compounds with a conventional fluoride toothpaste on the development of plaque and gingivitis. Journal of clinical periodontology, 1989, Volume: 16, Issue:5 Topics: Adult; Dental Plaque; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Fluorides; Ging	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis. Journal of periodontal research, 1989, Volume: 24, Issue:1 Topics: Adult; Citrates; Citric Acid; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingivi	1989
The effect of a dentifrice containing triclosan and a copolymer on plaque formation and gingivitis: a 14-week clinical study. American journal of dentistry, 1989, Volume: 2 Spec No Topics: Adult; Dental Plaque; Dentifrices; Evaluation Studies as Topic; Female; Gingivitis; Humans; Male; Ma	1989
The influence of a dentifrice containing a zinc salt and a nonionic antimicrobial agent on the maintenance of gingival health. Journal of clinical periodontology, 1987, Volume: 14, Issue:8 Topics: Adult; Citrates; Citric Acid; Clinical Trials as Topic; Dental Plaque Index; Dentifrices; Double-Bli	1987
The effects of a dentifrice containing zinc citrate and 2,4,4' trichloro-2'-hydroxydiphenyl ether. Journal of periodontology, 1986, Volume: 57, Issue:9 Topics: Adult; Citrates; Citric Acid; Dental Plaque; Dentifrices; Double-Blind Method; Drug Combinations; Fe	1986
The effects of a dentifrice containing a zinc salt and a non-cationic antimicrobial agent on plaque and gingivitis. Journal of clinical periodontology, 1987, Volume: 14, Issue:3 Topics: Adolescent; Adult; Citrates; Citric Acid; Dental Plaque; Dentifrices; Double-Blind Method; Drug Comb	1987

