Page last updated: 2024-11-05

triclosan and Allergic Reaction

triclosan has been researched along with Allergic Reaction in 18 studies

Research Excerpts

ExcerptRelevanceReference
" These studies were conducted to investigate the role of dermal exposure to triclosan, an endocrine-disrupting compound, on the hypersensitivity response to ovalbumin (OVA) in a murine model of asthma."7.79Exposure to triclosan augments the allergic response to ovalbumin in a mouse model of asthma. ( Anderson, KL; Anderson, SE; Franko, J; Hubbs, AF; Kashon, ML; Lukomska, E; Meade, BJ, 2013)
" These studies were conducted to investigate the role of dermal exposure to triclosan, an endocrine-disrupting compound, on the hypersensitivity response to ovalbumin (OVA) in a murine model of asthma."3.79Exposure to triclosan augments the allergic response to ovalbumin in a mouse model of asthma. ( Anderson, KL; Anderson, SE; Franko, J; Hubbs, AF; Kashon, ML; Lukomska, E; Meade, BJ, 2013)
"Triclosan is an anti-microbial chemical incorporated into products that are applied to the skin of healthcare workers."1.91Exposure to the anti-microbial chemical triclosan disrupts keratinocyte function and skin integrity in a model of reconstructed human epidermis. ( Anderson, SE; Baur, R; Kashon, M; Lukomska, E; Shane, HL; Weatherly, LM, 2023)
"Current rhinitis was associated with the highest levels of triclosan, whereas no association was seen for current asthma."1.39Triclosan exposure and allergic sensitization in Norwegian children. ( Bertelsen, RJ; Calafat, AM; Carlsen, KH; London, SJ; Longnecker, MP; Lødrup Carlsen, KC; Løvik, M, 2013)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19908 (44.44)18.7374
1990's0 (0.00)18.2507
2000's1 (5.56)29.6817
2010's5 (27.78)24.3611
2020's4 (22.22)2.80

Authors

AuthorsStudies
Tang, N1
Wang, D1
Chen, X1
Zhang, M1
Lv, W1
Wang, X1
Baur, R3
Kashon, M2
Lukomska, E5
Weatherly, LM3
Shane, HL3
Anderson, SE5
Friend, SA1
Lin, MH1
Chiu, SY1
Ho, WC1
Chi, KH1
Liu, TY1
Wang, IJ1
Lee-Sarwar, K1
Hauser, R1
Calafat, AM2
Ye, X1
O'Connor, GT1
Sandel, M1
Bacharier, LB1
Zeiger, RS1
Laranjo, N1
Gold, DR1
Weiss, ST1
Litonjua, AA1
Savage, JH1
Marshall, NB1
Nayak, AP1
Long, CM1
Hettick, JM1
Hampton, T1
Bertelsen, RJ1
Longnecker, MP1
Løvik, M1
Carlsen, KH1
London, SJ1
Lødrup Carlsen, KC1
Franko, J1
Kashon, ML1
Anderson, KL1
Hubbs, AF1
Meade, BJ1
LIEBERMAN, A1
McELROY, WT1
WESTON, TE1
SCHEIFFARTH, F1
ROBINSON, JP1
SAWYER, M1
NAJJAR, VA1
ANDERSON, JR1
SPAIN, WC1
ROSTON, EH1
MAYER, RL1
Levy, SB1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Residual Effect of Chlorhexidine 2% / Isopropyl Alcohol 70% Compared to Triclosan 1% / Isopropyl Alcohol 70%[NCT01762904]Phase 3135 participants (Actual)Interventional2013-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Detect Presence of Allergy or Skin Reaction by the Antiseptic Application

"135 units of measurement to test two antiseptics and two controls. Principal unit of measurement: four determinations of bacterial counts in a subject for antiseptics and controls to test each of the application sites.~All volunteers was provided with a neutral soap without antiseptics for use of two weeks. 2% chlorhexidine in 70% isopropyl alcohol and 1% triclosan in 70% isopropyl alcohol, Deionized water redistilled and Scrub the skin without prior application of any substance was tested. We prepared four skin's areas of 25 cm2, two in each forearm. The solution remained on the skin for 60s, 3h and 24h.~Presence of allergy or any skin reaction at 24 hours after the antiseptic application." (NCT01762904)
Timeframe: 24 hours

Interventionparticipants (Median)
Whole Group of 135 Units of Measurement0

Evaluate the Effect on the Skin Flora Application Process of Antiseptics by Sterile Swab

