trichodermamide-a and Colonic-Neoplasms

Trichodermamides A (1) and B (2), two modified dipeptides, have been isolated from cultures of the marine-derived fungus Trichoderma virens. The trichodermamides possess a rare cyclic O-alkyl-oxime functionality incorporated into a six-membered ring. The structure of trichodermamide B was established by X-ray diffraction analysis, while the structure assignment of trichodermamide A, and determination of the absolute stereochemistry, was accomplished by spectral and chemical methods. Trichodermamide B displayed significant in vitro cytotoxicity against HCT-116 human colon carcinoma with an IC(50) of 0.32 microg/mL.

Topics: Antineoplastic Agents; Colonic Neoplasms; Crystallography, X-Ray; Dipeptides; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Molecular Structure; Papua New Guinea; Stereoisomerism; Trichoderma; Tumor Cells, Cultured