Page last updated: 2024-11-05

triclosan and Bacterial Disease

triclosan has been researched along with Bacterial Disease in 17 studies

Research Excerpts

ExcerptRelevanceReference
"Controlling bacterial infections in plants is a major challenge owing to the appearance of resistant strains."5.91Resistance-driven innovations in the discovery of bactericides: novel triclosan derivatives decorating isopropanolamine moiety as promising anti-biofilm agents against destructive plant bacterial diseases. ( Feng, YM; Liu, LW; Liu, SS; Wang, PY; Xiao, WL; Yang, S; Zhang, H; Zhang, JJ; Zhang, JR; Zhou, X, 2023)
"Hydrogen-rich water has a significant protective effect on OGD/R-causing HT22 cell injury, and the mechanism may be related to the inhibition of autophagy."4.40Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023)
"Controlling bacterial infections in plants is a major challenge owing to the appearance of resistant strains."1.91Resistance-driven innovations in the discovery of bactericides: novel triclosan derivatives decorating isopropanolamine moiety as promising anti-biofilm agents against destructive plant bacterial diseases. ( Feng, YM; Liu, LW; Liu, SS; Wang, PY; Xiao, WL; Yang, S; Zhang, H; Zhang, JJ; Zhang, JR; Zhou, X, 2023)
"The triclosan glycosides were also generally found to be more water soluble and much more selective than the underivatized triclosan, making them ideal both for the targeted inhibition of bacterial growth and as agents for the selective recovery of bacteria from mixed cultures."1.51Synthesis and antibacterial profiles of targeted triclosan derivatives. ( Bovill, RA; Howse, GL; Osborn, HMI; Stephens, PJ, 2019)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19903 (17.65)18.7374
1990's1 (5.88)18.2507
2000's4 (23.53)29.6817
2010's4 (23.53)24.3611
2020's5 (29.41)2.80

Authors

AuthorsStudies
Howse, GL1
Bovill, RA1
Stephens, PJ1
Osborn, HMI1
Vieira, D1
Angel, SN1
Honjol, Y1
Masse, M1
Gruenheid, S1
Harvey, EJ1
Merle, G1
Ardila, CM1
Bedoya-García, JA1
Zhang, JJ1
Feng, YM1
Zhang, JR1
Xiao, WL1
Liu, SS1
Zhou, X1
Zhang, H1
Wang, PY1
Liu, LW1
Yang, S1
Kuti, BP1
Ogunlesi, TA1
Oduwole, O1
Oringanje, C1
Udoh, EE1
Meremikwu, MM1
Bayston, R1
Ashraf, W1
Pelegrin, I1
Fowkes, K1
Bienemann, AS1
Singleton, WGB1
Scott, IS1
Qu, H1
Knabe, C1
Radin, S1
Garino, J1
Ducheyne, P1
Ortalda, C1
Noli, C1
Cena, T1
Geraldo, IM1
Gilman, A1
Shintre, MS1
Modak, SM1
Gómez-Alonso, A1
García-Criado, FJ1
Parreño-Manchado, FC1
García-Sánchez, JE1
García-Sánchez, E1
Parreño-Manchado, A1
Zambrano-Cuadrado, Y1
Aliaga, A1
Castells, A1
Kriznik, D1
Lalosević, J1
Marrón, J1
Moragas, J1
Ocaña, J1
Schindléry, C1
Faoagali, JL1
George, N1
Fong, J1
Davy, J1
Dowser, M1
Levy, SB1
Li, Q1
Lee, JY1
Castillo, R1
Hixon, MS1
Pujol, C1
Doppalapudi, VR1
Shepard, HM1
Wahl, GM1
Lobl, TJ1
Chan, MF1
Allegra, F1
Cainelli, T1
Csermely, E1
Gelmetti, C1
Gandola, M1
Martina, G1
Santini, R1
Tomasini, C1
Zanca, A1
Bodey, GP1
Ebersole, R1
Hong, HC1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Residual Effect of Chlorhexidine 2% / Isopropyl Alcohol 70% Compared to Triclosan 1% / Isopropyl Alcohol 70%[NCT01762904]Phase 3135 participants (Actual)Interventional2013-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Detect Presence of Allergy or Skin Reaction by the Antiseptic Application

