trichostatin-a and Long-QT-Syndrome

trichostatin-a has been researched along with Long-QT-Syndrome* in 1 studies

Other Studies

1 other study(ies) available for trichostatin-a and Long-QT-Syndrome

Article	Year
Changes in cardiac Nav1.5 expression, function, and acetylation by pan-histone deacetylase inhibitors. American journal of physiology. Heart and circulatory physiology, 2016, 11-01, Volume: 311, Issue:5 Histone deacetylase (HDAC) inhibitors are small molecule anticancer therapeutics that exhibit limiting cardiotoxicities including QT interval prolongation and life-threatening cardiac arrhythmias. Because the molecular mechanisms for HDAC inhibitor-induced cardiotoxicity are poorly understood, we performed whole cell patch voltage-clamp experiments to measure cardiac sodium currents (I Topics: Animals; Animals, Newborn; Arrhythmias, Cardiac; Blotting, Western; Depsipeptides; Gap Junctions; Heart Ventricles; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Immunoprecipitation; Induced Pluripotent Stem Cells; Long QT Syndrome; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Real-Time Polymerase Chain Reaction; Vorinostat	2016

Article

Year

Changes in cardiac Nav1.5 expression, function, and acetylation by pan-histone deacetylase inhibitors.

American journal of physiology. Heart and circulatory physiology, 2016, 11-01, Volume: 311, Issue:5

Histone deacetylase (HDAC) inhibitors are small molecule anticancer therapeutics that exhibit limiting cardiotoxicities including QT interval prolongation and life-threatening cardiac arrhythmias. Because the molecular mechanisms for HDAC inhibitor-induced cardiotoxicity are poorly understood, we performed whole cell patch voltage-clamp experiments to measure cardiac sodium currents (I

Topics: Animals; Animals, Newborn; Arrhythmias, Cardiac; Blotting, Western; Depsipeptides; Gap Junctions; Heart Ventricles; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Immunoprecipitation; Induced Pluripotent Stem Cells; Long QT Syndrome; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Real-Time Polymerase Chain Reaction; Vorinostat

2016