trichostatin-a has been researched along with Demyelinating-Diseases* in 1 studies
1 other study(ies) available for trichostatin-a and Demyelinating-Diseases
| Article | Year |
|---|---|
In vivo conversion of astrocytes to oligodendrocyte lineage cells using chemicals: targeting gliosis for myelin repair.
It would be clinically ideal to target astrocytes in vivo for conversion into oligodendrocyte lineage cells to reduce astrogliosis and generate new myelinating cells.. Here, we prepared a GFP-labeled human astrocyte cell line, treated with epigenetic modifiers trichostatin A or 5-azacytidine and transplanted them into cuprizone-induced demyelinated mice brains. The fate of the transplanted astrocytes was studied at days 7, 14 and 28 post-transplantation.. GFP. These findings seem promising for the application of epigenetic modifiers, especially their targeted delivery to glial scars to treat demyelinating diseases. Topics: Animals; Astrocytes; Azacitidine; Brain; Cell Differentiation; Cell Lineage; Cell Transplantation; Cellular Reprogramming Techniques; Demyelinating Diseases; Epigenomics; Gliosis; Humans; Hydroxamic Acids; Male; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia | 2018 |