"135 units of measurement to test two antiseptics and two controls. Principal unit of measurement: four determinations of bacterial counts in a subject for antiseptics and controls to test each of the application sites.~All volunteers was provided with a neutral soap without antiseptics for use of two weeks. 2% chlorhexidine in 70% isopropyl alcohol and 1% triclosan in 70% isopropyl alcohol, Deionized water redistilled and Scrub the skin without prior application of any substance was tested. We prepared four skin's areas of 25 cm2, two in each forearm. The solution remained on the skin for 60s, 3h and 24h.~Presence of allergy or any skin reaction at 24 hours after the antiseptic application." (NCT01762904)
Timeframe: 24 hours

Interventionparticipants (Median)
Whole Group of 135 Units of Measurement0

Evaluate the Effect on the Skin Flora Application Process of Antiseptics by Sterile Swab

"135 units of measurement to test two controls. Principal unit of measurement: four determinations of bacterial counts in a subject for antiseptics and controls to test each of the application sites.~All volunteers was provided with a neutral soap without antiseptics for use of two weeks. Deionized water redistilled (Control 2: Control with scrub) and Scrub the skin without prior application of any substance (Control1: Control without scrub) was tested. Were prepared two skin's areas of 25 cm2 randomly selected. The solution remained on the skin for 60s, 3h and 24h.~Cultures was taken with a scrub-cup of 5 cm2 pressed over the skin, added a 3 mL of culture broth. The skin was scrub with a sterile rubber policeman for 1 minute and the procedure conducted once again. Both aliquots came together in a sterile tube, a sample of 50 microliters were spread in a plate containing a neutralizing agar and were incubated at 35°C for 24 h." (NCT01762904)
Timeframe: 24 hrs

Intervention(CFU/cm2) (Median)
Control 1: without scrub 0 hControl 2: scrub with Deionized water redisti 0 hControl 1: without scrub 3 hControl 2: scrub with Deionized water redisti 3 hControl 1: without scrub 24 hControl 2: scrub with Deionized water redisti 24 h
Whole Group of 135 Units of Measurement4802162889628896

Evaluate the Residual Effect of Chlorhexidine 2% / Isopropyl Alcohol 70% Administered Topically

"135 determinations to evaluate residual effect of 2% chlorhexidine in 70% isopropyl alcohol.~All volunteers was provided with a neutral soap without antiseptics for use of two weeks. 2% chlorhexidine in 70% isopropyl alcohol was tested. Were prepared the skin area of 25 cm2 randomly selected. The solution remained on the skin for 60s, 3h and 24h, everyone on different days.~Cultures was taken with a scrub-cup of 5 cm2 pressed over the skin, added a 3 mL of culture broth. The skin was scrub with a sterile rubber policeman for 1 minute and the procedure conducted once again. Both aliquots came together in a sterile tube, a sample of 50 microliters were spread in a plate containing a neutralizing agar and were incubated at 35°C for 24 h." (NCT01762904)
Timeframe: 24 hours

Intervention(CFU/cm2) (Median)
0 h3 h24 h
Whole Group of 135 Units of Measurement244824

Evaluate the Residual Effect of Triclosan 1% / Isopropyl Alcohol 70% Administered Topically.

"135 determinations to test 1% triclosan in 70% isopropyl alcohol.~All volunteers was provided with a neutral soap without antiseptics for use of two weeks. 1% triclosan in 70% isopropyl alcohol was tested. Were prepared the skin area of 25 cm2 randomly selected. The solution remained on the skin for 60s, 3h and 24h, everyone on different days.~Cultures was taken with a scrub-cup of 5 cm2 pressed over the skin, added a 3 mL of culture broth. The skin was scrub with a sterile rubber policeman for 1 minute and the procedure conducted once again. Both aliquots came together in a sterile tube, a sample of 50 microliters were spread in a plate containing a neutralizing agar and were incubated at 35°C for 24 h." (NCT01762904)
Timeframe: 24 hours

Intervention(CFU/cm2) (Median)
0 h3 h24 h
Whole Group of 135 Units of Measurement484896

Reviews

3 reviews available for triclosan and Bacterial Disease

ArticleYear
Bacterial resistance to antiseptics used in dentistry: A systematic scoping review of randomized clinical trials.
    International journal of dental hygiene, 2023, Volume: 21, Issue:1

    Topics: Anti-Infective Agents, Local; Bacterial Infections; Chlorhexidine; Dentistry; Humans; Randomized Con

2023
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
Hand hygiene for the prevention of infections in neonates.
    The Cochrane database of systematic reviews, 2021, 01-20, Volume: 1

    Topics: Age Factors; Anti-Infective Agents, Local; Bacterial Infections; Bias; Chlorhexidine; Cross-Over Stu