"135 units of measurement to test two controls. Principal unit of measurement: four determinations of bacterial counts in a subject for antiseptics and controls to test each of the application sites.~All volunteers was provided with a neutral soap without antiseptics for use of two weeks. Deionized water redistilled (Control 2: Control with scrub) and Scrub the skin without prior application of any substance (Control1: Control without scrub) was tested. Were prepared two skin's areas of 25 cm2 randomly selected. The solution remained on the skin for 60s, 3h and 24h.~Cultures was taken with a scrub-cup of 5 cm2 pressed over the skin, added a 3 mL of culture broth. The skin was scrub with a sterile rubber policeman for 1 minute and the procedure conducted once again. Both aliquots came together in a sterile tube, a sample of 50 microliters were spread in a plate containing a neutralizing agar and were incubated at 35°C for 24 h." (NCT01762904)
Timeframe: 24 hrs

Intervention(CFU/cm2) (Median)
Control 1: without scrub 0 hControl 2: scrub with Deionized water redisti 0 hControl 1: without scrub 3 hControl 2: scrub with Deionized water redisti 3 hControl 1: without scrub 24 hControl 2: scrub with Deionized water redisti 24 h
Whole Group of 135 Units of Measurement4802162889628896

Evaluate the Residual Effect of Chlorhexidine 2% / Isopropyl Alcohol 70% Administered Topically

"135 determinations to evaluate residual effect of 2% chlorhexidine in 70% isopropyl alcohol.~All volunteers was provided with a neutral soap without antiseptics for use of two weeks. 2% chlorhexidine in 70% isopropyl alcohol was tested. Were prepared the skin area of 25 cm2 randomly selected. The solution remained on the skin for 60s, 3h and 24h, everyone on different days.~Cultures was taken with a scrub-cup of 5 cm2 pressed over the skin, added a 3 mL of culture broth. The skin was scrub with a sterile rubber policeman for 1 minute and the procedure conducted once again. Both aliquots came together in a sterile tube, a sample of 50 microliters were spread in a plate containing a neutralizing agar and were incubated at 35°C for 24 h." (NCT01762904)
Timeframe: 24 hours

Intervention(CFU/cm2) (Median)
0 h3 h24 h
Whole Group of 135 Units of Measurement244824

Evaluate the Residual Effect of Triclosan 1% / Isopropyl Alcohol 70% Administered Topically.

"135 determinations to test 1% triclosan in 70% isopropyl alcohol.~All volunteers was provided with a neutral soap without antiseptics for use of two weeks. 1% triclosan in 70% isopropyl alcohol was tested. Were prepared the skin area of 25 cm2 randomly selected. The solution remained on the skin for 60s, 3h and 24h, everyone on different days.~Cultures was taken with a scrub-cup of 5 cm2 pressed over the skin, added a 3 mL of culture broth. The skin was scrub with a sterile rubber policeman for 1 minute and the procedure conducted once again. Both aliquots came together in a sterile tube, a sample of 50 microliters were spread in a plate containing a neutralizing agar and were incubated at 35°C for 24 h." (NCT01762904)
Timeframe: 24 hours

Intervention(CFU/cm2) (Median)
0 h3 h24 h
Whole Group of 135 Units of Measurement484896

Reviews

1 review available for triclosan and Allergic Reaction

ArticleYear
Maternal bisphenol A and triclosan exposure and allergic diseases in childhood: a meta-analysis of cohort studies.
    Environmental science and pollution research international, 2022, Volume: 29, Issue:55

    Topics: Benzhydryl Compounds; Child; Cohort Studies; Female; Humans; Hypersensitivity; Maternal Exposure; Pr

2022

Other Studies

17 other studies available for triclosan and Allergic Reaction

ArticleYear
Exposure to the anti-microbial chemical triclosan disrupts keratinocyte function and skin integrity in a model of reconstructed human epidermis.
    Journal of immunotoxicology, 2023, Volume: 20, Issue:1

    Topics: Animals; Cell Differentiation; Cytokines; Epidermis; Humans; Hypersensitivity; Keratinocytes; Mice;

2023
Exposure to the anti-microbial chemical triclosan disrupts keratinocyte function and skin integrity in a model of reconstructed human epidermis.
    Journal of immunotoxicology, 2023, Volume: 20, Issue:1

    Topics: Animals; Cell Differentiation; Cytokines; Epidermis; Humans; Hypersensitivity; Keratinocytes; Mice;

2023
Exposure to the anti-microbial chemical triclosan disrupts keratinocyte function and skin integrity in a model of reconstructed human epidermis.
    Journal of immunotoxicology, 2023, Volume: 20, Issue:1

    Topics: Animals; Cell Differentiation; Cytokines; Epidermis; Humans; Hypersensitivity; Keratinocytes; Mice;

2023
Exposure to the anti-microbial chemical triclosan disrupts keratinocyte function and skin integrity in a model of reconstructed human epidermis.
    Journal of immunotoxicology, 2023, Volume: 20, Issue:1