Article	Year
Novel findings on anti-plaque effects of stannous fluoride. American journal of dentistry, 2022, Volume: 35, Issue:6 Topics: Dental Plaque; Dental Plaque Index; Dentifrices; Double-Blind Method; Gingivitis; Humans; Sodium Flu	2022
Novel findings on anti-plaque effects of stannous fluoride. American journal of dentistry, 2022, Volume: 35, Issue:6 Topics: Dental Plaque; Dental Plaque Index; Dentifrices; Double-Blind Method; Gingivitis; Humans; Sodium Flu	2022
Novel findings on anti-plaque effects of stannous fluoride. American journal of dentistry, 2022, Volume: 35, Issue:6 Topics: Dental Plaque; Dental Plaque Index; Dentifrices; Double-Blind Method; Gingivitis; Humans; Sodium Flu	2022
Novel findings on anti-plaque effects of stannous fluoride. American journal of dentistry, 2022, Volume: 35, Issue:6 Topics: Dental Plaque; Dental Plaque Index; Dentifrices; Double-Blind Method; Gingivitis; Humans; Sodium Flu	2022
Triclosan could boost fluoride in toothpastes. British dental journal, 2014, Volume: 216, Issue:3 Topics: Anti-Infective Agents, Local; Dental Caries; Dental Plaque; Fluorides, Topical; Gingival Hemorrhage;	2014
Manage patients in peri-implant health. Journal of the New Jersey Dental Association, 2014,Fall, Volume: 85, Issue:4 Topics: Anti-Infective Agents, Local; Cariostatic Agents; Dental Implants; Dental Plaque; Dental Plaque Inde	2014
Little difference between triclosan and stannous fluoride dentifrices on gingival inflammation. Evidence-based dentistry, 2015, Volume: 16, Issue:1 Topics: Anti-Infective Agents, Local; Cariostatic Agents; Dental Plaque; Dentifrices; Gingivitis; Humans; Ti	2015
The efficacy of a new dentifrice with caries, plaque, gingivitis, calculus, tooth whitening, and oral malodor benefits. The Journal of clinical dentistry, 2008, Volume: 19, Issue:3 Topics: Complex Mixtures; Dental Calculus; Dental Caries; Dental Plaque; Dentifrices; Fluorides; Gingivitis;	2008
[Mouthwash solutions with microencapsuled natural extracts: Efficiency for dental plaque and gingivitis]. Revue de stomatologie et de chirurgie maxillo-faciale, 2010, Volume: 111, Issue:3 Topics: Aloe; Anti-Infective Agents, Local; Antioxidants; Camellia sinensis; Chlorhexidine; Citrus paradisi;	2010
Superior management of plaque and gingivitis through the use of a triclosan/copolymer dentifrice. The Journal of clinical dentistry, 2010, Volume: 21, Issue:4 Topics: Dental Plaque; Dentifrices; Drug Combinations; Gingivitis; Humans; Maleates; Polyethylenes; Silicic	2010
A dentifrice with multiple benefits. American journal of dentistry, 2011, Volume: 24 Spec No A Topics: Dental Caries; Dental Plaque; Dentin Sensitivity; Gingivitis; Humans; Maleates; Polyethylenes; Silic	2011
A multi-tasking dentifrice for the 21st century. American journal of dentistry, 2011, Volume: 24 Spec No A Topics: Cariostatic Agents; Dental Caries; Dental Plaque; Dentin Desensitizing Agents; Dentin Sensitivity; D	2011
Effectiveness of a triclosan/copolymer dentifrice on microbiological and inflammatory parameters. Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 2004, Volume: 25, Issue:7 Suppl 1 Topics: Actinomyces; Adult; Aggregatibacter actinomycetemcomitans; Animals; Anti-Infective Agents, Local; Ba	2004
Rationale for the daily use of a dentifrice containing triclosan in the maintenance of oral health. Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 2004, Volume: 25, Issue:7 Suppl 1 Topics: Anti-Infective Agents, Local; Cariostatic Agents; Complex Mixtures; Dental Calculus; Dental Plaque;	2004
Inhibition of experimental periodontitis by a topical boron-based antimicrobial. Journal of dental research, 2008, Volume: 87, Issue:2 Topics: Alveolar Bone Loss; Animals; Anti-Bacterial Agents; Anti-Infective Agents, Local; Anti-Inflammatory	2008
The effect of triclosan on mediators of gingival inflammation. Journal of clinical periodontology, 1995, Volume: 22, Issue:6 Topics: Anti-Infective Agents, Local; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Cells, Cul	1995
Triclosan protects the skin against dermatitis caused by sodium lauryl sulphate exposure. Journal of clinical periodontology, 1994, Volume: 21, Issue:10 Topics: Anti-Inflammatory Agents, Non-Steroidal; Dermatitis, Contact; Dermatitis, Irritant; Erythema; Female	1994
Triclosan reduces prostaglandin biosynthesis in human gingival fibroblasts challenged with interleukin-1 in vitro. Journal of clinical periodontology, 1996, Volume: 23, Issue:10 Topics: Adult; Anti-Infective Agents, Local; Arachidonic Acids; Cells, Cultured; Child; Cyclooxygenase Inhib	1996
Microbiological studies of the prevention and control of plaque and gingivitis by a zinc and triclosan-containing dentifrice. Newsletter (International Academy of Periodontology), 1991, Volume: 1, Issue:1 Topics: Bacteria; Dental Plaque; Drug Combinations; Gingivitis; Humans; Microbial Sensitivity Tests; Triclos	1991
Triclosan/copolymer/fluoride dentifrices: a new technology for the prevention of plaque, calculus, gingivitis and caries. American journal of dentistry, 1990, Volume: 3 Spec No Topics: Dental Calculus; Dental Caries; Dental Plaque; Dentifrices; Drug Combinations; Gingivitis; Humans; M	1990

triclosan and Gingivitis

Research Excerpts

Research

Studies (128)

Authors

Clinical Trials (16)

Trial Overview

Trial Outcomes

Dental Plaque Score

Dental Plaque Score

Dental Plaque Score

Dental Plaque Score

Gingivitis Scores

Gingivitis Scores

Gingivitis Scores

Gingivitis Scores

Change From Baseline in Gingival Index (Loe & Silness 1963) to Day 35

Change From Baseline in Plaque Index (Silness & Loe 1964) to Day 35

Gingivitis Assessment After 12 Weeks of Dentifrice Use

Gingivitis Assessment After 6 Weeks of Dentifrice Use

Plaque Assessment After 12 Weeks of Dentifrice Use

Plaque Assessment After 6 Weeks of Dentifrice Use

Bleeding Assessment Per Participant at 6 Months

Bleeding Index Per Participant at 3 Months

Gingivitis Index Per Participant at 3 Months

Gingivitis Index Score Per Participant at 6 Months

Plaque Index Score Per Participant at 3 Months

Plaque Index Score Per Participant at 6 Months

Reviews

Trials

Other Studies

Intervention	score on a scale (Mean)
3M™ Oral Rinse	2.12
Vehicle Control Oral Rinse	2.70
PerioShield™ Oral Health Rinse	2.23
Water	2.84