2021

Trials

4 trials available for triclosan and Bacterial Disease

ArticleYear
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
An overview of two comparative multicentre trials with halometasone/triclosan cream in acute superficial bacterial skin infections.
    The Journal of international medical research, 1983, Volume: 11 Suppl 1

    Topics: Administration, Topical; Adolescent; Adult; Anti-Inflammatory Agents; Bacterial Infections; Betameth

1983
Comparison of the antibacterial efficacy of 4% chlorhexidine gluconate and 1% triclosan handwash products in an acute clinical ward.
    American journal of infection control, 1999, Volume: 27, Issue:4

    Topics: Anti-Infective Agents, Local; Bacterial Infections; Chlorhexidine; Colony Count, Microbial; Gram-Neg

1999
Randomized trial of a hexachlorophene preparation and P-300 bacteriostatic soaps.
    The Journal of investigative dermatology, 1976, Volume: 67, Issue:4

    Topics: Bacterial Infections; Drug Combinations; Hexachlorophene; Humans; Phenyl Ethers; Salicylanilides; Sk

1976

Other Studies

11 other studies available for triclosan and Bacterial Disease

ArticleYear
Synthesis and antibacterial profiles of targeted triclosan derivatives.
    European journal of medicinal chemistry, 2019, Jan-15, Volume: 162

    Topics: Anti-Bacterial Agents; Anti-Infective Agents, Local; Bacteria; Bacterial Infections; Glucosides; Mic

2019
Engineering surgical stitches to prevent bacterial infection.
    Scientific reports, 2022, 01-17, Volume: 12, Issue:1

    Topics: Anti-Bacterial Agents; Anti-Infective Agents, Local; Bacterial Infections; Coated Materials, Biocomp

2022
Resistance-driven innovations in the discovery of bactericides: novel triclosan derivatives decorating isopropanolamine moiety as promising anti-biofilm agents against destructive plant bacterial diseases.
    Pest management science, 2023, Volume: 79, Issue:7

    Topics: Anti-Bacterial Agents; Bacterial Infections; Microbial Sensitivity Tests; Oryza; Oxadiazoles; Plant

2023
An external ventricular drainage catheter impregnated with rifampicin, trimethoprim and triclosan, with extended activity against MDR Gram-negative bacteria: an in vitro and in vivo study.
    The Journal of antimicrobial chemotherapy, 2019, 10-01, Volume: 74, Issue:10

    Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; Catheter-Related Infections; Catheterization;

2019
Percutaneous external fixator pins with bactericidal micron-thin sol-gel films for the prevention of pin tract infection.
    Biomaterials, 2015, Volume: 62

    Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents, Local; Bacterial Infections; Bone Nails; Coat

2015
Efficacy of an ethanol/guar/triclosan/glycerine gel on bacteria and yeast loads in canine pododermatitis: a pilot study.
    The Journal of small animal practice, 2016, Volume: 57, Issue:4

    Topics: Animals; Anti-Infective Agents, Local; Bacterial Infections; Dog Diseases; Dogs; Ethanol; Female; Fo

2016
Rapid antibacterial activity of 2 novel hand soaps: evaluation of the risk of development of bacterial resistance to the antibacterial agents.
    Infection control and hospital epidemiology, 2008, Volume: 29, Issue:8

    Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents, Local; Bacterial Infections; Benzethonium; Bi

2008
Study of the efficacy of Coated VICRYL Plus Antibacterial suture (coated Polyglactin 910 suture with Triclosan) in two animal models of general surgery.
    The Journal of infection, 2007, Volume: 54, Issue:1

    Topics: Anastomosis, Surgical; Animals; Anti-Infective Agents, Local; Antigens, CD; Bacterial Infections; Co

2007
Antibacterial household products: cause for concern.
    Emerging infectious diseases, 2001, Volume: 7, Issue:3 Suppl

    Topics: Anti-Infective Agents, Local; Bacteria; Bacterial Infections; Drug Resistance, Microbial; Household

2001
NB2001, a novel antibacterial agent with broad-spectrum activity and enhanced potency against beta-lactamase-producing strains.
    Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:5

    Topics: Bacterial Infections; beta-Lactamases; Cephalosporins; Drug Design; Escherichia coli; Gram-Negative

2002
[Clinical observations and statistical evaluation of the action of a new topical antimicrobial and antimycotic agent in pediatric skin diseases. Polycentric research].
    Minerva pediatrica, 1978, Nov-15, Volume: 30, Issue:21

    Topics: Bacterial Infections; Child; Child, Preschool; Dermatomycoses; Drug Evaluation; Eczema; Female; Huma

1978