    Topics: Animals; Cell Differentiation; Cytokines; Epidermis; Humans; Hypersensitivity; Keratinocytes; Mice;

2023
Topical Application of the Antimicrobial Agent Triclosan Induces NLRP3 Inflammasome Activation and Mitochondrial Dysfunction.
    Toxicological sciences : an official journal of the Society of Toxicology, 2020, 07-01, Volume: 176, Issue:1

    Topics: Animals; Anti-Infective Agents; Carrier Proteins; Hypersensitivity; Inflammasomes; Macrophages; Memb

2020
Effect of triclosan on the pathogenesis of allergic diseases among children.
    Journal of exposure science & environmental epidemiology, 2022, Volume: 32, Issue:1

    Topics: Asthma; Child; Child, Preschool; Dermatitis, Atopic; Humans; Hypersensitivity; Immunoglobulin E; Mal

2022
Prenatal and early-life triclosan and paraben exposure and allergic outcomes.
    The Journal of allergy and clinical immunology, 2018, Volume: 142, Issue:1

    Topics: Child, Preschool; Cross-Sectional Studies; Female; Humans; Hypersensitivity; Longitudinal Studies; M

2018
Topical application of the anti-microbial chemical triclosan induces immunomodulatory responses through the S100A8/A9-TLR4 pathway.
    Journal of immunotoxicology, 2017, Volume: 14, Issue:1

    Topics: Administration, Topical; Allergens; Animals; Anti-Infective Agents; Antibodies, Blocking; Calgranuli

2017
Research provides new insights on how hygiene affects asthma and allergies.
    JAMA, 2011, Apr-13, Volume: 305, Issue:14

    Topics: Anti-Infective Agents; Asthma; Bacteria; Environmental Exposure; Fungi; Humans; Hygiene; Hypersensit

2011
Triclosan exposure and allergic sensitization in Norwegian children.
    Allergy, 2013, Volume: 68, Issue:1

    Topics: Allergens; Asthma; Child; Environmental Exposure; Female; Humans; Hypersensitivity; Immunoglobulin E

2013
Exposure to triclosan augments the allergic response to ovalbumin in a mouse model of asthma.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 132, Issue:1

    Topics: Administration, Cutaneous; Animals; Anti-Infective Agents; Asthma; Bronchoalveolar Lavage Fluid; Dis

2013
The allergic basis of Fiedler's myocarditis; with discussion of two case histories.
    Geriatrics, 1957, Volume: 12, Issue:8

    Topics: Humans; Hypersensitivity; Immune System Diseases; Myocarditis; Triclosan

1957
The etiology of anaphylactic shock; the basis for drug therapy in allergic individuals.
    The South Dakota journal of medicine and pharmacy, 1959, Volume: 12, Issue:1

    Topics: Anaphylaxis; Humans; Hypersensitivity; Immune System Diseases; Triclosan

1959
AN ALLERGIC BASIS FOR NON-SPECIFIC URETHRITIS.
    The British journal of venereal diseases, 1965, Volume: 41

    Topics: Antigen-Antibody Reactions; Humans; Hypersensitivity; Skin Tests; Triclosan; Urethritis

1965
[The pathophysiological basis of the allergy doctrine].
    Zeitschrift fur Laryngologie, Rhinologie, Otologie und ihre Grenzgebiete, 1955, Volume: 34, Issue:1

    Topics: Hypersensitivity; Immune System Diseases; Triclosan

1955
Theoretical basis for allergic reations.
    Research publications - Association for Research in Nervous and Mental Disease, 1962, Volume: 39

    Topics: Humans; Hypersensitivity; Immune System Diseases; Triclosan

1962
The allergic basis of certain otorhinolaryngologic complaints.
    The New Orleans medical and surgical journal, 1951, Volume: 103, Issue:7

    Topics: Humans; Hypersensitivity; Immune System Diseases; Triclosan

1951
The case for histamine as the basis of allergic reactions; attempts at its neutralization.
    Pennsylvania medical journal (1928), 1951, Volume: 54, Issue:4

    Topics: Histamine; Humans; Hypersensitivity; Immune System Diseases; Triclosan

1951
The experimental basis of antihistaminic therapy.
    Practica oto-rhino-laryngologica, 1949, Volume: 11, Issue:1

    Topics: Anaphylaxis; Histamine; Hypersensitivity; Immune System Diseases; Otolaryngology; Triclosan

1949
Antibacterial household products: cause for concern.
    Emerging infectious diseases, 2001, Volume: 7, Issue:3 Suppl

    Topics: Anti-Infective Agents, Local; Bacteria; Bacterial Infections; Drug Resistance, Microbial; Household

2001